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Western blot
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ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [66]
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- Western blot [6]
- Immunohistochemistry [1]
- Flow cytometry [1]
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- Product number
- ABIN151071 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Egl Nine Homolog 1 (C. Elegans) (EGLN1) (AA 1-50) antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified
- Reactivity
- Human, Mouse, Rat, Simian
- Host
- Rabbit
- Epitope
- AA 1-50
- Vial size
- 0.1 mg
- Storage
- Store at 4°C. Do not freeze.
- Handling
- Do not freeze.
Submitted references Hypoxia-stimulated membrane trafficking requires T-plastin.
The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels.
Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.
A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity.
Androgen Receptor-Mediated Genomic Androgen Action Augments Ischemia-Induced Neovascularization.
Prolyl hydroxylase-2 inhibits liver tumor cell proliferation and cyclin D1 expression in a hydroxylase-dependent manner.
Prolyl-4-Hydroxylase 2 Potentially Contributes to Hepatocellular Carcinoma-Associated Erythrocytosis by Maintaining Hepatocyte Nuclear Factor-4α Expression.
Myeloid translocation gene-16 co-repressor promotes degradation of hypoxia-inducible factor 1.
Overexpression of hypoxia-inducible factor prolyl hydoxylase-2 attenuates hypoxia-induced vascular endothelial growth factor expression in luteal cells.
Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult.
Prolyl-4-hydroxylase domain protein 2 controls NF-κB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus.
Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27.
Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo.
Methylene blue-induced neuronal protective mechanism against hypoxia-reoxygenation stress.
Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR.
Endothelin-1 regulates hypoxia-inducible factor-1α and -2α stability through prolyl hydroxylase domain 2 inhibition in human lymphatic endothelial cells.
Chronic hypoxemia in late gestation decreases cardiomyocyte number but does not change expression of hypoxia-responsive genes.
Prolyl-4-hydroxylase 2 enhances hypoxia-induced glioblastoma cell death by regulating the gene expression of hypoxia-inducible factor-α.
High-density lipoproteins augment hypoxia-induced angiogenesis via regulation of post-translational modulation of hypoxia-inducible factor 1α.
Silencing of HIF prolyl-hydroxylase 2 gene in the renal medulla attenuates salt-sensitive hypertension in Dahl S rats.
Negative regulation of HIF in skeletal muscle of elite endurance athletes: a tentative mechanism promoting oxidative metabolism.
Prolyl-4-hydroxylase 3 (PHD3) expression is downregulated during epithelial-to-mesenchymal transition.
Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer.
Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1α in a p53-independent manner.
Hypoxia-inducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial-mesenchymal transition in renal tubular cells.
Knockdown of prolyl-4-hydroxylase domain 2 inhibits tumor growth of human breast cancer MDA-MB-231 cells by affecting TGF-β1 processing.
Investigation of possible endogenous hypoxia markers in colorectal cancer.
Dysregulation of hypoxia-inducible factor by presenilin/γ-secretase loss-of-function mutations.
Prolyl hydroxylase domain 2 protein is a strong prognostic marker in human gastric cancer.
Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells.
BMP2 sensitizes glioblastoma stem-like cells to Temozolomide by affecting HIF-1α stability and MGMT expression.
Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1α activity in hypoxia.
Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling.
Role of reactive oxygen species in the regulation of HIF-1 by prolyl hydroxylase 2 under mild hypoxia.
Some causes of the variable shape of flocks of birds.
Prolyl hydroxylase PHD3 enhances the hypoxic survival and G1 to S transition of carcinoma cells.
Activation of the HIF prolyl hydroxylase by the iron chaperones PCBP1 and PCBP2.
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.
Hypoxia-inducible factor-1α contributes to the profibrotic action of angiotensin II in renal medullary interstitial cells.
Prolyl-4-hydroxylase PHD2- and hypoxia-inducible factor 2-dependent regulation of amphiregulin contributes to breast tumorigenesis.
Inactivation of prolyl hydroxylase domain (PHD) protein by epigallocatechin (EGCG) stabilizes hypoxia-inducible factor (HIF-1α) and induces hepcidin (Hamp) in rat kidney.
Induction of hypoxia inducible factor (HIF-1α) in rat kidneys by iron chelation with the hydroxypyridinone, CP94.
The function of hypoxia-inducible factor (HIF) is independent of the endoplasmic reticulum protein OS-9.
MVPA is associated with lower weight gain in 8-10 year old children: a prospective study with 1 year follow-up.
Prolyl hydroxylase domain (PHD) 2 affects cell migration and F-actin formation via RhoA/rho-associated kinase-dependent cofilin phosphorylation.
Increased chemoresistance induced by inhibition of HIF-prolyl-hydroxylase domain enzymes.
Retention of prolyl hydroxylase PHD2 in the cytoplasm prevents PHD2-induced anchorage-independent carcinoma cell growth.
Expression of the cellular oxygen sensor PHD2 (EGLN-1) predicts radiation sensitivity in squamous cell cancer of the head and neck.
Prolyl hydroxylase 2 deficiency limits proliferation of vascular smooth muscle cells by hypoxia-inducible factor-1{alpha}-dependent mechanisms.
Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment.
Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response.
Prolyl hydroxylase PHD3 activates oxygen-dependent protein aggregation.
Glutamate receptor dynamics in dendritic microdomains.
The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability.
Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys.
Mucin 1 oncoprotein blocks hypoxia-inducible factor 1alpha activation in a survival response to hypoxia.
Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways.
Dynamic HIF1A regulation during human placental development.
Immunodetection of human telomerase reverse-transcriptase (hTERT) re-appraised: nucleolin and telomerase cross paths.
Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness.
Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression.
Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung.
Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway.
Endogenous 2-oxoacids differentially regulate expression of oxygen sensors.
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor.
A conserved family of prolyl-4-hydroxylases that modify HIF.
Wottawa M, Naas S, Böttger J, van Belle GJ, Möbius W, Revelo NH, Heidenreich D, von Ahlen M, Zieseniss A, Kröhnert K, Lutz S, Lenz C, Urlaub H, Rizzoli SO, Katschinski DM
Acta physiologica (Oxford, England) 2017 Sep;221(1):59-73
Acta physiologica (Oxford, England) 2017 Sep;221(1):59-73
The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels.
Miles AL, Burr SP, Grice GL, Nathan JA
eLife 2017 Mar 15;6
eLife 2017 Mar 15;6
Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.
Burr SP, Costa AS, Grice GL, Timms RT, Lobb IT, Freisinger P, Dodd RB, Dougan G, Lehner PJ, Frezza C, Nathan JA
Cell metabolism 2016 Nov 8;24(5):740-752
Cell metabolism 2016 Nov 8;24(5):740-752
A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity.
Mysore VS, Szablowski J, Dervan PB, Frost PJ
Molecular cancer research : MCR 2016 Mar;14(3):253-66
Molecular cancer research : MCR 2016 Mar;14(3):253-66
Androgen Receptor-Mediated Genomic Androgen Action Augments Ischemia-Induced Neovascularization.
Lam YT, Lecce L, Tan JT, Bursill CA, Handelsman DJ, Ng MK
Endocrinology 2016 Dec;157(12):4853-4864
Endocrinology 2016 Dec;157(12):4853-4864
Prolyl hydroxylase-2 inhibits liver tumor cell proliferation and cyclin D1 expression in a hydroxylase-dependent manner.
Tao Y, Lin F, Li R, Shen J, Wang Z
The international journal of biochemistry & cell biology 2016 Aug;77(Pt A):129-140
The international journal of biochemistry & cell biology 2016 Aug;77(Pt A):129-140
Prolyl-4-Hydroxylase 2 Potentially Contributes to Hepatocellular Carcinoma-Associated Erythrocytosis by Maintaining Hepatocyte Nuclear Factor-4α Expression.
Sun W, Kosyna FK, Jelkmann W, Depping R
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015;37(6):2257-64
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015;37(6):2257-64
Myeloid translocation gene-16 co-repressor promotes degradation of hypoxia-inducible factor 1.
Kumar P, Gullberg U, Olsson I, Ajore R
PloS one 2015;10(5):e0123725
PloS one 2015;10(5):e0123725
Overexpression of hypoxia-inducible factor prolyl hydoxylase-2 attenuates hypoxia-induced vascular endothelial growth factor expression in luteal cells.
Zhang Z, Pang X, Tang Z, Yin D, Wang Z
Molecular medicine reports 2015 Sep;12(3):3809-3814
Molecular medicine reports 2015 Sep;12(3):3809-3814
Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult.
Vogler M, Zieseniss A, Hesse AR, Levent E, Tiburcy M, Heinze E, Burzlaff N, Schley G, Eckardt KU, Willam C, Katschinski DM
Pflugers Archiv : European journal of physiology 2015 Oct;467(10):2141-9
Pflugers Archiv : European journal of physiology 2015 Oct;467(10):2141-9
Prolyl-4-hydroxylase domain protein 2 controls NF-κB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus.
Li J, Yuan W, Jiang S, Ye W, Yang H, Shapiro IM, Risbud MV
The Journal of biological chemistry 2015 Mar 13;290(11):7195-207
The Journal of biological chemistry 2015 Mar 13;290(11):7195-207
Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27.
Högel H, Miikkulainen P, Bino L, Jaakkola PM
Molecular cancer 2015 Jul 30;14:143
Molecular cancer 2015 Jul 30;14:143
Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo.
Hsiao HW, Hsu TS, Liu WH, Hsieh WC, Chou TF, Wu YJ, Jiang ST, Lai MZ
Nature communications 2015 Feb 19;6:6353
Nature communications 2015 Feb 19;6:6353
Methylene blue-induced neuronal protective mechanism against hypoxia-reoxygenation stress.
Ryou MG, Choudhury GR, Li W, Winters A, Yuan F, Liu R, Yang SH
Neuroscience 2015 Aug 20;301:193-203
Neuroscience 2015 Aug 20;301:193-203
Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR.
Henze AT, Garvalov BK, Seidel S, Cuesta AM, Ritter M, Filatova A, Foss F, Dopeso H, Essmann CL, Maxwell PH, Reifenberger G, Carmeliet P, Acker-Palmer A, Acker T
Nature communications 2014 Nov 25;5:5582
Nature communications 2014 Nov 25;5:5582
Endothelin-1 regulates hypoxia-inducible factor-1α and -2α stability through prolyl hydroxylase domain 2 inhibition in human lymphatic endothelial cells.
Caprara V, Scappa S, Garrafa E, Di Castro V, Rosanò L, Bagnato A, Spinella F
Life sciences 2014 Nov 24;118(2):185-90
Life sciences 2014 Nov 24;118(2):185-90
Chronic hypoxemia in late gestation decreases cardiomyocyte number but does not change expression of hypoxia-responsive genes.
Botting KJ, McMillen IC, Forbes H, Nyengaard JR, Morrison JL
Journal of the American Heart Association 2014 Jul 28;3(4)
Journal of the American Heart Association 2014 Jul 28;3(4)
Prolyl-4-hydroxylase 2 enhances hypoxia-induced glioblastoma cell death by regulating the gene expression of hypoxia-inducible factor-α.
Sun W, Jelkmann W, Depping R
Cell death & disease 2014 Jul 10;5:e1322
Cell death & disease 2014 Jul 10;5:e1322
High-density lipoproteins augment hypoxia-induced angiogenesis via regulation of post-translational modulation of hypoxia-inducible factor 1α.
Tan JT, Prosser HC, Vanags LZ, Monger SA, Ng MK, Bursill CA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Jan;28(1):206-17
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Jan;28(1):206-17
Silencing of HIF prolyl-hydroxylase 2 gene in the renal medulla attenuates salt-sensitive hypertension in Dahl S rats.
Zhu Q, Hu J, Han WQ, Zhang F, Li PL, Wang Z, Li N
American journal of hypertension 2014 Jan;27(1):107-13
American journal of hypertension 2014 Jan;27(1):107-13
Negative regulation of HIF in skeletal muscle of elite endurance athletes: a tentative mechanism promoting oxidative metabolism.
Lindholm ME, Fischer H, Poellinger L, Johnson RS, Gustafsson T, Sundberg CJ, Rundqvist H
American journal of physiology. Regulatory, integrative and comparative physiology 2014 Aug 1;307(3):R248-55
American journal of physiology. Regulatory, integrative and comparative physiology 2014 Aug 1;307(3):R248-55
Prolyl-4-hydroxylase 3 (PHD3) expression is downregulated during epithelial-to-mesenchymal transition.
Place TL, Nauseef JT, Peterson MK, Henry MD, Mezhir JJ, Domann FE
PloS one 2013;8(12):e83021
PloS one 2013;8(12):e83021
Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer.
Rawluszko AA, Bujnicka KE, Horbacka K, Krokowicz P, Jagodziński PP
BMC cancer 2013 Nov 6;13:526
BMC cancer 2013 Nov 6;13:526
Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1α in a p53-independent manner.
Wu S, Kasim V, Kano MR, Tanaka S, Ohba S, Miura Y, Miyata K, Liu X, Matsuhashi A, Chung UI, Yang L, Kataoka K, Nishiyama N, Miyagishi M
Cancer research 2013 Mar 15;73(6):1787-99
Cancer research 2013 Mar 15;73(6):1787-99
Hypoxia-inducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial-mesenchymal transition in renal tubular cells.
Han WQ, Zhu Q, Hu J, Li PL, Zhang F, Li N
Biochimica et biophysica acta 2013 Jun;1833(6):1454-62
Biochimica et biophysica acta 2013 Jun;1833(6):1454-62
Knockdown of prolyl-4-hydroxylase domain 2 inhibits tumor growth of human breast cancer MDA-MB-231 cells by affecting TGF-β1 processing.
Wottawa M, Leisering P, Ahlen Mv, Schnelle M, Vogel S, Malz C, Bordoli MR, Camenisch G, Hesse A, Napp J, Alves F, Kristiansen G, Farhat K, Katschinski DM
International journal of cancer 2013 Jun 15;132(12):2787-98
International journal of cancer 2013 Jun 15;132(12):2787-98
Investigation of possible endogenous hypoxia markers in colorectal cancer.
Verstraete M, Debucquoy A, Devos E, Sagaert X, Penninckx F, Begg A, Haustermans K
International journal of radiation biology 2013 Jan;89(1):9-15
International journal of radiation biology 2013 Jan;89(1):9-15
Dysregulation of hypoxia-inducible factor by presenilin/γ-secretase loss-of-function mutations.
Kaufmann MR, Barth S, Konietzko U, Wu B, Egger S, Kunze R, Marti HH, Hick M, Müller U, Camenisch G, Wenger RH
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Jan 30;33(5):1915-26
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Jan 30;33(5):1915-26
Prolyl hydroxylase domain 2 protein is a strong prognostic marker in human gastric cancer.
Kamphues C, Wittschieber D, Klauschen F, Kasajima A, Dietel M, Schmidt SC, Glanemann M, Bahra M, Neuhaus P, Weichert W, Stenzinger A
Pathobiology : journal of immunopathology, molecular and cellular biology 2012;79(1):11-7
Pathobiology : journal of immunopathology, molecular and cellular biology 2012;79(1):11-7
Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells.
De Saedeleer CJ, Copetti T, Porporato PE, Verrax J, Feron O, Sonveaux P
PloS one 2012;7(10):e46571
PloS one 2012;7(10):e46571
BMP2 sensitizes glioblastoma stem-like cells to Temozolomide by affecting HIF-1α stability and MGMT expression.
Persano L, Pistollato F, Rampazzo E, Della Puppa A, Abbadi S, Frasson C, Volpin F, Indraccolo S, Scienza R, Basso G
Cell death & disease 2012 Oct 18;3:e412
Cell death & disease 2012 Oct 18;3:e412
Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1α activity in hypoxia.
Fujita N, Markova D, Anderson DG, Chiba K, Toyama Y, Shapiro IM, Risbud MV
The Journal of biological chemistry 2012 May 11;287(20):16975-86
The Journal of biological chemistry 2012 May 11;287(20):16975-86
Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling.
Wollenick K, Hu J, Kristiansen G, Schraml P, Rehrauer H, Berchner-Pfannschmidt U, Fandrey J, Wenger RH, Stiehl DP
Nucleic acids research 2012 Mar;40(5):1928-43
Nucleic acids research 2012 Mar;40(5):1928-43
Role of reactive oxygen species in the regulation of HIF-1 by prolyl hydroxylase 2 under mild hypoxia.
Niecknig H, Tug S, Reyes BD, Kirsch M, Fandrey J, Berchner-Pfannschmidt U
Free radical research 2012 Jun;46(6):705-17
Free radical research 2012 Jun;46(6):705-17
Some causes of the variable shape of flocks of birds.
Hemelrijk CK, Hildenbrandt H
PloS one 2011;6(8):e22479
PloS one 2011;6(8):e22479
Prolyl hydroxylase PHD3 enhances the hypoxic survival and G1 to S transition of carcinoma cells.
Högel H, Rantanen K, Jokilehto T, Grenman R, Jaakkola PM
PloS one 2011;6(11):e27112
PloS one 2011;6(11):e27112
Activation of the HIF prolyl hydroxylase by the iron chaperones PCBP1 and PCBP2.
Nandal A, Ruiz JC, Subramanian P, Ghimire-Rijal S, Sinnamon RA, Stemmler TL, Bruick RK, Philpott CC
Cell metabolism 2011 Nov 2;14(5):647-57
Cell metabolism 2011 Nov 2;14(5):647-57
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.
Luo W, Hu H, Chang R, Zhong J, Knabel M, O'Meally R, Cole RN, Pandey A, Semenza GL
Cell 2011 May 27;145(5):732-44
Cell 2011 May 27;145(5):732-44
Hypoxia-inducible factor-1α contributes to the profibrotic action of angiotensin II in renal medullary interstitial cells.
Wang Z, Tang L, Zhu Q, Yi F, Zhang F, Li PL, Li N
Kidney international 2011 Feb;79(3):300-10
Kidney international 2011 Feb;79(3):300-10
Prolyl-4-hydroxylase PHD2- and hypoxia-inducible factor 2-dependent regulation of amphiregulin contributes to breast tumorigenesis.
Bordoli MR, Stiehl DP, Borsig L, Kristiansen G, Hausladen S, Schraml P, Wenger RH, Camenisch G
Oncogene 2011 Feb 3;30(5):548-60
Oncogene 2011 Feb 3;30(5):548-60
Inactivation of prolyl hydroxylase domain (PHD) protein by epigallocatechin (EGCG) stabilizes hypoxia-inducible factor (HIF-1α) and induces hepcidin (Hamp) in rat kidney.
Manalo DJ, Baek JH, Buehler PW, Struble E, Abraham B, Alayash AI
Biochemical and biophysical research communications 2011 Dec 16;416(3-4):421-6
Biochemical and biophysical research communications 2011 Dec 16;416(3-4):421-6
Induction of hypoxia inducible factor (HIF-1α) in rat kidneys by iron chelation with the hydroxypyridinone, CP94.
Baek JH, Reiter CE, Manalo DJ, Buehler PW, Hider RC, Alayash AI
Biochimica et biophysica acta 2011 Apr-Jun;1809(4-6):262-8
Biochimica et biophysica acta 2011 Apr-Jun;1809(4-6):262-8
The function of hypoxia-inducible factor (HIF) is independent of the endoplasmic reticulum protein OS-9.
Brockmeier U, Platzek C, Schneider K, Patak P, Bernardini A, Fandrey J, Metzen E
PloS one 2011 Apr 29;6(4):e19151
PloS one 2011 Apr 29;6(4):e19151
MVPA is associated with lower weight gain in 8-10 year old children: a prospective study with 1 year follow-up.
Fisher A, Hill C, Webber L, Purslow L, Wardle J
PloS one 2011 Apr 28;6(4):e18576
PloS one 2011 Apr 28;6(4):e18576
Prolyl hydroxylase domain (PHD) 2 affects cell migration and F-actin formation via RhoA/rho-associated kinase-dependent cofilin phosphorylation.
Vogel S, Wottawa M, Farhat K, Zieseniss A, Schnelle M, Le-Huu S, von Ahlen M, Malz C, Camenisch G, Katschinski DM
The Journal of biological chemistry 2010 Oct 29;285(44):33756-63
The Journal of biological chemistry 2010 Oct 29;285(44):33756-63
Increased chemoresistance induced by inhibition of HIF-prolyl-hydroxylase domain enzymes.
Brökers N, Le-Huu S, Vogel S, Hagos Y, Katschinski DM, Kleinschmidt M
Cancer science 2010 Jan;101(1):129-36
Cancer science 2010 Jan;101(1):129-36
Retention of prolyl hydroxylase PHD2 in the cytoplasm prevents PHD2-induced anchorage-independent carcinoma cell growth.
Jokilehto T, Högel H, Heikkinen P, Rantanen K, Elenius K, Sundström J, Jaakkola PM
Experimental cell research 2010 Apr 15;316(7):1169-78
Experimental cell research 2010 Apr 15;316(7):1169-78
Expression of the cellular oxygen sensor PHD2 (EGLN-1) predicts radiation sensitivity in squamous cell cancer of the head and neck.
Luukkaa M, Jokilehto T, Kronqvist P, Vahlberg T, Grénman R, Jaakkola P, Minn H
International journal of radiation biology 2009;85(10):900-8
International journal of radiation biology 2009;85(10):900-8
Prolyl hydroxylase 2 deficiency limits proliferation of vascular smooth muscle cells by hypoxia-inducible factor-1{alpha}-dependent mechanisms.
Schultz K, Murthy V, Tatro JB, Beasley D
American journal of physiology. Lung cellular and molecular physiology 2009 Jun;296(6):L921-7
American journal of physiology. Lung cellular and molecular physiology 2009 Jun;296(6):L921-7
Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment.
Chan DA, Kawahara TL, Sutphin PD, Chang HY, Chi JT, Giaccia AJ
Cancer cell 2009 Jun 2;15(6):527-38
Cancer cell 2009 Jun 2;15(6):527-38
Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response.
Aprelikova O, Pandolfi S, Tackett S, Ferreira M, Salnikow K, Ward Y, Risinger JI, Barrett JC, Niederhuber J
Cancer research 2009 Jan 15;69(2):616-24
Cancer research 2009 Jan 15;69(2):616-24
Prolyl hydroxylase PHD3 activates oxygen-dependent protein aggregation.
Rantanen K, Pursiheimo J, Högel H, Himanen V, Metzen E, Jaakkola PM
Molecular biology of the cell 2008 May;19(5):2231-40
Molecular biology of the cell 2008 May;19(5):2231-40
Glutamate receptor dynamics in dendritic microdomains.
Newpher TM, Ehlers MD
Neuron 2008 May 22;58(4):472-97
Neuron 2008 May 22;58(4):472-97
The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability.
Barth S, Nesper J, Hasgall PA, Wirthner R, Nytko KJ, Edlich F, Katschinski DM, Stiehl DP, Wenger RH, Camenisch G
Molecular and cellular biology 2007 May;27(10):3758-68
Molecular and cellular biology 2007 May;27(10):3758-68
Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys.
Li N, Yi F, Sundy CM, Chen L, Hilliker ML, Donley DK, Muldoon DB, Li PL
American journal of physiology. Renal physiology 2007 Jan;292(1):F207-16
American journal of physiology. Renal physiology 2007 Jan;292(1):F207-16
Mucin 1 oncoprotein blocks hypoxia-inducible factor 1alpha activation in a survival response to hypoxia.
Yin L, Kharbanda S, Kufe D
The Journal of biological chemistry 2007 Jan 5;282(1):257-66
The Journal of biological chemistry 2007 Jan 5;282(1):257-66
Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways.
Elvidge GP, Glenny L, Appelhoff RJ, Ratcliffe PJ, Ragoussis J, Gleadle JM
The Journal of biological chemistry 2006 Jun 2;281(22):15215-26
The Journal of biological chemistry 2006 Jun 2;281(22):15215-26
Dynamic HIF1A regulation during human placental development.
Ietta F, Wu Y, Winter J, Xu J, Wang J, Post M, Caniggia I
Biology of reproduction 2006 Jul;75(1):112-21
Biology of reproduction 2006 Jul;75(1):112-21
Immunodetection of human telomerase reverse-transcriptase (hTERT) re-appraised: nucleolin and telomerase cross paths.
Wu YL, Dudognon C, Nguyen E, Hillion J, Pendino F, Tarkanyi I, Aradi J, Lanotte M, Tong JH, Chen GQ, Ségal-Bendirdjian E
Journal of cell science 2006 Jul 1;119(Pt 13):2797-806
Journal of cell science 2006 Jul 1;119(Pt 13):2797-806
Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness.
Jokilehto T, Rantanen K, Luukkaa M, Heikkinen P, Grenman R, Minn H, Kronqvist P, Jaakkola PM
Clinical cancer research : an official journal of the American Association for Cancer Research 2006 Feb 15;12(4):1080-7
Clinical cancer research : an official journal of the American Association for Cancer Research 2006 Feb 15;12(4):1080-7
Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression.
McMahon S, Charbonneau M, Grandmont S, Richard DE, Dubois CM
The Journal of biological chemistry 2006 Aug 25;281(34):24171-81
The Journal of biological chemistry 2006 Aug 25;281(34):24171-81
Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung.
Asikainen TM, Schneider BK, Waleh NS, Clyman RI, Ho WB, Flippin LA, Günzler V, White CW
Proceedings of the National Academy of Sciences of the United States of America 2005 Jul 19;102(29):10212-7
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Proceedings of the National Academy of Sciences of the United States of America 2002 Oct 15;99(21):13459-64
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Science (New York, N.Y.) 2001 Nov 9;294(5545):1337-40
Science (New York, N.Y.) 2001 Nov 9;294(5545):1337-40
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