13129-1-AP

antibody from Proteintech Group

Targeting: NTRK2 TRKB

Provider product page for 13129-1-AP

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Immunohistochemistry

Antibody data

Antibody Data
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References [57]
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Product number: 13129-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#13129-1-AP, RRID:AB_2155156
Product name: TrkB antibody
Antibody type: Polyclonal
Description: TrkB antibody (Cat. #13129-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, pig and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat, Porcine
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

NTRK2 protein structure - 13129-1-AP shown in red.

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Frontiers in pharmacology 2024;15:1366683

Catalpol rescues LPS-induced cognitive impairment via inhibition of NF-Κb-regulated neuroinflammation and up-regulation of TrkB-mediated BDNF secretion in mice.

Hu W, Zou L, Yu N, Wu Z, Yang W, Wu T, Liu Y, Pu Y, Jiang Y, Zhang J, Zhu H, Cheng F, Feng S
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117345

Obligatory role of microglia-mobilized hippocampal CREB-BDNF signaling in the prophylactic effect of β-glucan on chronic stress-induced depression-like behaviors in mice.

Zhao C, Shi R, Lu X, Yang R, Chen Z, Chen B, Hu W, Ren J, Peng J, Zhu T, Zhu H, Huang C
European journal of pharmacology 2024 Feb 5;964:176288

Agomirs upregulating carboxypeptidase E expression rescue hippocampal neurogenesis and memory deficits in Alzheimer's disease.

Jiang D, Liu H, Li T, Zhao S, Yang K, Yao F, Zhou B, Feng H, Wang S, Shen J, Tang J, Zhang YX, Wang Y, Guo C, Tang TS
Translational neurodegeneration 2024 Apr 26;13(1):24

Body Weight Support Treadmill Training Combined With Sciatic Nerve Electrical Stimulation Ameliorating Motor Function by Enhancing PI3K/Akt Proteins Expression via BDNF/TrkB Signaling Pathway in Rats with Spinal Cord Injury.

Xu Q, Li Z, Su J, Hu M, Yin Q, Chen S, Song J, Chen H
World neurosurgery 2023 Oct;178:e239-e253

Antidepressant effects of 70% ethanolic extract of Lonicerae japonicae flos and it contained chlorogenic acid via upregulation of BDNF-TrkB pathway in the hippocampus of mice.

Qin L, Wang J, Wu X, Song L, Zhang Y, Gong M, Wang Y, Li B
Brain research bulletin 2023 Nov;204:110796

The total alkaloids of Sophora alopecuroides L. improve depression-like behavior in mice via BDNF-mediated AKT/mTOR signaling pathway.

Li J, Zhang M, Pei Y, Yang Q, Zheng L, Wang G, Sun Y, Yang W, Liu L
Journal of ethnopharmacology 2023 Nov 15;316:116723

The hippocampal FTO-BDNF-TrkB pathway is required for novel object recognition memory reconsolidation in mice.

Chang R, Zhu S, Peng J, Lang Z, Zhou X, Liao H, Zou J, Zeng P, Tan S
Translational psychiatry 2023 Nov 14;13(1):349

Prenatal alcohol exposure enhanced alcohol preference and susceptibility to PTSD in a sex-dependent manner through the synaptic HCN1 channel.

Yao H, Wang C, Xia Z
Journal of affective disorders 2023 Mar 1;324:143-152

ProBDNF Upregulation in Murine Hind Limb Ischemia Reperfusion Injury: A Driver of Inflammation.

Aby K, Antony R, Li Y
Biology 2023 Jun 24;12(7)

A whole transcriptome profiling analysis for antidepressant mechanism of Xiaoyaosan mediated synapse loss via BDNF/trkB/PI3K signal axis in CUMS rats.

Meng P, Zhang X, Liu TT, Liu J, Luo Y, Xie MX, Yang H, Fang R, Guo DW, Zhong ZY, Wang YH, Ge JW
BMC complementary medicine and therapies 2023 Jun 15;23(1):198

Modulatory effect of n-3 polyunsaturated fatty acids on depressive-like behaviors in rats with chronic sleep deprivation: potential involvement of melatonin receptor pathway and brain lipidome.

Chang CH, Wu HC, Hsieh YR, Lai WD, Tung TH, Huang JJ, Kao WY, Huang SY
Food & function 2023 Jul 3;14(13):5977-5993

BDNF/TrkB Is a Crucial Regulator in the Inflammation-Mediated Odontoblastic Differentiation of Dental Pulp Stem Cells.

Kim JH, Irfan M, Hossain MA, George A, Chung S
Cells 2023 Jul 14;12(14)

Tanshinone IIA ameliorates chronic unpredictable mild stress-induced depression-like behavior and cognitive impairment in rats through the BDNF/TrkB/GAT1 signaling pathway.

Liu SZ, Yang J, Chen LL, Wang P, Lin L
European journal of pharmacology 2023 Jan 5;938:175385

Reduced mastication during growth inhibits cognitive function by affecting trigeminal ganglia and modulating Wnt signaling pathway and ARHGAP33 molecular transmission.

Misawa-Omori E, Okihara H, Ogawa T, Abe Y, Kato C, Ishidori H, Fujita A, Kokai S, Ono T
Neuropeptides 2023 Dec;102:102370

β-glucan, a specific immuno-stimulant, produces rapid antidepressant effects by stimulating ERK1/2-dependent synthesis of BDNF in the hippocampus.

Chen B, Zhao C, Zhu H, Lu X, Liu H, Lu Q, Zhu T, Huang C
European journal of pharmacology 2023 Dec 15;961:176161

Microglial stimulation triggered by intranasal lipopolysaccharide administration produces antidepressant-like effect through ERK1/2-mediated BDNF synthesis in the hippocampus.

Ni M, Zheng M, Chen B, Lu X, Zhao H, Zhu T, Cheng L, Han H, Ye T, Liu H, Ye Y, Huang C, Yuan X
Neuropharmacology 2023 Dec 1;240:109693

The effects of acupuncture on depression by regulating BDNF-related balance via lateral habenular nucleus BDNF/TrkB/CREB signaling pathway in rats.

Tong T, Chen Y, Hao C, Shen J, Chen W, Cheng W, Yan S, Li J, Li Y, Gulizhaerkezi T, Zeng J, Meng X
Behavioural brain research 2023 Aug 5;451:114509

Dl-3-n-Butylphthalide Improves Neuroinflammation in Mice with Repeated Cerebral Ischemia-Reperfusion Injury through the Nrf2-Mediated Antioxidant Response and TLR4/MyD88/NF-κB Signaling Pathway.

Gao Y, Hu M, Niu X, Li M, Xu L, Xiao Y, Zhang J, Wang H, Li L, Chu B, Lv P
Oxidative medicine and cellular longevity 2022;2022:8652741

Effect of β-hydroxybutyrate on behavioral alterations, molecular and morphological changes in CNS of multiple sclerosis mouse model.

Sun W, Wen M, Liu M, Wang Q, Liu Q, Li L, Siebert HC, Loers G, Zhang R, Zhang N
Frontiers in aging neuroscience 2022;14:1075161

Antidepressant effect of Jujuboside A on corticosterone-induced depression in mice.

Li H, Li J, Zhang T, Xie X, Gong J
Biochemical and biophysical research communications 2022 Sep 10;620:56-62

ERK1/2-dependent BDNF synthesis and signaling is required for the antidepressant effect of microglia stimulation.

Lu X, Liu H, Cai Z, Hu Z, Ye M, Gu Y, Wang Y, Wang D, Lu Q, Shen Z, Shen X, Huang C
Brain, behavior, and immunity 2022 Nov;106:147-160

Involvement of the BDNF-TrkB-KCC2 pathway in neuropathic pain after brachial plexus avulsion.

Zhao S, Wang F, Wang L, Xu Y, Lv L, Duan W, Bai R, Meng Z, Shao X
Brain and behavior 2022 Mar;12(3):e2464

The BDNF-TrkB-CREB Signalling Pathway Is Involved in Bisphenol S-Induced Neurotoxicity in Male Mice by Regulating Methylation.

Li YZ, Wu ZY, Zhu BQ, Wang YX, Kan YQ, Zeng HC
Toxics 2022 Jul 23;10(8)

Effect of Qingyangshen glycosides on social defeat mice model.

Liu D, Wang J, Chang L, Zhu Q, Jiang N, Azhar M, Zeng G
Journal of ethnopharmacology 2022 Jul 15;293:115253

A missing piece of the puzzle in pulmonary fibrosis: anoikis resistance promotes fibroblast activation.

Yin J, Wang J, Zhang X, Liao Y, Luo W, Wang S, Ding J, Huang J, Chen M, Wang W, Fang S, Chao J
Cell & bioscience 2022 Feb 25;12(1):21

Peptide OM-LV20 promotes structural and functional recovery of spinal cord injury in rats.

Zhao J, Pang A, Yin S, Yang M, Zhang X, Zhang R, Liu J, Gu Y, Li S, Hu Y, Zhang Y, Ba Y, Meng B, Yang X
Biochemical and biophysical research communications 2022 Apr 2;598:124-130

Cbl-b modulated TrkA ubiquitination and function in the dorsal root ganglion of mice.

Chen HK, Li YZ, Ge AN, Zhu YB, Wu SJ, Bai X, Bai HH, Liu YN
European journal of pharmacology 2022 Apr 15;921:174876

Baihe Jizihuang Tang Ameliorates Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior: Integrating Network Pharmacology and Brain-Gut Axis Evaluation.

Zhu JP, Wu HY, Zi Y, Xia XB, Xie MZ, Yuan ZY
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5554363

Electroacupuncture Ameliorates Depressive-Like Behaviors in Poststroke Rats via Activating the tPA/BDNF/TrkB Pathway.

Dong H, Qin YQ, Sun YC, Yao HJ, Cheng XK, Yu Y, Lu SS
Neuropsychiatric disease and treatment 2021;17:1057-1067

Injection of Anti-proBDNF Attenuates Hippocampal-Dependent Learning and Memory Dysfunction in Mice With Sepsis-Associated Encephalopathy.

Cui YH, Zhou SF, Liu Y, Wang S, Li F, Dai RP, Hu ZL, Li CQ
Frontiers in neuroscience 2021;15:665757

Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway.

Yang Y, Yi J, Pan M, Hu B, Duan H
Drug design, development and therapy 2021;15:1409-1422

Proteomic Analysis of Emodin Treatment in Neuropathic Pain Reveals Dysfunction of the Calcium Signaling Pathway.

Chen P, Lin D, Wang C, Song C, Wang W, Qu J, Wu Z
Journal of pain research 2021;14:613-622

Synergic Neuroprotection Between Ligusticum Chuanxiong Hort and Borneol Against Ischemic Stroke by Neurogenesis via Modulating Reactive Astrogliosis and Maintaining the Blood-Brain Barrier.

Yu B, Yao Y, Zhang X, Ruan M, Zhang Z, Xu L, Liang T, Lu J
Frontiers in pharmacology 2021;12:666790

Jiedu Tongluo Granules Ameliorates Post-stroke Depression Rat Model via Regulating NMDAR/BDNF Signaling Pathway.

Zhao A, Ma B, Xu L, Yao M, Zhang Y, Xue B, Ren J, Chang D, Liu J
Frontiers in pharmacology 2021;12:662003

BDNF modulated KCC2 ubiquitylation in spinal cord dorsal horn of mice.

Ma JJ, Zhang TY, Diao XT, Yao L, Li YX, Suo ZW, Yang X, Hu XD, Liu YN
European journal of pharmacology 2021 Sep 5;906:174205

Tetrahydropalmatine Regulates BDNF through TrkB/CAM Interaction to Alleviate the Neurotoxicity Induced by Methamphetamine.

Liu L, Liu M, Zhao W, Zhao YL, Wang Y
ACS chemical neuroscience 2021 Sep 15;12(18):3373-3386

Dopamine receptor 2 downregulation and brain-derived neurotrophic factor upregulation in the paraventricular nucleus are correlated with brown adipose tissue thermogenesis in rats with bilateral substantia nigra lesions.

Zhang Y, Zhou L, Lian H, Zhang Y, Tong S, Wang Z
Journal of chemical neuroanatomy 2021 Nov;117:102016

Role of the BDNF/TrkB/CREB signaling pathway in the cytotoxicity of bisphenol S in SK-N-SH cells.

He QZ, Zhu BQ, Xu XN, Zeng HC
Journal of biochemical and molecular toxicology 2021 Jun;35(6):1-11

Effects of Compound 511 on BDNF-TrkB Signaling in the Mice Ventral Tegmental Area in Morphine-Induced Conditioned Place Preference.

Zhang H, Wang Q, Sun Q, Qin F, Nie D, Li Q, Gu Y, Jiang Y, Lu S, Lu Z
Cellular and molecular neurobiology 2021 Jul;41(5):961-975

Water treadmill training protects the integrity of the blood-spinal cord barrier following SCI via the BDNF/TrkB-CREB signalling pathway.

Ying X, Xie Q, Yu X, Li S, Wu Q, Chen X, Yue J, Zhou K, Tu W, Jiang S
Neurochemistry international 2021 Feb;143:104945

Enhanced pro-BDNF-p75NTR pathway activity in denervated skeletal muscle.

Aby K, Antony R, Eichholz M, Srinivasan R, Li Y
Life sciences 2021 Dec 1;286:120067

Perinatal exposure to BDE-47 exacerbated autistic-like behaviors and impairments of dendritic development in a valproic acid-induced rat model of autism.

Li Z, You M, Che X, Dai Y, Xu Y, Wang Y
Ecotoxicology and environmental safety 2021 Apr 1;212:112000

LMP1 promotes nasopharyngeal carcinoma metastasis through NTRK2-mediated anoikis resistance.

Li Z, Zhou Z, Wu X, Zhou Q, Liao C, Liu Y, Li D, Shen L, Feng D, Yang L
American journal of cancer research 2020;10(7):2083-2099

Alpha-synuclein is involved in manganese-induced spatial memory and synaptic plasticity impairments via TrkB/Akt/Fyn-mediated phosphorylation of NMDA receptors.

Ma Z, Liu K, Li XR, Wang C, Liu C, Yan DY, Deng Y, Liu W, Xu B
Cell death & disease 2020 Oct 8;11(10):834

Anti-Alzheimer's disease activity of secondary metabolites from Xanthoceras sorbifolia Bunge.

Li W, Lu Q, Li X, Liu H, Sun L, Lu X, Zhao Y, Liu P
Food & function 2020 Mar 1;11(3):2067-2079

Bexarotene Improve Depression-Like Behaviour in Mice by Protecting Against Neuro-inflammation and Synaptic Damage.

Yuan C, Dai C, Li Z, Zheng L, Zhao M, Dong S
Neurochemical research 2020 Jul;45(7):1500-1509

Curcumin protects rat hippocampal neurons against pseudorabies virus by regulating the BDNF/TrkB pathway.

Yang B, Luo G, Zhang C, Feng L, Luo X, Gan L
Scientific reports 2020 Dec 17;10(1):22204

Catalpol Enhances Neurogenesis And Inhibits Apoptosis Of New Neurons Via BDNF, But Not The BDNF/Trkb Pathway.

Zhu HF, Shao Y, Qin L, Wang JH, Feng S, Jiang YB, Wan D
Drug design, development and therapy 2019;13:4145-4157

Chaihu-Shugan-San and absorbed meranzin hydrate induce anti-atherosclerosis and behavioral improvements in high-fat diet ApoE(-/-) mice via anti-inflammatory and BDNF-TrkB pathway.

Li L, Yu AL, Wang ZL, Chen K, Zheng W, Zhou JJ, Xie Q, Yan HB, Ren P, Huang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108893

Hyperbaric oxygen therapy reduces apoptosis and dendritic/synaptic degeneration via the BDNF/TrkB signaling pathways in SCI rats.

Ying X, Tu W, Li S, Wu Q, Chen X, Zhou Y, Hu J, Yang G, Jiang S
Life sciences 2019 Jul 15;229:187-199

OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice.

Yuan C, Guo X, Zhou Q, Du F, Jiang W, Zhou X, Liu P, Chi T, Ji X, Gao J, Chen C, Lang H, Xu J, Liu D, Yang Y, Qiu S, Tang X, Chen G, Zou L
Biochimica et biophysica acta. Molecular basis of disease 2019 Jan;1865(1):161-180

Volatile Oil from Acorus gramineus Ameliorates the Injury Neurons in the Hippocampus of Amyloid Beta 1-42 Injected Mice.

Gao N, Liu H, Li S, Tu X, Tian S, Liu J, Li G, Ma Y
Anatomical record (Hoboken, N.J. : 2007) 2019 Dec;302(12):2261-2270

Neuroprotective effect of 1-Deoxynojirimycin on cognitive impairment, β-amyloid deposition, and neuroinflammation in the SAMP8 mice.

Chen W, Liang T, Zuo W, Wu X, Shen Z, Wang F, Li C, Zheng Y, Peng G
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Oct;106:92-97

Perinatal exposure to nonylphenol impairs dendritic outgrowth of cerebellar Purkinje cells in progeny.

You M, Gu W, Li M, Qiu Z, Li S, Jiang Z, Yao D, Xu Y, Wang Y
Chemosphere 2018 Nov;211:758-766

Activation of BDNF-TrkB signaling pathway-regulated brain inflammation in pentylenetetrazole-induced seizures in zebrafish.

Jin M, Sheng W, Han L, He Q, Ji X, Liu K
Fish & shellfish immunology 2018 Dec;83:26-36

ERK1/2-mediated disruption of BDNF-TrkB signaling causes synaptic impairment contributing to fluoride-induced developmental neurotoxicity.

Chen J, Niu Q, Xia T, Zhou G, Li P, Zhao Q, Xu C, Dong L, Zhang S, Wang A
Toxicology 2018 Dec 1;410:222-230

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The TrkB antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TrkB. This antibody recognizes human,mouse,rat antigen. The TrkB antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 13129-1-AP.pdf

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