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- Antibody Data
- Antigen structure
- References [103]
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- Product number
- 13129-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13129-1-AP, RRID:AB_2155156
- Product name
- TrkB antibody
- Antibody type
- Polyclonal
- Description
- TrkB antibody (Cat. #13129-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, pig and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat, Porcine
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Lactoferrin inhibits anoikis-resistance and metastasis of nasopharyngeal carcinoma cells via the AKT signaling pathway.
Multiscale analysis of resolvin D1 biosynthesis and its neuroprotective role in intracerebral hemorrhage.
Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4-Mediated Acute Hepatitis.
Targeting wild type NTRK decreases brain metastases of lung cancers non-driven by NTRK fusions.
Integrating neurotrophic and anti-inflammatory pathways: press-needle acupuncture as a multi-target therapy for adolescent depression.
Roudoukou-Suanzaoren Ameliorates Chronic Restraint-Induced Anxiety- and Depression-Like Behaviors in Mice via the Gut-Brain Axis.
Pan-cancer analysis of NTRK2 (TRKB) and the anticancer effect of its inhibitor Lucitanib in glioma.
New co-drugs of O-demethylvenlafaxine and NSAIDs exert antidepressant effects by alleviating inflammation, oxidative stress, and increasing neurotransmitter.
Astrocytic BDNF Modulates Sensitivity to Stress-Induced Anxiety-Like Behaviors.
Network Pharmacology Combined with Animal Models to Investigate the Mechanism of ChangPu YuJin Tang in the Treatment of Tourette Syndrome.
Proteomics of stress-induced cardiomyopathy: insights from differential expression, protein interaction networks, and functional pathway enrichment in an isoproterenol-induced TTC mouse model.
The Role of SIRT1-BDNF Signaling Pathway in Fluoride-Induced Toxicity for Glial BV-2 Cells.
Arbutin ameliorated depression by inhibiting neuroinflammation and modulating intestinal flora.
Antidepressant effects of total phenols and total saponins of Kai-Xin-San mediated by synaptic plasticity induced by BDNF/TrkB/Akt pathway.
The role of REST in regulating the BDNF/TrkB signalling pathway in nano-alumina induced cognitive dysfunction in zebrafish.
Acupuncture improves depressive-like behaviors in CUMS rats by modulating lateral habenula synaptic plasticity via the BDNF/ERK/mTOR pathway.
Early maternal separation potentiates the impact of later social isolation in inducing depressive-like behavior via oxidative stress in adult rats.
Disruption of axonal transport in Parkinson's disease: the role of pathological α-Syn and AMPK/p38 MAPK signaling.
Exercise-induced Activation of SIRT1/BDNF/mTORC1 Signaling Pathway: A Novel Mechanism to Reduce Neuroinflammation and Improve Post-stroke Depression.
Bone-brain communication mediates the amelioration of Polgonatum cyrtonema Hua polysaccharide on fatigue in chronic sleep-deprived mice.
Allium Macrostemon Bge. Attenuates the Cognitive Decline of Aging Mice by Enhancing BDNF/TrkB Pathway.
Muscone enhances synaptic function in vascular dementia through activating BDNF-TrkB-NP2 signaling pathway.
Cell type specific differences in transcriptome profiles of adipose derived stem cells and vaginal fibroblasts in patients with pelvic organ prolapse.
The SLC26A4-AS1/NTRK2 axis in breast cancer: insights into the ceRNA network and implications for prognosis and immune microenvironment.
Electroacupuncture Neural Stimulation Mitigates Bladder Dysfunction and Mechanical Allodynia in Cyclophosphamide Induced Cystitis through Downregulation of the BDNF-TrkB Signaling Pathway.
Alpha-synuclein Fibrils Inhibit Activation of the BDNF/ERK Signaling Loop in the mPFC to Induce Parkinson's Disease-like Alterations with Depression.
TSPO activation ameliorates maternal immune activation induced PV interneuron deficits via BDNF/TrkB signaling.
Deciphering the polypharmacology of Dingzhi Xiaowan against comorbid depression: Integrated metabolomics of brain tissue and network pharmacology analysis in chronic restraint stress (CRS)-LPS model.
Effects of arabinoxylan on BDNF/TrkB/p-CREB signaling pathway in the prefrontal cortex and intestinal microbiome in post-stroke depressed rats.
A new specific GluN2B partial antagonist ameliorates brain injury caused by ischemic stroke in rats.
Hippocampal SENP3 mediates chronic stress-induced depression-like behaviors by impairing the CREB-BDNF signaling.
Methamphetamine inhibits huntingtin-associated protein 1-mediated tyrosine receptor kinase B endocytosis resulting the neuroprotective dysfunction of brain-derived neurotrophic factor.
Geniposide Protects Against Myocardial Infarction Injury via the Restoration in Gut Microbiota and Gut-Brain Axis.
Jiawei Kongsheng Zhenzhong Pill (JKZP) Alleviates Chronic Cerebral Hypoperfusion-Induced Hippocampal Synaptic Damage via S100A10/tPA/BDNF Pathway.
Neuromodulatory Effects of Arecoline on Anxiety-like Behavior in Mice Exposed to Chronic Unpredictable Mild Stress.
Long-term aerobic exercise improves learning memory capacity and effects on oxidative stress levels and Keap1/Nrf2/GPX4 pathway in the hippocampus of APP/PS1 mice.
Anti-neuroinflammatory effect of hydroxytyrosol: a potential strategy for anti-depressant development.
Rice Protein Peptides Ameliorate DSS-Induced Cognitive Impairment and Depressive Behavior in Mice by Modulating Phenylalanine Metabolism and the BDNF/TRKB/CREB Pathway.
Plasma-derived exosome miR-10a-5p promotes premature ovarian failure by target BDNF via the TrkB/Akt/mTOR signaling pathway.
Yeast Extract Peptides Alleviate Depression in Chronic Restraint Stress Rats by Alleviating Hippocampal Neuronal Apoptosis and Dysbiosis of the Gut Microbiota.
MiR-204 regulates autophagy and cell viability by targeting BDNF and inhibiting the NTRK2-dependent PI3K/Akt/mTOR pathway in a human granulosa cell line exposed to bisphenol A.
Intranasal LAG3 antibody infusion induces a rapid antidepressant effect via the hippocampal ERK1/2-BDNF signaling pathway in chronically stressed mice.
Therapeutic benefits of central LH receptor agonism in the APP/PS1 AD model involve trophic and immune regulation and are reproductive status dependent.
Mecp2 Deficiency in Peripheral Sensory Neuron Improves Cognitive Function by Enhancing Hippocampal Dendritic Spine Densities in Mice.
Catalpol rescues LPS-induced cognitive impairment via inhibition of NF-Κb-regulated neuroinflammation and up-regulation of TrkB-mediated BDNF secretion in mice.
TrkB receptor interacts with mGlu(2) receptor and mediates antipsychotic-like effects of mGlu(2) receptor activation in the mouse.
Obligatory role of microglia-mobilized hippocampal CREB-BDNF signaling in the prophylactic effect of β-glucan on chronic stress-induced depression-like behaviors in mice.
Resolvin D1 combined with exercise rehabilitation alleviates neurological injury in mice with intracranial hemorrhage via the BDNF/TrkB/PI3K/AKT pathway.
LncRNA-MSTRG.19083.1 Targets NTRK2 as a miR-429-y Sponge to Regulate Circadian Rhythm via the cAMP Pathway in Yak Testis and Cryptorchidism.
Agomirs upregulating carboxypeptidase E expression rescue hippocampal neurogenesis and memory deficits in Alzheimer's disease.
Body Weight Support Treadmill Training Combined With Sciatic Nerve Electrical Stimulation Ameliorating Motor Function by Enhancing PI3K/Akt Proteins Expression via BDNF/TrkB Signaling Pathway in Rats with Spinal Cord Injury.
Antidepressant effects of 70% ethanolic extract of Lonicerae japonicae flos and it contained chlorogenic acid via upregulation of BDNF-TrkB pathway in the hippocampus of mice.
The total alkaloids of Sophora alopecuroides L. improve depression-like behavior in mice via BDNF-mediated AKT/mTOR signaling pathway.
The hippocampal FTO-BDNF-TrkB pathway is required for novel object recognition memory reconsolidation in mice.
Prenatal alcohol exposure enhanced alcohol preference and susceptibility to PTSD in a sex-dependent manner through the synaptic HCN1 channel.
ProBDNF Upregulation in Murine Hind Limb Ischemia Reperfusion Injury: A Driver of Inflammation.
A whole transcriptome profiling analysis for antidepressant mechanism of Xiaoyaosan mediated synapse loss via BDNF/trkB/PI3K signal axis in CUMS rats.
Modulatory effect of n-3 polyunsaturated fatty acids on depressive-like behaviors in rats with chronic sleep deprivation: potential involvement of melatonin receptor pathway and brain lipidome.
BDNF/TrkB Is a Crucial Regulator in the Inflammation-Mediated Odontoblastic Differentiation of Dental Pulp Stem Cells.
Tanshinone IIA ameliorates chronic unpredictable mild stress-induced depression-like behavior and cognitive impairment in rats through the BDNF/TrkB/GAT1 signaling pathway.
Reduced mastication during growth inhibits cognitive function by affecting trigeminal ganglia and modulating Wnt signaling pathway and ARHGAP33 molecular transmission.
β-glucan, a specific immuno-stimulant, produces rapid antidepressant effects by stimulating ERK1/2-dependent synthesis of BDNF in the hippocampus.
Microglial stimulation triggered by intranasal lipopolysaccharide administration produces antidepressant-like effect through ERK1/2-mediated BDNF synthesis in the hippocampus.
The effects of acupuncture on depression by regulating BDNF-related balance via lateral habenular nucleus BDNF/TrkB/CREB signaling pathway in rats.
Dl-3-n-Butylphthalide Improves Neuroinflammation in Mice with Repeated Cerebral Ischemia-Reperfusion Injury through the Nrf2-Mediated Antioxidant Response and TLR4/MyD88/NF-κB Signaling Pathway.
Effect of β-hydroxybutyrate on behavioral alterations, molecular and morphological changes in CNS of multiple sclerosis mouse model.
Antidepressant effect of Jujuboside A on corticosterone-induced depression in mice.
ERK1/2-dependent BDNF synthesis and signaling is required for the antidepressant effect of microglia stimulation.
Involvement of the BDNF-TrkB-KCC2 pathway in neuropathic pain after brachial plexus avulsion.
The BDNF-TrkB-CREB Signalling Pathway Is Involved in Bisphenol S-Induced Neurotoxicity in Male Mice by Regulating Methylation.
Effect of Qingyangshen glycosides on social defeat mice model.
A missing piece of the puzzle in pulmonary fibrosis: anoikis resistance promotes fibroblast activation.
Peptide OM-LV20 promotes structural and functional recovery of spinal cord injury in rats.
Cbl-b modulated TrkA ubiquitination and function in the dorsal root ganglion of mice.
Baihe Jizihuang Tang Ameliorates Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior: Integrating Network Pharmacology and Brain-Gut Axis Evaluation.
Electroacupuncture Ameliorates Depressive-Like Behaviors in Poststroke Rats via Activating the tPA/BDNF/TrkB Pathway.
Injection of Anti-proBDNF Attenuates Hippocampal-Dependent Learning and Memory Dysfunction in Mice With Sepsis-Associated Encephalopathy.
Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway.
Proteomic Analysis of Emodin Treatment in Neuropathic Pain Reveals Dysfunction of the Calcium Signaling Pathway.
Synergic Neuroprotection Between Ligusticum Chuanxiong Hort and Borneol Against Ischemic Stroke by Neurogenesis via Modulating Reactive Astrogliosis and Maintaining the Blood-Brain Barrier.
Jiedu Tongluo Granules Ameliorates Post-stroke Depression Rat Model via Regulating NMDAR/BDNF Signaling Pathway.
BDNF modulated KCC2 ubiquitylation in spinal cord dorsal horn of mice.
Tetrahydropalmatine Regulates BDNF through TrkB/CAM Interaction to Alleviate the Neurotoxicity Induced by Methamphetamine.
Dopamine receptor 2 downregulation and brain-derived neurotrophic factor upregulation in the paraventricular nucleus are correlated with brown adipose tissue thermogenesis in rats with bilateral substantia nigra lesions.
Role of the BDNF/TrkB/CREB signaling pathway in the cytotoxicity of bisphenol S in SK-N-SH cells.
Effects of Compound 511 on BDNF-TrkB Signaling in the Mice Ventral Tegmental Area in Morphine-Induced Conditioned Place Preference.
Water treadmill training protects the integrity of the blood-spinal cord barrier following SCI via the BDNF/TrkB-CREB signalling pathway.
Enhanced pro-BDNF-p75NTR pathway activity in denervated skeletal muscle.
Perinatal exposure to BDE-47 exacerbated autistic-like behaviors and impairments of dendritic development in a valproic acid-induced rat model of autism.
LMP1 promotes nasopharyngeal carcinoma metastasis through NTRK2-mediated anoikis resistance.
Alpha-synuclein is involved in manganese-induced spatial memory and synaptic plasticity impairments via TrkB/Akt/Fyn-mediated phosphorylation of NMDA receptors.
Anti-Alzheimer's disease activity of secondary metabolites from Xanthoceras sorbifolia Bunge.
Bexarotene Improve Depression-Like Behaviour in Mice by Protecting Against Neuro-inflammation and Synaptic Damage.
Curcumin protects rat hippocampal neurons against pseudorabies virus by regulating the BDNF/TrkB pathway.
Catalpol Enhances Neurogenesis And Inhibits Apoptosis Of New Neurons Via BDNF, But Not The BDNF/Trkb Pathway.
Chaihu-Shugan-San and absorbed meranzin hydrate induce anti-atherosclerosis and behavioral improvements in high-fat diet ApoE(-/-) mice via anti-inflammatory and BDNF-TrkB pathway.
Hyperbaric oxygen therapy reduces apoptosis and dendritic/synaptic degeneration via the BDNF/TrkB signaling pathways in SCI rats.
OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice.
Volatile Oil from Acorus gramineus Ameliorates the Injury Neurons in the Hippocampus of Amyloid Beta 1-42 Injected Mice.
Neuroprotective effect of 1-Deoxynojirimycin on cognitive impairment, β-amyloid deposition, and neuroinflammation in the SAMP8 mice.
Perinatal exposure to nonylphenol impairs dendritic outgrowth of cerebellar Purkinje cells in progeny.
Activation of BDNF-TrkB signaling pathway-regulated brain inflammation in pentylenetetrazole-induced seizures in zebrafish.
ERK1/2-mediated disruption of BDNF-TrkB signaling causes synaptic impairment contributing to fluoride-induced developmental neurotoxicity.
Wang Y, Fu Y, Deng X, Xu X, Wu Y, He J, Guo Q, Zou G
International journal of clinical and experimental pathology 2026;19(1):1-13
International journal of clinical and experimental pathology 2026;19(1):1-13
Multiscale analysis of resolvin D1 biosynthesis and its neuroprotective role in intracerebral hemorrhage.
Xiaoyu L, Ziyou Z, Zhenlin L, Zhuang L, Kai S, Siqi W, Tong L, Yunfei L, Weixiu Z, Yifan W, Chun S, Bensi Z
Prostaglandins & other lipid mediators 2026 Mar;183:107063
Prostaglandins & other lipid mediators 2026 Mar;183:107063
Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4-Mediated Acute Hepatitis.
Zhu W, Cui Y, Zhou Y, Zheng Y, Huang L, Jin L, Zhang Q, Chen P, Lin M, Ye J, Xiong Y, Huh JY, Hu X, Li X, Luo W, Liang G
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 25;:e21164
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 25;:e21164
Targeting wild type NTRK decreases brain metastases of lung cancers non-driven by NTRK fusions.
Contreras-Zárate MJ, Jaramillo-Gómez JA, Marquez-Ortiz RA, Pham TC, Koliavas S, Ormond DR, Navarro AC, Nemenoff RA, Camidge DR, Cittelly DM
bioRxiv : the preprint server for biology 2026 Mar 20;
bioRxiv : the preprint server for biology 2026 Mar 20;
Integrating neurotrophic and anti-inflammatory pathways: press-needle acupuncture as a multi-target therapy for adolescent depression.
Zhang H, Rong Y, Ning R, Yan Z, Zhao Y, Chen Y
The International journal of neuroscience 2026 Mar 12;:1-16
The International journal of neuroscience 2026 Mar 12;:1-16
Roudoukou-Suanzaoren Ameliorates Chronic Restraint-Induced Anxiety- and Depression-Like Behaviors in Mice via the Gut-Brain Axis.
Wang X, Xu J, Li M, Du L, Wang C, Zhang C
Journal of agricultural and food chemistry 2026 Mar 11;74(9):7607-7620
Journal of agricultural and food chemistry 2026 Mar 11;74(9):7607-7620
Pan-cancer analysis of NTRK2 (TRKB) and the anticancer effect of its inhibitor Lucitanib in glioma.
Li X, Xue R, Wei C, Zhang S, Sun Y, Hu Y, Zhang Y
Computational biology and chemistry 2026 Aug;123:108985
Computational biology and chemistry 2026 Aug;123:108985
New co-drugs of O-demethylvenlafaxine and NSAIDs exert antidepressant effects by alleviating inflammation, oxidative stress, and increasing neurotransmitter.
Song Y, Song J, Liu S, Zhang J, Liu Z, Chen H, Wang S, Zhuang T, Zhang G
International immunopharmacology 2026 Apr 15;175:116456
International immunopharmacology 2026 Apr 15;175:116456
Astrocytic BDNF Modulates Sensitivity to Stress-Induced Anxiety-Like Behaviors.
Li WP, Liu GY, Wang SY, Hu J, Ji WJ, Zhu JM, Chang QY, Li TY, Wei GR, Shang JQ, Li HZ, Peng FH, Zhao YY, Su XH, Xie W
Research (Washington, D.C.) 2025;8:0818
Research (Washington, D.C.) 2025;8:0818
Network Pharmacology Combined with Animal Models to Investigate the Mechanism of ChangPu YuJin Tang in the Treatment of Tourette Syndrome.
Lu MQ, Shi ZG, Shang J, Gao L, Gao WJ, Gao L
Combinatorial chemistry & high throughput screening 2025;28(1):166-184
Combinatorial chemistry & high throughput screening 2025;28(1):166-184
Proteomics of stress-induced cardiomyopathy: insights from differential expression, protein interaction networks, and functional pathway enrichment in an isoproterenol-induced TTC mouse model.
Tian L, Liu B, Ren Y, Cui J, Pang Z
PeerJ 2025;13:e18984
PeerJ 2025;13:e18984
The Role of SIRT1-BDNF Signaling Pathway in Fluoride-Induced Toxicity for Glial BV-2 Cells.
Yang B, Wang F, Yang X, Yuan X, Yang Y, Chen X, Tian T, Chen F, Tang D, He Z, Liu Y, Li Y
Biological trace element research 2025 Sep;203(9):4789-4806
Biological trace element research 2025 Sep;203(9):4789-4806
Arbutin ameliorated depression by inhibiting neuroinflammation and modulating intestinal flora.
Cao Y, Zhao K, Zhao Y, Ni Y, Zhang Z, Yuan X, Ning J, Song Q, Zhao F, He L, Chen T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156944
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156944
Antidepressant effects of total phenols and total saponins of Kai-Xin-San mediated by synaptic plasticity induced by BDNF/TrkB/Akt pathway.
Tang YN, Bai YF, Dong A, Rao QL, Wu HH, Wang CG, Xu YT
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120423
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120423
The role of REST in regulating the BDNF/TrkB signalling pathway in nano-alumina induced cognitive dysfunction in zebrafish.
Zhang J, Wang S, Jin Z, Ma L, Wang Y, Zhang H, Nie J, Niu Q
Ecotoxicology and environmental safety 2025 Sep 15;303:118998
Ecotoxicology and environmental safety 2025 Sep 15;303:118998
Acupuncture improves depressive-like behaviors in CUMS rats by modulating lateral habenula synaptic plasticity via the BDNF/ERK/mTOR pathway.
Yan S, Liu J, Zhang T, Li J, Zeng J, Li M, Aslam MS, Shen J, Tong T, You Z, Liu S, Li P, Li J, Gong K, Wei S, Hao C, Meng X
Molecular brain 2025 Oct 8;18(1):77
Molecular brain 2025 Oct 8;18(1):77
Early maternal separation potentiates the impact of later social isolation in inducing depressive-like behavior via oxidative stress in adult rats.
Chen Y, Du J, Lei M, Ji N, Zhang W, Li C, Zhang B
Psychopharmacology 2025 Nov;242(11):2503-2515
Psychopharmacology 2025 Nov;242(11):2503-2515
Disruption of axonal transport in Parkinson's disease: the role of pathological α-Syn and AMPK/p38 MAPK signaling.
Yang X, Ma Z, Lian P, Wu Y, Liu K, Zhang Z, Tang Z, Xu Y, Cao X
NPJ Parkinson's disease 2025 May 6;11(1):114
NPJ Parkinson's disease 2025 May 6;11(1):114
Exercise-induced Activation of SIRT1/BDNF/mTORC1 Signaling Pathway: A Novel Mechanism to Reduce Neuroinflammation and Improve Post-stroke Depression.
Tang J, Lu L, Yuan J, Feng L
Actas espanolas de psiquiatria 2025 Mar;53(2):366-378
Actas espanolas de psiquiatria 2025 Mar;53(2):366-378
Bone-brain communication mediates the amelioration of Polgonatum cyrtonema Hua polysaccharide on fatigue in chronic sleep-deprived mice.
Zhang T, Li XY, Kuang DD, Pan LH, Li QM, Luo JP, Zha XQ
International journal of biological macromolecules 2025 Mar;296:139706
International journal of biological macromolecules 2025 Mar;296:139706
Allium Macrostemon Bge. Attenuates the Cognitive Decline of Aging Mice by Enhancing BDNF/TrkB Pathway.
Sheng R, Zhao M, Pu K, Zhou Y, Zeng L, Chen Y, Wang P, Liu X, Xu S
Food science & nutrition 2025 Mar;13(3):e70010
Food science & nutrition 2025 Mar;13(3):e70010
Muscone enhances synaptic function in vascular dementia through activating BDNF-TrkB-NP2 signaling pathway.
Huang P, Sun H, Chen Y, Li J, Peng Y, Ge C, Zhu K, Zhou X, Chang D, Wang N
International immunopharmacology 2025 Mar 6;149:114232
International immunopharmacology 2025 Mar 6;149:114232
Cell type specific differences in transcriptome profiles of adipose derived stem cells and vaginal fibroblasts in patients with pelvic organ prolapse.
Tchoukalova YD, Nair AA, Chen X, Zhang N, Myers CE, Badreldin A, Dudakovic A, Lott LG, Rebecca AM, Yi J, Cornella JL, van Wijnen AJ
Gene 2025 Mar 20;942:149230
Gene 2025 Mar 20;942:149230
The SLC26A4-AS1/NTRK2 axis in breast cancer: insights into the ceRNA network and implications for prognosis and immune microenvironment.
Lan M, Qin S, Wei J, Wu L, Lu Z, Huang W
Discover oncology 2025 Mar 16;16(1):329
Discover oncology 2025 Mar 16;16(1):329
Electroacupuncture Neural Stimulation Mitigates Bladder Dysfunction and Mechanical Allodynia in Cyclophosphamide Induced Cystitis through Downregulation of the BDNF-TrkB Signaling Pathway.
Su Y, Yang F, Xie JC, Zhang C, Luo RX, Li WS, Liu BL, Su MZ
eNeuro 2025 Mar 10;12(3)
eNeuro 2025 Mar 10;12(3)
Alpha-synuclein Fibrils Inhibit Activation of the BDNF/ERK Signaling Loop in the mPFC to Induce Parkinson's Disease-like Alterations with Depression.
Ma Z, Xu Y, Lian P, Wu Y, Liu K, Zhang Z, Tang Z, Yang X, Cao X
Neuroscience bulletin 2025 Jun;41(6):951-969
Neuroscience bulletin 2025 Jun;41(6):951-969
TSPO activation ameliorates maternal immune activation induced PV interneuron deficits via BDNF/TrkB signaling.
Mao MJ, Yu HL, Liu QZ, Wen YZ, Jiang M, Yuan HM, Zeng HB, Zhang LD, Feng SW
Psychopharmacology 2025 Jun;242(6):1303-1319
Psychopharmacology 2025 Jun;242(6):1303-1319
Deciphering the polypharmacology of Dingzhi Xiaowan against comorbid depression: Integrated metabolomics of brain tissue and network pharmacology analysis in chronic restraint stress (CRS)-LPS model.
Chu H, Sun N, Tang Q, Yu X, Li L, Chang H
Journal of ethnopharmacology 2025 Jun 12;349:119960
Journal of ethnopharmacology 2025 Jun 12;349:119960
Effects of arabinoxylan on BDNF/TrkB/p-CREB signaling pathway in the prefrontal cortex and intestinal microbiome in post-stroke depressed rats.
Bi BY, Lin L, Huang L, Zhou J, Yan WJ, Huang L, Wang J, Li XB
BMC neuroscience 2025 Jul 13;26(1):40
BMC neuroscience 2025 Jul 13;26(1):40
A new specific GluN2B partial antagonist ameliorates brain injury caused by ischemic stroke in rats.
Fan Y, Wu H, Yin D, Liu Q, Yuan C, Zhong T, Xia B, Xiong L, Li Y, Zeng L, Li Y, Li Y, Tang L
Bioorganic chemistry 2025 Jul 1;161:108547
Bioorganic chemistry 2025 Jul 1;161:108547
Hippocampal SENP3 mediates chronic stress-induced depression-like behaviors by impairing the CREB-BDNF signaling.
Gao Z, Peng J, Zhang Y, Chen Z, Song R, Song Z, Feng Q, Sun M, Zhu H, Lu X, Yang R, Huang C
Neuropharmacology 2025 Jan 1;262:110203
Neuropharmacology 2025 Jan 1;262:110203
Methamphetamine inhibits huntingtin-associated protein 1-mediated tyrosine receptor kinase B endocytosis resulting the neuroprotective dysfunction of brain-derived neurotrophic factor.
Shen B, Wu Z, Lv M, Yang G, Cao Y, Zhang Y, Shu J, Dong W, Hou Z, Jing D, Zhang X, Hou Y, Xu J, Hong S, Li L
Toxicology 2025 Feb;511:154047
Toxicology 2025 Feb;511:154047
Geniposide Protects Against Myocardial Infarction Injury via the Restoration in Gut Microbiota and Gut-Brain Axis.
Chen J, Zhu T, Yang J, Shen M, Wang D, Gu B, Xu J, Zhang M, Hao X, Tang Z, Tong J, Du Y, Zhang B, Li H, Xu M
Journal of cellular and molecular medicine 2025 Feb;29(3):e70406
Journal of cellular and molecular medicine 2025 Feb;29(3):e70406
Jiawei Kongsheng Zhenzhong Pill (JKZP) Alleviates Chronic Cerebral Hypoperfusion-Induced Hippocampal Synaptic Damage via S100A10/tPA/BDNF Pathway.
Wu Q, Zhou Y, Ou C, Gao Z, Wu X, Zhao Y, Wang Y, Wu Z, Yu H
Brain and behavior 2025 Feb;15(2):e70328
Brain and behavior 2025 Feb;15(2):e70328
Neuromodulatory Effects of Arecoline on Anxiety-like Behavior in Mice Exposed to Chronic Unpredictable Mild Stress.
Zhang X, Wang D, Cui J, Fan B, Wang F, Lu C
International journal of molecular sciences 2025 Dec 29;27(1)
International journal of molecular sciences 2025 Dec 29;27(1)
Long-term aerobic exercise improves learning memory capacity and effects on oxidative stress levels and Keap1/Nrf2/GPX4 pathway in the hippocampus of APP/PS1 mice.
Wang S, Zhou Y, Wu Y, Lang Y, Mao Y, Pan G, Gao Z
Frontiers in neuroscience 2024;18:1505650
Frontiers in neuroscience 2024;18:1505650
Anti-neuroinflammatory effect of hydroxytyrosol: a potential strategy for anti-depressant development.
Li S, Shao H, Sun T, Guo X, Zhang X, Zeng Q, Fang S, Liu X, Wang F, Liu F, Ling P
Frontiers in pharmacology 2024;15:1366683
Frontiers in pharmacology 2024;15:1366683
Rice Protein Peptides Ameliorate DSS-Induced Cognitive Impairment and Depressive Behavior in Mice by Modulating Phenylalanine Metabolism and the BDNF/TRKB/CREB Pathway.
He Y, Tian Y, Xiong H, Deng Z, Zhang H, Guo F, Sun Y
Journal of agricultural and food chemistry 2024 Sep 11;72(36):19812-19825
Journal of agricultural and food chemistry 2024 Sep 11;72(36):19812-19825
Plasma-derived exosome miR-10a-5p promotes premature ovarian failure by target BDNF via the TrkB/Akt/mTOR signaling pathway.
Bao Z, Li J, Cai J, Yao S, Yang N, Yang J, Zhao B, Chen Y, Wu X
International journal of biological macromolecules 2024 Oct;277(Pt 1):134195
International journal of biological macromolecules 2024 Oct;277(Pt 1):134195
Yeast Extract Peptides Alleviate Depression in Chronic Restraint Stress Rats by Alleviating Hippocampal Neuronal Apoptosis and Dysbiosis of the Gut Microbiota.
Zou Z, Xiao N, Chen Z, Lin X, Li Y, Li P, Cheng Q, Du B
Molecular nutrition & food research 2024 Nov;68(21):e2300467
Molecular nutrition & food research 2024 Nov;68(21):e2300467
MiR-204 regulates autophagy and cell viability by targeting BDNF and inhibiting the NTRK2-dependent PI3K/Akt/mTOR pathway in a human granulosa cell line exposed to bisphenol A.
Li C, Cui Z, Liu Z, Fan H, Lan Y, Luo J, Ruan F, Huang Y, Chu K, Wu Y, Xia D, Zhou J
Ecotoxicology and environmental safety 2024 Nov 15;287:117304
Ecotoxicology and environmental safety 2024 Nov 15;287:117304
Intranasal LAG3 antibody infusion induces a rapid antidepressant effect via the hippocampal ERK1/2-BDNF signaling pathway in chronically stressed mice.
Fang Y, Pan H, Zhu H, Wang H, Ye M, Ren J, Peng J, Li J, Lu X, Huang C
Neuropharmacology 2024 Nov 15;259:110118
Neuropharmacology 2024 Nov 15;259:110118
Therapeutic benefits of central LH receptor agonism in the APP/PS1 AD model involve trophic and immune regulation and are reproductive status dependent.
Mey M, Bhatta S, Suresh S, Labrador LM, Piontkivska H, Casadesus G
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167165
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167165
Mecp2 Deficiency in Peripheral Sensory Neuron Improves Cognitive Function by Enhancing Hippocampal Dendritic Spine Densities in Mice.
Feng Y, Wang J, Liu J, Zhou Y, Jiang Y, Zhou W, Wu F, Liu X, Luo L
Cells 2024 Jun 6;13(11)
Cells 2024 Jun 6;13(11)
Catalpol rescues LPS-induced cognitive impairment via inhibition of NF-Κb-regulated neuroinflammation and up-regulation of TrkB-mediated BDNF secretion in mice.
Hu W, Zou L, Yu N, Wu Z, Yang W, Wu T, Liu Y, Pu Y, Jiang Y, Zhang J, Zhu H, Cheng F, Feng S
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117345
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117345
TrkB receptor interacts with mGlu(2) receptor and mediates antipsychotic-like effects of mGlu(2) receptor activation in the mouse.
Philibert CE, Disdier C, Lafon PA, Bouyssou A, Oosterlaken M, Galant S, Pizzoccaro A, Tuduri P, Ster J, Liu J, Kniazeff J, Pin JP, Rondard P, Marin P, Vandermoere F
Science advances 2024 Jan 26;10(4):eadg1679
Science advances 2024 Jan 26;10(4):eadg1679
Obligatory role of microglia-mobilized hippocampal CREB-BDNF signaling in the prophylactic effect of β-glucan on chronic stress-induced depression-like behaviors in mice.
Zhao C, Shi R, Lu X, Yang R, Chen Z, Chen B, Hu W, Ren J, Peng J, Zhu T, Zhu H, Huang C
European journal of pharmacology 2024 Feb 5;964:176288
European journal of pharmacology 2024 Feb 5;964:176288
Resolvin D1 combined with exercise rehabilitation alleviates neurological injury in mice with intracranial hemorrhage via the BDNF/TrkB/PI3K/AKT pathway.
Xiaoyu L, Dandan L, Tianzhao O, Ziyou Z, Zhenlin L, Zhuang L, Mingrui L, Yusong H, Yangyang Z, Yanjiao L, Chun S, Siqi W, Tong L, Bensi Z
Scientific reports 2024 Dec 28;14(1):31447
Scientific reports 2024 Dec 28;14(1):31447
LncRNA-MSTRG.19083.1 Targets NTRK2 as a miR-429-y Sponge to Regulate Circadian Rhythm via the cAMP Pathway in Yak Testis and Cryptorchidism.
Li T, Yan Q, Nan J, Huang X, Wang R, Zhang Y, Zhao X, Wang Q
International journal of molecular sciences 2024 Dec 18;25(24)
International journal of molecular sciences 2024 Dec 18;25(24)
Agomirs upregulating carboxypeptidase E expression rescue hippocampal neurogenesis and memory deficits in Alzheimer's disease.
Jiang D, Liu H, Li T, Zhao S, Yang K, Yao F, Zhou B, Feng H, Wang S, Shen J, Tang J, Zhang YX, Wang Y, Guo C, Tang TS
Translational neurodegeneration 2024 Apr 26;13(1):24
Translational neurodegeneration 2024 Apr 26;13(1):24
Body Weight Support Treadmill Training Combined With Sciatic Nerve Electrical Stimulation Ameliorating Motor Function by Enhancing PI3K/Akt Proteins Expression via BDNF/TrkB Signaling Pathway in Rats with Spinal Cord Injury.
Xu Q, Li Z, Su J, Hu M, Yin Q, Chen S, Song J, Chen H
World neurosurgery 2023 Oct;178:e239-e253
World neurosurgery 2023 Oct;178:e239-e253
Antidepressant effects of 70% ethanolic extract of Lonicerae japonicae flos and it contained chlorogenic acid via upregulation of BDNF-TrkB pathway in the hippocampus of mice.
Qin L, Wang J, Wu X, Song L, Zhang Y, Gong M, Wang Y, Li B
Brain research bulletin 2023 Nov;204:110796
Brain research bulletin 2023 Nov;204:110796
The total alkaloids of Sophora alopecuroides L. improve depression-like behavior in mice via BDNF-mediated AKT/mTOR signaling pathway.
Li J, Zhang M, Pei Y, Yang Q, Zheng L, Wang G, Sun Y, Yang W, Liu L
Journal of ethnopharmacology 2023 Nov 15;316:116723
Journal of ethnopharmacology 2023 Nov 15;316:116723
The hippocampal FTO-BDNF-TrkB pathway is required for novel object recognition memory reconsolidation in mice.
Chang R, Zhu S, Peng J, Lang Z, Zhou X, Liao H, Zou J, Zeng P, Tan S
Translational psychiatry 2023 Nov 14;13(1):349
Translational psychiatry 2023 Nov 14;13(1):349
Prenatal alcohol exposure enhanced alcohol preference and susceptibility to PTSD in a sex-dependent manner through the synaptic HCN1 channel.
Yao H, Wang C, Xia Z
Journal of affective disorders 2023 Mar 1;324:143-152
Journal of affective disorders 2023 Mar 1;324:143-152
ProBDNF Upregulation in Murine Hind Limb Ischemia Reperfusion Injury: A Driver of Inflammation.
Aby K, Antony R, Li Y
Biology 2023 Jun 24;12(7)
Biology 2023 Jun 24;12(7)
A whole transcriptome profiling analysis for antidepressant mechanism of Xiaoyaosan mediated synapse loss via BDNF/trkB/PI3K signal axis in CUMS rats.
Meng P, Zhang X, Liu TT, Liu J, Luo Y, Xie MX, Yang H, Fang R, Guo DW, Zhong ZY, Wang YH, Ge JW
BMC complementary medicine and therapies 2023 Jun 15;23(1):198
BMC complementary medicine and therapies 2023 Jun 15;23(1):198
Modulatory effect of n-3 polyunsaturated fatty acids on depressive-like behaviors in rats with chronic sleep deprivation: potential involvement of melatonin receptor pathway and brain lipidome.
Chang CH, Wu HC, Hsieh YR, Lai WD, Tung TH, Huang JJ, Kao WY, Huang SY
Food & function 2023 Jul 3;14(13):5977-5993
Food & function 2023 Jul 3;14(13):5977-5993
BDNF/TrkB Is a Crucial Regulator in the Inflammation-Mediated Odontoblastic Differentiation of Dental Pulp Stem Cells.
Kim JH, Irfan M, Hossain MA, George A, Chung S
Cells 2023 Jul 14;12(14)
Cells 2023 Jul 14;12(14)
Tanshinone IIA ameliorates chronic unpredictable mild stress-induced depression-like behavior and cognitive impairment in rats through the BDNF/TrkB/GAT1 signaling pathway.
Liu SZ, Yang J, Chen LL, Wang P, Lin L
European journal of pharmacology 2023 Jan 5;938:175385
European journal of pharmacology 2023 Jan 5;938:175385
Reduced mastication during growth inhibits cognitive function by affecting trigeminal ganglia and modulating Wnt signaling pathway and ARHGAP33 molecular transmission.
Misawa-Omori E, Okihara H, Ogawa T, Abe Y, Kato C, Ishidori H, Fujita A, Kokai S, Ono T
Neuropeptides 2023 Dec;102:102370
Neuropeptides 2023 Dec;102:102370
β-glucan, a specific immuno-stimulant, produces rapid antidepressant effects by stimulating ERK1/2-dependent synthesis of BDNF in the hippocampus.
Chen B, Zhao C, Zhu H, Lu X, Liu H, Lu Q, Zhu T, Huang C
European journal of pharmacology 2023 Dec 15;961:176161
European journal of pharmacology 2023 Dec 15;961:176161
Microglial stimulation triggered by intranasal lipopolysaccharide administration produces antidepressant-like effect through ERK1/2-mediated BDNF synthesis in the hippocampus.
Ni M, Zheng M, Chen B, Lu X, Zhao H, Zhu T, Cheng L, Han H, Ye T, Liu H, Ye Y, Huang C, Yuan X
Neuropharmacology 2023 Dec 1;240:109693
Neuropharmacology 2023 Dec 1;240:109693
The effects of acupuncture on depression by regulating BDNF-related balance via lateral habenular nucleus BDNF/TrkB/CREB signaling pathway in rats.
Tong T, Chen Y, Hao C, Shen J, Chen W, Cheng W, Yan S, Li J, Li Y, Gulizhaerkezi T, Zeng J, Meng X
Behavioural brain research 2023 Aug 5;451:114509
Behavioural brain research 2023 Aug 5;451:114509
Dl-3-n-Butylphthalide Improves Neuroinflammation in Mice with Repeated Cerebral Ischemia-Reperfusion Injury through the Nrf2-Mediated Antioxidant Response and TLR4/MyD88/NF-κB Signaling Pathway.
Gao Y, Hu M, Niu X, Li M, Xu L, Xiao Y, Zhang J, Wang H, Li L, Chu B, Lv P
Oxidative medicine and cellular longevity 2022;2022:8652741
Oxidative medicine and cellular longevity 2022;2022:8652741
Effect of β-hydroxybutyrate on behavioral alterations, molecular and morphological changes in CNS of multiple sclerosis mouse model.
Sun W, Wen M, Liu M, Wang Q, Liu Q, Li L, Siebert HC, Loers G, Zhang R, Zhang N
Frontiers in aging neuroscience 2022;14:1075161
Frontiers in aging neuroscience 2022;14:1075161
Antidepressant effect of Jujuboside A on corticosterone-induced depression in mice.
Li H, Li J, Zhang T, Xie X, Gong J
Biochemical and biophysical research communications 2022 Sep 10;620:56-62
Biochemical and biophysical research communications 2022 Sep 10;620:56-62
ERK1/2-dependent BDNF synthesis and signaling is required for the antidepressant effect of microglia stimulation.
Lu X, Liu H, Cai Z, Hu Z, Ye M, Gu Y, Wang Y, Wang D, Lu Q, Shen Z, Shen X, Huang C
Brain, behavior, and immunity 2022 Nov;106:147-160
Brain, behavior, and immunity 2022 Nov;106:147-160
Involvement of the BDNF-TrkB-KCC2 pathway in neuropathic pain after brachial plexus avulsion.
Zhao S, Wang F, Wang L, Xu Y, Lv L, Duan W, Bai R, Meng Z, Shao X
Brain and behavior 2022 Mar;12(3):e2464
Brain and behavior 2022 Mar;12(3):e2464
The BDNF-TrkB-CREB Signalling Pathway Is Involved in Bisphenol S-Induced Neurotoxicity in Male Mice by Regulating Methylation.
Li YZ, Wu ZY, Zhu BQ, Wang YX, Kan YQ, Zeng HC
Toxics 2022 Jul 23;10(8)
Toxics 2022 Jul 23;10(8)
Effect of Qingyangshen glycosides on social defeat mice model.
Liu D, Wang J, Chang L, Zhu Q, Jiang N, Azhar M, Zeng G
Journal of ethnopharmacology 2022 Jul 15;293:115253
Journal of ethnopharmacology 2022 Jul 15;293:115253
A missing piece of the puzzle in pulmonary fibrosis: anoikis resistance promotes fibroblast activation.
Yin J, Wang J, Zhang X, Liao Y, Luo W, Wang S, Ding J, Huang J, Chen M, Wang W, Fang S, Chao J
Cell & bioscience 2022 Feb 25;12(1):21
Cell & bioscience 2022 Feb 25;12(1):21
Peptide OM-LV20 promotes structural and functional recovery of spinal cord injury in rats.
Zhao J, Pang A, Yin S, Yang M, Zhang X, Zhang R, Liu J, Gu Y, Li S, Hu Y, Zhang Y, Ba Y, Meng B, Yang X
Biochemical and biophysical research communications 2022 Apr 2;598:124-130
Biochemical and biophysical research communications 2022 Apr 2;598:124-130
Cbl-b modulated TrkA ubiquitination and function in the dorsal root ganglion of mice.
Chen HK, Li YZ, Ge AN, Zhu YB, Wu SJ, Bai X, Bai HH, Liu YN
European journal of pharmacology 2022 Apr 15;921:174876
European journal of pharmacology 2022 Apr 15;921:174876
Baihe Jizihuang Tang Ameliorates Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior: Integrating Network Pharmacology and Brain-Gut Axis Evaluation.
Zhu JP, Wu HY, Zi Y, Xia XB, Xie MZ, Yuan ZY
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5554363
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5554363
Electroacupuncture Ameliorates Depressive-Like Behaviors in Poststroke Rats via Activating the tPA/BDNF/TrkB Pathway.
Dong H, Qin YQ, Sun YC, Yao HJ, Cheng XK, Yu Y, Lu SS
Neuropsychiatric disease and treatment 2021;17:1057-1067
Neuropsychiatric disease and treatment 2021;17:1057-1067
Injection of Anti-proBDNF Attenuates Hippocampal-Dependent Learning and Memory Dysfunction in Mice With Sepsis-Associated Encephalopathy.
Cui YH, Zhou SF, Liu Y, Wang S, Li F, Dai RP, Hu ZL, Li CQ
Frontiers in neuroscience 2021;15:665757
Frontiers in neuroscience 2021;15:665757
Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway.
Yang Y, Yi J, Pan M, Hu B, Duan H
Drug design, development and therapy 2021;15:1409-1422
Drug design, development and therapy 2021;15:1409-1422
Proteomic Analysis of Emodin Treatment in Neuropathic Pain Reveals Dysfunction of the Calcium Signaling Pathway.
Chen P, Lin D, Wang C, Song C, Wang W, Qu J, Wu Z
Journal of pain research 2021;14:613-622
Journal of pain research 2021;14:613-622
Synergic Neuroprotection Between Ligusticum Chuanxiong Hort and Borneol Against Ischemic Stroke by Neurogenesis via Modulating Reactive Astrogliosis and Maintaining the Blood-Brain Barrier.
Yu B, Yao Y, Zhang X, Ruan M, Zhang Z, Xu L, Liang T, Lu J
Frontiers in pharmacology 2021;12:666790
Frontiers in pharmacology 2021;12:666790
Jiedu Tongluo Granules Ameliorates Post-stroke Depression Rat Model via Regulating NMDAR/BDNF Signaling Pathway.
Zhao A, Ma B, Xu L, Yao M, Zhang Y, Xue B, Ren J, Chang D, Liu J
Frontiers in pharmacology 2021;12:662003
Frontiers in pharmacology 2021;12:662003
BDNF modulated KCC2 ubiquitylation in spinal cord dorsal horn of mice.
Ma JJ, Zhang TY, Diao XT, Yao L, Li YX, Suo ZW, Yang X, Hu XD, Liu YN
European journal of pharmacology 2021 Sep 5;906:174205
European journal of pharmacology 2021 Sep 5;906:174205
Tetrahydropalmatine Regulates BDNF through TrkB/CAM Interaction to Alleviate the Neurotoxicity Induced by Methamphetamine.
Liu L, Liu M, Zhao W, Zhao YL, Wang Y
ACS chemical neuroscience 2021 Sep 15;12(18):3373-3386
ACS chemical neuroscience 2021 Sep 15;12(18):3373-3386
Dopamine receptor 2 downregulation and brain-derived neurotrophic factor upregulation in the paraventricular nucleus are correlated with brown adipose tissue thermogenesis in rats with bilateral substantia nigra lesions.
Zhang Y, Zhou L, Lian H, Zhang Y, Tong S, Wang Z
Journal of chemical neuroanatomy 2021 Nov;117:102016
Journal of chemical neuroanatomy 2021 Nov;117:102016
Role of the BDNF/TrkB/CREB signaling pathway in the cytotoxicity of bisphenol S in SK-N-SH cells.
He QZ, Zhu BQ, Xu XN, Zeng HC
Journal of biochemical and molecular toxicology 2021 Jun;35(6):1-11
Journal of biochemical and molecular toxicology 2021 Jun;35(6):1-11
Effects of Compound 511 on BDNF-TrkB Signaling in the Mice Ventral Tegmental Area in Morphine-Induced Conditioned Place Preference.
Zhang H, Wang Q, Sun Q, Qin F, Nie D, Li Q, Gu Y, Jiang Y, Lu S, Lu Z
Cellular and molecular neurobiology 2021 Jul;41(5):961-975
Cellular and molecular neurobiology 2021 Jul;41(5):961-975
Water treadmill training protects the integrity of the blood-spinal cord barrier following SCI via the BDNF/TrkB-CREB signalling pathway.
Ying X, Xie Q, Yu X, Li S, Wu Q, Chen X, Yue J, Zhou K, Tu W, Jiang S
Neurochemistry international 2021 Feb;143:104945
Neurochemistry international 2021 Feb;143:104945
Enhanced pro-BDNF-p75NTR pathway activity in denervated skeletal muscle.
Aby K, Antony R, Eichholz M, Srinivasan R, Li Y
Life sciences 2021 Dec 1;286:120067
Life sciences 2021 Dec 1;286:120067
Perinatal exposure to BDE-47 exacerbated autistic-like behaviors and impairments of dendritic development in a valproic acid-induced rat model of autism.
Li Z, You M, Che X, Dai Y, Xu Y, Wang Y
Ecotoxicology and environmental safety 2021 Apr 1;212:112000
Ecotoxicology and environmental safety 2021 Apr 1;212:112000
LMP1 promotes nasopharyngeal carcinoma metastasis through NTRK2-mediated anoikis resistance.
Li Z, Zhou Z, Wu X, Zhou Q, Liao C, Liu Y, Li D, Shen L, Feng D, Yang L
American journal of cancer research 2020;10(7):2083-2099
American journal of cancer research 2020;10(7):2083-2099
Alpha-synuclein is involved in manganese-induced spatial memory and synaptic plasticity impairments via TrkB/Akt/Fyn-mediated phosphorylation of NMDA receptors.
Ma Z, Liu K, Li XR, Wang C, Liu C, Yan DY, Deng Y, Liu W, Xu B
Cell death & disease 2020 Oct 8;11(10):834
Cell death & disease 2020 Oct 8;11(10):834
Anti-Alzheimer's disease activity of secondary metabolites from Xanthoceras sorbifolia Bunge.
Li W, Lu Q, Li X, Liu H, Sun L, Lu X, Zhao Y, Liu P
Food & function 2020 Mar 1;11(3):2067-2079
Food & function 2020 Mar 1;11(3):2067-2079
Bexarotene Improve Depression-Like Behaviour in Mice by Protecting Against Neuro-inflammation and Synaptic Damage.
Yuan C, Dai C, Li Z, Zheng L, Zhao M, Dong S
Neurochemical research 2020 Jul;45(7):1500-1509
Neurochemical research 2020 Jul;45(7):1500-1509
Curcumin protects rat hippocampal neurons against pseudorabies virus by regulating the BDNF/TrkB pathway.
Yang B, Luo G, Zhang C, Feng L, Luo X, Gan L
Scientific reports 2020 Dec 17;10(1):22204
Scientific reports 2020 Dec 17;10(1):22204
Catalpol Enhances Neurogenesis And Inhibits Apoptosis Of New Neurons Via BDNF, But Not The BDNF/Trkb Pathway.
Zhu HF, Shao Y, Qin L, Wang JH, Feng S, Jiang YB, Wan D
Drug design, development and therapy 2019;13:4145-4157
Drug design, development and therapy 2019;13:4145-4157
Chaihu-Shugan-San and absorbed meranzin hydrate induce anti-atherosclerosis and behavioral improvements in high-fat diet ApoE(-/-) mice via anti-inflammatory and BDNF-TrkB pathway.
Li L, Yu AL, Wang ZL, Chen K, Zheng W, Zhou JJ, Xie Q, Yan HB, Ren P, Huang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108893
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108893
Hyperbaric oxygen therapy reduces apoptosis and dendritic/synaptic degeneration via the BDNF/TrkB signaling pathways in SCI rats.
Ying X, Tu W, Li S, Wu Q, Chen X, Zhou Y, Hu J, Yang G, Jiang S
Life sciences 2019 Jul 15;229:187-199
Life sciences 2019 Jul 15;229:187-199
OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice.
Yuan C, Guo X, Zhou Q, Du F, Jiang W, Zhou X, Liu P, Chi T, Ji X, Gao J, Chen C, Lang H, Xu J, Liu D, Yang Y, Qiu S, Tang X, Chen G, Zou L
Biochimica et biophysica acta. Molecular basis of disease 2019 Jan;1865(1):161-180
Biochimica et biophysica acta. Molecular basis of disease 2019 Jan;1865(1):161-180
Volatile Oil from Acorus gramineus Ameliorates the Injury Neurons in the Hippocampus of Amyloid Beta 1-42 Injected Mice.
Gao N, Liu H, Li S, Tu X, Tian S, Liu J, Li G, Ma Y
Anatomical record (Hoboken, N.J. : 2007) 2019 Dec;302(12):2261-2270
Anatomical record (Hoboken, N.J. : 2007) 2019 Dec;302(12):2261-2270
Neuroprotective effect of 1-Deoxynojirimycin on cognitive impairment, β-amyloid deposition, and neuroinflammation in the SAMP8 mice.
Chen W, Liang T, Zuo W, Wu X, Shen Z, Wang F, Li C, Zheng Y, Peng G
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Oct;106:92-97
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Oct;106:92-97
Perinatal exposure to nonylphenol impairs dendritic outgrowth of cerebellar Purkinje cells in progeny.
You M, Gu W, Li M, Qiu Z, Li S, Jiang Z, Yao D, Xu Y, Wang Y
Chemosphere 2018 Nov;211:758-766
Chemosphere 2018 Nov;211:758-766
Activation of BDNF-TrkB signaling pathway-regulated brain inflammation in pentylenetetrazole-induced seizures in zebrafish.
Jin M, Sheng W, Han L, He Q, Ji X, Liu K
Fish & shellfish immunology 2018 Dec;83:26-36
Fish & shellfish immunology 2018 Dec;83:26-36
ERK1/2-mediated disruption of BDNF-TrkB signaling causes synaptic impairment contributing to fluoride-induced developmental neurotoxicity.
Chen J, Niu Q, Xia T, Zhou G, Li P, Zhao Q, Xu C, Dong L, Zhang S, Wang A
Toxicology 2018 Dec 1;410:222-230
Toxicology 2018 Dec 1;410:222-230
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TrkB antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TrkB. This antibody recognizes human,mouse,rat antigen. The TrkB antibody has been validated for the following applications: ELISA, WB analysis.
