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- Antibody Data
- Antigen structure
- References [3]
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- Product number
- P01388 - Provider product page
- Provider
- Boster Biological Technology
- Product name
- Anti-Phospho-TrkB (Y817) NTRK2 Rabbit Monoclonal Antibody
- Antibody type
- Monoclonal
- Description
- Monoclonal antibody for TrkB/NTRK2 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: IP, IF, IHC, ICC, WB. Reactive species: Human, Mouse, Rat TrkB/NTRK2 information: Molecular Weight: 91999 MW; Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Endosome membrane ; Single-pass type I membrane protein . Internalized to endosomes upon ligand-binding; Tissue Specificity: Isoform TrkB is expressed in the central and peripheral nervous system. In the central nervous system (CNS), expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophthalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is mainly expressed in the brain but also detected in other tissues including pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in the brain.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Antibody clone number
- EGA-14
- Vial size
- 100ug/vial
- Storage
- Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Submitted references Yueliang Yin Ameliorates Endometrial Receptivity in Mice with Embryo Implantation Failure by Reducing Pyroptosis and Activating BDNF/TrkB Pathway.
Carboxypeptidase E conditional knockout mice exhibit learning and memory deficits and neurodegeneration.
Inhibition of protein tyrosine phosphatase 1B protects against sevoflurane-induced neurotoxicity mediated by ER stress in developing brain.
Jiang M, Huang L, Wang Y, Wang Y, Kang Q, Chen C, Hu Y, Li J, Wang T
Molecular nutrition & food research 2023 Dec;67(23):e2300339
Molecular nutrition & food research 2023 Dec;67(23):e2300339
Carboxypeptidase E conditional knockout mice exhibit learning and memory deficits and neurodegeneration.
Fan FC, Du Y, Zheng WH, Loh YP, Cheng Y
Translational psychiatry 2023 Apr 26;13(1):135
Translational psychiatry 2023 Apr 26;13(1):135
Inhibition of protein tyrosine phosphatase 1B protects against sevoflurane-induced neurotoxicity mediated by ER stress in developing brain.
Liu B, Ou G, Chen Y, Zhang J
Brain research bulletin 2019 Mar;146:28-39
Brain research bulletin 2019 Mar;146:28-39
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Supportive validation
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- Boster Biological Technology (provider)
- Main image
- Experimental details
- Western blot analysis of Phospho-TrkB (Y817) expression in SH-SY5Y cell lysate treated with BDNF.
- Additional image
