Antibody data
- Antibody Data
- Antigen structure
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- Product number
- APR02059G - Provider product page
- Provider
- Leading Biology
- Product name
- CDK12 / CRKRS Antibody (C-Terminus)
- Antibody type
- Polyclonal
- Description
- Cyclin-dependent kinase that phosphorylates the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
- Reactivity
- Human, Mouse, Canine, Hamster, Rabbit, Simian
- Host
- Rabbit
- Storage
- Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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