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- Antibody Data
- Antigen structure
- References [5]
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- Product number
- 26816-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- CDK12/CRKRS antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CDK12/CRKRS antibody (Cat. #26816-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Identifying human pre-mRNA cleavage and polyadenylation factors by genome-wide CRISPR screens using a dual fluorescence readthrough reporter.
THOC5 complexes with DDX5, DDX17, and CDK12 to regulate R loop structures and transcription elongation rate.
JWA suppresses proliferation in trastuzumab-resistant breast cancer by downregulating CDK12.
CDK12 inhibition enhances sensitivity of HER2+ breast cancers to HER2-tyrosine kinase inhibitor via suppressing PI3K/AKT.
Expression pattern of CDK12 protein in gastric cancer and its positive correlation with CD8(+) cell density and CCL12 expression.
Ni Z, Ahmed N, Nabeel-Shah S, Guo X, Pu S, Song J, Marcon E, Burke GL, Tong AHY, Chan K, Ha KCH, Blencowe BJ, Moffat J, Greenblatt JF
Nucleic acids research 2024 May 8;52(8):4483-4501
Nucleic acids research 2024 May 8;52(8):4483-4501
THOC5 complexes with DDX5, DDX17, and CDK12 to regulate R loop structures and transcription elongation rate.
Polenkowski M, Allister AB, Burbano de Lara S, Pierce A, Geary B, El Bounkari O, Wiehlmann L, Hoffmann A, Whetton AD, Tamura T, Tran DDH
iScience 2023 Jan 20;26(1):105784
iScience 2023 Jan 20;26(1):105784
JWA suppresses proliferation in trastuzumab-resistant breast cancer by downregulating CDK12.
Liang Y, Qian C, Xie Y, Huang X, Chen J, Ren Y, Fu Z, Li Y, Zeng T, Yang F, Zhou J, Li W, Yin Y, Wang C
Cell death discovery 2021 Oct 22;7(1):306
Cell death discovery 2021 Oct 22;7(1):306
CDK12 inhibition enhances sensitivity of HER2+ breast cancers to HER2-tyrosine kinase inhibitor via suppressing PI3K/AKT.
Li H, Wang J, Yi Z, Li C, Wang H, Zhang J, Wang T, Nan P, Lin F, Xu D, Qian H, Ma F
European journal of cancer (Oxford, England : 1990) 2021 Mar;145:92-108
European journal of cancer (Oxford, England : 1990) 2021 Mar;145:92-108
Expression pattern of CDK12 protein in gastric cancer and its positive correlation with CD8(+) cell density and CCL12 expression.
Ji J, Zhou C, Wu J, Cai Q, Shi M, Zhang H, Yu Y, Zhu Z, Zhang J
International journal of medical sciences 2019;16(8):1142-1148
International journal of medical sciences 2019;16(8):1142-1148
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