HPA008038

antibody from Atlas Antibodies

Targeting: CDK12 CRK7, CRKR, CRKRS, KIAA0904

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

HPA008038

Provider

Atlas Antibodies

Proper citation

Atlas Antibodies Cat#HPA008038, RRID:AB_1078570

Product name

Anti-CDK12

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human CDK12, Gene description: cyclin-dependent kinase 12, Alternative Gene Names: CRK7, CRKR, CRKRS, KIAA0904, Validated applications: ICC, IHC, Uniprot ID: Q9NYV4, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.1 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

CDK12 loss drives prostate cancer progression, transcription-replication conflicts, and synthetic lethality with paralog CDK13

Tien J, Luo J, Chang Y, Zhang Y, Cheng Y, Wang X, Yang J, Mannan R, Mahapatra S, Shah P, Wang X, Todd A, Eyunni S, Cheng C, Rebernick R, Xiao L, Bao Y, Neiswender J, Brough R, Pettitt S, Cao X, Miner S, Zhou L, Wu Y, Labanca E, Wang Y, Parolia A, Cieslik M, Robinson D, Wang Z, Feng F, Chou J, Lord C, Ding K, Chinnaiyan A
Cell Reports Medicine 2024;5(10):101758

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Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition

Chang Y, Wang X, Yang J, Tien J, Mannan R, Cruz G, Zhang Y, Vo J, Magnuson B, Mahapatra S, Cho H, Dhanasekaran S, Wang C, Wang Z, Zhou L, Zhou K, Zhou Y, Zhang P, Huang W, Xiao L, Liu W, Hamadeh R, Su F, Wang R, Miner S, Cao X, Cheng Y, Mehra R, Ding K, Chinnaiyan A
Cell Reports Medicine 2024;5(10):101752

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Tien J, Chang Y, Zhang Y, Chou J, Cheng Y, Wang X, Yang J, Mannan R, Shah P, Wang X, Todd A, Eyunni S, Cheng C, Rebernick R, Xiao L, Bao Y, Neiswender J, Brough R, Pettitt S, Cao X, Miner S, Zhou L, Wu Y, Labanca E, Wang Y, Parolia A, Cieslik M, Robinson D, Wang Z, Feng F, Lord C, Ding K, Chinnaiyan A
2024

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Yang Y, Badura M, O’Leary P, Delavan H, Robinson T, Egusa E, Zhong X, Swinderman J, Li H, Zhang M, Kim M, Ashworth A, Feng F, Chou J, Yang L
2024

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CDK12 Is Necessary to Promote Epidermal Differentiation Through Transcription Elongation

Li J, Tiwari M, Chen Y, Luanpitpong S, Sen G
Stem Cells 2022;40(4):435-445