21066-1-AP

antibody from Proteintech Group

Targeting: MLKL FLJ34389

Provider product page for 21066-1-AP

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Antibody Data
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References [89]
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Product number: 21066-1-AP - Provider product page
Provider: Proteintech Group
Product name: MLKL antibody
Antibody type: Polyclonal
Description: KD/KO validated MLKL antibody (Cat. #21066-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

MLKL protein structure - 21066-1-AP shown in red.

Submitted references Curcumol Induces Necroptosis of Hepatic Stellate Cells by Targeting KAT8 to Suppress HK2 Lactylation and Promote HUWE1-Dependent Ubiquitination.

Guo X, Lin Y, Jiang Y, Wang M, Li Y, Gao Y, Chen B, Bao Z, Tian H, Chu X, Zhang Z, Shao J, Zhang F, Wang H, Xuan J, Xu X, Zheng S
International journal of biological sciences 2026;22(3):1648-1673

HIF-1α drives pyroptosis in extravillous trophoblasts by suppressing PPAR-γ to activate the NLRP3 inflammasome in RA-complicated pregnancy.

Zhang T, Zhao Y, He W, Chen Y, Liu Q, Tang Y, Geng S, Xu L, Tao L, Yu Z, Zhang X, Yang Y, Zhao J, Zhang L
International immunopharmacology 2026 Jun 1;178:116522

USP39 inhibits MLKL phosphorylation and deubiquitination to suppress necroptosis of nucleus pulposus cells and attenuate intervertebral disc degeneration.

Zhu Z, Lin X, Kong F, Wang Z, Liang Y, Ji C, Chen H, Sun K, Wang C, Xu X, Shi J
Journal of orthopaedic translation 2026 Jan;56:101039

Ginseng Polysaccharides Protect Against Endoplasmic Reticulum Stress-Induced Damage via PI3K/Akt Signalling Pathway in Bovine Ovarian Granulosa Cells.

Wang H, Fang Y, Huang L, Yang X, Ma X, Lyu Y, Jing G, Ding H, Liu H, Lyu W
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Shh-S100A10 axis curbs neuronal PANoptosis after ischemic stroke.

Wang L, Tang H, Wen J, Yang Q, Huang J, Zhao Y, Ren Y, Yang Q
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ACT001 alleviates sepsis-induced acute lung injury by downregulating PANoptosis via the JAK2/STAT3 pathway.

Zhang N, Zhang H, Ping J, Shen N, Fang T, Fu Q
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Prognostic Value of C-Reactive Protein, Procalcitonin, and Interferon-Alpha in COVID-19 and Their Association with PANoptosis: A Cohort Study in Guangxi, China.

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Journal of inflammation research 2025;18:15527-15542

Integrated Single-Cell and Transcriptome Analysis with Experimental Validation Reveals PANoptosis-Related Gene Signatures in the Immune Microenvironment of Autoimmune Thyroiditis.

Zhao Z, Liu Z, Wang Q, Gao H, Song N, Yang X
Journal of inflammation research 2025;18:12123-12143

Gestational zearalenone causes fetal intrauterine growth restriction partially through deriving ROS-Drp1 mediated placental PANoptosis.

Liu JR, Wu FN, Lin S, Chen C, Liu Y, Fan JW, Hong Q, Chen YH
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Acetyl-CoA Short-Chain Synthetase-2 Regulates Myocardial Ischemia/Reperfusion Injury by Targeting Histone Acetylation.

Chen X, Xu Q, Ding W, Wang Y, Wang P, Zhao C, Ao X, Wang J
Journal of cardiovascular translational research 2025 Oct;18(5):1100-1112

Simultaneous inhibition of pannexin-1 by probenecid and caspases by Z-VAD-fmk attenuates apoptosis and necroptosis in a rat model of cerebral ischemia-reperfusion.

Colak E, Oz S, Ozkara E, Burukoglu Donmez D, Ozdemir AO, Gunes HV, Colak E
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Tubastatin A alleviates post-resuscitation myocardial damage possibly via inhibiting GSDME-mediated pyroptosis and MLKL-mediated necroptosis in a porcine model of cardiac arrest.

Lai L, Fang Y, Xie L, Zhao X, Xu J, Lan P
Resuscitation plus 2025 Nov;26:101158

Ozone controls the metabolism of tryptophan protecting against sepsis-induced intestinal damage by activating aryl hydrocarbon receptor.

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CNS neuroscience & therapeutics 2025 Feb;31(2):e70293

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Huang X, Lin K, Chen W, Zhang D, Khan M, Ye X, Wang B, Chen C, Tian Y, Yuan Y, Lin J
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Early Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Infection Induces Necroptosis in Immune Cells of Peripheral Lymphoid Organs.

Xu J, Huo C, Yang Y, Han J, Zhou L, Hu Y, Yang H
Viruses 2025 Feb 20;17(3)

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Wu J, Deng Y, Gao Y, Wei B
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Long D, Xu Y, Li X, Zeng Y, Tang Z, Liu L, Liu Y, Zong X, Yang S, Wang D
Chemico-biological interactions 2025 Aug 1;416:111550

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The anti-cancer drug candidate CBL0137 induced necroptosis via forming left-handed Z-DNA and its binding protein ZBP1 in liver cells.

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Khan M, Huang X, Ye X, Zhang D, Wang B, Xu A, Li R, Ren A, Chen C, Song J, Zheng R, Yuan Y, Lin J
Annals of medicine 2024 Dec;56(1):2405079

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Li C, Shi Y, Chen S, Chen L, Zeng L, Xiang L, Li Y, Sun W, Zhang H, Wen S, Lin J
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HIST3H2A promotes the progression of prostate cancer through inhibiting cell necroptosis.

Yang L, Ruan Y, Xu H
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Modulation of YBX1-mediated PANoptosis inhibition by PPM1B and USP10 confers chemoresistance to oxaliplatin in gastric cancer.

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Cancer letters 2024 Apr 10;587:216712

Physiological ischemic training improves cardiac function through the attenuation of cardiomyocyte apoptosis and the activation of the vagus nerve in chronic heart failure.

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RNA-sequencing approach for exploring the protective mechanisms of dexmedetomidine on pancreatic injury in severe acute pancreatitis.

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N-acetyl-L-cysteine alleviated the oxidative stress-induced inflammation and necroptosis caused by excessive NiCl(2) in primary spleen lymphocytes.

Zhang X, Xu L, Ma W, Shi B, Liu Q, Song Y, Fang C, Liu P, Qiao S, Cai J, Zhang Z
Frontiers in immunology 2023;14:1146645

Whether the Subacute MPTP-Treated Mouse is as Suitable as a Classic Model of Parkinsonism.

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Neuromolecular medicine 2023 Sep;25(3):360-374

SCD1 and monounsaturated lipids are required for autophagy and survival of adipocytes.

Mori H, Peterson SK, Simmermon R, Overmyer KA, Nishii A, Paulsson E, Li Z, Jen A, Uranga RM, Maung J, Yacawych WT, Lewis KT, Schill RL, Hetrick T, Seino R, Inoki K, Coon JJ, MacDougald OA
bioRxiv : the preprint server for biology 2023 Oct 27;

Sulconazole Induces PANoptosis by Triggering Oxidative Stress and Inhibiting Glycolysis to Increase Radiosensitivity in Esophageal Cancer.

Liu LX, Heng JH, Deng DX, Zhao H, Zheng ZY, Liao LD, Lin W, Xu XE, Li EM, Xu LY
Molecular & cellular proteomics : MCP 2023 Jun;22(6):100551

Identification of necroptosis-related gene TRAF5 as potential target of diagnosing atherosclerosis and assessing its stability.

Peng Z, Wang K, Wang S, Wu R, Yao C
BMC medical genomics 2023 Jun 17;16(1):139

Thymol Ameliorates Aspergillus fumigatus Keratitis by Downregulating the TLR4/ MyD88/ NF-kB/ IL-1β Signal Expression and Reducing Necroptosis and Pyroptosis.

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Journal of microbiology and biotechnology 2023 Jan 28;33(1):43-50

MLKL deficiency attenuated hepatocyte oxidative DNA damage by activating mitophagy to suppress macrophage cGAS-STING signaling during liver ischemia and reperfusion injury.

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Acteoside attenuates RSV-induced lung injury by suppressing necroptosis and regulating metabolism.

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Polymyxin B Reduces Brain Injury in Ischemic Stroke Rat Through a Mechanism Involving Targeting ESCRT-III Machinery and RIPK1/RIPK3/MLKL Pathway.

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A necroptotic-independent function of MLKL in regulating endothelial cell adhesion molecule expression.

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FKBP12 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation.

Wang Z, Feng J, Yu J, Chen G
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Dexmedetomidine Preconditioning Protects Cardiomyocytes Against Hypoxia/Reoxygenation-Induced Necroptosis by Inhibiting HMGB1-Mediated Inflammation.

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Archivum immunologiae et therapiae experimentalis 2019 Aug;67(4):249-261

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The American journal of Chinese medicine 2018;46(6):1263-1279

Necrostatin-1 promotes ectopic periodontal tissue like structure regeneration in LPS-treated PDLSCs.

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PloS one 2018;13(11):e0207760

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Dihydrotanshinone I, a natural product, ameliorates DSS-induced experimental ulcerative colitis in mice.

Guo Y, Wu X, Wu Q, Lu Y, Shi J, Chen X
Toxicology and applied pharmacology 2018 Apr 1;344:35-45

Neuroprotective Effect of β-Caryophyllene on Cerebral Ischemia-Reperfusion Injury via Regulation of Necroptotic Neuronal Death and Inflammation: In Vivo and in Vitro.

Yang M, Lv Y, Tian X, Lou J, An R, Zhang Q, Li M, Xu L, Dong Z
Frontiers in neuroscience 2017;11:583

A novel sgRNA selection system for CRISPR-Cas9 in mammalian cells.

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Biochemical and biophysical research communications 2016 Mar 18;471(4):528-32

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Submitted by: Proteintech Group (provider)
Main image
Experimental details: HepG2 cells were subjected to SDS PAGE followed by western blot with 21066-1-AP( MLKL Antibody) at dilution of 1:300
Other comments: WB
Appendix: 21066-1-AP.pdf

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