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- Antibody Data
- Antigen structure
- References [178]
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- Product number
- 66675-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- MLKL antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated MLKL antibody (Cat. #66675-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, Mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 3D4C6
- Vial size
- 20ul, 150ul
Submitted references L-2-aminoadipic acid inhibits porcine epidemic diarrhea virus replication by targeting and reducing cellular autophagy.
Severe fever with thrombocytopenia syndrome virus infection of the male reproductive tract induces pathology and inflammation.
Sangbaipi Decoction mitigates influenza pneumonia in mice by inhibiting ZBP1-mediated PANoptosis.
DEAF1 confers resistance to adriamycin-induced apoptosis and pyroptosis in multiple myeloma.
Targeting ROS-metabolism dual pathways to trigger PANoptosis by cobalt-vanadium oxides biomimetic nanocakes for tumor immunotherapy.
NPM3 functions as a lactyltransferase to promote necroptosis in male diabetic cardiomyopathy mice models via FASN transcription modulation.
FAK/SRC-JNK axis promotes ferroptosis via upregulating ACSL4 expression.
Mitochondrial Targeting of GSDMD-N and p-MLKL Drives PANoptosis in benzo[a]pyrene-Induced Hepatotoxicity.
Astragalus Polysaccharide Alleviated Septic Associated Acute Kidney Injury Through Dual Mechanisms of RIPK1-Dependent Necroptosis and Autophagy in Macrophage.
Endogenous oxidized phospholipid POVPC triggers pulmonary epithelial ferroptosis in acute lung injury and is restrained by RCN3.
Identifying cathepsin B as a key regulator of programmed cell death in acute pancreatitis.
Transferrin receptor serves a role in promoting PANoptosis in thyroid cancer.
Gasdermin D Cleavage and Cytokine Release, Indicative of Pyroptotic Cell Death, Induced by Ophiobolin A in Breast Cancer Cell Lines.
AHR-CYP1A1 Axis Perturbation and Necroptosis in 1,2-Dichloroethane Hepatotoxicity: Elucidation by an Integrated Network Toxicology and In Vitro Validation.
ZBP1 Mediates Renal Tubular Injury in Diabetic Nephropathy Through RIPK3-mediated Necroptosis.
Ginseng Polysaccharides Protect Against Endoplasmic Reticulum Stress-Induced Damage via PI3K/Akt Signalling Pathway in Bovine Ovarian Granulosa Cells.
Treating acute respiratory distress syndrome with a multifaceted nanomedicine: Inhibition of PANoptosis and enhancement of lung barrier integrity.
Inducible CD147 up-regulation boosts extended SARS-CoV-2 infection triggering severe COVID-19 independent of ACE2.
Hepatocyte PLAGL2 deficiency alleviates MASH through MYD88-licensed inactivation of inflammasome.
Macrophage C3aR1 Mediates Sepsis-Induced Myocardial Injury by Triggering Neutrophil Necroptosis.
Geum japonicum Thunb. var. Chinese-P.decorata H.Andres herbal pair ameliorates CIRI-induced neuronal injury by facilitating mitochondrial transfer via the CD38/Miro1 signaling pathway.
Inducible Nitric Oxide Deficiency Attenuates Necroptosis in Psoriasis-Like Dermatitis in Mice by Reducing Oxidative Stress.
USP25 regulates atherosclerosis by restricting RIPK1-mediated inflammatory responses.
Sortilin is Associated with PGRN-Mediated Endoplasmic Reticulum Stress and Activation of Microglia in a Rat Model of Degenerative Cervical Myelopathy.
Identification of human MLKL Cys184 and HSPBP1 Cys201 as novel cellular targets for necroptosis.
Identification and validation of key PANoptosis-related genes via integrative machine learning and single-cell sequencing in AILI.
Voltage-dependent anion channel 1 oligomerization regulates PANoptosis in retinal ischemia-reperfusion injury.
AQP1 Affects Necroptosis by Targeting RIPK1 in Endothelial Cells of Atherosclerosis.
Oxidative stress and inflammation combine to exacerbate cochlear damage and sensorineural hearing loss in C57BL/6 mice.
TLR4 Induces PANoptosis in Annulus Fibrosus Cells by Activating NLRP12 in Intervertebral Disc Degeneration.
Investigating the Role of Salidroside in Alleviating Acute Pancreatitis by Inhibiting the RIPK1/RIPK3/MLKL Pathway-Mediated Necroptosis in Pancreatic Acinar Cells in Rats.
Mongolian medicine Wulanwendusu-11 alleviates myocardial ischemia-reperfusion injury by modulating the intestinal microbiota and associated metabolic pathways.
Integrated metabolomic and transcriptomic analysis reveals the effects and mechanisms of Jingfang Baidu powder on acute lung injury.
Gambogic acid targets HSP90 to alleviate DSS-induced colitis via inhibiting the necroptosis of intestinal epithelial cells.
Macrophage caspase-8 inhibition accelerates necrotic core expansion in atheroma plaque in mice.
Oxidative stress-mediated PANoptosis and ferroptosis: Exploration of multimodal cell death triggered by an AIE-active nano-photosensitizer via photodynamic therapy.
Unraveling ancient wisdom: The molecular mechanism of Gujin Luyan Xuming decoction in combating cerebral ischemia-reperfusion injury.
Danggui buxue decoction attenuates doxorubicin-induced cardiotoxicity by inhibiting ZBP1-mediated PANoptosis in vivo and in vitro.
High-dose ascorbic acid selectively induces pyroptosis in LKB1-deficient lung cancer and sensitizes immunotherapy.
Gestational zearalenone causes fetal intrauterine growth restriction partially through deriving ROS-Drp1 mediated placental PANoptosis.
Mitochondrial dysfunction triggers Zbp1-mediated necroptosis and inflammation in acute lung injury.
Knockout of Mlkl alleviates myocardial damage and inflammation induced by T-2 toxin with low selenium conditions.
Antibody-DNA nanostructure conjugates exhibit inhibited effects on CT26 cells and prevent upregulation of PD-1 in the tumor microenvironment.
7 I, a structurally modified sinomenine, exerts dual anti-GBM effects by inhibiting glioblastoma proliferation and inducing necroptosis which further mediates lysosomal cell death.
Melatonin alleviates sepsis-induced acute lung injury by inhibiting necroptosis via reducing circulating mtDNA release.
Lactoferrin Alleviates LPS-Induced Oxidative Stress and Necroptosis in Liver by Promoting Mitophagy.
Orientia tsutsugamushi Modulates RIPK3 Cellular Levels but Does Not Inhibit Necroptosis.
Antibody-DNA nanostructure conjugate enables targeted delivery of gemcitabine to tumor and improves the anti-tumor efficacy.
ZBP1 senses splicing aberration through Z-RNA to promote cell death.
Cadmium exposure induces Leydig cell injury via necroptosis caused by oxidative stress and TNF-α/TNFR1 signaling.
SIRT1 Alleviates Mitochondrial Fission and Necroptosis in Cerebral Ischemia/Reperfusion Injury via SIRT1-RIP1 Signaling Pathway.
Panoptosis Targets the Mechanism of PRDX1 Involvement in Acute Myocardial Infarction via ZBP1.
Chronic exposure to liquid crystal monomer EBCN at environmentally relevant concentrations induces testicular dysfunction via the gut-testis axis.
Pristimerin ameliorates colitis‑induced intestinal mucosal injury by inhibiting intestinal epithelial necroptosis.
Transforming Growth Factor-β-Activated Protein 1 (TAK1) Regulates Necroptosis in Age-Related Hearing Loss.
Targeting Cancer With Bifunctional Peptides: Mechanism of Cell Entry and Inciting Cell Death.
STING-mediated mitochondrial DNA release exacerbates PANoptosis in liver ischemia reperfusion injury.
FDA-approved phensuximide inhibits RIPK1-dependent immunogenic cell death.
Circular RNA-OGDH promotes PANoptosis in diabetic cardiomyopathy: A novel mechanistic insight.
Baitouweng decoction modulates gut microbial production of indole-3-propionic acid and epithelial necroptosis to alleviate DSS-induced colitis in mice.
Deoxypodophyllotoxin inhibited the growth of malignant pleural mesothelioma by inducing necroptosis and mitotic catastrophe.
Short-term exposure to low doses of aflatoxin B1 aggravates nonalcoholic steatohepatitis by TLR4-mediated necroptosis.
Cleaving PINK1 or PGAM5? Involvement of PARL in Methamphetamine-Induced Excessive Mitophagy and Neuronal Necroptosis.
P2Y(14)R activation facilitates liver regeneration via CREB/DNMT3b/Dact-2/β-Catenin signals in acute liver failure.
The interactive toxic effect of homocysteine and copper on cardiac microvascular endothelial cells during ischemia-reperfusion injury.
Hypoxia-mediated SUMOylation of FADD exacerbates endothelial cell injury via the RIPK1-RIPK3-MLKL signaling axis.
Ferroptosis and PANoptosis under hypoxia pivoting on the crosstalk between DHODH and GPX4 in corneal epithelium.
Exercise alleviates programmed necrosis in myocardial ischemia-reperfusion injury through adipose tissue-derived exosomal miR-17-3p targeting CAMKII.
MLKL Modulates Necroptosis and Neuroinflammation in a Mouse Model of MS.
MLKL-Mediated Necroptosis Predominantly Contributes to Immune-Associated Myocardial Damage.
Bavachinin exerts anti-tumor effects by activating TLR4/STING axis-dependent PANoptosis and synergistically enhances chemosensitivity in endometrial cancer.
RIPK1 Drives JAK1-STAT3 Signaling to Promote CXCL1-Mediated Neutrophil Recruitment in Sepsis-Induced Lung Injury.
Inhibition of Pannexin1 alleviates the damage of pilocarpine-induced status epilepticus through diminishing inflammatory PANoptosis-like neuron death.
Sestrin2 alleviates sepsis-induced immunosuppression of dendritic cells by regulating mitochondrial dynamics.
Trimethylamine N-oxide Induced Chronic Kidney Injury by Triggering PANoptosis.
RIPK3-MLKL dependent necroptosis mediates depressive-like behavior by facilitating neuroinflammation.
Astragalus polysaccharide reduces the severity of acute pancreatitis under a high-fat diet through enriching L. reuteri and propionate.
Deubiquitination of RIPK3 by OTUB2 potentiates neuronal necroptosis after ischemic stroke.
Electret-Inspired Charge-Injected Hydrogel for Scar-Free Healing of Bacterially Infected Burns Through Bioelectrical Stimulation and Immune Modulation.
A Small Molecule Inhibitor of Leucine Carboxyl Methyltransferase-1 Inhibits Cancer Cell Survival.
Neutrophil extracellular traps trigger alveolar epithelial cell necroptosis through the cGAS-STING pathway during acute lung injury in mice.
KAE ameliorates LPS-mediated acute lung injury by inhibiting PANoptosis through the intracellular DNA-cGAS-STING axis.
Inhibition of the RIP3/MLKL/TRPM7 necroptotic pathway ameliorates diabetes mellitus-induced erectile dysfunction by reducing cell death, fibrosis, and inflammation.
Zinc oxide nanoparticles disrupt the mammary epithelial barrier via Z-DNA binding protein 1-triggered PANoptosis.
AIBP protects drug-induced liver injury by inhibiting MAPK-mediated NR4A1 expression.
Integrated Studies on Male Reproductive Toxicity of Decabromodiphenyl Ethane in Zebrafish Spermatozoa Ex Vivo, Male Zebrafish in Vivo, and GC-1 Cells in Vitro.
Residue Y362 is crucial for FLIP(L) to impart catalytic activity to pro-caspase-8 to suppress necroptosis.
A ZBP1 isoform blocks ZBP1-mediated cell death.
Urolithin A's Role in Alleviating Severe Acute Pancreatitis via Endoplasmic Reticulum-Mitochondrial Calcium Channel Modulation.
Gancao decoction attenuates hepatic necroptosis via activating caspase 8 in cholestatic liver injury.
Imbalance of programmed cell death patterns mediated by dendritic cell subsets in systemic lupus erythematosus and lupus nephritis.
Effect of lipopolysaccharide on TAK1-mediated hepatocyte PANoptosis through Toll-like receptor 4 during acute liver failure.
Involvement of necroptotic cell death in macrophages in progression of bleomycin and LPS-induced acute exacerbation of idiopathic pulmonary fibrosis.
S100A8/A9(hi) neutrophils induce mitochondrial dysfunction and PANoptosis in endothelial cells via mitochondrial complex I deficiency during sepsis.
Systematic analysis of PANoptosis-related genes identifies XIAP as a functional oncogene in breast cancer.
Regulation of cardiac ferroptosis in diabetic human heart failure: uncovering molecular pathways and key targets.
Honokiol Mitigates Metabolic-Associated Fatty Liver Disease by Regulating Nrf2 and RIPK3 Signaling Pathways.
Mitophagy-regulated Necroptosis plays a vital role in the nephrotoxicity of Fumonisin B1 in vivo and in vitro.
An immunohistochemical atlas of necroptotic pathway expression.
lncRNA FLJ20021 regulates CDK1-mediated PANoptosis in a ZBP1-dependent manner to increase the sensitivity of laryngeal cancer-resistant cells to cisplatin.
Shengxian decoction improves lung function in rats with bleomycin-induced idiopathic pulmonary fibrosis through the inhibition of PANoptosis.
Neutrophil extracellular traps aggravate intestinal epithelial necroptosis in ischaemia-reperfusion by regulating TLR4/RIPK3/FUNDC1-required mitophagy.
An investigation of the distributions of ferroptosis and necroptosis mediators in the maternal-fetal interface at different days of rat pregnancy.
Infant feces-derived Lactobacillus gasseri FWJL-4 mitigates experimental necrotizing enterocolitis via acetate production.
The traditional herb Sargentodoxa cuneata alleviates DSS-induced colitis by attenuating epithelial barrier damage via blocking necroptotic signaling.
VDAC1, as a downstream molecule of MLKL, participates in OGD/R-induced necroptosis by inducing mitochondrial damage.
A slow-releasing donor of hydrogen sulfide inhibits neuronal cell death via anti-PANoptosis in rats with spinal cord ischemia‒reperfusion injury.
CGRP is essential for protection against alveolar epithelial cell necroptosis by activating the AMPK/L-OPA1 signaling pathway during acute lung injury.
Transcriptotype-Driven Discovery of Apigenin as a Therapy against Cholestatic Liver Fibrosis: Through Inhibition of PANoptosis and Following Type-I Interferon Responses.
Integrating bioinformatics and experimental validation to Investigate IRF1 as a novel biomarker for nucleus pulposus cells necroptosis in intervertebral disc degeneration.
DL-3-n-Butylphthalide Ameliorates Post-stroke Emotional Disorders by Suppressing Neuroinflammation and PANoptosis.
Reversal of hepatic accumulation of nordeoxycholic acid underlines the beneficial effects of cholestyramine on alcohol-associated liver disease in mice.
Mitochondrial dysfunction induced by HIF-1α under hypoxia contributes to the development of gastric mucosal lesions.
Nanointegrative Glycoengineering-Activated Necroptosis of Triple Negative Breast Cancer Stem Cells Enables Self-Amplifiable Immunotherapy for Systemic Tumor Rejection.
Sodium sulfite triggered hepatic apoptosis, necroptosis, and pyroptosis by inducing mitochondrial damage in mice and AML-12 cells.
NLRP6 induces RIP1 kinase-dependent necroptosis via TAK1-mediated p38(MAPK)/MK2 phosphorylation in S. typhimurium infection.
PCSK9 Promotes Hypoxia-Induced EC Pyroptosis by Regulating Smac Mitochondrion-Cytoplasm Translocation in Critical Limb Ischemia.
Brazilin inhibits bladder cancer by promoting cell necroptosis.
Quizartinib inhibits necroptosis by targeting receptor-interacting serine/threonine protein kinase 1.
IFN-γ promotes PANoptosis in Pasteurella multocida toxin-induced pneumonia in mice.
Effect of doramectin on programmed cell death pathway in glioma cells.
LncRNA MALAT1 Promoted Neuronal Necroptosis in Cerebral Ischemia-reperfusion Mice by Stabilizing HSP90.
Polystyrene microplastics with different sizes induce the apoptosis and necroptosis in liver through the PTEN/PI3K/AKT/autophagy axis.
Repurposing crizotinib to target RIPK1-dependent cell death.
Echinacea Polyphenols Inhibit NLRP3-Dependent Pyroptosis, Apoptosis, and Necroptosis via Suppressing NO Production during Lipopolysaccharide-Induced Acute Lung Injury.
Apoptosis-induced nuclear expulsion in tumor cells drives S100a4-mediated metastatic outgrowth through the RAGE pathway.
Deletion of Bak1 alleviates microglial necroptosis and neuroinflammation after experimental subarachnoid hemorrhage.
Role of the Peli1-RIPK1 Signaling Axis in Methamphetamine-Induced Neuroinflammation.
Necroptosis of macrophage is a key pathological feature in biliary atresia via GDCA/S1PR2/ZBP1/p-MLKL axis.
Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads to retinal ganglion cell PANoptosis in glaucoma.
STING deficiency protects against wasp venom-induced acute kidney injury.
Cisatracurium besylate rescues Mycobacterium Tuberculosis-infected macrophages from necroptosis and enhances the bactericidal effect of isoniazid.
Polysaccharide from Strongylocentrotus nudus eggs regulates intestinal epithelial autophagy through CD36/PI3K-Akt pathway to ameliorate inflammatory bowel disease.
Nucleoporin Seh1 maintains Schwann cell homeostasis by regulating genome stability and necroptosis.
Triptolide leads to hepatic intolerance to exogenous lipopolysaccharide and natural-killer-cell mediated hepatocellular damage by inhibiting MHC class I molecules.
MLKL signaling regulates macrophage polarization in acute pancreatitis through CXCL10.
Repositioning linifanib as a potent anti-necroptosis agent for sepsis.
Lactoferrin attenuated urban particulate matter-induced nephrotoxicity by regulating the CSF2/CENPE axis.
Serinc2 deficiency exacerbates sepsis-induced cardiomyopathy by enhancing necroptosis and apoptosis.
Skp2-mediated MLKL degradation confers cisplatin-resistant in non-small cell lung cancer cells.
Repurposing of the FGFR inhibitor AZD4547 as a potent inhibitor of necroptosis by selectively targeting RIPK1.
Liraglutide Attenuates Myocardial Ischemia/Reperfusion Injury Through the Inhibition of Necroptosis by Activating GLP-1R/PI3K/Akt Pathway.
Ameliorative effects of epigallocatechin-3-gallate nanoparticles on 2,4-dinitrochlorobenzene induced atopic dermatitis: A potential mechanism of inflammation-related necroptosis.
Adenosine Kinase Inhibition Prevents Severe Acute Pancreatitis via Suppressing Inflammation and Acinar Cell Necroptosis.
Protective effect of inhibiting necroptosis on gentamicin-induced nephrotoxicity.
Enhanced nuclear localization of phosphorylated MLKL predicts adverse events in patients with dilated cardiomyopathy.
Serpina3c deficiency induced necroptosis promotes non-alcoholic fatty liver disease through β-catenin/Foxo1/TLR4 signaling.
Zinc finger protein 91 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation.
Myo-inositol oxygenase overexpression exacerbates cadmium-induced kidney injury via oxidant stress and necroptosis.
Contribution of Necroptosis to Myofiber Death in Idiopathic Inflammatory Myopathies.
MiR-29a-3p Improves Acute Lung Injury by Reducing Alveolar Epithelial Cell PANoptosis.
LncRNA 122049 suppresses apoptosis of renal tubular epithelial cells in ischemic AKI by targeting the miR-330-5p/ELK1 axis.
L-OPA1 deficiency aggravates necroptosis of alveolar epithelial cells through impairing mitochondrial function during acute lung injury in mice.
Dysmyelination by Oligodendrocyte-Specific Ablation of Ninj2 Contributes to Depressive-Like Behaviors.
Thioredoxin reductase 3 suppression promotes colitis and carcinogenesis via activating pyroptosis and necrosis.
Pressure Drives Rapid Burst-Like Coordinated Cellular Motion from 3D Cancer Aggregates.
Caspase-8 is involved in pyroptosis, necroptosis and the maturation and release of IL-1β in Aspergillus fumigatus keratitis.
Targeting Cell Membranes, Depleting ROS by Dithiane and Thioketal-Containing Polymers with Pendant Cholesterols Delivering Necrostatin-1 for Glaucoma Treatment.
Developmental exposure to chlorpyrifos causes neuroinflammation via necroptosis in mouse hippocampus and human microglial cell line.
Taurine inhibits necroptosis helps to alleviate inflammatory and injury induced by Klebsiella infection.
Necrostatin-1 Against Sevoflurane-Induced Cognitive Dysfunction Involves Activation of BDNF/TrkB Pathway and Inhibition of Necroptosis in Aged Rats.
4-Hydroxy-2-Nonenal Promotes Cardiomyocyte Necroptosis via Stabilizing Receptor-Interacting Serine/Threonine-Protein Kinase 1.
Expression of the ACE2 Virus Entry Protein in the Nervus Terminalis Reveals the Potential for an Alternative Route to Brain Infection in COVID-19.
RIPK3-Dependent Necroptosis Is Induced and Restricts Viral Replication in Human Astrocytes Infected With Zika Virus.
Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy.
PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination.
Metformin attenuates hypothalamic inflammation via downregulation of RIPK1-independent microglial necroptosis in diet-induced obese mice.
Inhibition of adenosine kinase attenuates myocardial ischaemia/reperfusion injury.
Differential role of MLKL in alcohol-associated and non-alcohol-associated fatty liver diseases in mice and humans.
M10, a Myricetin-3-O-b-D-Lactose Sodium Salt, Prevents Ulcerative Colitis Through Inhibiting Necroptosis in Mice.
Protective effect of astaxanthin against SnS(2) nanoflowers induced testes toxicity by suppressing RIPK1-RIPK3-MLKL signaling in mice.
A new perspective of triptolide-associated hepatotoxicity: the relevance of NF- κ B and NF- κ B-mediated cellular FLICE-inhibitory protein.
Insights into mechanisms of pranoprofen-induced apoptosis and necroptosis in human corneal stromal cells.
TRADD Mediates RIPK1-Independent Necroptosis Induced by Tumor Necrosis Factor.
The bromodomain protein BRD4 positively regulates necroptosis via modulating MLKL expression.
Quetiapine induces myocardial necroptotic cell death through bidirectional regulation of cannabinoid receptors.
FKBP12 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation.
A new perspective of triptolide-associated hepatotoxicity: Liver hypersensitivity upon LPS stimulation.
Ma X, Cui H, Song R, Huang Y, Li Y, Ma J, Chen H, Ma S, Wei Z
Veterinary microbiology 2026 May;316:110967
Veterinary microbiology 2026 May;316:110967
Severe fever with thrombocytopenia syndrome virus infection of the male reproductive tract induces pathology and inflammation.
Zhang Y, Zhang L, Xu H, Yin X, Zheng X, Cui N, Lv H, Zhang X, Fang L, Zhang L, Chen H, Liu W, Li H
Nature microbiology 2026 May;11(5):1286-1301
Nature microbiology 2026 May;11(5):1286-1301
Sangbaipi Decoction mitigates influenza pneumonia in mice by inhibiting ZBP1-mediated PANoptosis.
Zhang C, Yu G, Liu M, Du R, Ma J, Gu X, Rong L, Lv X, Cui Q
Journal of ethnopharmacology 2026 May 10;362:121348
Journal of ethnopharmacology 2026 May 10;362:121348
DEAF1 confers resistance to adriamycin-induced apoptosis and pyroptosis in multiple myeloma.
Deng Z, Wei Y, Liu S, Chen L, Wang X, Liu Z, Liu L, Wang Y, Lv X, Sun S, Ni H, Gu C, Yang Y
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2026 Mar;85:101344
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2026 Mar;85:101344
Targeting ROS-metabolism dual pathways to trigger PANoptosis by cobalt-vanadium oxides biomimetic nanocakes for tumor immunotherapy.
Du S, Ma G, Li X, Chao M, Fan L, Zhao Z, Tang R, Li J, Jing C, Liu Y, Yu D, Liu Z, Gao F
Biomaterials 2026 Mar;326:123726
Biomaterials 2026 Mar;326:123726
NPM3 functions as a lactyltransferase to promote necroptosis in male diabetic cardiomyopathy mice models via FASN transcription modulation.
Xu H, Jiang X, Wang F, Meng F, Liu Y, Huang J, Li J, Zhu M
Nature communications 2026 Mar 9;17(1)
Nature communications 2026 Mar 9;17(1)
FAK/SRC-JNK axis promotes ferroptosis via upregulating ACSL4 expression.
Qin J, Ma S, Wang J, Huang S, Luan J, He J, Hou G, Sun N, Zhang W, Gao M
Cell death & disease 2026 Mar 20;17(1)
Cell death & disease 2026 Mar 20;17(1)
Mitochondrial Targeting of GSDMD-N and p-MLKL Drives PANoptosis in benzo[a]pyrene-Induced Hepatotoxicity.
Zhang R, Zhang C, Jia Y, Lu J, Guan S
Journal of agricultural and food chemistry 2026 Mar 18;74(10):8758-8770
Journal of agricultural and food chemistry 2026 Mar 18;74(10):8758-8770
Astragalus Polysaccharide Alleviated Septic Associated Acute Kidney Injury Through Dual Mechanisms of RIPK1-Dependent Necroptosis and Autophagy in Macrophage.
Wang L, Zhang W, Wang Z, Zhang W, Zhang L, Li J, Mao Z, Zhang J, Liang T, Ge R, Zhang Y, Yan C, Zhang J, Liang T
Phytotherapy research : PTR 2026 Mar 17;
Phytotherapy research : PTR 2026 Mar 17;
Endogenous oxidized phospholipid POVPC triggers pulmonary epithelial ferroptosis in acute lung injury and is restrained by RCN3.
Wang Z, Chang J, Shi X, Ding F, Ma RZ, Wang J, Ma Y, Jin J
Free radical biology & medicine 2026 Jul;250:189-202
Free radical biology & medicine 2026 Jul;250:189-202
Identifying cathepsin B as a key regulator of programmed cell death in acute pancreatitis.
Xie X, Jia Y, Wang Z, Zhang H, Lu J, Cao F, Li F
International immunopharmacology 2026 Jul 1;180:116680
International immunopharmacology 2026 Jul 1;180:116680
Transferrin receptor serves a role in promoting PANoptosis in thyroid cancer.
Ma S, Ma Z, Shen J, Liu H, Yang H, Hu Y, Ying S
Oncology letters 2026 Jan;31(1):41
Oncology letters 2026 Jan;31(1):41
Gasdermin D Cleavage and Cytokine Release, Indicative of Pyroptotic Cell Death, Induced by Ophiobolin A in Breast Cancer Cell Lines.
Ranganathan S, Ojo T, Subramanian A, Tobin J, Kornienko A, Boari A, Evidente A, Benton ML, Romo D, Taube JH
International journal of molecular sciences 2026 Jan 7;27(2)
International journal of molecular sciences 2026 Jan 7;27(2)
AHR-CYP1A1 Axis Perturbation and Necroptosis in 1,2-Dichloroethane Hepatotoxicity: Elucidation by an Integrated Network Toxicology and In Vitro Validation.
Liu Y, Luo H, Tian Z, Dong H, Ma D, Meng X, Liu N
Toxics 2026 Jan 30;14(2)
Toxics 2026 Jan 30;14(2)
ZBP1 Mediates Renal Tubular Injury in Diabetic Nephropathy Through RIPK3-mediated Necroptosis.
Hu Z, Ma Y, Wang Y, Wang J, Liu X, Chen C, Zhu W, Qi X, Wu Y
Inflammation 2026 Jan 3;49(1):24
Inflammation 2026 Jan 3;49(1):24
Ginseng Polysaccharides Protect Against Endoplasmic Reticulum Stress-Induced Damage via PI3K/Akt Signalling Pathway in Bovine Ovarian Granulosa Cells.
Wang H, Fang Y, Huang L, Yang X, Ma X, Lyu Y, Jing G, Ding H, Liu H, Lyu W
Cells 2026 Jan 17;15(2)
Cells 2026 Jan 17;15(2)
Treating acute respiratory distress syndrome with a multifaceted nanomedicine: Inhibition of PANoptosis and enhancement of lung barrier integrity.
Cui Y, Wang X, Lu C, Ran L, Guo Z, Yao J, Yu T, Liu X, Li F, Li C, Meng Y, Zhou W
Materials today. Bio 2026 Feb;36:102748
Materials today. Bio 2026 Feb;36:102748
Inducible CD147 up-regulation boosts extended SARS-CoV-2 infection triggering severe COVID-19 independent of ACE2.
Wang K, Lin P, Chen R, Huang Q, Zhao Y, Zhang L, Zhao Y, Zhong L, Xu K, Bao L, Wang Y, Qin C, Wu G, Zhang H, Geng J, Zhang Z, Wei D, Chen X, Tang H, Yang L, Yang X, Sun X, Yao R, Zhao Y, Qin W, Yang Z, Chen L, Bian H, Chen ZN, Zhu P
Signal transduction and targeted therapy 2026 Feb 3;11(1):42
Signal transduction and targeted therapy 2026 Feb 3;11(1):42
Hepatocyte PLAGL2 deficiency alleviates MASH through MYD88-licensed inactivation of inflammasome.
Duan R, Wang X, Wang Q, Zhou X, Gao S, Sun Y, Feng Q, Li Z, Yang Z, Ding J, Chen Z, Duan J, Yang Y
Cell reports 2026 Feb 24;45(2):116942
Cell reports 2026 Feb 24;45(2):116942
Macrophage C3aR1 Mediates Sepsis-Induced Myocardial Injury by Triggering Neutrophil Necroptosis.
Xu J, He Z, Zhang R, Peng C, Cai Z, Zhao X, Wang W
Journal of cellular and molecular medicine 2026 Apr;30(8):e71145
Journal of cellular and molecular medicine 2026 Apr;30(8):e71145
Geum japonicum Thunb. var. Chinese-P.decorata H.Andres herbal pair ameliorates CIRI-induced neuronal injury by facilitating mitochondrial transfer via the CD38/Miro1 signaling pathway.
Sun F, She R, Yang T, Chen B, Liao Z, Liao J, Mei Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157928
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157928
Inducible Nitric Oxide Deficiency Attenuates Necroptosis in Psoriasis-Like Dermatitis in Mice by Reducing Oxidative Stress.
Sun M, Guo P, Guo Q, Li H, Huang J, Luo J, Zhu Q, Zhu Y, Yuan Q, Song S, He J, Su L, Xing W, Hu L
The Journal of investigative dermatology 2026 Apr;146(4):986-997.e12
The Journal of investigative dermatology 2026 Apr;146(4):986-997.e12
USP25 regulates atherosclerosis by restricting RIPK1-mediated inflammatory responses.
Su X, Zhou B, Xu Y, Du X, Chen J, Yin M, Miao X, Zhao Y, Wang D, Zhu Z, Li Z, Cai F, Wang W, Wu G, Huang J, Song W, Wang X
EBioMedicine 2026 Apr;126:106213
EBioMedicine 2026 Apr;126:106213
Sortilin is Associated with PGRN-Mediated Endoplasmic Reticulum Stress and Activation of Microglia in a Rat Model of Degenerative Cervical Myelopathy.
Lei L, Wang X, Zhang J, Zhao J
Neuromolecular medicine 2026 Apr 25;28(1)
Neuromolecular medicine 2026 Apr 25;28(1)
Identification of human MLKL Cys184 and HSPBP1 Cys201 as novel cellular targets for necroptosis.
Shao H, Wu J, Han Q, Xu L, Dai P, Wang R, Li J, Wu W, Hao Y, Hou R, Chai Y, Cheng Z, Wang P, Xue L, Han T, Zhuang C
Cell death & disease 2026 Apr 22;
Cell death & disease 2026 Apr 22;
Identification and validation of key PANoptosis-related genes via integrative machine learning and single-cell sequencing in AILI.
Li S, He C, Wang M, Ran B, Li G, Dong G, Zhang H, Mei C, Song Y, Yu Q, Chen S, Zhu C, Li J
iScience 2026 Apr 17;29(4):115183
iScience 2026 Apr 17;29(4):115183
Voltage-dependent anion channel 1 oligomerization regulates PANoptosis in retinal ischemia-reperfusion injury.
Wan H, Ban X, He Y, Yang Y, Hu X, Shang L, Wan X, Zhang Q, Xiong K
Neural regeneration research 2026 Apr 1;21(4):1652-1664
Neural regeneration research 2026 Apr 1;21(4):1652-1664
AQP1 Affects Necroptosis by Targeting RIPK1 in Endothelial Cells of Atherosclerosis.
Wang P, Zheng L, Yang Y, Yue X, Liu J, Fan K, Zhou H, Dong H
Vascular health and risk management 2025;21:139-152
Vascular health and risk management 2025;21:139-152
Oxidative stress and inflammation combine to exacerbate cochlear damage and sensorineural hearing loss in C57BL/6 mice.
Su Z, Chen Y, Liu Y, Cao J, Cui J, Chen H, Li Q
Frontiers in neuroscience 2025;19:1563428
Frontiers in neuroscience 2025;19:1563428
TLR4 Induces PANoptosis in Annulus Fibrosus Cells by Activating NLRP12 in Intervertebral Disc Degeneration.
Zheng F, Cao L, Fu J, Luo M, Yue W, Ma Y, Chen B, Zhai Y, Liu C
Journal of inflammation research 2025;18:16789-16804
Journal of inflammation research 2025;18:16789-16804
Investigating the Role of Salidroside in Alleviating Acute Pancreatitis by Inhibiting the RIPK1/RIPK3/MLKL Pathway-Mediated Necroptosis in Pancreatic Acinar Cells in Rats.
Lin Y, Ma X, Zhang L, Gu H, Fu X, Li P
Journal of inflammation research 2025;18:14857-14869
Journal of inflammation research 2025;18:14857-14869
Mongolian medicine Wulanwendusu-11 alleviates myocardial ischemia-reperfusion injury by modulating the intestinal microbiota and associated metabolic pathways.
Wuyunsiqin, Bai T, Yang D, Hashentuya, Namila, Jin C, Tana, Zhao P, Wang M, Menggenduxi
Frontiers in microbiology 2025;16:1693472
Frontiers in microbiology 2025;16:1693472
Integrated metabolomic and transcriptomic analysis reveals the effects and mechanisms of Jingfang Baidu powder on acute lung injury.
Zhu Z, Cui B, Dai R, Hu G, Xu S, Zhao X, Wang W, Li X
Frontiers in pharmacology 2025;16:1649883
Frontiers in pharmacology 2025;16:1649883
Gambogic acid targets HSP90 to alleviate DSS-induced colitis via inhibiting the necroptosis of intestinal epithelial cells.
Wang Y, Liu S, Lu K, Xu E, Wang Z
Frontiers in pharmacology 2025;16:1586705
Frontiers in pharmacology 2025;16:1586705
Macrophage caspase-8 inhibition accelerates necrotic core expansion in atheroma plaque in mice.
Pilot T, Solier S, Jalil A, Magnani C, Vanden Berghe T, Vandenabeele P, Masson D, Solary E, Thomas C
Frontiers in immunology 2025;16:1513637
Frontiers in immunology 2025;16:1513637
Oxidative stress-mediated PANoptosis and ferroptosis: Exploration of multimodal cell death triggered by an AIE-active nano-photosensitizer via photodynamic therapy.
Wang Y, Chai C, Lin W, Cao J, Li Z, Jin Y, Xu Y, Zhang J, Qu Y, Zhan J, Zhao T, Chen Y, Gao M, Huang C, Li M
Theranostics 2025;15(14):6665-6685
Theranostics 2025;15(14):6665-6685
Unraveling ancient wisdom: The molecular mechanism of Gujin Luyan Xuming decoction in combating cerebral ischemia-reperfusion injury.
Cai Y, Deng Y, Liu J, Zhang M, Huang Y, Liang W, Zhu J, He Q, Zhao Y, Ning W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157093
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157093
Danggui buxue decoction attenuates doxorubicin-induced cardiotoxicity by inhibiting ZBP1-mediated PANoptosis in vivo and in vitro.
Zhang L, Kong HW, Song XY, Sheng LS, Huang NN, Liu Y, Sun R
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157037
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157037
High-dose ascorbic acid selectively induces pyroptosis in LKB1-deficient lung cancer and sensitizes immunotherapy.
Sun X, Cai X, Li S, Pi R, Guo Z, Jiang J, Wang P, Xiong J, Liu Z, Rong Z, Yu Z, Zhang X, Chen J, Han D, Zhang Y, Tan J, Lin Y, Zou Z, Ai H, Kang F, Guo X, Dong Z, Wu D, Bai X
Cell reports. Medicine 2025 Sep 16;6(9):102291
Cell reports. Medicine 2025 Sep 16;6(9):102291
Gestational zearalenone causes fetal intrauterine growth restriction partially through deriving ROS-Drp1 mediated placental PANoptosis.
Liu JR, Wu FN, Lin S, Chen C, Liu Y, Fan JW, Hong Q, Chen YH
Ecotoxicology and environmental safety 2025 Sep 1;302:118636
Ecotoxicology and environmental safety 2025 Sep 1;302:118636
Mitochondrial dysfunction triggers Zbp1-mediated necroptosis and inflammation in acute lung injury.
Zhou M, Li Y, Ren Y, Li Y, Xiang J, Deng F, Geng G, Luo J, Yu J, Fu Z, Ding F, Liu B
Biomolecules & biomedicine 2025 Oct 29;26(5):814-829
Biomolecules & biomedicine 2025 Oct 29;26(5):814-829
Knockout of Mlkl alleviates myocardial damage and inflammation induced by T-2 toxin with low selenium conditions.
Zhang X, Yi C, Liu Y, Shi Y, Zhang M, Cui Y, Yang X, Wang Y, Chen J, Li X
Ecotoxicology and environmental safety 2025 Oct 15;305:119137
Ecotoxicology and environmental safety 2025 Oct 15;305:119137
Antibody-DNA nanostructure conjugates exhibit inhibited effects on CT26 cells and prevent upregulation of PD-1 in the tumor microenvironment.
Li C, Chen F, Wu J, Ren J, Li Y, Li S, Xia Z
International journal of biological macromolecules 2025 Nov;330(Pt 3):148101
International journal of biological macromolecules 2025 Nov;330(Pt 3):148101
7 I, a structurally modified sinomenine, exerts dual anti-GBM effects by inhibiting glioblastoma proliferation and inducing necroptosis which further mediates lysosomal cell death.
Yang H, Jiang B, Li W, Du G, Xu F, Zhang Y, Yang Y, Zhang S, Cao W, Li X, Zhang X, Ji T, Wang J
British journal of pharmacology 2025 May;182(10):2310-2331
British journal of pharmacology 2025 May;182(10):2310-2331
Melatonin alleviates sepsis-induced acute lung injury by inhibiting necroptosis via reducing circulating mtDNA release.
Peng Y, Xu J, Wei L, Luo M, Chen S, Wei X, Luo S, Su Z, Wang Z
Molecular medicine (Cambridge, Mass.) 2025 May 7;31(1):176
Molecular medicine (Cambridge, Mass.) 2025 May 7;31(1):176
Lactoferrin Alleviates LPS-Induced Oxidative Stress and Necroptosis in Liver by Promoting Mitophagy.
Guan S, Lu S, Zhang R, Wang Y, Yao X, Deng X, Lu J
Journal of agricultural and food chemistry 2025 May 14;73(19):11948-11959
Journal of agricultural and food chemistry 2025 May 14;73(19):11948-11959
Orientia tsutsugamushi Modulates RIPK3 Cellular Levels but Does Not Inhibit Necroptosis.
Siff TE, Allen PE, Armistead DL, Hunt JR, Rolland SJ, Agaisse H, Carlyon JA
Pathogens (Basel, Switzerland) 2025 May 14;14(5)
Pathogens (Basel, Switzerland) 2025 May 14;14(5)
Antibody-DNA nanostructure conjugate enables targeted delivery of gemcitabine to tumor and improves the anti-tumor efficacy.
Li C, Xia Z, Li S, Yu H
Journal of controlled release : official journal of the Controlled Release Society 2025 May 10;381:113613
Journal of controlled release : official journal of the Controlled Release Society 2025 May 10;381:113613
ZBP1 senses splicing aberration through Z-RNA to promote cell death.
Yang ZH, Wu P, Zhang BX, Yang CR, Huang J, Wu L, Guo SH, Zhou Y, Mao Y, Yin Y, Wu X, Cheng P, Li B, Zhou R, Shen HM, Nie S, Cai ZY, Mo W
Molecular cell 2025 May 1;85(9):1775-1789.e5
Molecular cell 2025 May 1;85(9):1775-1789.e5
Cadmium exposure induces Leydig cell injury via necroptosis caused by oxidative stress and TNF-α/TNFR1 signaling.
Zheng X, Sun Y, Wang J, Yin Y, Li Z, Liu B, Hu H, Xu J, Dai Y, Kanwar YS, Tang Y
Biochemical and biophysical research communications 2025 May 1;761:151717
Biochemical and biophysical research communications 2025 May 1;761:151717
SIRT1 Alleviates Mitochondrial Fission and Necroptosis in Cerebral Ischemia/Reperfusion Injury via SIRT1-RIP1 Signaling Pathway.
Wei X, Guo H, Huang G, Luo H, Gong L, Meng P, Liu J, Zhang W, Mei Z
MedComm 2025 Mar;6(3):e70118
MedComm 2025 Mar;6(3):e70118
Panoptosis Targets the Mechanism of PRDX1 Involvement in Acute Myocardial Infarction via ZBP1.
Sun Y, Ji C, Zhang Y, Liu S, Ye Y, Li T, Wu S, Sun T, Yin H, Yan W, Jin W
Journal of cellular biochemistry 2025 Mar;126(3):e70026
Journal of cellular biochemistry 2025 Mar;126(3):e70026
Chronic exposure to liquid crystal monomer EBCN at environmentally relevant concentrations induces testicular dysfunction via the gut-testis axis.
Wu J, Lv D, Lin W, Mao Y, Xia Y, Feng L, Zhao T, Mao X, Shu F, Guo H
Journal of hazardous materials 2025 Mar 15;486:137033
Journal of hazardous materials 2025 Mar 15;486:137033
Pristimerin ameliorates colitis‑induced intestinal mucosal injury by inhibiting intestinal epithelial necroptosis.
Liu S, Wang Y, Lu K, Shi Y, Wang Z, Xu E
Molecular medicine reports 2025 Jun;31(6)
Molecular medicine reports 2025 Jun;31(6)
Transforming Growth Factor-β-Activated Protein 1 (TAK1) Regulates Necroptosis in Age-Related Hearing Loss.
Wang H, Lv Y, Zhao H, Hao Z, Zhai X, Wang Y, Qiu J, Chen L, Zhou J, Cui L, Sun Y
Aging cell 2025 Jun;24(6):e70013
Aging cell 2025 Jun;24(6):e70013
Targeting Cancer With Bifunctional Peptides: Mechanism of Cell Entry and Inciting Cell Death.
Setiawan MF, Rudan O, Schmidt-Wolf IGH
Cancer science 2025 Jun;116(6):1730-1744
Cancer science 2025 Jun;116(6):1730-1744
STING-mediated mitochondrial DNA release exacerbates PANoptosis in liver ischemia reperfusion injury.
Wu C, Miao H, Yi Z, Jia H, Huang A, Zhang H, Liu Z, Sun X, Zheng Y, Gao L, Ma S
International immunopharmacology 2025 Jun 5;157:114778
International immunopharmacology 2025 Jun 5;157:114778
FDA-approved phensuximide inhibits RIPK1-dependent immunogenic cell death.
Kim BJ, Hong SM, Noh HJ, Kim J, Seon SY, Lee JE, Jeong DH, Park JM, Park S, Lee S, Kang J, Lee D, Morgan MJ, Kim YS
Cell death & disease 2025 Jun 2;16(1):426
Cell death & disease 2025 Jun 2;16(1):426
Circular RNA-OGDH promotes PANoptosis in diabetic cardiomyopathy: A novel mechanistic insight.
Guan J, Shi X, Ma J, Yin Y, Song G, Li Y, Chen X, Yan Y, Wang D, Liu S, Liu G, Zheng M, Ma F
The Journal of biological chemistry 2025 Jul;301(7):110280
The Journal of biological chemistry 2025 Jul;301(7):110280
Baitouweng decoction modulates gut microbial production of indole-3-propionic acid and epithelial necroptosis to alleviate DSS-induced colitis in mice.
Hu J, Chen H, Zhu L, Tong Y, Cheng C, Yan G, Shen H
Chinese medicine 2025 Jul 31;20(1):119
Chinese medicine 2025 Jul 31;20(1):119
Deoxypodophyllotoxin inhibited the growth of malignant pleural mesothelioma by inducing necroptosis and mitotic catastrophe.
Zhong C, Wang S, Zhang J, Zheng Q, Lei Y, Xu Y, Ren T, Sun R
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156786
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156786
Short-term exposure to low doses of aflatoxin B1 aggravates nonalcoholic steatohepatitis by TLR4-mediated necroptosis.
Zeng J, Chen L, Tang J, Xue J, Wang Q, Feng X, Chen X, Huang K, Gan F
Free radical biology & medicine 2025 Jan;226:129-142
Free radical biology & medicine 2025 Jan;226:129-142
Cleaving PINK1 or PGAM5? Involvement of PARL in Methamphetamine-Induced Excessive Mitophagy and Neuronal Necroptosis.
An D, Zhang C, Zhou P, Wang Y, Meng S, Chen Y, Xu W, Xuan J, Xiong J, Cheng J, Gao R, Wang J, Chen X
CNS neuroscience & therapeutics 2025 Feb;31(2):e70293
CNS neuroscience & therapeutics 2025 Feb;31(2):e70293
P2Y(14)R activation facilitates liver regeneration via CREB/DNMT3b/Dact-2/β-Catenin signals in acute liver failure.
Zhou M, Li Y, Qian J, Dong X, Guo Y, Yin L, Liu C, Hao K, Hu Q
Acta pharmaceutica Sinica. B 2025 Feb;15(2):919-933
Acta pharmaceutica Sinica. B 2025 Feb;15(2):919-933
The interactive toxic effect of homocysteine and copper on cardiac microvascular endothelial cells during ischemia-reperfusion injury.
Liu X, Liu H, Wang N, Lai S, Qiu C, Gao S, Huang T, Zhang W
Chemico-biological interactions 2025 Feb 25;408:111387
Chemico-biological interactions 2025 Feb 25;408:111387
Hypoxia-mediated SUMOylation of FADD exacerbates endothelial cell injury via the RIPK1-RIPK3-MLKL signaling axis.
Yang L, Wen Y, Yuan Z, Zhao D, Weng P, Li Y, Chen Q, Zhang W, Hu H, Yu C
Cell death & disease 2025 Feb 21;16(1):121
Cell death & disease 2025 Feb 21;16(1):121
Ferroptosis and PANoptosis under hypoxia pivoting on the crosstalk between DHODH and GPX4 in corneal epithelium.
Wu MF, Peng X, Zhang MC, Guo H, Xie HT
Free radical biology & medicine 2025 Feb 16;228:173-182
Free radical biology & medicine 2025 Feb 16;228:173-182
Exercise alleviates programmed necrosis in myocardial ischemia-reperfusion injury through adipose tissue-derived exosomal miR-17-3p targeting CAMKII.
Liu Z, Lu W, He Y, Yu F
Archives of biochemistry and biophysics 2025 Dec;774:110640
Archives of biochemistry and biophysics 2025 Dec;774:110640
MLKL Modulates Necroptosis and Neuroinflammation in a Mouse Model of MS.
Xiao M, Gao G, Mu J, Sun Q, Zhao Y, Fan X
Inflammation 2025 Dec;48(6):4240-4256
Inflammation 2025 Dec;48(6):4240-4256
MLKL-Mediated Necroptosis Predominantly Contributes to Immune-Associated Myocardial Damage.
Sun J, Wu W, Wang Y, Zhang J, Qiu S, Guan Z, Shi C, Ma J, Xu Y
Inflammation 2025 Dec;48(6):3878-3897
Inflammation 2025 Dec;48(6):3878-3897
Bavachinin exerts anti-tumor effects by activating TLR4/STING axis-dependent PANoptosis and synergistically enhances chemosensitivity in endometrial cancer.
Shu W, Chen G, Zhang J, Dong K, Zhou T, Cheng S, Zhang T, Zhang J, Li H, Yao Y, Yu S, Liu Y, Zhou X, Shen X, Wang H
Biochemical pharmacology 2025 Dec;242(Pt 2):117321
Biochemical pharmacology 2025 Dec;242(Pt 2):117321
RIPK1 Drives JAK1-STAT3 Signaling to Promote CXCL1-Mediated Neutrophil Recruitment in Sepsis-Induced Lung Injury.
Sun H, Li X, Gao S, Jiang Y, Wu X, Chen Z, Wu H, Hua Q, Zu R, Xiang H, Ben-Ami R, Miao C, Tan L, Li Y, Wang J, Chen W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e07123
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e07123
Inhibition of Pannexin1 alleviates the damage of pilocarpine-induced status epilepticus through diminishing inflammatory PANoptosis-like neuron death.
Sun B, Wu J, Li Z, Zhang Y, Lu X, Wang J, Xu X
International immunopharmacology 2025 Dec 3;166:115639
International immunopharmacology 2025 Dec 3;166:115639
Sestrin2 alleviates sepsis-induced immunosuppression of dendritic cells by regulating mitochondrial dynamics.
Sun B, Wang JD, Wu MY, Chen HY, Yang SQ, Chen YM, Fu Y, Chen ZH, Yao YM
Free radical biology & medicine 2025 Dec 1;240:583-596
Free radical biology & medicine 2025 Dec 1;240:583-596
Trimethylamine N-oxide Induced Chronic Kidney Injury by Triggering PANoptosis.
Shao D, Bai L, Chen Q, Chen Y, Qiu Z, Liu Y, Jin S, Wu Y, Dai J
Physiological research 2025 Aug 31;74(4):613-622
Physiological research 2025 Aug 31;74(4):613-622
RIPK3-MLKL dependent necroptosis mediates depressive-like behavior by facilitating neuroinflammation.
Zheng H, Xu ZY, Hu T, Wu YL, Huang CW, Li JM, Cao ZY, Wang W, Jiang CL, Su WJ
Journal of neuroimmunology 2025 Aug 15;405:578643
Journal of neuroimmunology 2025 Aug 15;405:578643
Astragalus polysaccharide reduces the severity of acute pancreatitis under a high-fat diet through enriching L. reuteri and propionate.
Wang Q, Liu X, Du Z, Zheng Y, Meng Z, Lv Z, Wang L, Xue D
International journal of biological macromolecules 2025 Apr;298:140021
International journal of biological macromolecules 2025 Apr;298:140021
Deubiquitination of RIPK3 by OTUB2 potentiates neuronal necroptosis after ischemic stroke.
Mei F, Deng D, Cao Z, Lou L, Chen K, Hu M, Zhu Z, Shen J, Zhang J, Liang J, Huang J, Bao M, Waisman A, Wang X
EMBO molecular medicine 2025 Apr;17(4):679-695
EMBO molecular medicine 2025 Apr;17(4):679-695
Electret-Inspired Charge-Injected Hydrogel for Scar-Free Healing of Bacterially Infected Burns Through Bioelectrical Stimulation and Immune Modulation.
Liu M, Wang Y, Wang H, Qi L, Shang Y, Song J, Feng X, Chen Y, Memon WA, Shen Y, Wu X, Cao J, Zhao Y, Jiang Z, Liu D, Shafique S, Li S, Lu G, Wei Z, Liu Z, Zhou K, Quan Y, Zhang X, Zou X, Wang X, Liu N, Zhang Y, Hu Y, Han C, Wang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2411889
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2411889
A Small Molecule Inhibitor of Leucine Carboxyl Methyltransferase-1 Inhibits Cancer Cell Survival.
Arosarena OA, Saribas AS, Papadopoulos EP
Frontiers in drug discovery 2024;4
Frontiers in drug discovery 2024;4
Neutrophil extracellular traps trigger alveolar epithelial cell necroptosis through the cGAS-STING pathway during acute lung injury in mice.
Sha HX, Liu YB, Qiu YL, Zhong WJ, Yang NS, Zhang CY, Duan JX, Xiong JB, Guan CX, Zhou Y
International journal of biological sciences 2024;20(12):4713-4730
International journal of biological sciences 2024;20(12):4713-4730
KAE ameliorates LPS-mediated acute lung injury by inhibiting PANoptosis through the intracellular DNA-cGAS-STING axis.
Chen Y, Wu X, Jiang Z, Li X
Frontiers in pharmacology 2024;15:1461931
Frontiers in pharmacology 2024;15:1461931
Inhibition of the RIP3/MLKL/TRPM7 necroptotic pathway ameliorates diabetes mellitus-induced erectile dysfunction by reducing cell death, fibrosis, and inflammation.
Niu L, Yang P, Zhu B, Jin X, Yang C, Zhang X, Liu Y, Zhang R, Liu F
Frontiers in pharmacology 2024;15:1436013
Frontiers in pharmacology 2024;15:1436013
Zinc oxide nanoparticles disrupt the mammary epithelial barrier via Z-DNA binding protein 1-triggered PANoptosis.
Zhu Z, Zhang Y, Wang R, Dong Y, Wu J, Shao L
Ecotoxicology and environmental safety 2024 Sep 15;283:116777
Ecotoxicology and environmental safety 2024 Sep 15;283:116777
AIBP protects drug-induced liver injury by inhibiting MAPK-mediated NR4A1 expression.
Ma T, Huang W, Ding Y, Ji R, Ge S, Liu Q, Liu Y, Chen J, Yan Y, Lu S, Ren Q, Fan Y, Mao R, Lu C
iScience 2024 Oct 18;27(10):110873
iScience 2024 Oct 18;27(10):110873
Integrated Studies on Male Reproductive Toxicity of Decabromodiphenyl Ethane in Zebrafish Spermatozoa Ex Vivo, Male Zebrafish in Vivo, and GC-1 Cells in Vitro.
Yang L, Zhang Y, Hua J, Song G, Li F, Zheng N, Zhang T, Xu Z, Ren X, Zhu B, Han Y, Guo Y, Han J, Zhou B
Environmental health perspectives 2024 Nov;132(11):117005
Environmental health perspectives 2024 Nov;132(11):117005
Residue Y362 is crucial for FLIP(L) to impart catalytic activity to pro-caspase-8 to suppress necroptosis.
Hong M, Wu X, He P, Peng R, Li L, Wu SQ, Zhao J, Han A, Zhang Y, Han J, Yang ZH
Cell reports 2024 Nov 26;43(11):114966
Cell reports 2024 Nov 26;43(11):114966
A ZBP1 isoform blocks ZBP1-mediated cell death.
Cai ZY, Wu P, Liang H, Xie YZ, Zhang BX, He CL, Yang CR, Li H, Mo W, Yang ZH
Cell reports 2024 May 28;43(5):114221
Cell reports 2024 May 28;43(5):114221
Urolithin A's Role in Alleviating Severe Acute Pancreatitis via Endoplasmic Reticulum-Mitochondrial Calcium Channel Modulation.
Kang H, Hu Q, Yang Y, Huang G, Li J, Zhao X, Zhu L, Su H, Tang W, Wan M
ACS nano 2024 May 28;18(21):13885-13898
ACS nano 2024 May 28;18(21):13885-13898
Gancao decoction attenuates hepatic necroptosis via activating caspase 8 in cholestatic liver injury.
Zou B, Zhang S, Li F, Weng F, Zhao J, Jin J, Yan D, Xu X, Chen G, Liu C, Yao C, Li Y, Qiu F
Journal of ethnopharmacology 2024 May 23;326:117909
Journal of ethnopharmacology 2024 May 23;326:117909
Imbalance of programmed cell death patterns mediated by dendritic cell subsets in systemic lupus erythematosus and lupus nephritis.
Xu R, Zhang Y, Cao Q, Liao S, Tang Y, Zhuang Q
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 2024 Mar 28;49(3):331-348
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 2024 Mar 28;49(3):331-348
Effect of lipopolysaccharide on TAK1-mediated hepatocyte PANoptosis through Toll-like receptor 4 during acute liver failure.
Li W, Zhang W, Zhang D, Shi C, Wang Y
International immunopharmacology 2024 Mar 10;129:111612
International immunopharmacology 2024 Mar 10;129:111612
Involvement of necroptotic cell death in macrophages in progression of bleomycin and LPS-induced acute exacerbation of idiopathic pulmonary fibrosis.
Koike A, Hayashi K, Fujimori K
European journal of pharmacology 2024 Jun 5;972:176572
European journal of pharmacology 2024 Jun 5;972:176572
S100A8/A9(hi) neutrophils induce mitochondrial dysfunction and PANoptosis in endothelial cells via mitochondrial complex I deficiency during sepsis.
Wang Y, Shi Y, Shao Y, Lu X, Zhang H, Miao C
Cell death & disease 2024 Jun 28;15(6):462
Cell death & disease 2024 Jun 28;15(6):462
Systematic analysis of PANoptosis-related genes identifies XIAP as a functional oncogene in breast cancer.
Qi Q, Zhu M, Li P, Mi Q, Xie Y, Li J, Wang C
Gene 2024 Jun 20;912:148355
Gene 2024 Jun 20;912:148355
Regulation of cardiac ferroptosis in diabetic human heart failure: uncovering molecular pathways and key targets.
Gawargi FI, Mishra PK
Cell death discovery 2024 Jun 1;10(1):268
Cell death discovery 2024 Jun 1;10(1):268
Honokiol Mitigates Metabolic-Associated Fatty Liver Disease by Regulating Nrf2 and RIPK3 Signaling Pathways.
Cao W, Chen Z, Lin C, Lin X, Chen Y, Zhang J
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2024 Jul;35(7):551-559
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2024 Jul;35(7):551-559
Mitophagy-regulated Necroptosis plays a vital role in the nephrotoxicity of Fumonisin B1 in vivo and in vitro.
Ping Z, Shuxia Z, Xinyu D, Kehe H, Xingxiang C, Chunfeng W
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Jul;189:114714
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Jul;189:114714
An immunohistochemical atlas of necroptotic pathway expression.
Chiou S, Al-Ani AH, Pan Y, Patel KM, Kong IY, Whitehead LW, Light A, Young SN, Barrios M, Sargeant C, Rajasekhar P, Zhu L, Hempel A, Lin A, Rickard JA, Hall C, Gangatirkar P, Yip RK, Cawthorne W, Jacobsen AV, Horne CR, Martin KR, Ioannidis LJ, Hansen DS, Day J, Wicks IP, Law C, Ritchie ME, Bowden R, Hildebrand JM, O'Reilly LA, Silke J, Giulino-Roth L, Tsui E, Rogers KL, Hawkins ED, Christensen B, Murphy JM, Samson AL
EMBO molecular medicine 2024 Jul;16(7):1717-1749
EMBO molecular medicine 2024 Jul;16(7):1717-1749
lncRNA FLJ20021 regulates CDK1-mediated PANoptosis in a ZBP1-dependent manner to increase the sensitivity of laryngeal cancer-resistant cells to cisplatin.
Yin X, Zhang H, Wang J, Bian Y, Jia Q, Yang Z, Shan C
Discover oncology 2024 Jul 5;15(1):265
Discover oncology 2024 Jul 5;15(1):265
Shengxian decoction improves lung function in rats with bleomycin-induced idiopathic pulmonary fibrosis through the inhibition of PANoptosis.
Liang Y, Yan Y, Liu N, Wang J, Fang C
Journal of ethnopharmacology 2024 Jul 15;329:118153
Journal of ethnopharmacology 2024 Jul 15;329:118153
Neutrophil extracellular traps aggravate intestinal epithelial necroptosis in ischaemia-reperfusion by regulating TLR4/RIPK3/FUNDC1-required mitophagy.
Chu C, Wang X, Chen F, Yang C, Shi L, Xu W, Wang K, Liu B, Wang C, Sun D, Li J, Ding W
Cell proliferation 2024 Jan;57(1):e13538
Cell proliferation 2024 Jan;57(1):e13538
An investigation of the distributions of ferroptosis and necroptosis mediators in the maternal-fetal interface at different days of rat pregnancy.
Tatar M, Tüfekci KK
Anatomia, histologia, embryologia 2024 Jan;53(1):e12991
Anatomia, histologia, embryologia 2024 Jan;53(1):e12991
Infant feces-derived Lactobacillus gasseri FWJL-4 mitigates experimental necrotizing enterocolitis via acetate production.
Pan LL, Sun Y, Dong X, Ren Z, Li B, Yang P, Zhang L, Sun J
Gut microbes 2024 Jan-Dec;16(1):2430541
Gut microbes 2024 Jan-Dec;16(1):2430541
The traditional herb Sargentodoxa cuneata alleviates DSS-induced colitis by attenuating epithelial barrier damage via blocking necroptotic signaling.
Wang Y, Zhang B, Liu S, Xu E, Wang Z
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117373
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117373
VDAC1, as a downstream molecule of MLKL, participates in OGD/R-induced necroptosis by inducing mitochondrial damage.
Wan H, Yang YD, Zhang Q, Chen YH, Hu XM, Huang YX, Shang L, Xiong K
Heliyon 2024 Jan 15;10(1):e23426
Heliyon 2024 Jan 15;10(1):e23426
A slow-releasing donor of hydrogen sulfide inhibits neuronal cell death via anti-PANoptosis in rats with spinal cord ischemia‒reperfusion injury.
Xie L, Wu H, He Q, Shi W, Zhang J, Xiao X, Yu T
Cell communication and signaling : CCS 2024 Jan 12;22(1):33
Cell communication and signaling : CCS 2024 Jan 12;22(1):33
CGRP is essential for protection against alveolar epithelial cell necroptosis by activating the AMPK/L-OPA1 signaling pathway during acute lung injury.
Jiang HL, Yang HH, Liu YB, Duan JX, Guan XX, Zhang CY, Zhong WJ, Jin L, Li D, Li Q, Zhou Y, Guan CX
Journal of cellular physiology 2024 Feb;239(2):e31169
Journal of cellular physiology 2024 Feb;239(2):e31169
Transcriptotype-Driven Discovery of Apigenin as a Therapy against Cholestatic Liver Fibrosis: Through Inhibition of PANoptosis and Following Type-I Interferon Responses.
Duan S, Li X, Han J, Yang Y, Luo R, Cai Y, Li X, Zheng Q, Guo J, Liu R
Antioxidants (Basel, Switzerland) 2024 Feb 20;13(3)
Antioxidants (Basel, Switzerland) 2024 Feb 20;13(3)
Integrating bioinformatics and experimental validation to Investigate IRF1 as a novel biomarker for nucleus pulposus cells necroptosis in intervertebral disc degeneration.
Zhou K, Wu S, Wu Z, Ran R, Song W, Dong H, Zhang H
Scientific reports 2024 Dec 3;14(1):30138
Scientific reports 2024 Dec 3;14(1):30138
DL-3-n-Butylphthalide Ameliorates Post-stroke Emotional Disorders by Suppressing Neuroinflammation and PANoptosis.
Cui Y, Hu Z, Wang L, Zhu B, Deng L, Zhang H, Wang X
Neurochemical research 2024 Aug;49(8):2215-2227
Neurochemical research 2024 Aug;49(8):2215-2227
Reversal of hepatic accumulation of nordeoxycholic acid underlines the beneficial effects of cholestyramine on alcohol-associated liver disease in mice.
Guo W, Zhong W, He L, Wei X, Hao L, Dong H, Yue R, Sun X, Yin X, Zhao J, Zhang X, Zhou Z
Hepatology communications 2024 Aug 1;8(8)
Hepatology communications 2024 Aug 1;8(8)
Mitochondrial dysfunction induced by HIF-1α under hypoxia contributes to the development of gastric mucosal lesions.
Xiao Y, Liu X, Xie K, Luo J, Zhang Y, Huang X, Luo J, Tan S
Clinical and translational medicine 2024 Apr;14(4):e1653
Clinical and translational medicine 2024 Apr;14(4):e1653
Nanointegrative Glycoengineering-Activated Necroptosis of Triple Negative Breast Cancer Stem Cells Enables Self-Amplifiable Immunotherapy for Systemic Tumor Rejection.
Zhao Y, Li Y, He J, Li M, Yao X, Yang H, Luo Z, Luo P, Su M
Advanced healthcare materials 2024 Apr;13(9):e2303337
Advanced healthcare materials 2024 Apr;13(9):e2303337
Sodium sulfite triggered hepatic apoptosis, necroptosis, and pyroptosis by inducing mitochondrial damage in mice and AML-12 cells.
Liu M, Lu J, Hu J, Chen Y, Deng X, Wang J, Zhang S, Guo J, Li W, Guan S
Journal of hazardous materials 2024 Apr 5;467:133719
Journal of hazardous materials 2024 Apr 5;467:133719
NLRP6 induces RIP1 kinase-dependent necroptosis via TAK1-mediated p38(MAPK)/MK2 phosphorylation in S. typhimurium infection.
Deng Q, Yang S, Huang K, Zhu Y, Sun L, Cao Y, Dong K, Li Y, Wu S, Huang R
iScience 2024 Apr 19;27(4):109339
iScience 2024 Apr 19;27(4):109339
PCSK9 Promotes Hypoxia-Induced EC Pyroptosis by Regulating Smac Mitochondrion-Cytoplasm Translocation in Critical Limb Ischemia.
Zhang M, Chen Y, Qiu Y, Sun J, He J, Liu Z, Shi J, Wei W, Wu G, Liang J
JACC. Basic to translational science 2023 Sep;8(9):1060-1077
JACC. Basic to translational science 2023 Sep;8(9):1060-1077
Brazilin inhibits bladder cancer by promoting cell necroptosis.
Yang X, Zhang S, He J, Zhao L, Chen L, Yang Y, Wang J, Yan L, Zhang T
Clinical and experimental pharmacology & physiology 2023 Sep;50(9):738-748
Clinical and experimental pharmacology & physiology 2023 Sep;50(9):738-748
Quizartinib inhibits necroptosis by targeting receptor-interacting serine/threonine protein kinase 1.
Li M, Wei J, Zhu G, Fu S, He X, Hu X, Yu Y, Mou Y, Wang J, You X, Xiao X, Gu T, Ye Z, Zha Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23178
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23178
IFN-γ promotes PANoptosis in Pasteurella multocida toxin-induced pneumonia in mice.
Xiao H, Zhao Q, Yuan J, Liang W, Wu R, Wen Y, Du S, Wang Y, Zhao S, Lang Y, Yan Q, Huang X, Cao S
Veterinary microbiology 2023 Oct;285:109848
Veterinary microbiology 2023 Oct;285:109848
Effect of doramectin on programmed cell death pathway in glioma cells.
Du S, Liang H, Zhou L, Chen C, Sun R, Zhang J, Meng X, Gao A
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2023 Oct;25(10):2871-2883
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2023 Oct;25(10):2871-2883
LncRNA MALAT1 Promoted Neuronal Necroptosis in Cerebral Ischemia-reperfusion Mice by Stabilizing HSP90.
Huang S, Hou D, Zhang L, Pei C, Liang J, Li J, Yang G, Yu D
Neurochemical research 2023 Nov;48(11):3457-3471
Neurochemical research 2023 Nov;48(11):3457-3471
Polystyrene microplastics with different sizes induce the apoptosis and necroptosis in liver through the PTEN/PI3K/AKT/autophagy axis.
Wang S, Wu H, Shi X, Wang Y, Xu S
The Science of the total environment 2023 Nov 15;899:165461
The Science of the total environment 2023 Nov 15;899:165461
Repurposing crizotinib to target RIPK1-dependent cell death.
Yu Y, Li M, Fu S, He X, Hu X, Zhu G, Wang J, You X, Mou Y, Ye Z, Wei J, Zha Y
International immunology 2023 May 8;35(5):221-230
International immunology 2023 May 8;35(5):221-230
Echinacea Polyphenols Inhibit NLRP3-Dependent Pyroptosis, Apoptosis, and Necroptosis via Suppressing NO Production during Lipopolysaccharide-Induced Acute Lung Injury.
Guo J, Luo Y, Zuo J, Teng J, Shen B, Liu X
Journal of agricultural and food chemistry 2023 May 17;71(19):7289-7298
Journal of agricultural and food chemistry 2023 May 17;71(19):7289-7298
Apoptosis-induced nuclear expulsion in tumor cells drives S100a4-mediated metastatic outgrowth through the RAGE pathway.
Park WY, Gray JM, Holewinski RJ, Andresson T, So JY, Carmona-Rivera C, Hollander MC, Yang HH, Lee M, Kaplan MJ, Cappell SD, Yang L
Nature cancer 2023 Mar;4(3):419-435
Nature cancer 2023 Mar;4(3):419-435
Deletion of Bak1 alleviates microglial necroptosis and neuroinflammation after experimental subarachnoid hemorrhage.
Qiu X, Tao Q, Zhang L, Kuang C, Xie Y, Zhang L, Yin S, Peng J, Jiang Y
Journal of neurochemistry 2023 Mar;164(6):829-846
Journal of neurochemistry 2023 Mar;164(6):829-846
Role of the Peli1-RIPK1 Signaling Axis in Methamphetamine-Induced Neuroinflammation.
Xu W, Yang T, Lou X, Chen J, Wang X, Hu M, An D, Gao R, Wang J, Chen X
ACS chemical neuroscience 2023 Mar 1;14(5):864-874
ACS chemical neuroscience 2023 Mar 1;14(5):864-874
Necroptosis of macrophage is a key pathological feature in biliary atresia via GDCA/S1PR2/ZBP1/p-MLKL axis.
Yang S, Chang N, Li W, Yang T, Xue R, Liu J, Zhang L, Yao X, Chen Y, Wang H, Yang L, Huang J, Li L
Cell death & disease 2023 Mar 1;14(3):175
Cell death & disease 2023 Mar 1;14(3):175
Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads to retinal ganglion cell PANoptosis in glaucoma.
Zeng Z, You M, Fan C, Rong R, Li H, Xia X
Redox biology 2023 Jun;62:102687
Redox biology 2023 Jun;62:102687
STING deficiency protects against wasp venom-induced acute kidney injury.
Lv Y, Lu L, Yu F, Gao Z, Yuan H, Hu F
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jul;72(7):1427-1440
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jul;72(7):1427-1440
Cisatracurium besylate rescues Mycobacterium Tuberculosis-infected macrophages from necroptosis and enhances the bactericidal effect of isoniazid.
Wen Q, Zhang J, Zhang Z, Chen L, Liu H, Han Z, Chen Y, Wang K, Liu J, Sai N, Zhou X, Zhou C, Hu S, Ma L
International immunopharmacology 2023 Jul;120:110291
International immunopharmacology 2023 Jul;120:110291
Polysaccharide from Strongylocentrotus nudus eggs regulates intestinal epithelial autophagy through CD36/PI3K-Akt pathway to ameliorate inflammatory bowel disease.
Zhou M, Zhi J, Zhi J, Xiong Z, Wu F, Lu Y, Hu Q
International journal of biological macromolecules 2023 Jul 31;244:125373
International journal of biological macromolecules 2023 Jul 31;244:125373
Nucleoporin Seh1 maintains Schwann cell homeostasis by regulating genome stability and necroptosis.
Wu M, Li M, Liu W, Yan M, Li L, Ding W, Nian X, Dai W, Sun D, Zhu Y, Huang Q, Lu X, Cai Z, Hong F, Li X, Zhang L, Liu Z, Mo W, Zhang X, Zhang L
Cell reports 2023 Jul 25;42(7):112802
Cell reports 2023 Jul 25;42(7):112802
Triptolide leads to hepatic intolerance to exogenous lipopolysaccharide and natural-killer-cell mediated hepatocellular damage by inhibiting MHC class I molecules.
Zhang H, Yuan Z, Wang J, Tang Q, Miao Y, Yuan Z, Huang X, Zhu Y, Nong C, Zhang L, Jiang Z, Yu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;109:154621
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;109:154621
MLKL signaling regulates macrophage polarization in acute pancreatitis through CXCL10.
Peng C, Tu G, Wang J, Wang Y, Wu P, Yu L, Li Z, Yu X
Cell death & disease 2023 Feb 24;14(2):155
Cell death & disease 2023 Feb 24;14(2):155
Repositioning linifanib as a potent anti-necroptosis agent for sepsis.
Yu L, Yang K, He X, Li M, Gao L, Zha Y
Cell death discovery 2023 Feb 10;9(1):57
Cell death discovery 2023 Feb 10;9(1):57
Lactoferrin attenuated urban particulate matter-induced nephrotoxicity by regulating the CSF2/CENPE axis.
Liu WC, Chiu HW, Chou CL, Chiu YJ, Lee YH
Environmental pollution (Barking, Essex : 1987) 2023 Feb 1;318:120871
Environmental pollution (Barking, Essex : 1987) 2023 Feb 1;318:120871
Serinc2 deficiency exacerbates sepsis-induced cardiomyopathy by enhancing necroptosis and apoptosis.
Hu S, Huang M, Mao S, Yang M, Ju H, Liu Z, Cheng M, Wu G
Biochemical pharmacology 2023 Dec;218:115903
Biochemical pharmacology 2023 Dec;218:115903
Skp2-mediated MLKL degradation confers cisplatin-resistant in non-small cell lung cancer cells.
Zhou H, Zhou L, Guan Q, Hou X, Wang C, Liu L, Wang J, Yu X, Li W, Liu H
Communications biology 2023 Aug 2;6(1):805
Communications biology 2023 Aug 2;6(1):805
Repurposing of the FGFR inhibitor AZD4547 as a potent inhibitor of necroptosis by selectively targeting RIPK1.
Wang ZW, Zou FM, Wang AL, Yang J, Jin R, Wang BL, Shen LJ, Qi S, Liu J, Liu J, Wang WC, Liu QS
Acta pharmacologica Sinica 2023 Apr;44(4):801-810
Acta pharmacologica Sinica 2023 Apr;44(4):801-810
Liraglutide Attenuates Myocardial Ischemia/Reperfusion Injury Through the Inhibition of Necroptosis by Activating GLP-1R/PI3K/Akt Pathway.
Zhou G, Wu H, Yang J, Ye M, Liu D, Li Y, Zhang D, Zhang J, Yang Q, Liu Y
Cardiovascular toxicology 2023 Apr;23(3-4):161-175
Cardiovascular toxicology 2023 Apr;23(3-4):161-175
Ameliorative effects of epigallocatechin-3-gallate nanoparticles on 2,4-dinitrochlorobenzene induced atopic dermatitis: A potential mechanism of inflammation-related necroptosis.
Han M, Wang X, Wang J, Lang D, Xia X, Jia Y, Chen Y
Frontiers in nutrition 2022;9:953646
Frontiers in nutrition 2022;9:953646
Adenosine Kinase Inhibition Prevents Severe Acute Pancreatitis via Suppressing Inflammation and Acinar Cell Necroptosis.
Sun S, Han Y, Zhang C, Liu H, Wang B, Cao S, Yuan Q, Wei S, Chen Y
Frontiers in cell and developmental biology 2022;10:827714
Frontiers in cell and developmental biology 2022;10:827714
Protective effect of inhibiting necroptosis on gentamicin-induced nephrotoxicity.
Hu BF, Gong Q, Chen SQ, Yue L, Ma WX, Wang F, Feng XW, Wang JN, Li C, Liu MM, Wang XF, Meng XM, Li J, Wen JG
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Sep;36(9):e22487
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Sep;36(9):e22487
Enhanced nuclear localization of phosphorylated MLKL predicts adverse events in patients with dilated cardiomyopathy.
Fujita Y, Yano T, Kanamori H, Nagahara D, Muranaka A, Kouzu H, Mochizuki A, Koyama M, Nagano N, Fujito T, Nishikawa R, Kamiyama N, Tanaka M, Kuno A, Tanno M, Miura T
ESC heart failure 2022 Oct;9(5):3435-3451
ESC heart failure 2022 Oct;9(5):3435-3451
Serpina3c deficiency induced necroptosis promotes non-alcoholic fatty liver disease through β-catenin/Foxo1/TLR4 signaling.
Qian LL, Ji JJ, Jiang Y, Guo JQ, Wu Y, Yang Z, Ma GS, Yao YY
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 May;36(5):e22316
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 May;36(5):e22316
Zinc finger protein 91 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation.
Zhong Y, Zhang ZH, Wang JY, Xing Y, Ri MH, Jin HL, Zuo HX, Li MY, Ma J, Jin X
Toxicology letters 2022 Mar 1;356:75-88
Toxicology letters 2022 Mar 1;356:75-88
Myo-inositol oxygenase overexpression exacerbates cadmium-induced kidney injury via oxidant stress and necroptosis.
Zheng X, Deng F, Sharma I, Kanwar YS
American journal of physiology. Renal physiology 2022 Mar 1;322(3):F344-F359
American journal of physiology. Renal physiology 2022 Mar 1;322(3):F344-F359
Contribution of Necroptosis to Myofiber Death in Idiopathic Inflammatory Myopathies.
Peng QL, Zhang YM, Liu YC, Liang L, Li WL, Tian XL, Zhang L, Yang HX, Lu X, Wang GC
Arthritis & rheumatology (Hoboken, N.J.) 2022 Jun;74(6):1048-1058
Arthritis & rheumatology (Hoboken, N.J.) 2022 Jun;74(6):1048-1058
MiR-29a-3p Improves Acute Lung Injury by Reducing Alveolar Epithelial Cell PANoptosis.
Cui Y, Wang X, Lin F, Li W, Zhao Y, Zhu F, Yang H, Rao M, Li Y, Liang H, Dai M, Liu B, Chen L, Han D, Lu R, Peng W, Zhang Y, Song C, Luo Y, Pan P
Aging and disease 2022 Jun;13(3):899-909
Aging and disease 2022 Jun;13(3):899-909
LncRNA 122049 suppresses apoptosis of renal tubular epithelial cells in ischemic AKI by targeting the miR-330-5p/ELK1 axis.
Xiao Y, Li X, Qiu S, Wang Y, Zhang D
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jul;36(7):e22395
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jul;36(7):e22395
L-OPA1 deficiency aggravates necroptosis of alveolar epithelial cells through impairing mitochondrial function during acute lung injury in mice.
Jiang HL, Yang HH, Liu YB, Zhang CY, Zhong WJ, Guan XX, Jin L, Hong JR, Yang JT, Tan XH, Li Q, Zhou Y, Guan CX
Journal of cellular physiology 2022 Jul;237(7):3030-3043
Journal of cellular physiology 2022 Jul;237(7):3030-3043
Dysmyelination by Oligodendrocyte-Specific Ablation of Ninj2 Contributes to Depressive-Like Behaviors.
Sun Y, Chen X, Ou Z, Wang Y, Chen W, Zhao T, Liu C, Chen Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Jan;9(3):e2103065
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Jan;9(3):e2103065
Thioredoxin reductase 3 suppression promotes colitis and carcinogenesis via activating pyroptosis and necrosis.
Liu Q, Du P, Zhu Y, Zhang X, Cai J, Zhang Z
Cellular and molecular life sciences : CMLS 2022 Jan 30;79(2):106
Cellular and molecular life sciences : CMLS 2022 Jan 30;79(2):106
Pressure Drives Rapid Burst-Like Coordinated Cellular Motion from 3D Cancer Aggregates.
Raghuraman S, Schubert AS, Bröker S, Jurado A, Müller A, Brandt M, Vos BE, Hofemeier AD, Abbasi F, Stehling M, Wittkowski R, Ivaska J, Betz T
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Feb;9(6):e2104808
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Feb;9(6):e2104808
Caspase-8 is involved in pyroptosis, necroptosis and the maturation and release of IL-1β in Aspergillus fumigatus keratitis.
Wang L, Yan H, Chen X, Lee J, Sun J, Liu G, Yang H, Lu D, Liu W, Che C
International immunopharmacology 2022 Dec;113(Pt A):109275
International immunopharmacology 2022 Dec;113(Pt A):109275
Targeting Cell Membranes, Depleting ROS by Dithiane and Thioketal-Containing Polymers with Pendant Cholesterols Delivering Necrostatin-1 for Glaucoma Treatment.
Rong R, Zhou X, Liang G, Li H, You M, Liang Z, Zeng Z, Xiao H, Ji D, Xia X
ACS nano 2022 Dec 27;16(12):21225-21239
ACS nano 2022 Dec 27;16(12):21225-21239
Developmental exposure to chlorpyrifos causes neuroinflammation via necroptosis in mouse hippocampus and human microglial cell line.
Tu Y, Yang Y, Wang Y, Wu N, Tao J, Yang G, You M
Environmental pollution (Barking, Essex : 1987) 2022 Dec 1;314:120217
Environmental pollution (Barking, Essex : 1987) 2022 Dec 1;314:120217
Taurine inhibits necroptosis helps to alleviate inflammatory and injury induced by Klebsiella infection.
Yin H, Wang Z, Yang S, Zheng X, Bao Y, Lin W, Huang C, Qiu L
Veterinary immunology and immunopathology 2022 Aug;250:110444
Veterinary immunology and immunopathology 2022 Aug;250:110444
Necrostatin-1 Against Sevoflurane-Induced Cognitive Dysfunction Involves Activation of BDNF/TrkB Pathway and Inhibition of Necroptosis in Aged Rats.
Yin C, Zhang Q, Zhao J, Li Y, Yu J, Li W, Wang Q
Neurochemical research 2022 Apr;47(4):1060-1072
Neurochemical research 2022 Apr;47(4):1060-1072
4-Hydroxy-2-Nonenal Promotes Cardiomyocyte Necroptosis via Stabilizing Receptor-Interacting Serine/Threonine-Protein Kinase 1.
Zhai X, Wang W, Sun S, Han Y, Li J, Cao S, Li R, Xu T, Yuan Q, Wang J, Wei S, Chen Y
Frontiers in cell and developmental biology 2021;9:721795
Frontiers in cell and developmental biology 2021;9:721795
Expression of the ACE2 Virus Entry Protein in the Nervus Terminalis Reveals the Potential for an Alternative Route to Brain Infection in COVID-19.
Bilinska K, von Bartheld CS, Butowt R
Frontiers in cellular neuroscience 2021;15:674123
Frontiers in cellular neuroscience 2021;15:674123
RIPK3-Dependent Necroptosis Is Induced and Restricts Viral Replication in Human Astrocytes Infected With Zika Virus.
Wen C, Yu Y, Gao C, Qi X, Cardona CJ, Xing Z
Frontiers in cellular and infection microbiology 2021;11:637710
Frontiers in cellular and infection microbiology 2021;11:637710
Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy.
Zhu J, Xin M, Xu C, He Y, Zhang W, Wang Z, Zhuang C
Acta pharmaceutica Sinica. B 2021 Oct;11(10):3193-3205
Acta pharmaceutica Sinica. B 2021 Oct;11(10):3193-3205
PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination.
Wang Y, Zhang Y, Zhang S, Kim B, Hull VL, Xu J, Prabhu P, Gregory M, Martinez-Cerdeno V, Zhan X, Deng W, Guo F
Cell reports 2021 Oct 5;37(1):109695
Cell reports 2021 Oct 5;37(1):109695
Metformin attenuates hypothalamic inflammation via downregulation of RIPK1-independent microglial necroptosis in diet-induced obese mice.
Li X, Cai Y, Luo J, Ding J, Yao G, Xiao X, Tang Y, Liang Z
Cell death discovery 2021 Nov 8;7(1):338
Cell death discovery 2021 Nov 8;7(1):338
Inhibition of adenosine kinase attenuates myocardial ischaemia/reperfusion injury.
Wang W, Wang B, Sun S, Cao S, Zhai X, Zhang C, Zhang Q, Yuan Q, Sun Y, Xue M, Ma J, Xu F, Wei S, Chen Y
Journal of cellular and molecular medicine 2021 Mar;25(6):2931-2943
Journal of cellular and molecular medicine 2021 Mar;25(6):2931-2943
Differential role of MLKL in alcohol-associated and non-alcohol-associated fatty liver diseases in mice and humans.
Miyata T, Wu X, Fan X, Huang E, Sanz-Garcia C, Ross CKC, Roychowdhury S, Bellar A, McMullen MR, Dasarathy J, Allende DS, Caballeria J, Sancho-Bru P, McClain CJ, Mitchell M, McCullough AJ, Radaeva S, Barton B, Szabo G, Dasarathy S, Nagy LE
JCI insight 2021 Feb 22;6(4)
JCI insight 2021 Feb 22;6(4)
M10, a Myricetin-3-O-b-D-Lactose Sodium Salt, Prevents Ulcerative Colitis Through Inhibiting Necroptosis in Mice.
Zhou XL, Yang J, Qu XJ, Meng J, Miao RR, Cui SX
Frontiers in pharmacology 2020;11:557312
Frontiers in pharmacology 2020;11:557312
Protective effect of astaxanthin against SnS(2) nanoflowers induced testes toxicity by suppressing RIPK1-RIPK3-MLKL signaling in mice.
Yuan L, Liang P, Qu Y, An T, Wang J, Deng X, Bai L, Shen P, Bai D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Nov;145:111736
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Nov;145:111736
A new perspective of triptolide-associated hepatotoxicity: the relevance of NF- κ B and NF- κ B-mediated cellular FLICE-inhibitory protein.
Yuan Z, Yuan Z, Hasnat M, Zhang H, Liang P, Sun L, Jiang Z, Zhang L
Acta pharmaceutica Sinica. B 2020 May;10(5):861-877
Acta pharmaceutica Sinica. B 2020 May;10(5):861-877
Insights into mechanisms of pranoprofen-induced apoptosis and necroptosis in human corneal stromal cells.
Lin Y, Yu M, Fan T
Toxicology letters 2020 Mar 1;320:9-18
Toxicology letters 2020 Mar 1;320:9-18
TRADD Mediates RIPK1-Independent Necroptosis Induced by Tumor Necrosis Factor.
Wang L, Chang X, Feng J, Yu J, Chen G
Frontiers in cell and developmental biology 2019;7:393
Frontiers in cell and developmental biology 2019;7:393
The bromodomain protein BRD4 positively regulates necroptosis via modulating MLKL expression.
Xiong Y, Li L, Zhang L, Cui Y, Wu C, Li H, Chen K, Yang Q, Xiang R, Hu Y, Huang S, Wei Y, Yang S
Cell death and differentiation 2019 Oct;26(10):1929-1941
Cell death and differentiation 2019 Oct;26(10):1929-1941
Quetiapine induces myocardial necroptotic cell death through bidirectional regulation of cannabinoid receptors.
Li X, Peng Z, Zhou Y, Wang J, Lin X, Dong X, Liu X, Jiang J, Jiang Y, Li L
Toxicology letters 2019 Oct 1;313:77-90
Toxicology letters 2019 Oct 1;313:77-90
FKBP12 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation.
Wang Z, Feng J, Yu J, Chen G
Journal of cell science 2019 May 20;132(10)
Journal of cell science 2019 May 20;132(10)
A new perspective of triptolide-associated hepatotoxicity: Liver hypersensitivity upon LPS stimulation.
Yuan Z, Zhang H, Hasnat M, Ding J, Chen X, Liang P, Sun L, Zhang L, Jiang Z
Toxicology 2019 Feb 15;414:45-56
Toxicology 2019 Feb 15;414:45-56
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