66675-1-Ig

antibody from Proteintech Group

Targeting: MLKL FLJ34389

Provider product page for 66675-1-Ig

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Product number: 66675-1-Ig - Provider product page
Provider: Proteintech Group
Product name: MLKL antibody
Antibody type: Monoclonal
Description: KD/KO validated MLKL antibody (Cat. #66675-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, Mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 3D4C6
Vial size: 20ul, 150ul

MLKL protein structure - 66675-1-Ig shown in red.

Submitted references A ZBP1 isoform blocks ZBP1-mediated cell death.

Cai ZY, Wu P, Liang H, Xie YZ, Zhang BX, He CL, Yang CR, Li H, Mo W, Yang ZH
Cell reports 2024 May 28;43(5):114221

Urolithin A's Role in Alleviating Severe Acute Pancreatitis via Endoplasmic Reticulum-Mitochondrial Calcium Channel Modulation.

Kang H, Hu Q, Yang Y, Huang G, Li J, Zhao X, Zhu L, Su H, Tang W, Wan M
ACS nano 2024 May 28;18(21):13885-13898

Gancao decoction attenuates hepatic necroptosis via activating caspase 8 in cholestatic liver injury.

Zou B, Zhang S, Li F, Weng F, Zhao J, Jin J, Yan D, Xu X, Chen G, Liu C, Yao C, Li Y, Qiu F
Journal of ethnopharmacology 2024 May 23;326:117909

Effect of lipopolysaccharide on TAK1-mediated hepatocyte PANoptosis through Toll-like receptor 4 during acute liver failure.

Li W, Zhang W, Zhang D, Shi C, Wang Y
International immunopharmacology 2024 Mar 10;129:111612

Involvement of necroptotic cell death in macrophages in progression of bleomycin and LPS-induced acute exacerbation of idiopathic pulmonary fibrosis.

Koike A, Hayashi K, Fujimori K
European journal of pharmacology 2024 Jun 5;972:176572

S100A8/A9(hi) neutrophils induce mitochondrial dysfunction and PANoptosis in endothelial cells via mitochondrial complex I deficiency during sepsis.

Wang Y, Shi Y, Shao Y, Lu X, Zhang H, Miao C
Cell death & disease 2024 Jun 28;15(6):462

Systematic analysis of PANoptosis-related genes identifies XIAP as a functional oncogene in breast cancer.

Qi Q, Zhu M, Li P, Mi Q, Xie Y, Li J, Wang C
Gene 2024 Jun 20;912:148355

Shengxian decoction improves lung function in rats with bleomycin-induced idiopathic pulmonary fibrosis through the inhibition of PANoptosis.

Liang Y, Yan Y, Liu N, Wang J, Fang C
Journal of ethnopharmacology 2024 Jul 15;329:118153

Neutrophil extracellular traps aggravate intestinal epithelial necroptosis in ischaemia-reperfusion by regulating TLR4/RIPK3/FUNDC1-required mitophagy.

Chu C, Wang X, Chen F, Yang C, Shi L, Xu W, Wang K, Liu B, Wang C, Sun D, Li J, Ding W
Cell proliferation 2024 Jan;57(1):e13538

An investigation of the distributions of ferroptosis and necroptosis mediators in the maternal-fetal interface at different days of rat pregnancy.

Tatar M, Tüfekci KK
Anatomia, histologia, embryologia 2024 Jan;53(1):e12991

The traditional herb Sargentodoxa cuneata alleviates DSS-induced colitis by attenuating epithelial barrier damage via blocking necroptotic signaling.

Wang Y, Zhang B, Liu S, Xu E, Wang Z
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117373

VDAC1, as a downstream molecule of MLKL, participates in OGD/R-induced necroptosis by inducing mitochondrial damage.

Wan H, Yang YD, Zhang Q, Chen YH, Hu XM, Huang YX, Shang L, Xiong K
Heliyon 2024 Jan 15;10(1):e23426

A slow-releasing donor of hydrogen sulfide inhibits neuronal cell death via anti-PANoptosis in rats with spinal cord ischemia‒reperfusion injury.

Xie L, Wu H, He Q, Shi W, Zhang J, Xiao X, Yu T
Cell communication and signaling : CCS 2024 Jan 12;22(1):33

CGRP is essential for protection against alveolar epithelial cell necroptosis by activating the AMPK/L-OPA1 signaling pathway during acute lung injury.

Jiang HL, Yang HH, Liu YB, Duan JX, Guan XX, Zhang CY, Zhong WJ, Jin L, Li D, Li Q, Zhou Y, Guan CX
Journal of cellular physiology 2024 Feb;239(2):e31169

Transcriptotype-Driven Discovery of Apigenin as a Therapy against Cholestatic Liver Fibrosis: Through Inhibition of PANoptosis and Following Type-I Interferon Responses.

Duan S, Li X, Han J, Yang Y, Luo R, Cai Y, Li X, Zheng Q, Guo J, Liu R
Antioxidants (Basel, Switzerland) 2024 Feb 20;13(3)

Mitochondrial dysfunction induced by HIF-1α under hypoxia contributes to the development of gastric mucosal lesions.

Xiao Y, Liu X, Xie K, Luo J, Zhang Y, Huang X, Luo J, Tan S
Clinical and translational medicine 2024 Apr;14(4):e1653

Sodium sulfite triggered hepatic apoptosis, necroptosis, and pyroptosis by inducing mitochondrial damage in mice and AML-12 cells.

Liu M, Lu J, Hu J, Chen Y, Deng X, Wang J, Zhang S, Guo J, Li W, Guan S
Journal of hazardous materials 2024 Apr 5;467:133719

NLRP6 induces RIP1 kinase-dependent necroptosis via TAK1-mediated p38(MAPK)/MK2 phosphorylation in S. typhimurium infection.

Deng Q, Yang S, Huang K, Zhu Y, Sun L, Cao Y, Dong K, Li Y, Wu S, Huang R
iScience 2024 Apr 19;27(4):109339

PCSK9 Promotes Hypoxia-Induced EC Pyroptosis by Regulating Smac Mitochondrion-Cytoplasm Translocation in Critical Limb Ischemia.

Zhang M, Chen Y, Qiu Y, Sun J, He J, Liu Z, Shi J, Wei W, Wu G, Liang J
JACC. Basic to translational science 2023 Sep;8(9):1060-1077

Brazilin inhibits bladder cancer by promoting cell necroptosis.

Yang X, Zhang S, He J, Zhao L, Chen L, Yang Y, Wang J, Yan L, Zhang T
Clinical and experimental pharmacology & physiology 2023 Sep;50(9):738-748

Quizartinib inhibits necroptosis by targeting receptor-interacting serine/threonine protein kinase 1.

Li M, Wei J, Zhu G, Fu S, He X, Hu X, Yu Y, Mou Y, Wang J, You X, Xiao X, Gu T, Ye Z, Zha Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23178

IFN-γ promotes PANoptosis in Pasteurella multocida toxin-induced pneumonia in mice.

Xiao H, Zhao Q, Yuan J, Liang W, Wu R, Wen Y, Du S, Wang Y, Zhao S, Lang Y, Yan Q, Huang X, Cao S
Veterinary microbiology 2023 Oct;285:109848

Effect of doramectin on programmed cell death pathway in glioma cells.

Du S, Liang H, Zhou L, Chen C, Sun R, Zhang J, Meng X, Gao A
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2023 Oct;25(10):2871-2883

LncRNA MALAT1 Promoted Neuronal Necroptosis in Cerebral Ischemia-reperfusion Mice by Stabilizing HSP90.

Huang S, Hou D, Zhang L, Pei C, Liang J, Li J, Yang G, Yu D
Neurochemical research 2023 Nov;48(11):3457-3471

Polystyrene microplastics with different sizes induce the apoptosis and necroptosis in liver through the PTEN/PI3K/AKT/autophagy axis.

Wang S, Wu H, Shi X, Wang Y, Xu S
The Science of the total environment 2023 Nov 15;899:165461

Repurposing crizotinib to target RIPK1-dependent cell death.

Yu Y, Li M, Fu S, He X, Hu X, Zhu G, Wang J, You X, Mou Y, Ye Z, Wei J, Zha Y
International immunology 2023 May 8;35(5):221-230

Echinacea Polyphenols Inhibit NLRP3-Dependent Pyroptosis, Apoptosis, and Necroptosis via Suppressing NO Production during Lipopolysaccharide-Induced Acute Lung Injury.

Guo J, Luo Y, Zuo J, Teng J, Shen B, Liu X
Journal of agricultural and food chemistry 2023 May 17;71(19):7289-7298

Apoptosis-induced nuclear expulsion in tumor cells drives S100a4-mediated metastatic outgrowth through the RAGE pathway.

Park WY, Gray JM, Holewinski RJ, Andresson T, So JY, Carmona-Rivera C, Hollander MC, Yang HH, Lee M, Kaplan MJ, Cappell SD, Yang L
Nature cancer 2023 Mar;4(3):419-435

Deletion of Bak1 alleviates microglial necroptosis and neuroinflammation after experimental subarachnoid hemorrhage.

Qiu X, Tao Q, Zhang L, Kuang C, Xie Y, Zhang L, Yin S, Peng J, Jiang Y
Journal of neurochemistry 2023 Mar;164(6):829-846

Role of the Peli1-RIPK1 Signaling Axis in Methamphetamine-Induced Neuroinflammation.

Xu W, Yang T, Lou X, Chen J, Wang X, Hu M, An D, Gao R, Wang J, Chen X
ACS chemical neuroscience 2023 Mar 1;14(5):864-874

Necroptosis of macrophage is a key pathological feature in biliary atresia via GDCA/S1PR2/ZBP1/p-MLKL axis.

Yang S, Chang N, Li W, Yang T, Xue R, Liu J, Zhang L, Yao X, Chen Y, Wang H, Yang L, Huang J, Li L
Cell death & disease 2023 Mar 1;14(3):175

Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads to retinal ganglion cell PANoptosis in glaucoma.

Zeng Z, You M, Fan C, Rong R, Li H, Xia X
Redox biology 2023 Jun;62:102687

STING deficiency protects against wasp venom-induced acute kidney injury.

Lv Y, Lu L, Yu F, Gao Z, Yuan H, Hu F
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jul;72(7):1427-1440

Cisatracurium besylate rescues Mycobacterium Tuberculosis-infected macrophages from necroptosis and enhances the bactericidal effect of isoniazid.

Wen Q, Zhang J, Zhang Z, Chen L, Liu H, Han Z, Chen Y, Wang K, Liu J, Sai N, Zhou X, Zhou C, Hu S, Ma L
International immunopharmacology 2023 Jul;120:110291

Polysaccharide from Strongylocentrotus nudus eggs regulates intestinal epithelial autophagy through CD36/PI3K-Akt pathway to ameliorate inflammatory bowel disease.

Zhou M, Zhi J, Zhi J, Xiong Z, Wu F, Lu Y, Hu Q
International journal of biological macromolecules 2023 Jul 31;244:125373

Nucleoporin Seh1 maintains Schwann cell homeostasis by regulating genome stability and necroptosis.

Wu M, Li M, Liu W, Yan M, Li L, Ding W, Nian X, Dai W, Sun D, Zhu Y, Huang Q, Lu X, Cai Z, Hong F, Li X, Zhang L, Liu Z, Mo W, Zhang X, Zhang L
Cell reports 2023 Jul 25;42(7):112802

Triptolide leads to hepatic intolerance to exogenous lipopolysaccharide and natural-killer-cell mediated hepatocellular damage by inhibiting MHC class I molecules.

Zhang H, Yuan Z, Wang J, Tang Q, Miao Y, Yuan Z, Huang X, Zhu Y, Nong C, Zhang L, Jiang Z, Yu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;109:154621

MLKL signaling regulates macrophage polarization in acute pancreatitis through CXCL10.

Peng C, Tu G, Wang J, Wang Y, Wu P, Yu L, Li Z, Yu X
Cell death & disease 2023 Feb 24;14(2):155

Repositioning linifanib as a potent anti-necroptosis agent for sepsis.

Yu L, Yang K, He X, Li M, Gao L, Zha Y
Cell death discovery 2023 Feb 10;9(1):57

Lactoferrin attenuated urban particulate matter-induced nephrotoxicity by regulating the CSF2/CENPE axis.

Liu WC, Chiu HW, Chou CL, Chiu YJ, Lee YH
Environmental pollution (Barking, Essex : 1987) 2023 Feb 1;318:120871

Serinc2 deficiency exacerbates sepsis-induced cardiomyopathy by enhancing necroptosis and apoptosis.

Hu S, Huang M, Mao S, Yang M, Ju H, Liu Z, Cheng M, Wu G
Biochemical pharmacology 2023 Dec;218:115903

Skp2-mediated MLKL degradation confers cisplatin-resistant in non-small cell lung cancer cells.

Zhou H, Zhou L, Guan Q, Hou X, Wang C, Liu L, Wang J, Yu X, Li W, Liu H
Communications biology 2023 Aug 2;6(1):805

Repurposing of the FGFR inhibitor AZD4547 as a potent inhibitor of necroptosis by selectively targeting RIPK1.

Wang ZW, Zou FM, Wang AL, Yang J, Jin R, Wang BL, Shen LJ, Qi S, Liu J, Liu J, Wang WC, Liu QS
Acta pharmacologica Sinica 2023 Apr;44(4):801-810

Liraglutide Attenuates Myocardial Ischemia/Reperfusion Injury Through the Inhibition of Necroptosis by Activating GLP-1R/PI3K/Akt Pathway.

Zhou G, Wu H, Yang J, Ye M, Liu D, Li Y, Zhang D, Zhang J, Yang Q, Liu Y
Cardiovascular toxicology 2023 Apr;23(3-4):161-175

Ameliorative effects of epigallocatechin-3-gallate nanoparticles on 2,4-dinitrochlorobenzene induced atopic dermatitis: A potential mechanism of inflammation-related necroptosis.

Han M, Wang X, Wang J, Lang D, Xia X, Jia Y, Chen Y
Frontiers in nutrition 2022;9:953646

Adenosine Kinase Inhibition Prevents Severe Acute Pancreatitis via Suppressing Inflammation and Acinar Cell Necroptosis.

Sun S, Han Y, Zhang C, Liu H, Wang B, Cao S, Yuan Q, Wei S, Chen Y
Frontiers in cell and developmental biology 2022;10:827714

Protective effect of inhibiting necroptosis on gentamicin-induced nephrotoxicity.

Hu BF, Gong Q, Chen SQ, Yue L, Ma WX, Wang F, Feng XW, Wang JN, Li C, Liu MM, Wang XF, Meng XM, Li J, Wen JG
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Sep;36(9):e22487

Enhanced nuclear localization of phosphorylated MLKL predicts adverse events in patients with dilated cardiomyopathy.

Fujita Y, Yano T, Kanamori H, Nagahara D, Muranaka A, Kouzu H, Mochizuki A, Koyama M, Nagano N, Fujito T, Nishikawa R, Kamiyama N, Tanaka M, Kuno A, Tanno M, Miura T
ESC heart failure 2022 Oct;9(5):3435-3451

Serpina3c deficiency induced necroptosis promotes non-alcoholic fatty liver disease through β-catenin/Foxo1/TLR4 signaling.

Qian LL, Ji JJ, Jiang Y, Guo JQ, Wu Y, Yang Z, Ma GS, Yao YY
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 May;36(5):e22316

Zinc finger protein 91 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation.

Zhong Y, Zhang ZH, Wang JY, Xing Y, Ri MH, Jin HL, Zuo HX, Li MY, Ma J, Jin X
Toxicology letters 2022 Mar 1;356:75-88

Myo-inositol oxygenase overexpression exacerbates cadmium-induced kidney injury via oxidant stress and necroptosis.

Zheng X, Deng F, Sharma I, Kanwar YS
American journal of physiology. Renal physiology 2022 Mar 1;322(3):F344-F359

Contribution of Necroptosis to Myofiber Death in Idiopathic Inflammatory Myopathies.

Peng QL, Zhang YM, Liu YC, Liang L, Li WL, Tian XL, Zhang L, Yang HX, Lu X, Wang GC
Arthritis & rheumatology (Hoboken, N.J.) 2022 Jun;74(6):1048-1058

MiR-29a-3p Improves Acute Lung Injury by Reducing Alveolar Epithelial Cell PANoptosis.

Cui Y, Wang X, Lin F, Li W, Zhao Y, Zhu F, Yang H, Rao M, Li Y, Liang H, Dai M, Liu B, Chen L, Han D, Lu R, Peng W, Zhang Y, Song C, Luo Y, Pan P
Aging and disease 2022 Jun;13(3):899-909

LncRNA 122049 suppresses apoptosis of renal tubular epithelial cells in ischemic AKI by targeting the miR-330-5p/ELK1 axis.

Xiao Y, Li X, Qiu S, Wang Y, Zhang D
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jul;36(7):e22395

L-OPA1 deficiency aggravates necroptosis of alveolar epithelial cells through impairing mitochondrial function during acute lung injury in mice.

Jiang HL, Yang HH, Liu YB, Zhang CY, Zhong WJ, Guan XX, Jin L, Hong JR, Yang JT, Tan XH, Li Q, Zhou Y, Guan CX
Journal of cellular physiology 2022 Jul;237(7):3030-3043

Dysmyelination by Oligodendrocyte-Specific Ablation of Ninj2 Contributes to Depressive-Like Behaviors.

Sun Y, Chen X, Ou Z, Wang Y, Chen W, Zhao T, Liu C, Chen Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Jan;9(3):e2103065

Thioredoxin reductase 3 suppression promotes colitis and carcinogenesis via activating pyroptosis and necrosis.

Liu Q, Du P, Zhu Y, Zhang X, Cai J, Zhang Z
Cellular and molecular life sciences : CMLS 2022 Jan 30;79(2):106

Pressure Drives Rapid Burst-Like Coordinated Cellular Motion from 3D Cancer Aggregates.

Raghuraman S, Schubert AS, Bröker S, Jurado A, Müller A, Brandt M, Vos BE, Hofemeier AD, Abbasi F, Stehling M, Wittkowski R, Ivaska J, Betz T
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Feb;9(6):e2104808

Caspase-8 is involved in pyroptosis, necroptosis and the maturation and release of IL-1β in Aspergillus fumigatus keratitis.

Wang L, Yan H, Chen X, Lee J, Sun J, Liu G, Yang H, Lu D, Liu W, Che C
International immunopharmacology 2022 Dec;113(Pt A):109275

Targeting Cell Membranes, Depleting ROS by Dithiane and Thioketal-Containing Polymers with Pendant Cholesterols Delivering Necrostatin-1 for Glaucoma Treatment.

Rong R, Zhou X, Liang G, Li H, You M, Liang Z, Zeng Z, Xiao H, Ji D, Xia X
ACS nano 2022 Dec 27;16(12):21225-21239

Developmental exposure to chlorpyrifos causes neuroinflammation via necroptosis in mouse hippocampus and human microglial cell line.

Tu Y, Yang Y, Wang Y, Wu N, Tao J, Yang G, You M
Environmental pollution (Barking, Essex : 1987) 2022 Dec 1;314:120217

Taurine inhibits necroptosis helps to alleviate inflammatory and injury induced by Klebsiella infection.

Yin H, Wang Z, Yang S, Zheng X, Bao Y, Lin W, Huang C, Qiu L
Veterinary immunology and immunopathology 2022 Aug;250:110444

Necrostatin-1 Against Sevoflurane-Induced Cognitive Dysfunction Involves Activation of BDNF/TrkB Pathway and Inhibition of Necroptosis in Aged Rats.

Yin C, Zhang Q, Zhao J, Li Y, Yu J, Li W, Wang Q
Neurochemical research 2022 Apr;47(4):1060-1072

4-Hydroxy-2-Nonenal Promotes Cardiomyocyte Necroptosis via Stabilizing Receptor-Interacting Serine/Threonine-Protein Kinase 1.

Zhai X, Wang W, Sun S, Han Y, Li J, Cao S, Li R, Xu T, Yuan Q, Wang J, Wei S, Chen Y
Frontiers in cell and developmental biology 2021;9:721795

Expression of the ACE2 Virus Entry Protein in the Nervus Terminalis Reveals the Potential for an Alternative Route to Brain Infection in COVID-19.

Bilinska K, von Bartheld CS, Butowt R
Frontiers in cellular neuroscience 2021;15:674123

RIPK3-Dependent Necroptosis Is Induced and Restricts Viral Replication in Human Astrocytes Infected With Zika Virus.

Wen C, Yu Y, Gao C, Qi X, Cardona CJ, Xing Z
Frontiers in cellular and infection microbiology 2021;11:637710

Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy.

Zhu J, Xin M, Xu C, He Y, Zhang W, Wang Z, Zhuang C
Acta pharmaceutica Sinica. B 2021 Oct;11(10):3193-3205

PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination.

Wang Y, Zhang Y, Zhang S, Kim B, Hull VL, Xu J, Prabhu P, Gregory M, Martinez-Cerdeno V, Zhan X, Deng W, Guo F
Cell reports 2021 Oct 5;37(1):109695

Metformin attenuates hypothalamic inflammation via downregulation of RIPK1-independent microglial necroptosis in diet-induced obese mice.

Li X, Cai Y, Luo J, Ding J, Yao G, Xiao X, Tang Y, Liang Z
Cell death discovery 2021 Nov 8;7(1):338

Inhibition of adenosine kinase attenuates myocardial ischaemia/reperfusion injury.

Wang W, Wang B, Sun S, Cao S, Zhai X, Zhang C, Zhang Q, Yuan Q, Sun Y, Xue M, Ma J, Xu F, Wei S, Chen Y
Journal of cellular and molecular medicine 2021 Mar;25(6):2931-2943

Differential role of MLKL in alcohol-associated and non-alcohol-associated fatty liver diseases in mice and humans.

Miyata T, Wu X, Fan X, Huang E, Sanz-Garcia C, Ross CKC, Roychowdhury S, Bellar A, McMullen MR, Dasarathy J, Allende DS, Caballeria J, Sancho-Bru P, McClain CJ, Mitchell M, McCullough AJ, Radaeva S, Barton B, Szabo G, Dasarathy S, Nagy LE
JCI insight 2021 Feb 22;6(4)

M10, a Myricetin-3-O-b-D-Lactose Sodium Salt, Prevents Ulcerative Colitis Through Inhibiting Necroptosis in Mice.

Zhou XL, Yang J, Qu XJ, Meng J, Miao RR, Cui SX
Frontiers in pharmacology 2020;11:557312

Protective effect of astaxanthin against SnS(2) nanoflowers induced testes toxicity by suppressing RIPK1-RIPK3-MLKL signaling in mice.

Yuan L, Liang P, Qu Y, An T, Wang J, Deng X, Bai L, Shen P, Bai D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Nov;145:111736

A new perspective of triptolide-associated hepatotoxicity: the relevance of NF- κ B and NF- κ B-mediated cellular FLICE-inhibitory protein.

Yuan Z, Yuan Z, Hasnat M, Zhang H, Liang P, Sun L, Jiang Z, Zhang L
Acta pharmaceutica Sinica. B 2020 May;10(5):861-877

Insights into mechanisms of pranoprofen-induced apoptosis and necroptosis in human corneal stromal cells.

Lin Y, Yu M, Fan T
Toxicology letters 2020 Mar 1;320:9-18

TRADD Mediates RIPK1-Independent Necroptosis Induced by Tumor Necrosis Factor.

Wang L, Chang X, Feng J, Yu J, Chen G
Frontiers in cell and developmental biology 2019;7:393

The bromodomain protein BRD4 positively regulates necroptosis via modulating MLKL expression.

Xiong Y, Li L, Zhang L, Cui Y, Wu C, Li H, Chen K, Yang Q, Xiang R, Hu Y, Huang S, Wei Y, Yang S
Cell death and differentiation 2019 Oct;26(10):1929-1941

Quetiapine induces myocardial necroptotic cell death through bidirectional regulation of cannabinoid receptors.

Li X, Peng Z, Zhou Y, Wang J, Lin X, Dong X, Liu X, Jiang J, Jiang Y, Li L
Toxicology letters 2019 Oct 1;313:77-90

FKBP12 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation.

Wang Z, Feng J, Yu J, Chen G
Journal of cell science 2019 May 20;132(10)

A new perspective of triptolide-associated hepatotoxicity: Liver hypersensitivity upon LPS stimulation.

Yuan Z, Zhang H, Hasnat M, Ding J, Chen X, Liang P, Sun L, Zhang L, Jiang Z
Toxicology 2019 Feb 15;414:45-56

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