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- Antibody Data
- Antigen structure
- References [15]
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- Product number
- 66675-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- MLKL antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated MLKL antibody (Cat. #66675-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, Mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 3D4C6
- Vial size
- 20ul, 150ul
Submitted references 4-Hydroxy-2-Nonenal Promotes Cardiomyocyte Necroptosis via Stabilizing Receptor-Interacting Serine/Threonine-Protein Kinase 1.
RIPK3-Dependent Necroptosis Is Induced and Restricts Viral Replication in Human Astrocytes Infected With Zika Virus.
Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy.
PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination.
Metformin attenuates hypothalamic inflammation via downregulation of RIPK1-independent microglial necroptosis in diet-induced obese mice.
Inhibition of adenosine kinase attenuates myocardial ischaemia/reperfusion injury.
M10, a Myricetin-3-O-b-D-Lactose Sodium Salt, Prevents Ulcerative Colitis Through Inhibiting Necroptosis in Mice.
Protective effect of astaxanthin against SnS2 nanoflowers induced testes toxicity by suppressing RIPK1-RIPK3-MLKL signaling in mice.
A new perspective of triptolide-associated hepatotoxicity: the relevance of NF- κ B and NF- κ B-mediated cellular FLICE-inhibitory protein.
Insights into mechanisms of pranoprofen-induced apoptosis and necroptosis in human corneal stromal cells.
TRADD Mediates RIPK1-Independent Necroptosis Induced by Tumor Necrosis Factor.
The bromodomain protein BRD4 positively regulates necroptosis via modulating MLKL expression.
Quetiapine induces myocardial necroptotic cell death through bidirectional regulation of cannabinoid receptors.
FKBP12 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation.
A new perspective of triptolide-associated hepatotoxicity: Liver hypersensitivity upon LPS stimulation.
Zhai X, Wang W, Sun S, Han Y, Li J, Cao S, Li R, Xu T, Yuan Q, Wang J, Wei S, Chen Y
Frontiers in cell and developmental biology 2021;9:721795
Frontiers in cell and developmental biology 2021;9:721795
RIPK3-Dependent Necroptosis Is Induced and Restricts Viral Replication in Human Astrocytes Infected With Zika Virus.
Wen C, Yu Y, Gao C, Qi X, Cardona CJ, Xing Z
Frontiers in cellular and infection microbiology 2021;11:637710
Frontiers in cellular and infection microbiology 2021;11:637710
Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy.
Zhu J, Xin M, Xu C, He Y, Zhang W, Wang Z, Zhuang C
Acta pharmaceutica Sinica. B 2021 Oct;11(10):3193-3205
Acta pharmaceutica Sinica. B 2021 Oct;11(10):3193-3205
PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination.
Wang Y, Zhang Y, Zhang S, Kim B, Hull VL, Xu J, Prabhu P, Gregory M, Martinez-Cerdeno V, Zhan X, Deng W, Guo F
Cell reports 2021 Oct 5;37(1):109695
Cell reports 2021 Oct 5;37(1):109695
Metformin attenuates hypothalamic inflammation via downregulation of RIPK1-independent microglial necroptosis in diet-induced obese mice.
Li X, Cai Y, Luo J, Ding J, Yao G, Xiao X, Tang Y, Liang Z
Cell death discovery 2021 Nov 8;7(1):338
Cell death discovery 2021 Nov 8;7(1):338
Inhibition of adenosine kinase attenuates myocardial ischaemia/reperfusion injury.
Wang W, Wang B, Sun S, Cao S, Zhai X, Zhang C, Zhang Q, Yuan Q, Sun Y, Xue M, Ma J, Xu F, Wei S, Chen Y
Journal of cellular and molecular medicine 2021 Mar;25(6):2931-2943
Journal of cellular and molecular medicine 2021 Mar;25(6):2931-2943
M10, a Myricetin-3-O-b-D-Lactose Sodium Salt, Prevents Ulcerative Colitis Through Inhibiting Necroptosis in Mice.
Zhou XL, Yang J, Qu XJ, Meng J, Miao RR, Cui SX
Frontiers in pharmacology 2020;11:557312
Frontiers in pharmacology 2020;11:557312
Protective effect of astaxanthin against SnS2 nanoflowers induced testes toxicity by suppressing RIPK1-RIPK3-MLKL signaling in mice.
Yuan L, Liang P, Qu Y, An T, Wang J, Deng X, Bai L, Shen P, Bai D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Nov;145:111736
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Nov;145:111736
A new perspective of triptolide-associated hepatotoxicity: the relevance of NF- κ B and NF- κ B-mediated cellular FLICE-inhibitory protein.
Yuan Z, Yuan Z, Hasnat M, Zhang H, Liang P, Sun L, Jiang Z, Zhang L
Acta pharmaceutica Sinica. B 2020 May;10(5):861-877
Acta pharmaceutica Sinica. B 2020 May;10(5):861-877
Insights into mechanisms of pranoprofen-induced apoptosis and necroptosis in human corneal stromal cells.
Lin Y, Yu M, Fan T
Toxicology letters 2020 Mar 1;320:9-18
Toxicology letters 2020 Mar 1;320:9-18
TRADD Mediates RIPK1-Independent Necroptosis Induced by Tumor Necrosis Factor.
Wang L, Chang X, Feng J, Yu J, Chen G
Frontiers in cell and developmental biology 2019;7:393
Frontiers in cell and developmental biology 2019;7:393
The bromodomain protein BRD4 positively regulates necroptosis via modulating MLKL expression.
Xiong Y, Li L, Zhang L, Cui Y, Wu C, Li H, Chen K, Yang Q, Xiang R, Hu Y, Huang S, Wei Y, Yang S
Cell death and differentiation 2019 Oct;26(10):1929-1941
Cell death and differentiation 2019 Oct;26(10):1929-1941
Quetiapine induces myocardial necroptotic cell death through bidirectional regulation of cannabinoid receptors.
Li X, Peng Z, Zhou Y, Wang J, Lin X, Dong X, Liu X, Jiang J, Jiang Y, Li L
Toxicology letters 2019 Oct 1;313:77-90
Toxicology letters 2019 Oct 1;313:77-90
FKBP12 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation.
Wang Z, Feng J, Yu J, Chen G
Journal of cell science 2019 May 20;132(10)
Journal of cell science 2019 May 20;132(10)
A new perspective of triptolide-associated hepatotoxicity: Liver hypersensitivity upon LPS stimulation.
Yuan Z, Zhang H, Hasnat M, Ding J, Chen X, Liang P, Sun L, Zhang L, Jiang Z
Toxicology 2019 Feb 15;414:45-56
Toxicology 2019 Feb 15;414:45-56
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