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- Antibody Data
- Antigen structure
- References [17]
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- Product number
- 24421-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- TALPID3 antibody
- Antibody type
- Polyclonal
- Description
- TALPID3 antibody (Cat. #24421-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, canine and has been validated for the following applications: IF, IHC, ELISA.
- Reactivity
- Human, Mouse, Canine
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Novel Pathogenic Biallelic Variants in KIAA0586 Expand the Variant Spectrum of Ciliopathies.
Glutamylation of centrosomes ensures their function by recruiting microtubule nucleation factors.
The Luminal Ring Protein C2CD3 Acts as a Radial In-to-Out Organizer of the Distal Centriole and Appendages.
The Kinesin Motor Kif9 Disrupts Primary Cilia Length by Mispositioning Centriolar Satellites.
Centriole structural integrity defects are a crucial feature of hydrolethalus syndrome.
The ARPKD Protein DZIP1L Regulates Ciliary Protein Entry by Modulating the Architecture and Function of Ciliary Transition Fibers.
Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis.
SARS-CoV-2 ORF10 impairs cilia by enhancing CUL2ZYG11B activity.
A ciliopathy complex builds distal appendages to initiate ciliogenesis.
FBW7 couples structural integrity with functional output of primary cilia.
Aurora Kinase A proximity map reveals centriolar satellites as regulators of its ciliary function.
TALPID3 and ANKRD26 selectively orchestrate FBF1 localization and cilia gating.
Talpid3-Mediated Centrosome Integrity Restrains Neural Progenitor Delamination to Sustain Neurogenesis by Stabilizing Adherens Junctions.
Centriolar satellites are required for efficient ciliogenesis and ciliary content regulation.
Deubiquitylase USP9X maintains centriolar satellite integrity by stabilizing pericentriolar material 1 protein.
Centrosomal protein CP110 controls maturation of the mother centriole during cilia biogenesis.
TALPID3 controls centrosome and cell polarity and the human ortholog KIAA0586 is mutated in Joubert syndrome (JBTS23).
Shen Y, He R, Lu C, Wang Z, Yu Y, Cao Z, Luo M
Cytoskeleton (Hoboken, N.J.) 2025 Sep 29;
Cytoskeleton (Hoboken, N.J.) 2025 Sep 29;
Glutamylation of centrosomes ensures their function by recruiting microtubule nucleation factors.
Hong SR, Chuang YC, Yang WT, Song CS, Yeh HW, Wu BH, Lin IH, Chou PC, Chen SC, Sharma L, Lu JC, Li RY, Chang YC, Liao KJ, Cheng HC, Wang WJ, Wang LH, Lin YC
The EMBO journal 2025 May;44(10):2976-2996
The EMBO journal 2025 May;44(10):2976-2996
The Luminal Ring Protein C2CD3 Acts as a Radial In-to-Out Organizer of the Distal Centriole and Appendages.
Bertiaux E, Louvel V, McCafferty CL, van den Hoek H, Batman U, Mukherjee S, Bournonville L, Mercey O, Mean I, Müller A, Van der Stappen P, Buss G, Daraspe J, Genoud C, Stearns T, Engel BD, Hamel V, Guichard P
bioRxiv : the preprint server for biology 2025 Jun 18;
bioRxiv : the preprint server for biology 2025 Jun 18;
The Kinesin Motor Kif9 Disrupts Primary Cilia Length by Mispositioning Centriolar Satellites.
Vicente JJ, Weiss J, Wagenbach M, Wordeman L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 31;39(14):e70841
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 31;39(14):e70841
Centriole structural integrity defects are a crucial feature of hydrolethalus syndrome.
Curinha A, Huang Z, Anglen T, Strong MA, Gliech CR, Jewett CE, Friskes A, Phan TP, Nicholas Z, Holland AJ
The Journal of cell biology 2025 Apr 7;224(4)
The Journal of cell biology 2025 Apr 7;224(4)
The ARPKD Protein DZIP1L Regulates Ciliary Protein Entry by Modulating the Architecture and Function of Ciliary Transition Fibers.
Chen H, Wu Z, Yan Z, Chen C, Zhang Y, Wang Q, Gao Y, Ling K, Hu J, Wei Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(24):e2308820
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(24):e2308820
Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis.
Hall EA, Kumar D, Prosser SL, Yeyati PL, Herranz-Pérez V, García-Verdugo JM, Rose L, McKie L, Dodd DO, Tennant PA, Megaw R, Murphy LC, Ferreira MF, Grimes G, Williams L, Quidwai T, Pelletier L, Reiter JF, Mill P
eLife 2023 Feb 15;12
eLife 2023 Feb 15;12
SARS-CoV-2 ORF10 impairs cilia by enhancing CUL2ZYG11B activity.
Wang L, Liu C, Yang B, Zhang H, Jiao J, Zhang R, Liu S, Xiao S, Chen Y, Liu B, Ma Y, Duan X, Guo Y, Guo M, Wu B, Wang X, Huang X, Yang H, Gui Y, Fang M, Zhang L, Duo S, Guo X, Li W
The Journal of cell biology 2022 Jul 4;221(7)
The Journal of cell biology 2022 Jul 4;221(7)
A ciliopathy complex builds distal appendages to initiate ciliogenesis.
Kumar D, Rains A, Herranz-Pérez V, Lu Q, Shi X, Swaney DL, Stevenson E, Krogan NJ, Huang B, Westlake C, Garcia-Verdugo JM, Yoder BK, Reiter JF
The Journal of cell biology 2021 Sep 6;220(9)
The Journal of cell biology 2021 Sep 6;220(9)
FBW7 couples structural integrity with functional output of primary cilia.
Petsouki E, Gerakopoulos V, Szeto N, Chang W, Humphrey MB, Tsiokas L
Communications biology 2021 Sep 13;4(1):1066
Communications biology 2021 Sep 13;4(1):1066
Aurora Kinase A proximity map reveals centriolar satellites as regulators of its ciliary function.
Arslanhan MD, Rauniyar N, Yates JR 3rd, Firat-Karalar EN
EMBO reports 2021 Aug 4;22(8):e51902
EMBO reports 2021 Aug 4;22(8):e51902
TALPID3 and ANKRD26 selectively orchestrate FBF1 localization and cilia gating.
Yan H, Chen C, Chen H, Hong H, Huang Y, Ling K, Hu J, Wei Q
Nature communications 2020 May 4;11(1):2196
Nature communications 2020 May 4;11(1):2196
Talpid3-Mediated Centrosome Integrity Restrains Neural Progenitor Delamination to Sustain Neurogenesis by Stabilizing Adherens Junctions.
Wang J, Li T, Wang JL, Xu Z, Meng W, Wu QF
Cell reports 2020 Dec 15;33(11):108495
Cell reports 2020 Dec 15;33(11):108495
Centriolar satellites are required for efficient ciliogenesis and ciliary content regulation.
Odabasi E, Gul S, Kavakli IH, Firat-Karalar EN
EMBO reports 2019 Jun;20(6)
EMBO reports 2019 Jun;20(6)
Deubiquitylase USP9X maintains centriolar satellite integrity by stabilizing pericentriolar material 1 protein.
Han KJ, Wu Z, Pearson CG, Peng J, Song K, Liu CW
Journal of cell science 2019 Jan 22;132(2)
Journal of cell science 2019 Jan 22;132(2)
Centrosomal protein CP110 controls maturation of the mother centriole during cilia biogenesis.
Yadav SP, Sharma NK, Liu C, Dong L, Li T, Swaroop A
Development (Cambridge, England) 2016 May 1;143(9):1491-501
Development (Cambridge, England) 2016 May 1;143(9):1491-501
TALPID3 controls centrosome and cell polarity and the human ortholog KIAA0586 is mutated in Joubert syndrome (JBTS23).
Stephen LA, Tawamie H, Davis GM, Tebbe L, Nürnberg P, Nürnberg G, Thiele H, Thoenes M, Boltshauser E, Uebe S, Rompel O, Reis A, Ekici AB, McTeir L, Fraser AM, Hall EA, Mill P, Daudet N, Cross C, Wolfrum U, Jamra RA, Davey MG, Bolz HJ
eLife 2015 Sep 19;4
eLife 2015 Sep 19;4
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TALPID3 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human TALPID3. This antibody recognizes human, mouse antigen. The TALPID3 antibody has been validated for the following applications: ELISA, WB analysis.
