Antibody data
- Antibody Data
- Antigen structure
- References [39]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 21646-1-AP - Provider product page

- Provider
- Proteintech Group
- Product name
- PRKG1 antibody
- Antibody type
- Polyclonal
- Description
- PRKG1 antibody (Cat. #21646-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Hederagenin Attenuates Cardiac Remodeling by Targeting Phosphodiesterase 9A.
Pluripotent stem-cell-based screening uncovers sildenafil as a mitochondrial disease therapy.
CIDEC impairs mitochondrial fitness and blocks protective autophagy via the inhibition of cGMP/PKG pathway to exert tumor-suppressive effects in breast cancer.
Vericiguat improves CKD-related vascular calcification through the NO/cGMP/PKG pathway.
Integrating single-cell sequencing and clinical insights to explore malignant transformation in odontogenic keratocyst.
Systematic reevaluation on the antipyretic, analgesic effects, and uncover the mechanisms of Chaiqin Qingning capsule, a traditional Chinese medicine, via establishing lipopolysaccharide - induced fever models, physical and chemical - stimuli pain models.
Inhibition of inducible nitric oxide synthase (iNOS) alleviates thoracic aortic aneurysm by regulating mitochondrial dynamics.
NAMPT modulates muscle fiber type transition in PAD myopathy via the cGMP-PKG signaling pathway.
Celastrol Ameliorates Hypoxia-Induced Pulmonary Hypertension by Regulation of the PDE5-cGMP-PKG Signaling Pathway.
EDNRB negatively regulates glycolysis to exhibit anti-tumor functions in prostate cancer by cGMP/PKG pathway.
Integrated transcriptomics and metabolomics unravel the key metabolic pathways involved in the therapeutic mechanism of Salvianic acid A against hepatic fibrosis.
Metformin inhibits the progression of castration-resistant prostate cancer by regulating PDE6D induced purine metabolic alternation and cGMP / PKG pathway activation.
Qifu yixin prescription ameliorates cardiac fibrosis by activating soluble guanylate cyclase (sGC) in heart failure.
Study on the mechanism of Xinmailong injection against chronic heart failure based on transcriptomics and proteomics.
Podophyllotoxin mediates hepatic toxicity via the C5a/C5aR/ROS/NLRP3 and cGMP/PKG/mTOR axis in rats based on toxicological evidence chain (TEC) concept by phosphoproteomic analysis.
E3 ubiquitin ligase CHIP facilitates cAMP and cGMP signalling cross-talk by polyubiquitinating PDE9A.
IGF2BP3 binds to FBXO32 to activate the cyclic guanosine monophosphate-protein kinase G pathway, promoting gastric cancer progression.
EDNRB inhibits the growth and migration of prostate cancer cells by activating the cGMP-PKG pathway.
Inflammation-Related Gene ADH1A Regulates the Polarization of Macrophage M1 and Influences the Malignant Progression of Gastric Cancer.
Vericiguat attenuates doxorubicin-induced cardiotoxicity through the PRKG1/PINK1/STING axis.
Sodium bicarbonate potentiates the antitumor effects of Olaparib in ovarian cancer via cGMP/PKG-mediated ROS scavenging and M1 macrophage transformation.
The Antipsychotic Drug Aripiprazole Suppresses Colorectal Cancer by Targeting LAMP2a to Induce RNH1/miR-99a/mTOR-Mediated Autophagy and Apoptosis.
Neuroprotective Potential of Nitroglycerin in Ischemic Stroke: Insights into Neural Glucose Metabolism and Endoplasmic Reticulum Stress Inhibition.
Salidroside enhances NO bioavailability and modulates arginine metabolism to alleviate pulmonary arterial hypertension.
Exercise training affects calcium ion transport by downregulating the CACNA2D1 protein to reduce hypertension-induced myocardial injury in mice.
Specific dilation pattern in placental circulation and the NO/sGC role in preeclampsia placental vessels.
Cucurbitacin C suppresses the progression of pancreatic ductal adenocarcinoma via inhibition of the cGMP-PKG-VASP axis.
Zhenwu decoction ameliorates cardiac hypertrophy through activating sGC (soluble guanylate cyclase) - cGMP (cyclic guanosine monophosphate) - PKG (protein kinase G) pathway.
Potential cardiotoxicity induced by Euodiae Fructus: In vivo and in vitro experiments and untargeted metabolomics research.
A novel phosphodiesterase 9A inhibitor LW33 protects against ischemic stroke through the cGMP/PKG/CREB pathway.
Myostatin Mutation Promotes Glycolysis by Increasing Phosphorylation of Phosphofructokinase via Activation of PDE5A-cGMP-PKG in Cattle Heart.
Emodin Interferes With Nitroglycerin-Induced Migraine in Rats Through CGMP-PKG Pathway.
Abnormal cGMP-dependent protein kinase I-mediated decidualization in preeclampsia.
NEK7 promotes gastric cancer progression as a cell proliferation regulator.
Upregulation of Connexin 40 Mediated by Nitric Oxide Attenuates Cerebral Vasospasm After Subarachnoid Hemorrhage via the Nitric Oxide-Cyclic Guanosine Monophosphate-Protein Kinase G Pathway.
Fluoride-induced unrestored arrest during haploid period of spermatogenesis via the regulation of DDX25 in rats.
Long non-coding RNA and mRNA profile analysis of metformin to reverse the pulmonary hypertension vascular remodeling induced by monocrotaline.
Empagliflozin prevents cardiomyopathy via sGC-cGMP-PKG pathway in type 2 diabetes mice.
Liraglutide suppresses obesity and induces brown fat-like phenotype via Soluble Guanylyl Cyclase mediated pathway in vivo and in vitro.
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Pluripotent stem-cell-based screening uncovers sildenafil as a mitochondrial disease therapy.
Zink A, Dai DF, Wittich A, Henke MT, Pedrotti G, Heiduschka S, Santamaria G, Pentimalli TM, Brueser C, Notopoulou S, Umar AR, Zhaivoron A, Petersilie L, Jerred C, Bergmans J, Neu LA, Schumacher F, Keller-Findeisen J, Rybak-Wolf A, Stach D, Reinshagen J, Haferkamp U, Krieg K, Zaliani A, Euro L, Di Donfrancesco A, Santanatoglia C, Cappellozza E, Suarez Cubero M, Pavez-Giani M, Bakumenko O, Meierhofer D, Foley A, Morales-Gonzalez S, Tolle I, Herebian D, Bonesso D, Cecchetto G, Wong SN, Moresco M, Maresca A, Decimo I, De Sanctis F, Adamo A, Adjobo-Hermans MJW, Duchi R, Barandalla M, Scaglia M, Perota A, Galli C, Kleuser B, Cyganek L, Mühlhausen C, Schlotawa L, Tiranti V, Mayatepek E, Szabo I, La Morgia C, Klopstock T, Carelli V, Distelmaier F, Rossi A, Rajewsky N, Ullah G, Jakobs S, Rose CR, Petrakis S, Edenhofer F, Koopman WJH, Lisowski P, Suomalainen A, Brunetti D, Del Sol A, Bottani E, Pless O, Schuelke M, Prigione A
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Cell 2026 Mar 19;189(6):1656-1679.e42
CIDEC impairs mitochondrial fitness and blocks protective autophagy via the inhibition of cGMP/PKG pathway to exert tumor-suppressive effects in breast cancer.
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Vericiguat improves CKD-related vascular calcification through the NO/cGMP/PKG pathway.
Li C, Li J, Yang C, Zhu Z, Zhang Y, Xiang Y
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International immunopharmacology 2026 Apr 15;175:116413
Integrating single-cell sequencing and clinical insights to explore malignant transformation in odontogenic keratocyst.
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Inhibition of inducible nitric oxide synthase (iNOS) alleviates thoracic aortic aneurysm by regulating mitochondrial dynamics.
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European journal of pharmacology 2025 Oct 15;1005:178071
NAMPT modulates muscle fiber type transition in PAD myopathy via the cGMP-PKG signaling pathway.
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Celastrol Ameliorates Hypoxia-Induced Pulmonary Hypertension by Regulation of the PDE5-cGMP-PKG Signaling Pathway.
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Phytotherapy research : PTR 2025 Mar;39(3):1549-1564
EDNRB negatively regulates glycolysis to exhibit anti-tumor functions in prostate cancer by cGMP/PKG pathway.
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Molecular and cellular endocrinology 2025 Mar 1;598:112459
Integrated transcriptomics and metabolomics unravel the key metabolic pathways involved in the therapeutic mechanism of Salvianic acid A against hepatic fibrosis.
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Metformin inhibits the progression of castration-resistant prostate cancer by regulating PDE6D induced purine metabolic alternation and cGMP / PKG pathway activation.
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Qifu yixin prescription ameliorates cardiac fibrosis by activating soluble guanylate cyclase (sGC) in heart failure.
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Study on the mechanism of Xinmailong injection against chronic heart failure based on transcriptomics and proteomics.
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Journal of pharmaceutical and biomedical analysis 2025 Jan 15;253:116529
Podophyllotoxin mediates hepatic toxicity via the C5a/C5aR/ROS/NLRP3 and cGMP/PKG/mTOR axis in rats based on toxicological evidence chain (TEC) concept by phosphoproteomic analysis.
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Ecotoxicology and environmental safety 2025 Jan 1;289:117441
E3 ubiquitin ligase CHIP facilitates cAMP and cGMP signalling cross-talk by polyubiquitinating PDE9A.
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IGF2BP3 binds to FBXO32 to activate the cyclic guanosine monophosphate-protein kinase G pathway, promoting gastric cancer progression.
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EDNRB inhibits the growth and migration of prostate cancer cells by activating the cGMP-PKG pathway.
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Inflammation-Related Gene ADH1A Regulates the Polarization of Macrophage M1 and Influences the Malignant Progression of Gastric Cancer.
Ma J, Shi Y, Lu Q, Huang D
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Journal of inflammation research 2024;17:4647-4665
Vericiguat attenuates doxorubicin-induced cardiotoxicity through the PRKG1/PINK1/STING axis.
Zeng X, Zhang H, Xu T, Mei X, Wang X, Yang Q, Luo Z, Zeng Q, Xu D, Ren H
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Translational research : the journal of laboratory and clinical medicine 2024 Nov;273:90-103
Sodium bicarbonate potentiates the antitumor effects of Olaparib in ovarian cancer via cGMP/PKG-mediated ROS scavenging and M1 macrophage transformation.
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The Antipsychotic Drug Aripiprazole Suppresses Colorectal Cancer by Targeting LAMP2a to Induce RNH1/miR-99a/mTOR-Mediated Autophagy and Apoptosis.
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Neuroprotective Potential of Nitroglycerin in Ischemic Stroke: Insights into Neural Glucose Metabolism and Endoplasmic Reticulum Stress Inhibition.
Jiang S, Ding Y, Wang H, Kim E, Geng X
Journal of the American Heart Association 2024 Dec 17;13(24):e035382
Journal of the American Heart Association 2024 Dec 17;13(24):e035382
Salidroside enhances NO bioavailability and modulates arginine metabolism to alleviate pulmonary arterial hypertension.
Li J, Zhang Z, Zhu C, Zheng X, Wang C, Jiang J, Zhang H
European journal of medical research 2024 Aug 17;29(1):423
European journal of medical research 2024 Aug 17;29(1):423
Exercise training affects calcium ion transport by downregulating the CACNA2D1 protein to reduce hypertension-induced myocardial injury in mice.
Gao S, Yao W, Zhou R, Pei Z
iScience 2024 Apr 19;27(4):109351
iScience 2024 Apr 19;27(4):109351
Specific dilation pattern in placental circulation and the NO/sGC role in preeclampsia placental vessels.
Tang J, Zhang Y, Zhang Z, Tao J, Wu J, Zheng Q, Xu T, Li N, Xu Z
Frontiers in endocrinology 2023;14:1182636
Frontiers in endocrinology 2023;14:1182636
Cucurbitacin C suppresses the progression of pancreatic ductal adenocarcinoma via inhibition of the cGMP-PKG-VASP axis.
Xu D, Liu A, Liu Q, Zhang H, Tian M, Bian Y, Zhang X, Ying M, Shen H
Biochemical pharmacology 2023 Nov;217:115810
Biochemical pharmacology 2023 Nov;217:115810
Zhenwu decoction ameliorates cardiac hypertrophy through activating sGC (soluble guanylate cyclase) - cGMP (cyclic guanosine monophosphate) - PKG (protein kinase G) pathway.
Chen L, Zhou X, Deng Y, Yang Y, Chen X, Chen Q, Liu Y, Fu X, Kwan HY, You Y, Jin W, Zhao X
Journal of ethnopharmacology 2023 Jan 10;300:115705
Journal of ethnopharmacology 2023 Jan 10;300:115705
Potential cardiotoxicity induced by Euodiae Fructus: In vivo and in vitro experiments and untargeted metabolomics research.
Zhang D, Lü J, Ren Z, Zhang X, Wu H, Sa R, Wang X, Wang Y, Lin Z, Zhang B
Frontiers in pharmacology 2022;13:1028046
Frontiers in pharmacology 2022;13:1028046
A novel phosphodiesterase 9A inhibitor LW33 protects against ischemic stroke through the cGMP/PKG/CREB pathway.
You JY, Liu XW, Bao YX, Shen ZN, Wang Q, He GY, Lu J, Zhang JG, Chen JW, Liu PQ
European journal of pharmacology 2022 Jun 15;925:174987
European journal of pharmacology 2022 Jun 15;925:174987
Myostatin Mutation Promotes Glycolysis by Increasing Phosphorylation of Phosphofructokinase via Activation of PDE5A-cGMP-PKG in Cattle Heart.
Gu M, Zhou X, Zhu L, Gao Y, Gao L, Bai C, Yang L, Li G
Frontiers in cell and developmental biology 2021;9:774185
Frontiers in cell and developmental biology 2021;9:774185
Emodin Interferes With Nitroglycerin-Induced Migraine in Rats Through CGMP-PKG Pathway.
Sun S, Zheng G, Zhou D, Zhu L, He X, Zhang C, Wang C, Yuan C
Frontiers in pharmacology 2021;12:758026
Frontiers in pharmacology 2021;12:758026
Abnormal cGMP-dependent protein kinase I-mediated decidualization in preeclampsia.
Chen J, Ren W, Lin L, Zeng S, Huang L, Tang J, Bi S, Pan J, Chen D, Du L
Hypertension research : official journal of the Japanese Society of Hypertension 2021 Mar;44(3):318-324
Hypertension research : official journal of the Japanese Society of Hypertension 2021 Mar;44(3):318-324
NEK7 promotes gastric cancer progression as a cell proliferation regulator.
Li YK, Zhu XR, Zhan Y, Yuan WZ, Jin WL
Cancer cell international 2021 Aug 21;21(1):438
Cancer cell international 2021 Aug 21;21(1):438
Upregulation of Connexin 40 Mediated by Nitric Oxide Attenuates Cerebral Vasospasm After Subarachnoid Hemorrhage via the Nitric Oxide-Cyclic Guanosine Monophosphate-Protein Kinase G Pathway.
Lan SH, Lai WT, Zheng SY, Yang L, Fang LC, Zhou L, Tang B, Duan J, Hong T
World neurosurgery 2020 Apr;136:e476-e486
World neurosurgery 2020 Apr;136:e476-e486
Fluoride-induced unrestored arrest during haploid period of spermatogenesis via the regulation of DDX25 in rats.
Han Y, Yu Y, Liang C, Shi Y, Zhu Y, Zheng H, Wang J, Zhang J
Environmental pollution (Barking, Essex : 1987) 2019 Oct;253:538-551
Environmental pollution (Barking, Essex : 1987) 2019 Oct;253:538-551
Long non-coding RNA and mRNA profile analysis of metformin to reverse the pulmonary hypertension vascular remodeling induced by monocrotaline.
Sun Z, Liu Y, Yu F, Xu Y, Yanli L, Liu N
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108933
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108933
Empagliflozin prevents cardiomyopathy via sGC-cGMP-PKG pathway in type 2 diabetes mice.
Xue M, Li T, Wang Y, Chang Y, Cheng Y, Lu Y, Liu X, Xu L, Li X, Yu X, Sun B, Chen L
Clinical science (London, England : 1979) 2019 Aug 15;133(15):1705-1720
Clinical science (London, England : 1979) 2019 Aug 15;133(15):1705-1720
Liraglutide suppresses obesity and induces brown fat-like phenotype via Soluble Guanylyl Cyclase mediated pathway in vivo and in vitro.
Zhu E, Yang Y, Zhang J, Li Y, Li C, Chen L, Sun B
Oncotarget 2016 Dec 6;7(49):81077-81089
Oncotarget 2016 Dec 6;7(49):81077-81089
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The PRKG1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human PRKG1. This antibody recognizes human antigen. The PRKG1 antibody has been validated for the following applications: ELISA, WB analysis.