21555-1-AP

antibody from Proteintech Group

Targeting: CYP26B1 P450RAI-2

Provider product page for 21555-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [15]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

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Product number: 21555-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#21555-1-AP, RRID:AB_10733471
Product name: CYP26B1 antibody
Antibody type: Polyclonal
Description: KD/KO validated CYP26B1 antibody (Cat. #21555-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CYP26B1 protein structure - 21555-1-AP shown in red.

Submitted references Wnt/β-Catenin Promotes the Osteoblastic Potential of BMP9 Through Down-Regulating Cyp26b1 in Mesenchymal Stem Cells.

Yao XT, Li PP, Liu J, Yang YY, Luo ZL, Jiang HT, He WG, Luo HH, Deng YX, He BC
Tissue engineering and regenerative medicine 2023 Aug;20(5):705-723

All-Trans Retinoic Acid Prevents the Progression of Gastric Precancerous Lesions by Regulating Disordered Retinoic Acid Metabolism.

Wu H, Zhao D, Wang C, Zhang D, Tang M, Qian S, Xu L, Xia T, Zhou J, Wang G, He Y, Gao L, Chen W, Li L, Yang W, Zhao Q, Hu C, Hu A
Nutrition and cancer 2022;74(9):3351-3362

All-trans Retinoic Acid has Limited Therapeutic Effects on Cognition and Hippocampal Protein Expression After Controlled Cortical Impact.

Svirsky SE, Ranellone NS, Parry M, Holets E, Henchir J, Li Y, Carlson SW, Dixon CE
Neuroscience 2022 Sep 1;499:130-141

Effects of high-dose all-trans retinoic acid on longitudinal bone growth of young rats.

Shen Q, Wang X, Bai H, Tan X, Liu X
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2022 Feb;62:101446

Differential Retinoic Acid Signaling in the Hippocampus of Aged Rats with and without Memory Impairment.

Wołoszynowska-Fraser MU, Rossi SL, Long JM, McCaffery PJ, Rapp PR
eNeuro 2021 Sep-Oct;8(5)

Dysregulated retinoic acid signaling in airway smooth muscle cells in asthma.

Defnet AE, Shah SD, Huang W, Shapiro P, Deshpande DA, Kane MA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Dec;35(12):e22016

Decay in Retinoic Acid Signaling in Varied Models of Alzheimer's Disease and In-Vitro Test of Novel Retinoic Acid Receptor Ligands (RAR-Ms) to Regulate Protective Genes.

Khatib T, Chisholm DR, Whiting A, Platt B, McCaffery P
Journal of Alzheimer's disease : JAD 2020;73(3):935-954

Increased Retinoic Acid Catabolism in Olfactory Sensory Neurons Activates Dormant Tissue-Specific Stem Cells and Accelerates Age-Related Metaplasia.

Håglin S, Berghard A, Bohm S
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 May 20;40(21):4116-4129

CYP26B1 declines postnatally in Sertoli cells independently of androgen action in the mouse testis.

Edelsztein NY, Kashimada K, Schteingart HF, Rey RA
Molecular reproduction and development 2020 Jan;87(1):66-77

Exome-wide analyses identify low-frequency variant in CYP26B1 and additional coding variants associated with esophageal squamous cell carcinoma.

Chang J, Zhong R, Tian J, Li J, Zhai K, Ke J, Lou J, Chen W, Zhu B, Shen N, Zhang Y, Zhu Y, Gong Y, Yang Y, Zou D, Peng X, Zhang Z, Zhang X, Huang K, Wu T, Wu C, Miao X, Lin D
Nature genetics 2018 Mar;50(3):338-343

Transcriptomics of Environmental Enrichment Reveals a Role for Retinoic Acid Signaling in Addiction.

Zhang Y, Kong F, Crofton EJ, Dragosljvich SN, Sinha M, Li D, Fan X, Koshy S, Hommel JD, Spratt HM, Luxon BA, Green TA
Frontiers in molecular neuroscience 2016;9:119

De Novo-Synthesized Retinoic Acid in Ovarian Antral Follicles Enhances FSH-Mediated Ovarian Follicular Cell Differentiation and Female Fertility.

Kawai T, Yanaka N, Richards JS, Shimada M
Endocrinology 2016 May;157(5):2160-72

The Stimulus-Dependent Gradient of Cyp26B1+ Olfactory Sensory Neurons Is Necessary for the Functional Integrity of the Olfactory Sensory Map.

Login H, Håglin S, Berghard A, Bohm S
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Oct 7;35(40):13807-18

Activity-dependent and graded BACE1 expression in the olfactory epithelium is mediated by the retinoic acid metabolizing enzyme CYP26B1.

Control of retinoid levels by CYP26B1 is important for lymphatic vascular development in the mouse embryo.

Bowles J, Secker G, Nguyen C, Kazenwadel J, Truong V, Frampton E, Curtis C, Skoczylas R, Davidson TL, Miura N, Hong YK, Koopman P, Harvey NL, François M
Developmental biology 2014 Feb 1;386(1):25-33

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human brain tissue were subjected to SDS PAGE followed by western blot with 21555-1-AP(CYP26B1 antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using CYP26B1 antibody 21555-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human hepatocirrhosis using 21555-1-AP(CYP26B1 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human hepatocirrhosis using 21555-1-AP(CYP26B1 antibody) at dilution of 1:50 (under 40x lens)
Sample type: tissue