AGTO-G061G

antibody from Creative Biolabs

Targeting: TNFRSF12A CD266, FN14, TweakR

No application information provided.

Antibody Data

Product number

AGTO-G061G

Provider

Creative Biolabs

Product name

Anti-TNFRSF12A immunotoxin ITEM-4 (scFv)-Gel

Antibody type

Monoclonal

Description

This immunotoxin was achieved by conjugating/fusing the Anti-TNFRSF12A scFv to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to TNFRSF12A overexpressed tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then, gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treating malignant melanoma.

Reactivity

Human

Host

Mouse