13-9018-82

antibody from Invitrogen Antibodies
Targeting: TNFRSF12A CD266, FN14, TweakR
Provider product page for 13-9018-82

Antibody data

Product number
13-9018-82 - Provider product page
Provider
Invitrogen Antibodies
Product name
CD266 (TWEAK Receptor) Monoclonal Antibody (ITEM-4), Biotin, eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: The ITEM-4 antibody reacts with human TWEAK Receptor/Fn14 (fibroblast growth factor-inducible 14 kDa protein). Fn14 is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region. Fn14 plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis. TWEAK-induced cell death via Fn14 includes both apoptosis and necrosis and can be blocked by an anti-TWEAK antibody, CARL-1. Fn14 is expressed on HUVEC and in some cancer tissues but not on freshly isolated PBMCs. Fn14 mRNA expression has been identified during liver regeneration. It has been reported that ITEM-4 cross-reacts with mouse Fn14. In the mouse, Fn14 is reported to be constitutively expressed by Colon 26 cell line.
Conjugate
Biotin
Antibody clone number
ITEM-4
Concentration
0.5 mg/mL
TNFRSF12A protein structure - 13-9018-82 shown in red.