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- Antibody Data
- Antigen structure
- References [3]
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- Validations
- Flow cytometry [1]
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- Product number
- 14-9019-82 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD266 (TWEAK Receptor) Monoclonal Antibody (ITEM-1), eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The ITEM-1 mAb reacts with human TWEAK Receptor/Fn14 (fibroblast growth factor-inducible 14 kDa protein). Fn14 is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region. Fn14 plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis. TWEAK-induced cell death via Fn14 includes both apoptosis and necrosis and can be blocked by an anti-TWEAK antibody, CARL-1. Fn14 is expressed on HUVEC and in some cancer tissues but not on freshly isolated PBMCs. Fn14 mRNA expression has been identified during liver regeneration.
- Antibody clone number
- ITEM-1
- Concentration
- 0.5 mg/mL
Submitted references Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death.
Multiple pathways of TWEAK-induced cell death.
Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells.
Nakayama M, Ishidoh K, Kojima Y, Harada N, Kominami E, Okumura K, Yagita H
Journal of immunology (Baltimore, Md. : 1950) 2003 Jan 1;170(1):341-8
Journal of immunology (Baltimore, Md. : 1950) 2003 Jan 1;170(1):341-8
Multiple pathways of TWEAK-induced cell death.
Nakayama M, Ishidoh K, Kayagaki N, Kojima Y, Yamaguchi N, Nakano H, Kominami E, Okumura K, Yagita H
Journal of immunology (Baltimore, Md. : 1950) 2002 Jan 15;168(2):734-43
Journal of immunology (Baltimore, Md. : 1950) 2002 Jan 15;168(2):734-43
Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells.
Harada N, Nakayama M, Nakano H, Fukuchi Y, Yagita H, Okumura K
Biochemical and biophysical research communications 2002 Dec 6;299(3):488-93
Biochemical and biophysical research communications 2002 Dec 6;299(3):488-93
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- Invitrogen Antibodies (provider)
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- Experimental details
- Staining of non-transfected (left) and human Fn14 transfected (right) L5178Y cells with 1.0 µg of Mouse IgG1 kappa Isotype Control Purified (cat-11-4714) (open histogram) or 0.5 µg of Anti-Human CD266 (TWEAK Receptor) Purified (filled histogram) followed by Anti-Mouse IgG FITC (cat-11-4011).Total viable cells were analyzed.
