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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Flow cytometry [1]
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- Product number
- 314103 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#314103, RRID:AB_2205623
- Product name
- Biotin anti-human/mouse CD266 (Fn14, TWEAK Receptor)
- Antibody type
- Monoclonal
- Antigen
- Human Fn14 transfected P815
- Description
- CD266 is a 14 kD transmembrane protein known as TWEAK receptor (TWEAK-R) or fibroblast growth factor inducible 14 (Fn14). It is member 12A of the tumor necrosis factor receptor superfamily (TNFRSF12A) expressed at low levels in a variety of tissues, such as heart, placenta, lung, muscle, and pancreas. TWEAK-R binds TWEAK (CD255) and interacts with the cytoplasmic proteins TRAF1, 2, and 3. The engagement of Fn14 can induce cell death and may play a role in inflammation, hepatocyte growth, and liver neoplasia.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Conjugate
- Biotin
- Isotype
- IgG
- Vial size
- 25 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C. Do not freeze.
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human Fn14 transfected cells stained with biotinylated ITEM-4, followed by Sav-PE
- Conjugate
- Biotin
