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- Antibody Data
- Antigen structure
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- Validations
- Flow cytometry [2]
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- Product number
- Ab183422 - Provider product page
- Provider
- Aladdin Scientific
- Product name
- Enavatuzumab (anti-TWEAKR)
- Antibody type
- Recombinant
- Description
- Enavatuzumab (anti-TWEAKR) is a humanized IgG1 monoclonal antibody targeting the receptor of TNF-like weak inducer of apoptosis (TWEAK). TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab (anti-TWEAKR) induces tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab (anti-TWEAKR) can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab (anti-TWEAKR) inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo.Purity>95% (SDS-PAGE&SEC)Endotoxin Level< 1.0EU/mg
- Reactivity
- Human
- Conjugate
- Unconjugated
- Vial size
- 100_g,10mg,1mg,5mg
- Concentration
- Lot by Lot
- Storage
- Store at -80_ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
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Supportive validation
- Submitted by
- Aladdin Scientific (provider)
- Main image
- Experimental details
- Enavatuzumab (anti-TWEAKR) (Ab183422) - Flow Cytometry Flow Cytometry analysis of MCF-7 cells labelling TWEAKR (red) with Enavatuzumab (anti-TWEAKR) (Ab183422). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
- Submitted by
- Aladdin Scientific (provider)
- Main image
- Experimental details
- Enavatuzumab (anti-TWEAKR) (Ab183422) - Flow Cytometry Transfected with Human TWEAKR protein of HEK293 cells were stained with Enavatuzumab (anti-TWEAKR) (Ab183422) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, the EC50 for this effect is 46.94 nM.
