HPA010022

antibody from Atlas Antibodies

Targeting: ALDH1A2 RALDH2

Provider product page for HPA010022

Western blot

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [28]
Comments [0]
Validations
Immunohistochemistry [1]

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Product number: HPA010022 - Provider product page
Provider: Atlas Antibodies
Proper citation: Atlas Antibodies Cat#HPA010022, RRID:AB_1844723
Product name: Anti-ALDH1A2
Antibody type: Polyclonal
Description: Polyclonal Antibody against Human ALDH1A2, Gene description: aldehyde dehydrogenase 1 family, member A2, Alternative Gene Names: RALDH2, Validated applications: IHC, WB, Uniprot ID: O94788, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100 µl
Concentration: 0.1 mg/ml
Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Handling: The antibody solution should be gently mixed before use.

ALDH1A2 protein structure - HPA010022 shown in red.

Submitted references Keratin 19 (Krt19) is a novel marker gene for epicardial cells

Xu J, Deng Y, Li G
Frontiers in Genetics 2024;15

Formation and function of the meningeal arachnoid barrier around the developing mouse brain

Derk J, Como C, Jones H, Joyce L, Kim S, Spencer B, Bonney S, O’Rourke R, Pawlikowski B, Doran K, Siegenthaler J
Developmental Cell 2023;58(8):635-644.e4

A comparative analysis of microglial inducible Cre lines

Faust T, Feinberg P, O’Connor C, Kawaguchi R, Chan A, Strasburger H, Frosch M, Boyle M, Masuda T, Amann L, Knobeloch K, Prinz M, Schaefer A, Schafer D
Cell Reports 2023;42(9):113031

Structural characterization of SLYM—a 4th meningeal membrane

Plá V, Bitsika S, Giannetto M, Ladron-de-Guevara A, Gahn-Martinez D, Mori Y, Nedergaard M, Møllgård K
Fluids and Barriers of the CNS 2023;20(1)

Meningeal origins and dynamics of perivascular fibroblast development on the mouse cerebral vasculature

Jones H, Coelho-Santos V, Bonney S, Abrams K, Shih A, Siegenthaler J
Development 2023;150(19)

Loss of Twist1 and balanced retinoic acid signaling from the meninges causes cortical folding in mice

Matrongolo M, Ho-Nguyen K, Jain M, Ang P, Reddy A, Schaper S, Tischfield M
Development 2023;150(18)

hESC‐Derived Epicardial Cells Promote Repair of Infarcted Hearts in Mouse and Swine

Luo X, Jiang Y, Li Q, Yu X, Ma T, Cao H, Ke M, Zhang P, Tan J, Gong Y, Wang L, Gao L, Yang H
Advanced Science 2023;10(27)

Techniques for visualizing fibroblast-vessel interactions in the developing and adult CNS

Jones H, Abrams K, Siegenthaler J
Neurophotonics 2022;9(02)

SMAlow/undetectable pericytes differentiate into microglia- and macrophage-like cells in ischemic brain

Nirwane A, Yao Y
Cellular and Molecular Life Sciences 2022;79(5)

Single-cell transcriptomic analysis identifies murine heart molecular features at embryonic and neonatal stages

Feng W, Bais A, He H, Rios C, Jiang S, Xu J, Chang C, Kostka D, Li G
Nature Communications 2022;13(1)

Tenogenic Induction From Induced Pluripotent Stem Cells Unveils the Trajectory Towards Tenocyte Differentiation

Yoshimoto Y, Uezumi A, Ikemoto-Uezumi M, Tanaka K, Yu X, Kurosawa T, Yambe S, Maehara K, Ohkawa Y, Sotomaru Y, Shukunami C
Frontiers in Cell and Developmental Biology 2022;10

Cdc42 activity in Sertoli cells is essential for maintenance of spermatogenesis

Heinrich A, Bhandary B, Potter S, Ratner N, DeFalco T
Cell Reports 2021;37(4):109885

Zhou R, Chen Z, Xiao Z, Wang S, Rong C
Frontiers in Oncology 2021;11

Retinoic acid synthesis by ALDH1A proteins is dispensable for meiosis initiation in the mouse fetal ovary

Chassot A, Le Rolle M, Jolivet G, Stevant I, Guigonis J, Da Silva F, Nef S, Pailhoux E, Schedl A, Ghyselinck N, Chaboissier M
Science Advances 2020;6(21)

Single-Cell Transcriptomic Analyses of the Developing Meninges Reveal Meningeal Fibroblast Diversity and Function

DeSisto J, O’Rourke R, Jones H, Pawlikowski B, Malek A, Bonney S, Guimiot F, Jones K, Siegenthaler J
Developmental Cell 2020;54(1):43-59.e4

Multipotent Vascular Progenitor Cells of the Mesothelium Lineage Generated from Human Pluripotent Stem Cells

Chen L, Dalton S
STAR Protocols 2020;1(1):100031

Wnt/β‐catenin signaling in the mouse embryonic cranial mesenchyme is required to sustain the emerging differentiated meningeal layers

DiNuoscio G, Atit R
genesis 2019;57(1)

Functional Characterization of the Osteoarthritis Genetic Risk Residing at ALDH1A2 Identifies rs12915901 as a Key Target Variant

Shepherd C, Zhu D, Skelton A, Combe J, Threadgold H, Zhu L, Vincent T, Stuart P, Reynard L, Loughlin J
Arthritis & Rheumatology 2018;70(10):1577-1587

Mode of Surgical Injury Influences the Source of Urothelial Progenitors during Bladder Defect Repair

Schäfer F, Algarrahi K, Savarino A, Yang X, Seager C, Franck D, Costa K, Liu S, Logvinenko T, Adam R, Mauney J
Stem Cell Reports 2017;9(6):2005-2017

Retinoic acid signaling is dispensable for somatic development and function in the mammalian ovary

Minkina A, Lindeman R, Gearhart M, Chassot A, Chaboissier M, Ghyselinck N, Bardwell V, Zarkower D
Developmental Biology 2017;424(2):208-220

Directed differentiation and long-term maintenance of epicardial cells derived from human pluripotent stem cells under fully defined conditions

Bao X, Lian X, Qian T, Bhute V, Han T, Palecek S
Nature Protocols 2017;12(9):1890-1900

Restoring Retinoic Acid Attenuates Intestinal Inflammation and Tumorigenesis in APCMin/+ Mice

Penny H, Prestwood T, Bhattacharya N, Sun F, Kenkel J, Davidson M, Shen L, Zuniga L, Seeley E, Pai R, Choi O, Tolentino L, Wang J, Napoli J, Engleman E
Cancer Immunology Research 2016;4(11):917-926

Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney

Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, Nishiyama S, Shibuya S, Haga H, Ogawa O, Shimizu A, Narumiya S, Kaisho T, Arita M, Yanagisawa M, Miyasaka M, Sharma K, Minato N, Kawamoto H, Yanagita M
JCI Insight 2016;1(11)

Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma

Seidensaal K, Nollert A, Feige A, Muller M, Fleming T, Gunkel N, Zaoui K, Grabe N, Weichert W, Weber K, Plinkert P, Simon C, Hess J
Molecular Cancer 2015;14(1)

Identification of Active Retinaldehyde Dehydrogenase Isoforms in the Postnatal Human Eye

Lewin A, Harper A, Wiechmann A, Moiseyev G, Ma J, Summers J
PLOS ONE 2015;10(3):e0122008

Seidensaal K, Nollert A, Feige A, Muller M, Fleming T, Gunkel N, Zaoui K, Grabe N, Weichert W, Weber K, Plinkert P, Simon C, Hess J
Molecular Cancer 2015 December;14(1)

Evaluation of protein biomarkers of prostate cancer aggressiveness

Rizzardi A, Rosener N, Koopmeiners J, Isaksson Vogel R, Metzger G, Forster C, Marston L, Tiffany J, McCarthy J, Turley E, Warlick C, Henriksen J, Schmechel S
BMC Cancer 2014;14(1)

Kostareli E, Holzinger D, Bogatyrova O, Hielscher T, Wichmann G, Keck M, Lahrmann B, Grabe N, Flechtenmacher C, Schmidt C, Seiwert T, Dyckhoff G, Dietz A, Höfler D, Pawlita M, Benner A, Bosch F, Plinkert P, Plass C, Weichenhan D, Hess J
Journal of Clinical Investigation 2013;123(6):2488-2501

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Supportive validation

Submitted by: Atlas Antibodies (provider)
Enhanced method: Orthogonal validation
Main image
Experimental details: Immunohistochemistry analysis in human endometrium and skin tissues using HPA010022 antibody. Corresponding ALDH1A2 RNA-seq data are presented for the same tissues.
Sample type: Human
Protocol: Protocol
Orthogonal method: Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.

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