Antibody data
- Antibody Data
- Antigen structure
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- Product number
- AMM01951G - Provider product page
- Provider
- Leading Biology
- Product name
- RNF144B Antibody (clone 4F1)
- Antibody type
- Monoclonal
- Description
- E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.
- Reactivity
- Human
- Host
- Mouse
- Antibody clone number
- 4F1
- Storage
- Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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