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- Antibody Data
- Antigen structure
- References [39]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 17256-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17256-1-AP, RRID:AB_2195894
- Product name
- SQRDL antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SQRDL antibody (Cat. #17256-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Hydrogen sulfide increases intracellular oxygen and inhibits the HIF response.
Elevation of H(2)S Underlies Social Deficits in Environmental Factor Double-Hit Autism Model.
Comprehensive analysis of SQOR involvement in ferroptosis resistance of pancreatic ductal adenocarcinoma in hypoxic environments.
Hydrogen sulfide-dependent activation of human sulfide quinone oxidoreductase.
Cth/Mpst double ablation results in early onset fatty liver disease in lean mice.
Gut sulfide metabolism modulates behavior and brain bioenergetics.
Hydrogen sulfide increases intracellular oxygen and regulates the HIF response.
The treatment of primary CoQ deficiency requires the targeting of multiple pathogenic mechanisms.
Protective role of 3-mercaptopyruvate sulfurtransferase (MPST) in the development of metabolic syndrome and vascular inflammation.
The double face of licorice-kansui herb pair: Cure or curse, depending on the combining ratio and mediated by hydrogen sulfide.
ASB1 engages with ELOB to facilitate SQOR ubiquitination and H(2)S homeostasis during spermiogenesis.
A novel hypoxia- and lactate metabolism-related prognostic signature to characterize the immune landscape and predict immunotherapy response in osteosarcoma.
Sulfide oxidation promotes hypoxic angiogenesis and neovascularization.
H(2)S preconditioning induces long-lived perturbations in O(2) metabolism.
Widespread S-persulfidation in activated macrophages as a protective mechanism against oxidative-inflammatory stress.
Sulfide:quinone oxidoreductase alleviates ferroptosis in acute kidney injury via ameliorating mitochondrial dysfunction of renal tubular epithelial cells.
CTH/MPST double ablation results in enhanced vasorelaxation and reduced blood pressure via upregulation of the eNOS/sGC pathway.
Sulfide oxidation promotes hypoxic angiogenesis and neovascularization.
Relation of Plasma Catecholamine Concentrations and Myocardial Mitochondrial Respiratory Activity in Anesthetized and Mechanically Ventilated, Cardiovascular Healthy Swine.
Hydrogen sulfide as an anti-calcification stratagem in human aortic valve: Altered biogenesis and mitochondrial metabolism of H(2)S lead to H(2)S deficiency in calcific aortic valve disease.
Hydrogen Sulfide Metabolizing Enzymes in the Intestinal Mucosa in Pediatric and Adult Inflammatory Bowel Disease.
Expanding the Reactive Sulfur Metabolome: Intracellular and Efflux Measurements of Small Oxoacids of Sulfur (SOS) and H(2)S in Human Primary Vascular Cell Culture.
Sulfide catabolism ameliorates hypoxic brain injury.
Coenzyme Q10 modulates sulfide metabolism and links the mitochondrial respiratory chain to pathways associated to one carbon metabolism.
Slc22a5 haploinsufficiency does not aggravate the phenotype of the long-chain acyl-CoA dehydrogenase KO mouse.
H(2)S-stimulated bioenergetics in chicken erythrocytes and the underlying mechanism.
3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics.
β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9(R239X) mice.
Hydrogen sulfide perturbs mitochondrial bioenergetics and triggers metabolic reprogramming in colon cells.
CoQ(10) supplementation rescues nephrotic syndrome through normalization of H(2)S oxidation pathway.
Coenzyme Q deficiency causes impairment of the sulfide oxidation pathway.
CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome.
Endogenous hydrogen sulfide production is essential for dietary restriction benefits.
Primary hepatocytes from mice lacking cysteine dioxygenase show increased cysteine concentrations and higher rates of metabolism of cysteine to hydrogen sulfide and thiosulfate.
Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanisms.
Enhanced synthesis and diminished degradation of hydrogen sulfide in experimental colitis: a site-specific, pro-resolution mechanism.
The cysteine dioxgenase knockout mouse: altered cysteine metabolism in nonhepatic tissues leads to excess H2S/HS(-) production and evidence of pancreatic and lung toxicity.
Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics.
Sulphide quinone reductase contributes to hydrogen sulphide metabolism in murine peripheral tissues but not in the CNS.
Brake J, Hanna DA, Kumar R, Peng Q, Landry AP, Singhal R, Weerapana E, Shah YM, Banerjee R
The Journal of biological chemistry 2026 Mar;302(3):111151
The Journal of biological chemistry 2026 Mar;302(3):111151
Elevation of H(2)S Underlies Social Deficits in Environmental Factor Double-Hit Autism Model.
Ma H, Xu Q, Dong S, Guo M, Liu H, Wang T, Wang M, Wang Y, Wu S
Neuroscience bulletin 2026 Mar 23;
Neuroscience bulletin 2026 Mar 23;
Comprehensive analysis of SQOR involvement in ferroptosis resistance of pancreatic ductal adenocarcinoma in hypoxic environments.
Lin Q, Guan S, Peng M, Zhang K, Zhang H, Mo T, Yu H
Frontiers in immunology 2025;16:1513589
Frontiers in immunology 2025;16:1513589
Hydrogen sulfide-dependent activation of human sulfide quinone oxidoreductase.
Roman JV, Shukla Y, Hanna DA, Mackson M, To TL, Mootha V, Banerjee R
The Journal of biological chemistry 2025 Oct;301(10):110681
The Journal of biological chemistry 2025 Oct;301(10):110681
Cth/Mpst double ablation results in early onset fatty liver disease in lean mice.
Katsouda A, Markou M, Valakos D, Theodorou I, Papapetropoulos A
Redox biology 2025 Jun;83:103641
Redox biology 2025 Jun;83:103641
Gut sulfide metabolism modulates behavior and brain bioenergetics.
Kumar R, Sykes DJ, Band VI, Schaller ML, Patel R, Vitvitsky V, Sajjakulnukit P, Singhal R, Wong HKA, Hourigan SK, Ichinose F, Lyssiotis CA, Shah YM, Banerjee R
Proceedings of the National Academy of Sciences of the United States of America 2025 Jun 24;122(25):e2503677122
Proceedings of the National Academy of Sciences of the United States of America 2025 Jun 24;122(25):e2503677122
Hydrogen sulfide increases intracellular oxygen and regulates the HIF response.
Brake J, Hanna DA, Kumar R, Peng Q, Landry AP, Singhal R, Weerapana E, Shah YM, Banerjee R
bioRxiv : the preprint server for biology 2025 Jul 24;
bioRxiv : the preprint server for biology 2025 Jul 24;
The treatment of primary CoQ deficiency requires the targeting of multiple pathogenic mechanisms.
González-García P, Jiménez-Sánchez L, Corral-Sarasa J, López-Herrador S, Torres-Rusillo S, Díaz-Casado ME, López LC
Communications medicine 2025 Jul 10;5(1):286
Communications medicine 2025 Jul 10;5(1):286
Protective role of 3-mercaptopyruvate sulfurtransferase (MPST) in the development of metabolic syndrome and vascular inflammation.
Zampas P, Li Z, Katsouda A, Varela A, Psarras S, Davos CH, Lefer DJ, Papapetropoulos A
Pharmacological research 2025 Jan;211:107542
Pharmacological research 2025 Jan;211:107542
The double face of licorice-kansui herb pair: Cure or curse, depending on the combining ratio and mediated by hydrogen sulfide.
Li N, Xue W, Wang C, Fan X, Yu J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:155692
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:155692
ASB1 engages with ELOB to facilitate SQOR ubiquitination and H(2)S homeostasis during spermiogenesis.
Lv J, Wu T, Xue J, Shen C, Gao W, Chen X, Guo Y, Liu M, Yu J, Huang X, Zheng B
Redox biology 2025 Feb;79:103484
Redox biology 2025 Feb;79:103484
A novel hypoxia- and lactate metabolism-related prognostic signature to characterize the immune landscape and predict immunotherapy response in osteosarcoma.
Wang Y, Wang X, Liu Y, Xu J, Zhu J, Zheng Y, Qi Q
Frontiers in immunology 2024;15:1467052
Frontiers in immunology 2024;15:1467052
Sulfide oxidation promotes hypoxic angiogenesis and neovascularization.
Kumar R, Vitvitsky V, Sethaudom A, Singhal R, Solanki S, Alibeckoff S, Hiraki HL, Bell HN, Andren A, Baker BM, Lyssiotis CA, Shah YM, Banerjee R
Nature chemical biology 2024 Oct;20(10):1294-1304
Nature chemical biology 2024 Oct;20(10):1294-1304
H(2)S preconditioning induces long-lived perturbations in O(2) metabolism.
Hanna DA, Diessl J, Guha A, Kumar R, Andren A, Lyssiotis C, Banerjee R
Proceedings of the National Academy of Sciences of the United States of America 2024 Mar 19;121(12):e2319473121
Proceedings of the National Academy of Sciences of the United States of America 2024 Mar 19;121(12):e2319473121
Widespread S-persulfidation in activated macrophages as a protective mechanism against oxidative-inflammatory stress.
Salti T, Braunstein I, Haimovich Y, Ziv T, Benhar M
Redox biology 2024 Jun;72:103125
Redox biology 2024 Jun;72:103125
Sulfide:quinone oxidoreductase alleviates ferroptosis in acute kidney injury via ameliorating mitochondrial dysfunction of renal tubular epithelial cells.
Cai F, Li D, Xie Y, Wang X, Ma H, Xu H, Cheng J, Zhuang H, Hua ZC
Redox biology 2024 Feb;69:102973
Redox biology 2024 Feb;69:102973
CTH/MPST double ablation results in enhanced vasorelaxation and reduced blood pressure via upregulation of the eNOS/sGC pathway.
Katsouda A, Markou M, Zampas P, Varela A, Davos CH, Vellecco V, Cirino G, Bucci M, Papapetropoulos A
Frontiers in pharmacology 2023;14:1090654
Frontiers in pharmacology 2023;14:1090654
Sulfide oxidation promotes hypoxic angiogenesis and neovascularization.
Kumar R, Vitvitsky V, Seth P, Hiraki HL, Bell H, Andren A, Singhal R, Baker BM, Lyssiotis CA, Shah YM, Banerjee R
bioRxiv : the preprint server for biology 2023 Mar 15;
bioRxiv : the preprint server for biology 2023 Mar 15;
Relation of Plasma Catecholamine Concentrations and Myocardial Mitochondrial Respiratory Activity in Anesthetized and Mechanically Ventilated, Cardiovascular Healthy Swine.
Abele N, Münz F, Zink F, Gröger M, Hoffmann A, Wolfschmitt EM, Hogg M, Calzia E, Waller C, Radermacher P, Merz T
International journal of molecular sciences 2023 Dec 9;24(24)
International journal of molecular sciences 2023 Dec 9;24(24)
Hydrogen sulfide as an anti-calcification stratagem in human aortic valve: Altered biogenesis and mitochondrial metabolism of H(2)S lead to H(2)S deficiency in calcific aortic valve disease.
Combi Z, Potor L, Nagy P, Sikura KÉ, Ditrói T, Jurányi EP, Galambos K, Szerafin T, Gergely P, Whiteman M, Torregrossa R, Ding Y, Beke L, Hendrik Z, Méhes G, Balla G, Balla J
Redox biology 2023 Apr;60:102629
Redox biology 2023 Apr;60:102629
Hydrogen Sulfide Metabolizing Enzymes in the Intestinal Mucosa in Pediatric and Adult Inflammatory Bowel Disease.
Stummer N, Weghuber D, Feichtinger RG, Huber S, Mayr JA, Kofler B, Neureiter D, Klieser E, Hochmann S, Lauth W, Schneider AM
Antioxidants (Basel, Switzerland) 2022 Nov 12;11(11)
Antioxidants (Basel, Switzerland) 2022 Nov 12;11(11)
Expanding the Reactive Sulfur Metabolome: Intracellular and Efflux Measurements of Small Oxoacids of Sulfur (SOS) and H(2)S in Human Primary Vascular Cell Culture.
Scrivner O, Ismaeel A, Kumar MR, Sorokolet K, Koutakis P, Farmer PJ
Molecules (Basel, Switzerland) 2021 Nov 26;26(23)
Molecules (Basel, Switzerland) 2021 Nov 26;26(23)
Sulfide catabolism ameliorates hypoxic brain injury.
Marutani E, Morita M, Hirai S, Kai S, Grange RMH, Miyazaki Y, Nagashima F, Traeger L, Magliocca A, Ida T, Matsunaga T, Flicker DR, Corman B, Mori N, Yamazaki Y, Batten A, Li R, Tanaka T, Ikeda T, Nakagawa A, Atochin DN, Ihara H, Olenchock BA, Shen X, Nishida M, Hanaoka K, Kevil CG, Xian M, Bloch DB, Akaike T, Hindle AG, Motohashi H, Ichinose F
Nature communications 2021 May 25;12(1):3108
Nature communications 2021 May 25;12(1):3108
Coenzyme Q10 modulates sulfide metabolism and links the mitochondrial respiratory chain to pathways associated to one carbon metabolism.
González-García P, Hidalgo-Gutiérrez A, Mascaraque C, Barriocanal-Casado E, Bakkali M, Ziosi M, Abdihankyzy UB, Sánchez-Hernández S, Escames G, Prokisch H, Martín F, Quinzii CM, López LC
Human molecular genetics 2020 Nov 25;29(19):3296-3311
Human molecular genetics 2020 Nov 25;29(19):3296-3311
Slc22a5 haploinsufficiency does not aggravate the phenotype of the long-chain acyl-CoA dehydrogenase KO mouse.
Ranea-Robles P, Yu C, van Vlies N, Vaz FM, Houten SM
Journal of inherited metabolic disease 2020 May;43(3):486-495
Journal of inherited metabolic disease 2020 May;43(3):486-495
H(2)S-stimulated bioenergetics in chicken erythrocytes and the underlying mechanism.
Jin Z, Zhang Q, Wondimu E, Verma R, Fu M, Shuang T, Arif HM, Wu L, Wang R
American journal of physiology. Regulatory, integrative and comparative physiology 2020 Jul 1;319(1):R69-R78
American journal of physiology. Regulatory, integrative and comparative physiology 2020 Jul 1;319(1):R69-R78
3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics.
Abdollahi Govar A, Törő G, Szaniszlo P, Pavlidou A, Bibli SI, Thanki K, Resto VA, Chao C, Hellmich MR, Szabo C, Papapetropoulos A, Módis K
British journal of pharmacology 2020 Feb;177(4):866-883
British journal of pharmacology 2020 Feb;177(4):866-883
β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9(R239X) mice.
Hidalgo-Gutiérrez A, Barriocanal-Casado E, Bakkali M, Díaz-Casado ME, Sánchez-Maldonado L, Romero M, Sayed RK, Prehn C, Escames G, Duarte J, Acuña-Castroviejo D, López LC
EMBO molecular medicine 2019 Jan;11(1)
EMBO molecular medicine 2019 Jan;11(1)
Hydrogen sulfide perturbs mitochondrial bioenergetics and triggers metabolic reprogramming in colon cells.
Libiad M, Vitvitsky V, Bostelaar T, Bak DW, Lee HJ, Sakamoto N, Fearon E, Lyssiotis CA, Weerapana E, Banerjee R
The Journal of biological chemistry 2019 Aug 9;294(32):12077-12090
The Journal of biological chemistry 2019 Aug 9;294(32):12077-12090
CoQ(10) supplementation rescues nephrotic syndrome through normalization of H(2)S oxidation pathway.
Kleiner G, Barca E, Ziosi M, Emmanuele V, Xu Y, Hidalgo-Gutierrez A, Qiao C, Tadesse S, Area-Gomez E, Lopez LC, Quinzii CM
Biochimica et biophysica acta. Molecular basis of disease 2018 Nov;1864(11):3708-3722
Biochimica et biophysica acta. Molecular basis of disease 2018 Nov;1864(11):3708-3722
Coenzyme Q deficiency causes impairment of the sulfide oxidation pathway.
Ziosi M, Di Meo I, Kleiner G, Gao XH, Barca E, Sanchez-Quintero MJ, Tadesse S, Jiang H, Qiao C, Rodenburg RJ, Scalais E, Schuelke M, Willard B, Hatzoglou M, Tiranti V, Quinzii CM
EMBO molecular medicine 2017 Jan;9(1):96-111
EMBO molecular medicine 2017 Jan;9(1):96-111
CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome.
Luna-Sánchez M, Hidalgo-Gutiérrez A, Hildebrandt TM, Chaves-Serrano J, Barriocanal-Casado E, Santos-Fandila Á, Romero M, Sayed RK, Duarte J, Prokisch H, Schuelke M, Distelmaier F, Escames G, Acuña-Castroviejo D, López LC
EMBO molecular medicine 2017 Jan;9(1):78-95
EMBO molecular medicine 2017 Jan;9(1):78-95
Endogenous hydrogen sulfide production is essential for dietary restriction benefits.
Hine C, Harputlugil E, Zhang Y, Ruckenstuhl C, Lee BC, Brace L, Longchamp A, Treviño-Villarreal JH, Mejia P, Ozaki CK, Wang R, Gladyshev VN, Madeo F, Mair WB, Mitchell JR
Cell 2015 Jan 15;160(1-2):132-44
Cell 2015 Jan 15;160(1-2):132-44
Primary hepatocytes from mice lacking cysteine dioxygenase show increased cysteine concentrations and higher rates of metabolism of cysteine to hydrogen sulfide and thiosulfate.
Jurkowska H, Roman HB, Hirschberger LL, Sasakura K, Nagano T, Hanaoka K, Krijt J, Stipanuk MH
Amino acids 2014 May;46(5):1353-65
Amino acids 2014 May;46(5):1353-65
Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanisms.
Szabo C, Ransy C, Módis K, Andriamihaja M, Murghes B, Coletta C, Olah G, Yanagi K, Bouillaud F
British journal of pharmacology 2014 Apr;171(8):2099-122
British journal of pharmacology 2014 Apr;171(8):2099-122
Enhanced synthesis and diminished degradation of hydrogen sulfide in experimental colitis: a site-specific, pro-resolution mechanism.
Flannigan KL, Ferraz JG, Wang R, Wallace JL
PloS one 2013;8(8):e71962
PloS one 2013;8(8):e71962
The cysteine dioxgenase knockout mouse: altered cysteine metabolism in nonhepatic tissues leads to excess H2S/HS(-) production and evidence of pancreatic and lung toxicity.
Roman HB, Hirschberger LL, Krijt J, Valli A, Kožich V, Stipanuk MH
Antioxidants & redox signaling 2013 Oct 20;19(12):1321-36
Antioxidants & redox signaling 2013 Oct 20;19(12):1321-36
Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics.
Módis K, Coletta C, Erdélyi K, Papapetropoulos A, Szabo C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Feb;27(2):601-11
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Feb;27(2):601-11
Sulphide quinone reductase contributes to hydrogen sulphide metabolism in murine peripheral tissues but not in the CNS.
Linden DR, Furne J, Stoltz GJ, Abdel-Rehim MS, Levitt MD, Szurszewski JH
British journal of pharmacology 2012 Apr;165(7):2178-90
British journal of pharmacology 2012 Apr;165(7):2178-90
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 17256-1-AP(SQRDL antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 17256-1-AP(SQRDL antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SQRDL antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SQRDL. This antibody recognizes human,mouse,rat antigen. The SQRDL antibody has been validated for the following applications: ELISA, WB, IHC analysis.
