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- References [140]
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- Product number
- 60188-1-Ig - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#60188-1-Ig, RRID:AB_10859484
- Product name
- WTAP antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated WTAP antibody (Cat. #60188-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 4A10G9
- Vial size
- 20ul, 150ul
Submitted references m6A deficiency induces dopaminergic neurodegeneration and progressive parkinsonism through a pathogenic loop with mitochondria.
Network medicine modeling of the m⁶A regulatory landscape identifies a KLF6-WTAP axis as a therapeutic target in pulmonary fibrosis.
A machine learning-based epigenetic signature reveals YTHDC1 stabilizes POU5F1 to oppose tumor progression.
Integrative Multi-Analysis Identifies METTL3-Regulated FGF19 and H6PD as Candidate Targets in Diabetic Cognitive Impairment.
WTAP stabilizes MMP12 expression to promote the malignant phenotypes of esophageal cancer cells.
MDM2-GPX4-ferroptosis regulatory axis exerts neurotoxic effects in intracerebral hemorrhage.
WTAP promotes the proliferation of multiple myeloma by regulating the hippo pathway through m(6)A modification of MAP6D1.
N6-methyladenosine (m(6)A) modification regulates LONP1 to inhibit coxsackievirus B3 replication by suppressing virus-induced ferroptosis.
HIV-1 Vpr activates microglia by upregulating m6A modification through ubiquitin-proteasome pathway-mediated degradation of the demethylase ALKBH5.
Toxicological Implications of m(6)A Dysregulation: SH3PXD2A-AS1-Driven PD-L1 Overexpression Promotes Immune Evasion in NSCLC.
m6A epigenetic signature in necrotizing enterocolitis: insights from murine to neonatal studies.
The m6A modification of SOX18 leads to increased PTX3 and cardiomyocyte pyroptosis in sepsis-induced cardiomyopathy.
Macrophage-derived exosome piR-50971 exacerbates sepsis-induced myocardial injury by inhibiting autophagy through the upregulation of N6-Methyladenosine modification of mTOR.
METTL3 Silencing Suppresses Cardiac Fibrosis Post Myocardial Infarction via m6A Modification of SMOC2.
METTL3 regulates rifampicin-induced CYP3A4 expression by activating PXR translation and nuclear import and stabilizing CYP3A4 mRNA.
WTAP targets SOX2 to inhibit trophoblast ferroptosis in the pathogenesis of preeclampsia via m6A-dependent ferroptosis regulation.
WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma.
RBM15-mediated m6A methylation of Entpd1/CD39 regulates extracellular ATP hydrolysis and alleviates myocardial ischemia-reperfusion injury.
WTAP Silencing protects human aortic smooth muscle cells from angiotensin II-induced senescence, apoptosis, ferroptosis, and inflammation by regulating PCSK9.
ADAP-METTL3 modulates the inflammatory responses of macrophages via m(6)A modification of Spry1.
PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m6A Methylation to Stabilize PARP1 mRNA.
WTAP-mediated m(6)A modification promotes drug sensitivity by regulating NR3C1 in prostate cancer.
WTAP regulates NCOA4-mediated ferroptosis via a YTHDF2-dependent mechanism in preeclampsia.
Sodium-myoinositol cotransporter-1 downstream of m6A methyltransferase WTAP exerts a potential carcinogenicity in diffuse large B-cell lymphoma progression.
WTAP-mediated m(6)A modification of PTPN1 contributes to ulcerative colitis pathogenesis through regulating colonic epithelial cell phenotypes.
WTAP improves chondrocyte loss and dysfunctions to ameliorate osteoarthritis through mediating the mA methylation and mRNA stability of IL-33.
Pathological α-synuclein dysregulates epitranscriptomic writer METTL3 to drive neuroinflammation in microglia.
IGF2BP1-HAX-1 positive feedback loop-mediated HAX-1 overexpression blocks autophagic flux and promotes chemoresistance in nasopharyngeal carcinoma.
The Flip Side of the Coin: METTL3 Serves as a Novel Cellular Senescence Accelerator via Negative Regulation of ITGA9.
Glutamine Attenuates Inflammation and Oxidative Stress in Ulcerative Colitis by Suppressing Wilms' Tumor 1 Associated Protein-Mediated N6-Methyladenosine Modification of Nuclear Receptor Coactivator 3.
Role of the USP7/FOXO3A axis in environmentally relevant doses of arsenic-induced lung carcinogenesis: Insights from bioinformatics analysis and model of human epithelial cell malignant transformation.
High glucose facilitates hepatocellular carcinoma cell proliferation and invasion via WTAP-mediated HK2 mRNA stability.
WTAP-mediated m6A modification of ARG2 mRNA Inhibits Its expression and drives prostate cancer malignant progression.
De novo assembly of RNA m(6)A modification factors into viral genome-associated nuclear bodies drives HCMV RNA accumulation.
Tanshinone IIA suppresses the proliferation and fibrosis of mesangial cell in diabetic nephropathy though WTAP-mediated m(6)A methylation.
UBE2D3 regulated by WTAP-mediated m6A modification inhibits temozolomide chemosensitivity in glioblastoma.
The m(6)A methyltransferase METTL3 drives neuroinflammation and neurotoxicity through stabilizing BATF mRNA in microglia.
M6A Methylation Regulators METTL3 and ALKBH5 are Risk Factors for EGFR-Mutant NSCLC.
IDO1 inhibits ferroptosis by regulating FTO-mediated m6A methylation and SLC7A11 mRNA stability during glioblastoma progression.
ALKBH5 alleviates lower extremity arteriosclerosis by regulating ITGB1 demethylation and influencing macrophage polarization.
Influenza NS1 drives N(6)-methyladenosine (m(6)A)-mediated autoregulation of viral mRNA splicing.
IGF2BP3-STAT3-METTL3 axis promotes malignant progression in hepatocellular carcinoma (HCC).
Betaine alleviates hepatic lipid metabolism disorder in finishing pigs fed a low-energy diet through regulating m(6)A RNA methylation.
METTL3 increases ferroptosis resistance to facilitate the tumor-like features of rheumatoid arthritis synovial fibroblasts through enhancing SLC7A11 mRNA stability in an m6A-IGF2BP2-dependent manner.
WTAP Promotes Atherosclerosis by Inducing Macrophage Pyroptosis and M1 Polarization through Upregulating NLRP3.
HDAC2-Mediated METTL3 Delactylation Promotes DNA Damage Repair and Chemotherapy Resistance in Triple-Negative Breast Cancer.
PRMT5-mediated methylation of METTL3 promotes cisplatin resistance in ovarian cancer by facilitating DNA repair mechanisms.
WTAP knockdown inhibits cell migration through regulating SNAIL1 expression in colorectal cancer.
The role of WTAP in regulating macrophage-mediated osteoimmune responses and tissue regeneration in periodontitis.
EXOSC2 Mediates the Pro-tumor Role of WTAP in Breast Cancer Cells via Activating the Wnt/β-Catenin Signal.
METTL14-mediated methylation of SLC25A3 mitigates mitochondrial damage in osteoblasts, leading to the improvement of osteoporosis.
Downregulated KLF4, induced by m6A modification, aggravates intestinal barrier dysfunction in inflammatory bowel disease.
Redox regulation of m(6)A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes.
The RNA m(6)A reader IGF2BP3 regulates NFAT1/IRF1 axis-mediated anti-tumor activity in gastric cancer.
WTAP regulates the production of reactive oxygen species, promotes malignant progression, and is closely related to the tumor microenvironment in glioblastoma.
N(6)-methyladenosine modification is not a general trait of viral RNA genomes.
Landscape of transcriptome-wide m(6)A modification in diabetic liver reveals rewiring of PI3K-Akt signaling after physical exercise.
WTAP and m(6)A-modified circRNAs modulation during stress response in acute myeloid leukemia progenitor cells.
The lncRNAMALAT1-WTAP axis: a novel layer of EMT regulation in hypoxic triple-negative breast cancer.
LncRNA CARMN m6A demethylation by ALKBH5 inhibits mutant p53-driven tumour progression through miR-5683/FGF2.
Antibiotic-Induced Gut Microbiota Dysbiosis Modulates Host Transcriptome and m(6)A Epitranscriptome via Bile Acid Metabolism.
Fat mass and obesity-related protein contributes to the development and maintenance of bone cancer pain in rats by abrogating m6A methylation of RNA.
Regulation of ULK1 by WTAP/IGF2BP3 axis enhances mitophagy and progression in epithelial ovarian cancer.
METTL14 contributes to acute lung injury by stabilizing NLRP3 expression in an IGF2BP2-dependent manner.
Demethylase FTO-Mediated m6A Modification of lncRNA MEG3 Activates Neuronal Pyroptosis via NLRP3 Signaling in Cerebral Ischemic Stroke.
WTAP-mediated m(6)A modification of FRZB triggers the inflammatory response via the Wnt signaling pathway in osteoarthritis.
METTL14-mediated m6A epitranscriptomic modification contributes to chemotherapy-induced neuropathic pain by stabilizing GluN2A expression via IGF2BP2.
WTAP and METTL14 regulate the m6A modification of DKK3 in renal tubular epithelial cells of diabetic nephropathy.
Off-Target Inhibition of Human Dihydroorotate Dehydrogenase (hDHODH) Highlights Challenges in the Development of Fat Mass and Obesity-Associated Protein (FTO) Inhibitors.
Chronic social isolation leads to abnormal behavior in male mice through the hippocampal METTL14 mediated epitranscriptomic RNA m6A modifications.
Endogenous RBM4 prevents Ang II-induced cardiomyocyte hypertrophy via downregulating the expression of PTBP1.
Unraveling the molecular complexity: Wtap/Ythdf1 and Lcn2 in novel traumatic brain injury secondary injury mechanisms.
LncRNA SNHG12 regulated by WTAP aggravated the oxygen-glucose deprivation/reperfusion-induced injury in bEnd.3 cell.
Engagement of N(6)-methyladenisine methylation of Gng4 mRNA in astrocyte dysfunction regulated by CircHECW2.
A LATS2 and ALKBH5 positive feedback loop supports their oncogenic roles.
Germline USP36 Mutation Confers Resistance to EGFR-TKIs by Upregulating MLLT3 Expression in Patients with Non-Small Cell Lung Cancer.
PIWI-interacting RNA-17458 is oncogenic and a potential therapeutic target in cervical cancer.
FTO alleviates cerebral ischemia/reperfusion-induced neuroinflammation by decreasing cGAS mRNA stability in an m6A-dependent manner.
Targeting histone deacetylase suppresses tumor growth through eliciting METTL14-modified m(6) A RNA methylation in ocular melanoma.
B4GALNT1 promotes carcinogenesis by regulating epithelial-mesenchymal transition in hepatocellular carcinoma based on pan-cancer analysis.
Hypericin Ameliorates Depression-like Behaviors via Neurotrophin Signaling Pathway Mediating m6A Epitranscriptome Modification.
N(6)-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice.
FLOT1, stabilized by WTAP/IGF2BP2 mediated N6-methyladenosine modification, predicts poor prognosis and promotes growth and invasion in gliomas.
The differences in biological behavior and gene expression characteristics between pure and mixed early gastric signet ring cell carcinomas.
The mRNA methyltransferase Mettl3 modulates cytokine mRNA stability and limits functional responses in mast cells.
NRP1 contributes to stemness and potentiates radioresistance via WTAP-mediated m6A methylation of Bcl-2 mRNA in breast cancer.
ALKBH1-mediated m(1) A demethylation of METTL3 mRNA promotes the metastasis of colorectal cancer by downregulating SMAD7 expression.
Integrated analysis of RNA methylation regulators crosstalk and immune infiltration for predictive and personalized therapy of diabetic nephropathy.
m (6) A RNA methylation orchestrates transcriptional dormancy during developmental pausing.
Downregulation of ALKBH5 rejuvenates aged human mesenchymal stem cells and enhances their therapeutic efficacy in myocardial infarction.
Systematic assessment of transcriptomic and metabolic reprogramming by blue light exposure coupled with aging.
The effect on m(6)A methylation writer complex by the reduced MATR3 in pterygium.
EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma.
WTAP promotes macrophage recruitment and increases VEGF secretion via N6-methyladenosine modification in corneal neovascularization.
WTAP-mediated m6A modification of IFNE is required for antiviral defense in condyloma acuminata.
A cleaved METTL3 potentiates the METTL3-WTAP interaction and breast cancer progression.
METTL14 reverses liver fibrosis by inhibiting NOVA2 through an m6A-YTHDF2-dependent mechanism.
3D-Printed β-Tricalcium Phosphate Scaffolds Promote Osteogenic Differentiation of Bone Marrow-Deprived Mesenchymal Stem Cells in an N6-methyladenosine-Dependent Manner.
METTL14 Regulates Intestine Cellular Senescence through m(6)A Modification of Lamin B Receptor.
Targeting Ferroptosis as a Novel Approach to Alleviate Aortic Dissection.
WTAP promotes oesophageal squamous cell carcinoma development by decreasing CPSF4 expression in an m(6)A-dependent manner.
Reduced N6-Methyladenosine Mediated by METTL3 Acetylation Promotes MTF1 Expression and Hepatocellular Carcinoma Cell Growth.
m(6)A methylation is required for dihydroartemisinin to alleviate liver fibrosis by inducing ferroptosis in hepatic stellate cells.
PDGF signaling inhibits mitophagy in glioblastoma stem cells through N(6)-methyladenosine.
New insights into the central sympathetic hyperactivity post-myocardial infarction: Roles of METTL3-mediated m(6) A methylation.
The pathological tissue expression pattern and clinical significance of m6A-regulatory genes in non-small cell lung cancer.
The landscape of m6A regulators in esophageal cancer: molecular characteristics, immuno-oncology features, and clinical relevance.
Exon junction complex shapes the m(6)A epitranscriptome.
The function of Wtap in N(6)-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells.
PGE(2) -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase.
Comprehensive analysis of RNA m6A methylation in pressure overload-induced cardiac hypertrophy.
Alteration of N6-Methyladenosine RNA Profiles in Cisplatin-Induced Acute Kidney Injury in Mice.
miR-139-5p Loss-Mediated WTAP Activation Contributes to Hepatocellular Carcinoma Progression by Promoting the Epithelial to Mesenchymal Transition.
METTL3-dependent RNA m(6)A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events.
mTORC1 promotes cell growth via m(6)A-dependent mRNA degradation.
Suppression of m6A mRNA modification by DNA hypermethylated ALKBH5 aggravates the oncological behavior of KRAS mutation/LKB1 loss lung cancer.
Oncogenic AURKA-enhanced N(6)-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.
Hypoxia induces chemoresistance of esophageal cancer cells to cisplatin through regulating the lncRNA-EMS/miR-758-3p/WTAP axis.
Arginine methylation of METTL14 promotes RNA N(6)-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells.
N6-methyladenosine (m(6)A) depletion regulates pluripotency exit by activating signaling pathways in embryonic stem cells.
Tumor Suppressor microRNA-138 Suppresses Low-Grade Glioma Development and Metastasis via Regulating IGF2BP2.
Identification of WTAP-related genes by weighted gene co-expression network analysis in ovarian cancer.
Validation strategies for antibodies targeting modified ribonucleotides.
Direct RNA sequencing reveals m(6)A modifications on adenovirus RNA are necessary for efficient splicing.
Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m(6)A Methylation.
ANKLE1 N(6) -Methyladenosine-related variant is associated with colorectal cancer risk by maintaining the genomic stability.
Alteration of N(6)-methyladenosine epitranscriptome profile in unilateral ureteral obstructive nephropathy.
Altered m(6)A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection.
Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.
AMPK facilitates intestinal long-chain fatty acid uptake by manipulating CD36 expression and translocation.
Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m(6)A machinery component Wtap/Fl(2)d.
Synaptic N(6)-methyladenosine (m(6)A) epitranscriptome reveals functional partitioning of localized transcripts.
METTL3 regulates WTAP protein homeostasis.
RNA m(6) A modification enzymes shape innate responses to DNA by regulating interferon β.
Region-specific RNA m(6)A methylation represents a new layer of control in the gene regulatory network in the mouse brain.
Overexpression of miR-29a reduces the oncogenic properties of glioblastoma stem cells by downregulating Quaking gene isoform 6.
WTAP Expression Predicts Poor Prognosis in Malignant Glioma Patients.
The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells.
Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation.
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.
Liu S, Ren Q, Mo G, Li Z, Huang H, Zhou Y, Miao Z, Cao X, Wu B, Xiao Z, Yu S, Wu G, Xia L, Cui J, Mo J, Li Y, Xia L, Shen J, Xiao S
The Journal of clinical investigation 2026 May 1;136(9)
The Journal of clinical investigation 2026 May 1;136(9)
Network medicine modeling of the m⁶A regulatory landscape identifies a KLF6-WTAP axis as a therapeutic target in pulmonary fibrosis.
Xu C, Zhou Z, Lin Y, Zhang S, Cai S, Li B, Wang Z
Journal of translational medicine 2026 Mar 5;24(1)
Journal of translational medicine 2026 Mar 5;24(1)
A machine learning-based epigenetic signature reveals YTHDC1 stabilizes POU5F1 to oppose tumor progression.
Fang C, Dai J, Weng Z, Zhang L, Xing Y, Liu D, Wu H, Li X, Liu Q, Su G
Journal of translational medicine 2026 Mar 20;24(1)
Journal of translational medicine 2026 Mar 20;24(1)
Integrative Multi-Analysis Identifies METTL3-Regulated FGF19 and H6PD as Candidate Targets in Diabetic Cognitive Impairment.
Fu J, Wang H, Yan J, Chen W, Wang R, Gao H, Li C
Biomolecules 2026 Mar 20;16(3)
Biomolecules 2026 Mar 20;16(3)
WTAP stabilizes MMP12 expression to promote the malignant phenotypes of esophageal cancer cells.
Zhao M, Zhang H, Han X, Wei Y, Zhang M, Hu B, Lv T, Zhang G
Regenerative therapy 2026 Jun;32:101101
Regenerative therapy 2026 Jun;32:101101
MDM2-GPX4-ferroptosis regulatory axis exerts neurotoxic effects in intracerebral hemorrhage.
Yu Y, Liu T, Cai Y, Song Y, Zhou H, Cao F, Jiang R
Neural regeneration research 2026 Jul 1;21(7):3063-3072
Neural regeneration research 2026 Jul 1;21(7):3063-3072
WTAP promotes the proliferation of multiple myeloma by regulating the hippo pathway through m(6)A modification of MAP6D1.
Xu H, Xu M, Ding J, Bao J
Leukemia & lymphoma 2026 Jan;67(1):148-163
Leukemia & lymphoma 2026 Jan;67(1):148-163
N6-methyladenosine (m(6)A) modification regulates LONP1 to inhibit coxsackievirus B3 replication by suppressing virus-induced ferroptosis.
Wang Q, Wang Y, Liu T, Wang H, Yuan M, Zhang T, Ji Z, Shen H
International journal of biological macromolecules 2026 Jan;335(Pt 1):149287
International journal of biological macromolecules 2026 Jan;335(Pt 1):149287
HIV-1 Vpr activates microglia by upregulating m6A modification through ubiquitin-proteasome pathway-mediated degradation of the demethylase ALKBH5.
Peng Q, Li W, Qian F, Zhu Y, Hu S, Shi Y, Xia Y, Liu W, Shu X, Wan P, Liu Y, Sun B
Virulence 2026 Dec;17(1):2645908
Virulence 2026 Dec;17(1):2645908
Toxicological Implications of m(6)A Dysregulation: SH3PXD2A-AS1-Driven PD-L1 Overexpression Promotes Immune Evasion in NSCLC.
Wu S, Chen J, Han Y, Dong Y, Shi H, Liu P, Chen Y, Yuan J, Cui W
Journal of biochemical and molecular toxicology 2026 Apr;40(4):e70784
Journal of biochemical and molecular toxicology 2026 Apr;40(4):e70784
m6A epigenetic signature in necrotizing enterocolitis: insights from murine to neonatal studies.
Chen Y, Wei Q, Gan Y, Wei B, Huang Q, Pan S, Chen Y
Frontiers in immunology 2025;16:1709677
Frontiers in immunology 2025;16:1709677
The m6A modification of SOX18 leads to increased PTX3 and cardiomyocyte pyroptosis in sepsis-induced cardiomyopathy.
Sun H, Qiao X, Peng X, Zhu H, Zhang L, Jiang L, Wang L, Xue C, Yang J, Yi W, Zhang B, Liu J, Duan W
Theranostics 2025;15(8):3532-3550
Theranostics 2025;15(8):3532-3550
Macrophage-derived exosome piR-50971 exacerbates sepsis-induced myocardial injury by inhibiting autophagy through the upregulation of N6-Methyladenosine modification of mTOR.
Wang J, Zhang J, Zhong S, Chen X, Liu HY, Lu C, Zhu H, Chen Y, Wang J, Yu J, Zhang X, Liu Y, Gao M
Burns & trauma 2025;13:tkaf045
Burns & trauma 2025;13:tkaf045
METTL3 Silencing Suppresses Cardiac Fibrosis Post Myocardial Infarction via m6A Modification of SMOC2.
He Y, Pan X, Liu Z, Zuo P, Sheng Z, Hao C, Tao Z, Chen Z, Song J, Ma G, Ling S
Journal of cellular and molecular medicine 2025 Sep;29(17):e70829
Journal of cellular and molecular medicine 2025 Sep;29(17):e70829
METTL3 regulates rifampicin-induced CYP3A4 expression by activating PXR translation and nuclear import and stabilizing CYP3A4 mRNA.
Wang J, Yu Y, Xiong Z, Wang P, Wang Z, Du A, Han S, Wang X, Zhang L
Biochemical pharmacology 2025 Sep;239:117016
Biochemical pharmacology 2025 Sep;239:117016
WTAP targets SOX2 to inhibit trophoblast ferroptosis in the pathogenesis of preeclampsia via m6A-dependent ferroptosis regulation.
Geng H, Zhou L, Zhang P, Li X, Guo Y, Cui H, Chen X
Cellular signalling 2025 Sep;133:111881
Cellular signalling 2025 Sep;133:111881
WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma.
Huang T, You Q, Liu J, Shen X, Huang D, Tao X, He Z, Wu C, Xi X, Yu S, Liu F, Wu Z, Mao W, Zhu S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(33):e06529
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(33):e06529
RBM15-mediated m6A methylation of Entpd1/CD39 regulates extracellular ATP hydrolysis and alleviates myocardial ischemia-reperfusion injury.
Yan Z, Cao H, Zhang X, Wang Y, Chang Q
International immunopharmacology 2025 Sep 23;162:115141
International immunopharmacology 2025 Sep 23;162:115141
WTAP Silencing protects human aortic smooth muscle cells from angiotensin II-induced senescence, apoptosis, ferroptosis, and inflammation by regulating PCSK9.
Pang H, Fu B, Wang P, Meng Y, Xie P, Hu X, Ma Q
Journal of bioenergetics and biomembranes 2025 Oct;57(4-5):231-244
Journal of bioenergetics and biomembranes 2025 Oct;57(4-5):231-244
ADAP-METTL3 modulates the inflammatory responses of macrophages via m(6)A modification of Spry1.
Dong A, Zhang P, Yang F, Wang Y, Liu H
Cell death & disease 2025 Oct 7;16(1):708
Cell death & disease 2025 Oct 7;16(1):708
PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m6A Methylation to Stabilize PARP1 mRNA.
Qi Z, He L, Xu Z, Luo X, Ji L, Lin C, Giuliano AE, Cui X, Deng Z, Wu J, Lin SL, Cui Y
Cancer research 2025 Oct 15;85(20):3949-3965
Cancer research 2025 Oct 15;85(20):3949-3965
WTAP-mediated m(6)A modification promotes drug sensitivity by regulating NR3C1 in prostate cancer.
Wang H, Zhang D, Ouyang Y, Li J, Pang G, Xie X, Huang H, Yan T, Pang X, Zhou Q, Xie B, Wang F, An S, Hu Y
Science China. Life sciences 2025 Nov;68(11):3151-3166
Science China. Life sciences 2025 Nov;68(11):3151-3166
WTAP regulates NCOA4-mediated ferroptosis via a YTHDF2-dependent mechanism in preeclampsia.
Li C, Li Z, Ma C, Xu L, Zhang N, Li Y, Lv Q, Li C, Zhao S
Clinical epigenetics 2025 Nov 19;17(1):195
Clinical epigenetics 2025 Nov 19;17(1):195
Sodium-myoinositol cotransporter-1 downstream of m6A methyltransferase WTAP exerts a potential carcinogenicity in diffuse large B-cell lymphoma progression.
Li X, He X, Sun Y, Yang W
Journal of translational medicine 2025 Nov 18;23(1):1310
Journal of translational medicine 2025 Nov 18;23(1):1310
WTAP-mediated m(6)A modification of PTPN1 contributes to ulcerative colitis pathogenesis through regulating colonic epithelial cell phenotypes.
Zhang Y, Li N, Zhang D, Zhang H
Human cell 2025 Nov 10;39(1):3
Human cell 2025 Nov 10;39(1):3
WTAP improves chondrocyte loss and dysfunctions to ameliorate osteoarthritis through mediating the mA methylation and mRNA stability of IL-33.
Yang W, Hu L, Tian Y, Yang Y, Guo W, Xiao K, Yang R, Yang H, Zhou Z, Cheng C
International journal of biological macromolecules 2025 May;306(Pt 3):141330
International journal of biological macromolecules 2025 May;306(Pt 3):141330
Pathological α-synuclein dysregulates epitranscriptomic writer METTL3 to drive neuroinflammation in microglia.
Miller C, Ealy A, Gregory A, Janarthanam C, Albers W, Richardson G, Jin H, Zenitsky G, Anantharam V, Kanthasamy A, Kanthasamy AG
Cell reports 2025 May 27;44(5):115618
Cell reports 2025 May 27;44(5):115618
IGF2BP1-HAX-1 positive feedback loop-mediated HAX-1 overexpression blocks autophagic flux and promotes chemoresistance in nasopharyngeal carcinoma.
Zhang S, Gu M, Yin H, Pan S, Xie H, Chen W, Gul S, Zhao Y, Wang Z, Zheng W, You Y, You B
Cellular and molecular life sciences : CMLS 2025 Mar 7;82(1):105
Cellular and molecular life sciences : CMLS 2025 Mar 7;82(1):105
The Flip Side of the Coin: METTL3 Serves as a Novel Cellular Senescence Accelerator via Negative Regulation of ITGA9.
Li Y, Huang L, Fang M, Ye L, Yang H, Wu W, Yuan Y, Cao K, Zheng HL, Sun X, Wu Y, Xiong XD, Liu X, Xu S
Aging and disease 2025 Mar 18;17(2):1034-1051
Aging and disease 2025 Mar 18;17(2):1034-1051
Glutamine Attenuates Inflammation and Oxidative Stress in Ulcerative Colitis by Suppressing Wilms' Tumor 1 Associated Protein-Mediated N6-Methyladenosine Modification of Nuclear Receptor Coactivator 3.
Jiang L, Liu S, Ye F, Yu X
Chemical biology & drug design 2025 Jun;105(6):e70110
Chemical biology & drug design 2025 Jun;105(6):e70110
Role of the USP7/FOXO3A axis in environmentally relevant doses of arsenic-induced lung carcinogenesis: Insights from bioinformatics analysis and model of human epithelial cell malignant transformation.
Chen X, Wang Y, Liu Z, He Y, Gao H, Guan X, Chen L, Chen S, Xing X, Chen W, Li D, Wang Q
Ecotoxicology and environmental safety 2025 Jun 1;297:118224
Ecotoxicology and environmental safety 2025 Jun 1;297:118224
High glucose facilitates hepatocellular carcinoma cell proliferation and invasion via WTAP-mediated HK2 mRNA stability.
Niu Y, Jia S, Xiao X, Tu K, Liu Q
Molecular and cellular biochemistry 2025 Jul;480(7):4149-4168
Molecular and cellular biochemistry 2025 Jul;480(7):4149-4168
WTAP-mediated m6A modification of ARG2 mRNA Inhibits Its expression and drives prostate cancer malignant progression.
Li J, Zheng Y, Chen C, Lin Z, Pan J, Jiang F, Zhong W
Mutation research 2025 Jul-Dec;831:111912
Mutation research 2025 Jul-Dec;831:111912
De novo assembly of RNA m(6)A modification factors into viral genome-associated nuclear bodies drives HCMV RNA accumulation.
Grande RC, Lin CC, Cammer M, Emesom ED, Khurram MA, Boutell C, Denes LT, Lionnet T, Wilson AC, Mohr I
Cell reports 2025 Jul 22;44(7):115826
Cell reports 2025 Jul 22;44(7):115826
Tanshinone IIA suppresses the proliferation and fibrosis of mesangial cell in diabetic nephropathy though WTAP-mediated m(6)A methylation.
Peng H, Zhang X
Scientific reports 2025 Jul 1;15(1):21261
Scientific reports 2025 Jul 1;15(1):21261
UBE2D3 regulated by WTAP-mediated m6A modification inhibits temozolomide chemosensitivity in glioblastoma.
Bao J, Sun R, Pan Z, Wei S
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jan;398(1):919-931
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jan;398(1):919-931
The m(6)A methyltransferase METTL3 drives neuroinflammation and neurotoxicity through stabilizing BATF mRNA in microglia.
Wu X, Liu H, Wang J, Zhang S, Hu Q, Wang T, Cui W, Shi Y, Bai H, Zhou J, Han L, Li L, Zhao T, Wu Y, Luo J, Feng D, Guo W, Ge S, Qu Y
Cell death and differentiation 2025 Jan;32(1):100-117
Cell death and differentiation 2025 Jan;32(1):100-117
M6A Methylation Regulators METTL3 and ALKBH5 are Risk Factors for EGFR-Mutant NSCLC.
Zhi Y, Liu S, Chang X, Guan W, Li R, Liu Q, Chen J, Ling J, Zhao X, Liu A, Chen J, Zhang X, Huang Y
Cancer control : journal of the Moffitt Cancer Center 2025 Jan-Dec;32:10732748251342685
Cancer control : journal of the Moffitt Cancer Center 2025 Jan-Dec;32:10732748251342685
IDO1 inhibits ferroptosis by regulating FTO-mediated m6A methylation and SLC7A11 mRNA stability during glioblastoma progression.
Tian Q, Dan G, Wang X, Zhu J, Chen C, Tang D, Wang Z, Chen D, Lei S, Yang C, Wang H, Guo B, Jin B, Chen T, Tang L
Cell death discovery 2025 Jan 25;11(1):22
Cell death discovery 2025 Jan 25;11(1):22
ALKBH5 alleviates lower extremity arteriosclerosis by regulating ITGB1 demethylation and influencing macrophage polarization.
Guan Z, Wang X, Xu C, Lu R
Heliyon 2025 Jan 15;11(1):e41495
Heliyon 2025 Jan 15;11(1):e41495
Influenza NS1 drives N(6)-methyladenosine (m(6)A)-mediated autoregulation of viral mRNA splicing.
Liao Y, Liu J, Wang P, Mok BW, Chen H
Emerging microbes & infections 2025 Dec;14(1):2572761
Emerging microbes & infections 2025 Dec;14(1):2572761
IGF2BP3-STAT3-METTL3 axis promotes malignant progression in hepatocellular carcinoma (HCC).
Xu Y, Cao Y, Yang J, Yu X, Yang L, Xie Y, Zhao J, Zhang Y
Human genomics 2025 Dec 25;20(1):21
Human genomics 2025 Dec 25;20(1):21
Betaine alleviates hepatic lipid metabolism disorder in finishing pigs fed a low-energy diet through regulating m(6)A RNA methylation.
Liang C, Fu R, Chen D, Tian G, He J, Zheng P, Yu J, Pu J, Yu B
Journal of animal science and biotechnology 2025 Dec 2;16(1):163
Journal of animal science and biotechnology 2025 Dec 2;16(1):163
METTL3 increases ferroptosis resistance to facilitate the tumor-like features of rheumatoid arthritis synovial fibroblasts through enhancing SLC7A11 mRNA stability in an m6A-IGF2BP2-dependent manner.
Xu Y, Liu W, Zai Z, Qian X, Hu W, Peng X, Chen F
International journal of biological macromolecules 2025 Aug;320(Pt 1):145698
International journal of biological macromolecules 2025 Aug;320(Pt 1):145698
WTAP Promotes Atherosclerosis by Inducing Macrophage Pyroptosis and M1 Polarization through Upregulating NLRP3.
Luo X, He C, Yang B, Yin S, Li K
Applied biochemistry and biotechnology 2025 Apr;197(4):2397-2416
Applied biochemistry and biotechnology 2025 Apr;197(4):2397-2416
HDAC2-Mediated METTL3 Delactylation Promotes DNA Damage Repair and Chemotherapy Resistance in Triple-Negative Breast Cancer.
He X, Li Y, Li J, Li Y, Chen S, Yan X, Xie Z, Du J, Chen G, Song J, Mei Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2413121
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2413121
PRMT5-mediated methylation of METTL3 promotes cisplatin resistance in ovarian cancer by facilitating DNA repair mechanisms.
Xia Q, Zhong R, Zheng J, Zhou X, Zhao X, Wang S, Wang B, Wu Q, Xie C, Kong B, Zhang Q, Huang T
Cell reports 2025 Apr 22;44(4):115484
Cell reports 2025 Apr 22;44(4):115484
WTAP knockdown inhibits cell migration through regulating SNAIL1 expression in colorectal cancer.
Han J, Zhang J, Shi H, Wen X
American journal of translational research 2024;16(12):8023-8031
American journal of translational research 2024;16(12):8023-8031
The role of WTAP in regulating macrophage-mediated osteoimmune responses and tissue regeneration in periodontitis.
Li Y, Yang Y, Niu Y, Li Y, Hu Z, Sun S, Chen Y, Hu B, Huang Y, Deng X
Frontiers in immunology 2024;15:1423378
Frontiers in immunology 2024;15:1423378
EXOSC2 Mediates the Pro-tumor Role of WTAP in Breast Cancer Cells via Activating the Wnt/β-Catenin Signal.
Lv CG, Cheng Y, Zhang L, Wu GG, Liang CY, Tao Z, Chen B
Molecular biotechnology 2024 Sep;66(9):2569-2582
Molecular biotechnology 2024 Sep;66(9):2569-2582
METTL14-mediated methylation of SLC25A3 mitigates mitochondrial damage in osteoblasts, leading to the improvement of osteoporosis.
Wang P, Zhou W, Chen F, Zhang X, Zhang Q, Chen Y, Zhang N
Experimental gerontology 2024 Sep;194:112496
Experimental gerontology 2024 Sep;194:112496
Downregulated KLF4, induced by m6A modification, aggravates intestinal barrier dysfunction in inflammatory bowel disease.
Zhu X, Wang J, Zhang H, Yue H, Zhu J, Li J, Wang K, Shen K, Yang K, Leng X, Xi Q, Shi T
Cellular and molecular life sciences : CMLS 2024 Nov 29;81(1):470
Cellular and molecular life sciences : CMLS 2024 Nov 29;81(1):470
Redox regulation of m(6)A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes.
De Jesus DF, Zhang Z, Brown NK, Li X, Xiao L, Hu J, Gaffrey MJ, Fogarty G, Kahraman S, Wei J, Basile G, Rana TM, Mathews C, Powers AC, Parent AV, Atkinson MA, Dhe-Paganon S, Eizirik DL, Qian WJ, He C, Kulkarni RN
Nature cell biology 2024 Mar;26(3):421-437
Nature cell biology 2024 Mar;26(3):421-437
The RNA m(6)A reader IGF2BP3 regulates NFAT1/IRF1 axis-mediated anti-tumor activity in gastric cancer.
Ge L, Rui Y, Wang C, Wu Y, Wang H, Wang J
Cell death & disease 2024 Mar 6;15(3):192
Cell death & disease 2024 Mar 6;15(3):192
WTAP regulates the production of reactive oxygen species, promotes malignant progression, and is closely related to the tumor microenvironment in glioblastoma.
Ji Q, Guo Y, Li Z, Zhang X
Aging 2024 Mar 25;16(6):5601-5617
Aging 2024 Mar 25;16(6):5601-5617
N(6)-methyladenosine modification is not a general trait of viral RNA genomes.
Baquero-Pérez B, Yonchev ID, Delgado-Tejedor A, Medina R, Puig-Torrents M, Sudbery I, Begik O, Wilson SA, Novoa EM, Díez J
Nature communications 2024 Mar 11;15(1):1964
Nature communications 2024 Mar 11;15(1):1964
Landscape of transcriptome-wide m(6)A modification in diabetic liver reveals rewiring of PI3K-Akt signaling after physical exercise.
Chen C, Jiang C, Lin T, Hu Y, Wu H, Xiang Q, Yang M, Wang S, Han X, Tao J
Acta physiologica (Oxford, England) 2024 Jun;240(6):e14154
Acta physiologica (Oxford, England) 2024 Jun;240(6):e14154
WTAP and m(6)A-modified circRNAs modulation during stress response in acute myeloid leukemia progenitor cells.
Iaiza A, Mazzanti G, Goeman F, Cesaro B, Cortile C, Corleone G, Tito C, Liccardo F, De Angelis L, Petrozza V, Masciarelli S, Blandino G, Fanciulli M, Fatica A, Fontemaggi G, Fazi F
Cellular and molecular life sciences : CMLS 2024 Jun 23;81(1):276
Cellular and molecular life sciences : CMLS 2024 Jun 23;81(1):276
The lncRNAMALAT1-WTAP axis: a novel layer of EMT regulation in hypoxic triple-negative breast cancer.
Dragonetti M, Turco C, Benedetti A, Goeman F, Forcato M, Scalera S, Allegretti M, Esposito G, Fazi F, Blandino G, Donzelli S, Fontemaggi G
Cell death discovery 2024 Jun 11;10(1):276
Cell death discovery 2024 Jun 11;10(1):276
LncRNA CARMN m6A demethylation by ALKBH5 inhibits mutant p53-driven tumour progression through miR-5683/FGF2.
Liu N, Jiang X, Zhang G, Long S, Li J, Jiang M, Jia G, Sun R, Zhang L, Zhang Y
Clinical and translational medicine 2024 Jul;14(7):e1777
Clinical and translational medicine 2024 Jul;14(7):e1777
Antibiotic-Induced Gut Microbiota Dysbiosis Modulates Host Transcriptome and m(6)A Epitranscriptome via Bile Acid Metabolism.
Yang M, Zheng X, Fan J, Cheng W, Yan TM, Lai Y, Zhang N, Lu Y, Qi J, Huo Z, Xu Z, Huang J, Jiao Y, Liu B, Pang R, Zhong X, Huang S, Luo GZ, Lee G, Jobin C, Eren AM, Chang EB, Wei H, Pan T, Wang X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(28):e2307981
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(28):e2307981
Fat mass and obesity-related protein contributes to the development and maintenance of bone cancer pain in rats by abrogating m6A methylation of RNA.
Liu B, Meng D, Luo M, Xu L, Yao M
Molecular pain 2024 Jan-Dec;20:17448069241295987
Molecular pain 2024 Jan-Dec;20:17448069241295987
Regulation of ULK1 by WTAP/IGF2BP3 axis enhances mitophagy and progression in epithelial ovarian cancer.
Wang J, Zheng F, Wang D, Yang Q
Cell death & disease 2024 Jan 29;15(1):97
Cell death & disease 2024 Jan 29;15(1):97
METTL14 contributes to acute lung injury by stabilizing NLRP3 expression in an IGF2BP2-dependent manner.
Cao F, Chen G, Xu Y, Wang X, Tang X, Zhang W, Song X, Yang X, Zeng W, Xie J
Cell death & disease 2024 Jan 13;15(1):43
Cell death & disease 2024 Jan 13;15(1):43
Demethylase FTO-Mediated m6A Modification of lncRNA MEG3 Activates Neuronal Pyroptosis via NLRP3 Signaling in Cerebral Ischemic Stroke.
Yan H, Huang W, Rao J, Yan D, Yuan J
Molecular neurobiology 2024 Feb;61(2):1023-1043
Molecular neurobiology 2024 Feb;61(2):1023-1043
WTAP-mediated m(6)A modification of FRZB triggers the inflammatory response via the Wnt signaling pathway in osteoarthritis.
An X, Wang R, Lv Z, Wu W, Sun Z, Wu R, Yan W, Jiang Q, Xu X
Experimental & molecular medicine 2024 Feb;56(1):156-167
Experimental & molecular medicine 2024 Feb;56(1):156-167
METTL14-mediated m6A epitranscriptomic modification contributes to chemotherapy-induced neuropathic pain by stabilizing GluN2A expression via IGF2BP2.
Lu W, Yang X, Zhong W, Chen G, Guo X, Ye Q, Xu Y, Qi Z, Ye Y, Zhang J, Wang Y, Wang X, Wang S, Zhao Q, Zeng W, Huang J, Ma H, Xie J
The Journal of clinical investigation 2024 Feb 6;134(6)
The Journal of clinical investigation 2024 Feb 6;134(6)
WTAP and METTL14 regulate the m6A modification of DKK3 in renal tubular epithelial cells of diabetic nephropathy.
Fu K, Jing C, Shi J, Mao S, Lu R, Yang M, Chen Y, Qian B, Wang Y, Li L
Biochemical and biophysical research communications 2024 Dec 17;738:150524
Biochemical and biophysical research communications 2024 Dec 17;738:150524
Off-Target Inhibition of Human Dihydroorotate Dehydrogenase (hDHODH) Highlights Challenges in the Development of Fat Mass and Obesity-Associated Protein (FTO) Inhibitors.
Tarullo M, Fernandez Rodriguez G, Iaiza A, Venezia S, Macone A, Incocciati A, Masciarelli S, Marchioni M, Giorgis M, Lolli ML, Fornaseri F, Proietti L, Grebien F, Rosignoli S, Paiardini A, Rotili D, Mai A, Bochenkova E, Caflisch A, Fazi F, Fatica A
ACS pharmacology & translational science 2024 Dec 13;7(12):4096-4111
ACS pharmacology & translational science 2024 Dec 13;7(12):4096-4111
Chronic social isolation leads to abnormal behavior in male mice through the hippocampal METTL14 mediated epitranscriptomic RNA m6A modifications.
Xu XF, Chen J, Long LH, Zhang AM, Yang JW, Li YJ, Chen L, Zhong XL, Xu Y, Cao WY
Journal of affective disorders 2024 Dec 1;366:262-272
Journal of affective disorders 2024 Dec 1;366:262-272
Endogenous RBM4 prevents Ang II-induced cardiomyocyte hypertrophy via downregulating the expression of PTBP1.
Sun W, Fang X, Zhang H, Lu Y, Wang P, Li J, Li M
Acta biochimica et biophysica Sinica 2024 Aug 7;57(3):365-377
Acta biochimica et biophysica Sinica 2024 Aug 7;57(3):365-377
Unraveling the molecular complexity: Wtap/Ythdf1 and Lcn2 in novel traumatic brain injury secondary injury mechanisms.
Ma C, Gou C, Sun S, Wang J, Wei X, Xing F, Xing N, Yuan J, Wang Z
Cell biology and toxicology 2024 Aug 7;40(1):65
Cell biology and toxicology 2024 Aug 7;40(1):65
LncRNA SNHG12 regulated by WTAP aggravated the oxygen-glucose deprivation/reperfusion-induced injury in bEnd.3 cell.
Long F, Zheng P, Su Q, Zhang Y, Wang D, Xiao Z, Wu M, Li J
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2024 Apr;33(4):107613
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2024 Apr;33(4):107613
Engagement of N(6)-methyladenisine methylation of Gng4 mRNA in astrocyte dysfunction regulated by CircHECW2.
Bai Y, Chang D, Ren H, Ju M, Wang Y, Chen B, Li H, Liu X, Li D, Huo X, Guo X, Tong M, Tan Y, Yao H, Han B
Acta pharmaceutica Sinica. B 2024 Apr;14(4):1644-1660
Acta pharmaceutica Sinica. B 2024 Apr;14(4):1644-1660
A LATS2 and ALKBH5 positive feedback loop supports their oncogenic roles.
Cao L, Han R, Zhao Y, Qin X, Li Q, Xiong H, Kong Y, Liu Z, Li Z, Dong F, Li T, Zhao X, Lei L, Zhao Q, Liu D, Wang B, Wu X
Cell reports 2024 Apr 23;43(4):114032
Cell reports 2024 Apr 23;43(4):114032
Germline USP36 Mutation Confers Resistance to EGFR-TKIs by Upregulating MLLT3 Expression in Patients with Non-Small Cell Lung Cancer.
Guan S, Chen X, Wei Y, Wang F, Xie W, Chen Y, Liang H, Zhu X, Yang Y, Fang W, Huang Y, Zhao H, Zhang X, Liu S, Zhuang W, Huang M, Wang X, Zhang L
Clinical cancer research : an official journal of the American Association for Cancer Research 2024 Apr 1;30(7):1382-1396
Clinical cancer research : an official journal of the American Association for Cancer Research 2024 Apr 1;30(7):1382-1396
PIWI-interacting RNA-17458 is oncogenic and a potential therapeutic target in cervical cancer.
Liu L, Li L, Zu W, Jing J, Liu G, Sun T, Xie Q
Journal of Cancer 2023;14(9):1648-1659
Journal of Cancer 2023;14(9):1648-1659
FTO alleviates cerebral ischemia/reperfusion-induced neuroinflammation by decreasing cGAS mRNA stability in an m6A-dependent manner.
Yu Z, Zheng L, Geng Y, Zhang Y, Wang Y, You G, Cai M, Li M, Cheng X, Zan J
Cellular signalling 2023 Sep;109:110751
Cellular signalling 2023 Sep;109:110751
Targeting histone deacetylase suppresses tumor growth through eliciting METTL14-modified m(6) A RNA methylation in ocular melanoma.
Zhuang A, Gu X, Ge T, Wang S, Ge S, Chai P, Jia R, Fan X
Cancer communications (London, England) 2023 Nov;43(11):1185-1206
Cancer communications (London, England) 2023 Nov;43(11):1185-1206
B4GALNT1 promotes carcinogenesis by regulating epithelial-mesenchymal transition in hepatocellular carcinoma based on pan-cancer analysis.
Liu W, Chen Y, Yang J, Guo M, Wang L
The journal of gene medicine 2023 Nov;25(11):e3552
The journal of gene medicine 2023 Nov;25(11):e3552
Hypericin Ameliorates Depression-like Behaviors via Neurotrophin Signaling Pathway Mediating m6A Epitranscriptome Modification.
Lei C, Li N, Chen J, Wang Q
Molecules (Basel, Switzerland) 2023 May 3;28(9)
Molecules (Basel, Switzerland) 2023 May 3;28(9)
N(6)-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice.
Wang X, Ding Y, Li R, Zhang R, Ge X, Gao R, Wang M, Huang Y, Zhang F, Zhao B, Liao W, Du J
Nature communications 2023 Mar 2;14(1):1185
Nature communications 2023 Mar 2;14(1):1185
FLOT1, stabilized by WTAP/IGF2BP2 mediated N6-methyladenosine modification, predicts poor prognosis and promotes growth and invasion in gliomas.
Song T, Hu Z, Zeng C, Luo H, Liu J
Heliyon 2023 Jun;9(6):e16280
Heliyon 2023 Jun;9(6):e16280
The differences in biological behavior and gene expression characteristics between pure and mixed early gastric signet ring cell carcinomas.
Wang X, Li X, Yang P, Qin X, Yu J, Cheng Y, Zhang G, Tang L
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2023 Jun;55(6):815-822
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2023 Jun;55(6):815-822
The mRNA methyltransferase Mettl3 modulates cytokine mRNA stability and limits functional responses in mast cells.
Leoni C, Bataclan M, Ito-Kureha T, Heissmeyer V, Monticelli S
Nature communications 2023 Jun 29;14(1):3862
Nature communications 2023 Jun 29;14(1):3862
NRP1 contributes to stemness and potentiates radioresistance via WTAP-mediated m6A methylation of Bcl-2 mRNA in breast cancer.
Wang Y, Zhang L, Sun XL, Lu YC, Chen S, Pei DS, Zhang LS
Apoptosis : an international journal on programmed cell death 2023 Feb;28(1-2):233-246
Apoptosis : an international journal on programmed cell death 2023 Feb;28(1-2):233-246
ALKBH1-mediated m(1) A demethylation of METTL3 mRNA promotes the metastasis of colorectal cancer by downregulating SMAD7 expression.
Chen W, Wang H, Mi S, Shao L, Xu Z, Xue M
Molecular oncology 2023 Feb;17(2):344-364
Molecular oncology 2023 Feb;17(2):344-364
Integrated analysis of RNA methylation regulators crosstalk and immune infiltration for predictive and personalized therapy of diabetic nephropathy.
Li J, Liu D, Ren J, Li G, Zhao Z, Zhao H, Yan Q, Duan J, Liu Z
Human genomics 2023 Feb 10;17(1):6
Human genomics 2023 Feb 10;17(1):6
m (6) A RNA methylation orchestrates transcriptional dormancy during developmental pausing.
Collignon E, Cho B, Fothergill-Robinson J, Furlan G, Ross RL, Limbach PA, Ramalho-Santos M
bioRxiv : the preprint server for biology 2023 Feb 1;
bioRxiv : the preprint server for biology 2023 Feb 1;
Downregulation of ALKBH5 rejuvenates aged human mesenchymal stem cells and enhances their therapeutic efficacy in myocardial infarction.
Gao X, Liang X, Liu B, Hong Y, He H, Shen Y, Chen J, Huang X, Hu B, Li W, Li X, Zhang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23294
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23294
Systematic assessment of transcriptomic and metabolic reprogramming by blue light exposure coupled with aging.
Huang J, Zhou F, Zhou H, Zheng X, Huo Z, Yang M, Xu Z, Liu R, Wang L, Wang X
PNAS nexus 2023 Dec;2(12):pgad390
PNAS nexus 2023 Dec;2(12):pgad390
The effect on m(6)A methylation writer complex by the reduced MATR3 in pterygium.
Guo Q, Han S
Acta histochemica 2023 Dec;125(8):152101
Acta histochemica 2023 Dec;125(8):152101
EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma.
Lv D, Zhong C, Dixit D, Yang K, Wu Q, Godugu B, Prager BC, Zhao G, Wang X, Xie Q, Bao S, He C, Heiland DH, Rosenfeld MG, Rich JN
Molecular cell 2023 Dec 7;83(23):4334-4351.e7
Molecular cell 2023 Dec 7;83(23):4334-4351.e7
WTAP promotes macrophage recruitment and increases VEGF secretion via N6-methyladenosine modification in corneal neovascularization.
Bai Y, Jiao X, Hu J, Xue W, Zhou Z, Wang W
Biochimica et biophysica acta. Molecular basis of disease 2023 Aug;1869(6):166708
Biochimica et biophysica acta. Molecular basis of disease 2023 Aug;1869(6):166708
WTAP-mediated m6A modification of IFNE is required for antiviral defense in condyloma acuminata.
Gu Z, Liu J, Qin L, Zhang Y, Cui W, Huang H, Liu L, Cao Y, Zhang H
Journal of dermatological science 2023 Aug;111(2):43-51
Journal of dermatological science 2023 Aug;111(2):43-51
A cleaved METTL3 potentiates the METTL3-WTAP interaction and breast cancer progression.
Yan C, Xiong J, Zhou Z, Li Q, Gao C, Zhang M, Yu L, Li J, Hu MM, Zhang CS, Cai C, Zhang H, Zhang J
eLife 2023 Aug 17;12
eLife 2023 Aug 17;12
METTL14 reverses liver fibrosis by inhibiting NOVA2 through an m6A-YTHDF2-dependent mechanism.
Hou X, Li Y, Song J, Peng L, Zhang W, Liu R, Yuan H, Feng T, Li J, Li W, Zhu C
Hepatology communications 2023 Aug 1;7(8)
Hepatology communications 2023 Aug 1;7(8)
3D-Printed β-Tricalcium Phosphate Scaffolds Promote Osteogenic Differentiation of Bone Marrow-Deprived Mesenchymal Stem Cells in an N6-methyladenosine-Dependent Manner.
Jiao X, Sun X, Li W, Chu W, Zhang Y, Li Y, Wang Z, Zhou X, Ma J, Xu C, Dai K, Wang J, Gan Y
International journal of bioprinting 2022;8(2):544
International journal of bioprinting 2022;8(2):544
METTL14 Regulates Intestine Cellular Senescence through m(6)A Modification of Lamin B Receptor.
Zhang Z, Xue M, Chen J, Wang Z, Ju F, Ni J, Sun J, Wu H, Zheng H, Lou Z, Zhang Y, Yang X, Chen S, Xi Y, Wang L
Oxidative medicine and cellular longevity 2022;2022:9096436
Oxidative medicine and cellular longevity 2022;2022:9096436
Targeting Ferroptosis as a Novel Approach to Alleviate Aortic Dissection.
Li N, Yi X, He Y, Huo B, Chen Y, Zhang Z, Wang Q, Li Y, Zhong X, Li R, Zhu XH, Fang Z, Wei X, Jiang DS
International journal of biological sciences 2022;18(10):4118-4134
International journal of biological sciences 2022;18(10):4118-4134
WTAP promotes oesophageal squamous cell carcinoma development by decreasing CPSF4 expression in an m(6)A-dependent manner.
Luo Q, Zhan X, Kuang Y, Sun M, Dong F, Sun E, Chen B
Medical oncology (Northwood, London, England) 2022 Sep 29;39(12):231
Medical oncology (Northwood, London, England) 2022 Sep 29;39(12):231
Reduced N6-Methyladenosine Mediated by METTL3 Acetylation Promotes MTF1 Expression and Hepatocellular Carcinoma Cell Growth.
Yang Y, Qian Cai Q, Sheng Fu L, Wei Dong Y, Fan F, Zhong Wu X
Chemistry & biodiversity 2022 Nov;19(11):e202200333
Chemistry & biodiversity 2022 Nov;19(11):e202200333
m(6)A methylation is required for dihydroartemisinin to alleviate liver fibrosis by inducing ferroptosis in hepatic stellate cells.
Shen M, Guo M, Li Y, Wang Y, Qiu Y, Shao J, Zhang F, Xu X, Yin G, Wang S, Chen A, Zhang Z, Zheng S
Free radical biology & medicine 2022 Mar;182:246-259
Free radical biology & medicine 2022 Mar;182:246-259
PDGF signaling inhibits mitophagy in glioblastoma stem cells through N(6)-methyladenosine.
Lv D, Gimple RC, Zhong C, Wu Q, Yang K, Prager BC, Godugu B, Qiu Z, Zhao L, Zhang G, Dixit D, Lee D, Shen JZ, Li X, Xie Q, Wang X, Agnihotri S, Rich JN
Developmental cell 2022 Jun 20;57(12):1466-1481.e6
Developmental cell 2022 Jun 20;57(12):1466-1481.e6
New insights into the central sympathetic hyperactivity post-myocardial infarction: Roles of METTL3-mediated m(6) A methylation.
Qi L, Hu H, Wang Y, Hu H, Wang K, Li P, Yin J, Shi Y, Wang Y, Zhao Y, Lyu H, Feng M, Xue M, Li X, Li Y, Yan S
Journal of cellular and molecular medicine 2022 Feb;26(4):1264-1280
Journal of cellular and molecular medicine 2022 Feb;26(4):1264-1280
The pathological tissue expression pattern and clinical significance of m6A-regulatory genes in non-small cell lung cancer.
Li Y, Zhang X, Cai J, Ren L, Liu B, Wu M, Lu W, Li R, Zhang C, Huang C, Tong J, Liu A, Zheng Y, Ren D, Guo Y, Huang Y
The journal of gene medicine 2022 Feb;24(2):e3397
The journal of gene medicine 2022 Feb;24(2):e3397
The landscape of m6A regulators in esophageal cancer: molecular characteristics, immuno-oncology features, and clinical relevance.
Li Z, Zheng C, Huang L, Yin X, Wang Z, Liu C, Li B
Annals of translational medicine 2022 Dec;10(24):1347
Annals of translational medicine 2022 Dec;10(24):1347
Exon junction complex shapes the m(6)A epitranscriptome.
Yang X, Triboulet R, Liu Q, Sendinc E, Gregory RI
Nature communications 2022 Dec 23;13(1):7904
Nature communications 2022 Dec 23;13(1):7904
The function of Wtap in N(6)-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells.
Ito-Kureha T, Leoni C, Borland K, Cantini G, Bataclan M, Metzger RN, Ammann G, Krug AB, Marsico A, Kaiser S, Canzar S, Feske S, Monticelli S, König J, Heissmeyer V
Nature immunology 2022 Aug;23(8):1208-1221
Nature immunology 2022 Aug;23(8):1208-1221
PGE(2) -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase.
Tao X, Du R, Guo S, Feng X, Yu T, OuYang Q, Chen Q, Fan X, Wang X, Guo C, Li X, Xue F, Chen S, Tong M, Lazarus M, Zuo S, Yu Y, Shen Y
The EMBO journal 2022 Aug 16;41(16):e110439
The EMBO journal 2022 Aug 16;41(16):e110439
Comprehensive analysis of RNA m6A methylation in pressure overload-induced cardiac hypertrophy.
Li W, Xing C, Bao L, Han S, Luo T, Wang Z, Fan H
BMC genomics 2022 Aug 11;23(1):576
BMC genomics 2022 Aug 11;23(1):576
Alteration of N6-Methyladenosine RNA Profiles in Cisplatin-Induced Acute Kidney Injury in Mice.
Li CM, Li M, Zhao WB, Ye ZC, Peng H
Frontiers in molecular biosciences 2021;8:654465
Frontiers in molecular biosciences 2021;8:654465
miR-139-5p Loss-Mediated WTAP Activation Contributes to Hepatocellular Carcinoma Progression by Promoting the Epithelial to Mesenchymal Transition.
Liu W, Gao X, Chen X, Zhao N, Sun Y, Zou Y, Guan Y, Yang L, Pei X, Wang G, Wang B, Li M, Song W
Frontiers in oncology 2021;11:611544
Frontiers in oncology 2021;11:611544
METTL3-dependent RNA m(6)A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events.
Zhao F, Xu Y, Gao S, Qin L, Austria Q, Siedlak SL, Pajdzik K, Dai Q, He C, Wang W, O'Donnell JM, Tang B, Zhu X
Molecular neurodegeneration 2021 Sep 30;16(1):70
Molecular neurodegeneration 2021 Sep 30;16(1):70
mTORC1 promotes cell growth via m(6)A-dependent mRNA degradation.
Cho S, Lee G, Pickering BF, Jang C, Park JH, He L, Mathur L, Kim SS, Jung S, Tang HW, Monette S, Rabinowitz JD, Perrimon N, Jaffrey SR, Blenis J
Molecular cell 2021 May 20;81(10):2064-2075.e8
Molecular cell 2021 May 20;81(10):2064-2075.e8
Suppression of m6A mRNA modification by DNA hypermethylated ALKBH5 aggravates the oncological behavior of KRAS mutation/LKB1 loss lung cancer.
Zhang D, Ning J, Okon I, Zheng X, Satyanarayana G, Song P, Xu S, Zou MH
Cell death & disease 2021 May 20;12(6):518
Cell death & disease 2021 May 20;12(6):518
Oncogenic AURKA-enhanced N(6)-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.
Peng F, Xu J, Cui B, Liang Q, Zeng S, He B, Zou H, Li M, Zhao H, Meng Y, Chen J, Liu B, Lv S, Chu P, An F, Wang Z, Huang J, Zhan Y, Liao Y, Lu J, Xu L, Zhang J, Sun Z, Li Z, Wang F, Lam EW, Liu Q
Cell research 2021 Mar;31(3):345-361
Cell research 2021 Mar;31(3):345-361
Hypoxia induces chemoresistance of esophageal cancer cells to cisplatin through regulating the lncRNA-EMS/miR-758-3p/WTAP axis.
Zhu ZJ, Pang Y, Jin G, Zhang HY, Wang WH, Liu JW, Tuo GX, Wu P, Yang Y, Wang ZQ, Wang K
Aging 2021 Jun 3;13(13):17155-17176
Aging 2021 Jun 3;13(13):17155-17176
Arginine methylation of METTL14 promotes RNA N(6)-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells.
Liu X, Wang H, Zhao X, Luo Q, Wang Q, Tan K, Wang Z, Jiang J, Cui J, Du E, Xia L, Du W, Chen D, Xia L, Xiao S
Nature communications 2021 Jun 18;12(1):3780
Nature communications 2021 Jun 18;12(1):3780
N6-methyladenosine (m(6)A) depletion regulates pluripotency exit by activating signaling pathways in embryonic stem cells.
Jin KX, Zuo R, Anastassiadis K, Klungland A, Marr C, Filipczyk A
Proceedings of the National Academy of Sciences of the United States of America 2021 Dec 21;118(51)
Proceedings of the National Academy of Sciences of the United States of America 2021 Dec 21;118(51)
Tumor Suppressor microRNA-138 Suppresses Low-Grade Glioma Development and Metastasis via Regulating IGF2BP2.
Yang Y, Liu X, Cheng L, Li L, Wei Z, Wang Z, Han G, Wan X, Wang Z, Zhang J, Chen C
OncoTargets and therapy 2020;13:2247-2260
OncoTargets and therapy 2020;13:2247-2260
Identification of WTAP-related genes by weighted gene co-expression network analysis in ovarian cancer.
Wang J, Xu J, Li K, Huang Y, Dai Y, Xu C, Kang Y
Journal of ovarian research 2020 Sep 30;13(1):119
Journal of ovarian research 2020 Sep 30;13(1):119
Validation strategies for antibodies targeting modified ribonucleotides.
Weichmann F, Hett R, Schepers A, Ito-Kureha T, Flatley A, Slama K, Hastert FD, Angstman NB, Cardoso MC, König J, Hüttelmaier S, Dieterich C, Canzar S, Helm M, Heissmeyer V, Feederle R, Meister G
RNA (New York, N.Y.) 2020 Oct;26(10):1489-1506
RNA (New York, N.Y.) 2020 Oct;26(10):1489-1506
Direct RNA sequencing reveals m(6)A modifications on adenovirus RNA are necessary for efficient splicing.
Price AM, Hayer KE, McIntyre ABR, Gokhale NS, Abebe JS, Della Fera AN, Mason CE, Horner SM, Wilson AC, Depledge DP, Weitzman MD
Nature communications 2020 Nov 26;11(1):6016
Nature communications 2020 Nov 26;11(1):6016
Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m(6)A Methylation.
Sun HL, Zhu AC, Gao Y, Terajima H, Fei Q, Liu S, Zhang L, Zhang Z, Harada BT, He YY, Bissonnette MB, Hung MC, He C
Molecular cell 2020 Nov 19;80(4):633-647.e7
Molecular cell 2020 Nov 19;80(4):633-647.e7
ANKLE1 N(6) -Methyladenosine-related variant is associated with colorectal cancer risk by maintaining the genomic stability.
Tian J, Ying P, Ke J, Zhu Y, Yang Y, Gong Y, Zou D, Peng X, Yang N, Wang X, Mei S, Zhang Y, Wang C, Zhong R, Chang J, Miao X
International journal of cancer 2020 Jun 15;146(12):3281-3293
International journal of cancer 2020 Jun 15;146(12):3281-3293
Alteration of N(6)-methyladenosine epitranscriptome profile in unilateral ureteral obstructive nephropathy.
Li X, Fan X, Yin X, Liu H, Yang Y
Epigenomics 2020 Jul;12(14):1157-1173
Epigenomics 2020 Jul;12(14):1157-1173
Altered m(6)A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection.
Gokhale NS, McIntyre ABR, Mattocks MD, Holley CL, Lazear HM, Mason CE, Horner SM
Molecular cell 2020 Feb 6;77(3):542-555.e8
Molecular cell 2020 Feb 6;77(3):542-555.e8
Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.
Zhang Y, Liu X, Liu L, Li J, Hu Q, Sun R
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 22;26:e919644
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 22;26:e919644
AMPK facilitates intestinal long-chain fatty acid uptake by manipulating CD36 expression and translocation.
Wu W, Wang S, Liu Q, Shan T, Wang X, Feng J, Wang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):4852-4869
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):4852-4869
Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m(6)A machinery component Wtap/Fl(2)d.
Knuckles P, Lence T, Haussmann IU, Jacob D, Kreim N, Carl SH, Masiello I, Hares T, Villaseñor R, Hess D, Andrade-Navarro MA, Biggiogera M, Helm M, Soller M, Bühler M, Roignant JY
Genes & development 2018 Mar 1;32(5-6):415-429
Genes & development 2018 Mar 1;32(5-6):415-429
Synaptic N(6)-methyladenosine (m(6)A) epitranscriptome reveals functional partitioning of localized transcripts.
Merkurjev D, Hong WT, Iida K, Oomoto I, Goldie BJ, Yamaguti H, Ohara T, Kawaguchi SY, Hirano T, Martin KC, Pellegrini M, Wang DO
Nature neuroscience 2018 Jul;21(7):1004-1014
Nature neuroscience 2018 Jul;21(7):1004-1014
METTL3 regulates WTAP protein homeostasis.
Sorci M, Ianniello Z, Cruciani S, Larivera S, Ginistrelli LC, Capuano E, Marchioni M, Fazi F, Fatica A
Cell death & disease 2018 Jul 23;9(8):796
Cell death & disease 2018 Jul 23;9(8):796
RNA m(6) A modification enzymes shape innate responses to DNA by regulating interferon β.
Rubio RM, Depledge DP, Bianco C, Thompson L, Mohr I
Genes & development 2018 Dec 1;32(23-24):1472-1484
Genes & development 2018 Dec 1;32(23-24):1472-1484
Region-specific RNA m(6)A methylation represents a new layer of control in the gene regulatory network in the mouse brain.
Chang M, Lv H, Zhang W, Ma C, He X, Zhao S, Zhang ZW, Zeng YX, Song S, Niu Y, Tong WM
Open biology 2017 Sep;7(9)
Open biology 2017 Sep;7(9)
Overexpression of miR-29a reduces the oncogenic properties of glioblastoma stem cells by downregulating Quaking gene isoform 6.
Xi Z, Wang P, Xue Y, Shang C, Liu X, Ma J, Li Z, Li Z, Bao M, Liu Y
Oncotarget 2017 Apr 11;8(15):24949-24963
Oncotarget 2017 Apr 11;8(15):24949-24963
WTAP Expression Predicts Poor Prognosis in Malignant Glioma Patients.
Xi Z, Xue Y, Zheng J, Liu X, Ma J, Liu Y
Journal of molecular neuroscience : MN 2016 Oct;60(2):131-6
Journal of molecular neuroscience : MN 2016 Oct;60(2):131-6
The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells.
Lin S, Choe J, Du P, Triboulet R, Gregory RI
Molecular cell 2016 May 5;62(3):335-345
Molecular cell 2016 May 5;62(3):335-345
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Science (New York, N.Y.) 2015 Feb 27;347(6225):1002-6
Science (New York, N.Y.) 2015 Feb 27;347(6225):1002-6
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.
Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, Jia G, Yu M, Lu Z, Deng X, Dai Q, Chen W, He C
Nature chemical biology 2014 Feb;10(2):93-5
Nature chemical biology 2014 Feb;10(2):93-5
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 60188-1-Ig(WTAP antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human cervical cancer using 60188-1-Ig(WTAP antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The WTAP antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human WTAP. This antibody recognizes human,mouse,rat antigen. The WTAP antibody has been validated for the following applications: ELISA, WB, IHC analysis.
