323302

CD109 antibody from BioLegend
CPAMD7, DKFZp762L1111, FLJ38569
Flow cytometry
Recommended by provider

Antibody data

Product number
323302
Provider
BioLegend
Proper citation
BioLegend Cat#323302, RRID:AB_755966
Product name
Purified anti-human CD109
Provider product page
BioLegend - 323302
Antibody type
Monoclonal
Antigen
WERI-RB-1 retinoblastoma cell line
Description
The W7C5 monoclonal antibody recognizes human CD109 also known as the Gov platelet alloantigen. CD109 is a member of the alpha2-macroglobulin/complement gene family that is a GPI-linked cell surface antigen with a predicted molecular weight approximately 162 kD. CD109 contains a thioester motif characteristic of alpha-2-macroglobulin that undergoes autolytic cleavage under denaturing conditions. CD109 expression has been reported on CD34+ and CD34- bone marrow stem cells, CD34+ cells in the fetal liver, CD34+ acute myeloid leukemia cells, T cell lines, activated T lymphoblasts, activated platelets, and endothelial cells. It is also widely expressed in the brain, uterus, heart, lung, and trachea of adults. The function of CD109 is largely unknown although it has been implicated in refractoriness to platelet transfusion, neonatal alloimmune thrombocytopenia, and post-transfusion purpura.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Isotype
IgG
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
The antibody solution should be stored undiluted at 4°C.
Provider Type Product Number
- No reagents -