orb386086

antibody from Biorbyt

Targeting: TNFSF15 MGC129934, MGC129935, TL1, TL1A, VEGI, VEGI192A

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

orb386086

Provider

Biorbyt

Product name

TNFSF15 Antibody / VEGI / TL1A

Antibody type

Monoclonal

Description

TNF ligand-related molecule 1 is an anti-angiogenic cytokine that is also called Tumor necrosis factor superfamily, member 15 (TNFSF15) and Vascular endothelial growth inhibitor (VEGI/VEGI192A). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of TL1A has been reported as a marker of poor prognosis in breast cancer.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Antibody clone number

VEGI/1283

Vial size

20 ug

Storage

Store the TL1A antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).