CABT-BL8401

antibody from Creative Diagnostics

Targeting: TNFSF15 MGC129934, MGC129935, TL1, TL1A, VEGI, VEGI192A

Flow cytometry (Recommended by provider)

Antibody Data

Product number

CABT-BL8401

Provider

Creative Diagnostics

Product name

Anti-TNFSF15 Monoclonal antibody, clone Uboezt2b [PerCP-eFluor? 710]

Antibody type

Monoclonal

Description

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but the sequence of this transcript has not been determined.

Reactivity

Human, Mouse

Host

Mouse

Isotype

IgG