orb534084

antibody from Biorbyt

Targeting: TNFSF15 MGC129934, MGC129935, TL1, TL1A, VEGI, VEGI192A

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

orb534084

Provider

Biorbyt

Product name

TNFSF15 Antibody / VEGI / TL1A

Antibody type

Recombinant

Description

Vascular endothelial growth inhibitor (VEGI), also known as TNF-like ligand 1A (TL1A) and TNF superfamily member 15 (TNFSF15), is a protein that in humans is encoded by the TNFSF15 gene. TL1A/VEGI is an anti-angiogenic protein. It belongs to tumor necrosis factor (ligand) superfamily, where it is member 15. It is the sole known ligand for death receptor 3, and it can also be recognized by decoy receptor 3.TL1A/VEGI is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF-alpha and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 (death receptor 3) and TNFRSF6B (decoy receptor 3). It can activate both the NF-kB and MAPK signalling pathways, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. [Wiki]

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Antibody clone number

TLRM1-2R

Vial size

20 ug

Storage

Store the recombinant VEGI antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).