Antibody data
- Antibody Data
- Antigen structure
- References [7]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- FAB689P-100 - Provider product page
- Provider
- R&D Systems
- Product name
- Human GITR/TNFRSF18 PE-conjugated Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human GITR in direct ELISAs and Western blots. Does not cross-react with recombinant human (rh) 4-1BB, recombinant mouse (rm) 4-1BB, rhCD27, rmCD27, rhCD30, rmCD30, rhCD40, rmCD40, rhDR3, rhDR6, rhEDAR, rmEDAR, rhFas, rmFAS, rmGITR, rhHVEM, rhLymphotoxin R beta , rmLymphotoxin R beta , rhNGF R, rhOPG, rmOPG, rhRANK, rmRANK, rhTAJ, rhTNF RI, rmTNF RI, rhTNF RII, or rmTNF RII.
- Reactivity
- Human
- Host
- Mouse
- Antigen sequence
Q9Y5U5
- Isotype
- IgG
- Antibody clone number
- 110416
- Vial size
- 100 Tests
- Storage
- Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.
Submitted references Therapeutic immune monitoring of CD4+CD25+ T cells in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors.
Statins increase the frequency of circulating CD4+ FOXP3+ regulatory T cells in healthy individuals.
Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation.
Effects of the administration of high-dose interleukin-2 on immunoregulatory cell subsets in patients with advanced melanoma and renal cell cancer.
Systemic and local characterization of regulatory T cells in a chronic fungal infection in humans.
Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function.
In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures.
Lu Z, Xu N, Zhou X, Gao G, Li L, Huang J, Li Y, Lu Q, He B, Pan C, Liu X
Oncology letters 2017 Aug;14(2):1363-1372
Oncology letters 2017 Aug;14(2):1363-1372
Statins increase the frequency of circulating CD4+ FOXP3+ regulatory T cells in healthy individuals.
RodrÃguez-Perea AL, Montoya CJ, Olek S, Chougnet CA, Velilla PA
Journal of immunology research 2015;2015:762506
Journal of immunology research 2015;2015:762506
Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation.
Lages CS, Suffia I, Velilla PA, Huang B, Warshaw G, Hildeman DA, Belkaid Y, Chougnet C
Journal of immunology (Baltimore, Md. : 1950) 2008 Aug 1;181(3):1835-48
Journal of immunology (Baltimore, Md. : 1950) 2008 Aug 1;181(3):1835-48
Effects of the administration of high-dose interleukin-2 on immunoregulatory cell subsets in patients with advanced melanoma and renal cell cancer.
van der Vliet HJ, Koon HB, Yue SC, Uzunparmak B, Seery V, Gavin MA, Rudensky AY, Atkins MB, Balk SP, Exley MA
Clinical cancer research : an official journal of the American Association for Cancer Research 2007 Apr 1;13(7):2100-8
Clinical cancer research : an official journal of the American Association for Cancer Research 2007 Apr 1;13(7):2100-8
Systemic and local characterization of regulatory T cells in a chronic fungal infection in humans.
Cavassani KA, Campanelli AP, Moreira AP, Vancim JO, Vitali LH, Mamede RC, Martinez R, Silva JS
Journal of immunology (Baltimore, Md. : 1950) 2006 Nov 1;177(9):5811-8
Journal of immunology (Baltimore, Md. : 1950) 2006 Nov 1;177(9):5811-8
Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function.
Godfrey WR, Spoden DJ, Ge YG, Baker SR, Liu B, Levine BL, June CH, Blazar BR, Porter SB
Blood 2005 Jan 15;105(2):750-8
Blood 2005 Jan 15;105(2):750-8
In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures.
Godfrey WR, Ge YG, Spoden DJ, Levine BL, June CH, Blazar BR, Porter SB
Blood 2004 Jul 15;104(2):453-61
Blood 2004 Jul 15;104(2):453-61
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of GITR/TNFRSF18 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) treated with 1 μg/mL PHA for 24 hours were stained with Mouse Anti-Human GITR/TNFRSF18 PE-conjugated Mono-clonal Antibody (Catalog # FAB689P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.