Antibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations [0]
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- Product number
- AF524 - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse GITR/TNFRSF18 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Detects mouse GITR/TNFRSF18 in direct ELISAs and Western blots. In direct ELISAs, approximately 20% cross-reactivity with recombinant human (rh) GITR is observed, less than 2% cross-reactivity with recombinant mouse (rm) 4-1BB, rmCD27, rmCD30, rmCD40, rhDR6, rmFas, rhHVEM, rmLTR beta , rmTNF RI, and rmTNF RII is observed.
- Reactivity
- Mouse
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
Q8C4K3
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Glucocorticoid-induced tumour necrosis factor receptor-related protein: a key marker of functional regulatory T cells.
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.
GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations.
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.
Ronchetti S, Ricci E, Petrillo MG, Cari L, Migliorati G, Nocentini G, Riccardi C
Journal of immunology research 2015;2015:171520
Journal of immunology research 2015;2015:171520
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.
Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, Garner VE, Gonzalez-Munoz A, Clark J, Veijola R, Cubbon R, Chen SL, Rosa R, Cumiskey AM, Serreze DV, Gregory S, Rogers J, Lyons PA, Healy B, Smink LJ, Todd JA, Peterson LB, Wicker LS, Santamaria P
Nature genetics 2007 Mar;39(3):329-37
Nature genetics 2007 Mar;39(3):329-37
GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations.
Ronchetti S, Zollo O, Bruscoli S, Agostini M, Bianchini R, Nocentini G, Ayroldi E, Riccardi C
European journal of immunology 2004 Mar;34(3):613-622
European journal of immunology 2004 Mar;34(3):613-622
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.
Fontenot JD, Gavin MA, Rudensky AY
Nature immunology 2003 Apr;4(4):330-6
Nature immunology 2003 Apr;4(4):330-6
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