Antibody data
- Antibody Data
- Antigen structure
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- Product number
- AMRa00007G - Provider product page
- Provider
- Leading Biology
- Product name
- GITR / Tnfrsf18 (mouse) Antibody - With BSA and Azide
- Antibody type
- Monoclonal
- Description
- GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+ĀCD4+ĀTregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-ĪŗB activation, and abrogate the inhibitory function ofĀCD25+ĀCD4+ĀTregs. In vivoĀactivation of GITR causes development of autoimmune diseases and restores the suppressed immune response.
- Reactivity
- Mouse
- Host
- Rat
- Antibody clone number
- DTA-1
- Storage
- Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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