311603

antibody from BioLegend

Targeting: TNFRSF18 AITR, CD357, GITR

Antibody data

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Validation data

Product number: 311603 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#311603, RRID:AB_314886
Product name: PE anti-human CD357 (GITR)
Antibody type: Monoclonal
Antigen: GITR
Description: GITR (glucocorticoid-induced TNF receptor family-regulated gene) is a 25 kD TNF receptor superfamily member (also known as AITR and TNFRSF18). GITR is expressed on activated lymphocytes and is upregulated by T cell receptor engagement. The cytoplasmic domain of GITR is homologous to CD40, 4-1BB and CD27 and has been shown to interact with TRAF 1-3, but not TRAF 5 or 6. GITR signaling has been shown to regulate T cell proliferation and TCR-mediated apoptosis, and to break immunological self-tolerance. GITR binds GITRL and is involved in the development of regulatory T cells and to regulate the activity of Th1 subsets.
Reactivity: Human
Host: Mouse
Conjugate: Yellow dye
Isotype: IgG
Vial size: 25 tests
Storage: The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

TNFRSF18 protein structure - 311603 shown in red.