339509

antibody from BioLegend

Targeting: KIR2DL1 47.11, CD158A, cl-42, nkat1, p58.1

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

339509

Provider

BioLegend

Proper citation

BioLegend Cat#339509, RRID:AB_2565576

Product name

APC anti-human CD158 (KIR2DL1/S1/S3/S5)

Antibody type

Monoclonal

Antigen

Human NK cell clone LB2

Description

CD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs with long cytoplasmic domains contain ITIMs and posses inhibitory functions and others with short cytoplasmic region lack ITIM and have activation functions. 14 polymorphic KIR genes have been reported in humans. CD158 is mainly expressed on a subset of NK cells and a small population of CD8⁺ T cells. HLA-C is the ligand of CD158a/h.

Reactivity

Human

Host

Mouse

Conjugate

Red dye

Antibody clone number

HP-MA4

Vial size

25 tests

Storage

2°C-8°C

Handling

Ambient RT

Flow cytometry

Supportive validation

Submitted by

BioLegend (provider)

Main image

Experimental details

Human peripheral blood lymphocytes were stained with CD56 Alexa Fluor® 488 and CD158 (clone HP-MA4) APC (top) or mouse IgG2b, κ APC isotype control (bottom).

Conjugate

Red dye