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- Antibody Data
- Antigen structure
- References [6]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 11962-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11962-1-AP, RRID:AB_2142989
- Product name
- MCPH/BRIT1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MCPH/BRIT1 antibody (Cat. #11962-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Differential sensitivity of MCPH1- and BRCA2-deficient cancer cells to PARP-1 inhibition.
TOP2A inhibition and its cellular effects related to cell cycle checkpoint adaptation pathway.
Mitotic entry upon Topo II catalytic inhibition is controlled by Chk1 and Plk1.
Generation of a MCPH1 knockout human embryonic stem cell line by CRISPR/Cas9 technology.
MCPH1 Lack of Function Enhances Mitotic Cell Sensitivity Caused by Catalytic Inhibitors of Topo II.
Phosphorylation of MCPH1 isoforms during mitosis followed by isoform-specific degradation by APC/C-CDH1.
Chapman IG, Wu X, Veuger S, Jowsey PA
PloS one 2026;21(4):e0345514
PloS one 2026;21(4):e0345514
TOP2A inhibition and its cellular effects related to cell cycle checkpoint adaptation pathway.
Arroyo M, Fernández-Mimbrera MA, Gollini E, Esteve-Codina A, Sánchez A, Marchal JA
Scientific reports 2025 Jan 30;15(1):3831
Scientific reports 2025 Jan 30;15(1):3831
Mitotic entry upon Topo II catalytic inhibition is controlled by Chk1 and Plk1.
Arroyo M, Cañuelo A, Calahorra J, Hastert FD, Sánchez A, Clarke DJ, Marchal JA
The FEBS journal 2020 Nov;287(22):4933-4951
The FEBS journal 2020 Nov;287(22):4933-4951
Generation of a MCPH1 knockout human embryonic stem cell line by CRISPR/Cas9 technology.
Wang Z, Cui Y, Shan Y, Kang B, Shi L, Geng K, Han J
Stem cell research 2020 Dec;49:102105
Stem cell research 2020 Dec;49:102105
MCPH1 Lack of Function Enhances Mitotic Cell Sensitivity Caused by Catalytic Inhibitors of Topo II.
Arroyo M, Sánchez A, Cañuelo A, Heredia-Molina RF, Martínez-Molina E, Clarke DJ, Marchal JA
Genes 2020 Apr 8;11(4)
Genes 2020 Apr 8;11(4)
Phosphorylation of MCPH1 isoforms during mitosis followed by isoform-specific degradation by APC/C-CDH1.
Meyer SK, Dunn M, Vidler DS, Porter A, Blain PG, Jowsey PA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Feb;33(2):2796-2808
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Feb;33(2):2796-2808
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 11962-1-AP(BRIT1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The BRIT1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human BRIT1. This antibody recognizes human, mouse antigen. The BRIT1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
