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- Antibody Data
- Antigen structure
- References [4]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 11962-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11962-1-AP, RRID:AB_2142989
- Product name
- MCPH/BRIT1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MCPH/BRIT1 antibody (Cat. #11962-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Mitotic entry upon Topo II catalytic inhibition is controlled by Chk1 and Plk1.
Generation of a MCPH1 knockout human embryonic stem cell line by CRISPR/Cas9 technology.
MCPH1 Lack of Function Enhances Mitotic Cell Sensitivity Caused by Catalytic Inhibitors of Topo II.
Phosphorylation of MCPH1 isoforms during mitosis followed by isoform-specific degradation by APC/C-CDH1.
Arroyo M, Cañuelo A, Calahorra J, Hastert FD, Sánchez A, Clarke DJ, Marchal JA
The FEBS journal 2020 Nov;287(22):4933-4951
The FEBS journal 2020 Nov;287(22):4933-4951
Generation of a MCPH1 knockout human embryonic stem cell line by CRISPR/Cas9 technology.
Wang Z, Cui Y, Shan Y, Kang B, Shi L, Geng K, Han J
Stem cell research 2020 Dec;49:102105
Stem cell research 2020 Dec;49:102105
MCPH1 Lack of Function Enhances Mitotic Cell Sensitivity Caused by Catalytic Inhibitors of Topo II.
Arroyo M, Sánchez A, Cañuelo A, Heredia-Molina RF, Martínez-Molina E, Clarke DJ, Marchal JA
Genes 2020 Apr 8;11(4)
Genes 2020 Apr 8;11(4)
Phosphorylation of MCPH1 isoforms during mitosis followed by isoform-specific degradation by APC/C-CDH1.
Meyer SK, Dunn M, Vidler DS, Porter A, Blain PG, Jowsey PA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Feb;33(2):2796-2808
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Feb;33(2):2796-2808
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 11962-1-AP(BRIT1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The BRIT1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human BRIT1. This antibody recognizes human, mouse antigen. The BRIT1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
