10627-1-AP

antibody from Proteintech Group

Targeting: FADS1 D5D, FADS6, FADSD5, LLCDL1, TU12

Provider product page for 10627-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [22]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 10627-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10627-1-AP, RRID:AB_2231403
Product name: FADS1 antibody
Antibody type: Polyclonal
Description: FADS1 antibody (Cat. #10627-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

FADS1 protein structure - 10627-1-AP shown in red.

Submitted references Yizong Tongluo formula attenuates idiopathic pulmonary fibrosis and inflammatory injury by inhibiting HIF-1α/LSH/SCD1-mediated ferroptosis.

Ma X, Wang X, Jiang D, Tuerxun Y, Tao S, Li F, Wei Y, Yang L, Xi L, Wang L
Frontiers in immunology 2026;17:1760615

FADS1 contributes to anesthesia/surgery-induced cognitive impairment by aggravating omega-6 fatty acid metabolic disruption in aged mice.

Chen Z, Wu Q, Ma J, Shi Y, Zhang Q, Wu H, Zhang Y, Li Z, Ruan X, Xiong L, Cong P, Tian L
Journal of neuroinflammation 2026 Feb 11;23(1)

Lipid metabolism and osteonecrosis: unraveling causal mechanisms via multi-omics and mendelian randomization.

Chen Y, Zhou Z, Che H, Li D
Frontiers in physiology 2025;16:1642153

Reprogramming of Fatty Acid Metabolism via PPARα-Orchestrated FADS2 in Keratinocytes Modulates Skin Inflammation in Psoriasis.

Cai J, Zhou X, Zhuang Y, Cui L, Ma R, Chen Y, Yang N, Chen Q, Wang Y, Zhu P, Yao L, Yu Q, She X, Zhou X, Huang Y, Yu Z, Zhang X, Lu J, Shi Y, Guo C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e17049

Influence of fatty acid distribution on lipid metabolism and cognitive development in first-weaned mice.

Ni X, Li J, Xiong H, Deng Z, Sun Y
Food research international (Ottawa, Ont.) 2025 May;209:116292

Targeting PSMD14 combined with arachidonic acid induces synthetic lethality via FADS1 m(6)A modification in triple-negative breast cancer.

Yu Y, Hu J, Wang W, Lei H, Xi Z, Zhang P, Zhao E, Lu C, Chen H, Liu C, Li L
Science advances 2025 May 9;11(19):eadr3173

Fatty Acid Desaturase 1 Knockdown Promotes Wound Healing and Functional Recovery of the Corneal Epithelium in Diabetes.

Zhao Y, Dong Y, Zheng Q, Zhao Y, Ni Y, Qiu P, Chen C, Xu M, Hong C, Shen T
Investigative ophthalmology & visual science 2025 Jun 2;66(6):6

miRNA-novel-216 regulated fatty acid composition and progesterone synthesis in goat granulosa cells by targeting the TPD52.

Jia Y, Xu Q, Wang P, Liu Z, Zhang R, Liu K, Ling Y, Liu Y, Chu M
Reproduction (Cambridge, England) 2025 Feb 1;169(2)

ELOVL5 and VLDLR synergistically affect n-3 PUFA deposition in eggs of different chicken breeds.

Jiang C, Shi Y, Shi X, Yan J, Xuan L, Zhuang L, Li J, Xu G, Zheng J
Poultry science 2024 Sep;103(9):104016

Time-restricted feeding relieves high temperature-induced impairment on meat quality by activating the Nrf2/HO-1 pathway, modification of muscle fiber composition, and enriching the polyunsaturated fatty acids in pigs.

Li Z, Wang Y, Yuan P, Zhu Y, Hu P, Song T, Liu R, Liu HY, Cai D
Stress biology 2024 Sep 14;4(1):39

Construction and multiple validations of a robust ferroptosis-related prognostic model in bladder cancer: A comprehensive study.

Dai X, Yu K, Wang H, Zhong R, Zhang Z, Hou Y
Medicine 2024 Oct 18;103(42):e40133

Disruption of polyunsaturated fatty acid biosynthesis drives STING-dependent acute myeloid leukemia cell maturation and death.

Kanefsky J, Basse M, Sokei J, di Martino O, Valin L, Jaspers Y, Martinez E, Huhn J, Di Marcantonio D, Magee JA, Goldman AR, Tang HY, Ferraro F, Kemp S, Wiest DL, Sykes SM
The Journal of biological chemistry 2024 May;300(5):107214

Lipid unsaturation promotes BAX and BAK pore activity during apoptosis.

Dadsena S, Cuevas Arenas R, Vieira G, Brodesser S, Melo MN, García-Sáez AJ
Nature communications 2024 Jun 3;15(1):4700

Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents.

He Y, Kaya I, Shariatgorji R, Lundkvist J, Wahlberg LU, Nilsson A, Mamula D, Kehr J, Zareba-Paslawska J, Biverstål H, Chergui K, Zhang X, Andren PE, Svenningsson P
Nature communications 2023 Sep 19;14(1):5804

The lipoprotein-associated phospholipase A2 inhibitor Darapladib sensitises cancer cells to ferroptosis by remodelling lipid metabolism.

Oh M, Jang SY, Lee JY, Kim JW, Jung Y, Kim J, Seo J, Han TS, Jang E, Son HY, Kim D, Kim MW, Park JS, Song KH, Oh KJ, Kim WK, Bae KH, Huh YM, Kim SH, Kim D, Han BS, Lee SC, Hwang GS, Lee EW
Nature communications 2023 Sep 15;14(1):5728

The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition.

Ganji R, Paulo JA, Xi Y, Kline I, Zhu J, Clemen CS, Weihl CC, Purdy JG, Gygi SP, Raman M
Nature communications 2023 Feb 6;14(1):638

STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses.

Vila IK, Chamma H, Steer A, Saccas M, Taffoni C, Turtoi E, Reinert LS, Hussain S, Marines J, Jin L, Bonnefont X, Hubert M, Schwartz O, Paludan SR, Van Simaeys G, Doumont G, Sobhian B, Vlachakis D, Turtoi A, Laguette N
Cell metabolism 2022 Jan 4;34(1):125-139.e8

Increased lipogenesis is critical for self-renewal and growth of breast cancer stem cells: Impact of omega-3 fatty acids.

Luo H, Chen CY, Li X, Zhang X, Su CW, Liu Y, Cao T, Hao L, Wang M, Kang JX
Stem cells (Dayton, Ohio) 2021 Dec;39(12):1660-1670

Identification of FADS1 Through Common Gene Expression Profiles for Predicting Survival in Patients with Bladder Cancer.

Jiao F, Sun H, Yang Q, Sun H, Wang Z, Liu M, Chen J
Cancer management and research 2020;12:8325-8339

Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer.

Lee JY, Nam M, Son HY, Hyun K, Jang SY, Kim JW, Kim MW, Jung Y, Jang E, Yoon SJ, Kim J, Kim J, Seo J, Min JK, Oh KJ, Han BS, Kim WK, Bae KH, Song J, Kim J, Huh YM, Hwang GS, Lee EW, Lee SC
Proceedings of the National Academy of Sciences of the United States of America 2020 Dec 22;117(51):32433-32442

Reduced Expression of FADS1 Predicts Worse Prognosis in Non-Small-Cell Lung Cancer.

Wang D, Lin Y, Gao B, Yan S, Wu H, Li Y, Wu Q, Wei Y
Journal of Cancer 2016;7(10):1226-32

In vivo MRS assessment of altered fatty acyl unsaturation in liver tumor formation of a TGF alpha/c-myc transgenic mouse model.

Griffitts J, Tesiram Y, Reid GE, Saunders D, Floyd RA, Towner RA
Journal of lipid research 2009 Apr;50(4):611-22

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse brain tissue were subjected to SDS PAGE followed by western blot with 10627-1-AP(FADS1 antibody) at dilution of 1:1000
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The FADS1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human FADS1. This antibody recognizes human, mouse antigen. The FADS1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 10627-1-AP.pdf

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