19655-1-AP

antibody from Proteintech Group

Targeting: SIRT2 SIR2L

Provider product page for 19655-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [61]
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Product number: 19655-1-AP - Provider product page
Provider: Proteintech Group
Product name: SIRT2-Specific antibody
Antibody type: Polyclonal
Description: KD/KO validated SIRT2-Specific antibody (Cat. #19655-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SIRT2 protein structure - 19655-1-AP shown in red.

Submitted references Silent information regulator 2 deficiency exacerbates chronic cold exposure-induced colonic injury and p65 activation in mice.

Guo J, Zhang H, Hu H, Zhao T, Ji H, Ma L, Lu J, Yuan J, Xu B
Gene 2024 May 20;907:148276

The SP1/SIRT1/ACLY signaling axis mediates fatty acid oxidation in renal ischemia-reperfusion-induced renal fibrosis.

Wu H, Wang L, Kang P, Zhou X, Li W, Xia Z
International immunopharmacology 2024 May 10;132:112002

SIRT2-mediated deacetylation of ACLY promotes the progression of oesophageal squamous cell carcinoma.

Zhang X, Xu Y, Li S, Qin Y, Zhu G, Zhang Q, Zhang Y, Guan F, Fan T, Liu H
Journal of cellular and molecular medicine 2024 Mar;28(6):e18129

Tau induces inflammasome activation and microgliosis through acetylating NLRP3.

Zhang L, Gai Y, Liu Y, Meng D, Zeng Y, Luo Y, Zhang H, Wang Z, Yang M, Li Y, Liu Y, Lai Y, Yang J, Wu G, Chen Y, Zhu J, Liu S, Yu T, Zeng J, Wang J, Zhu D, Wang X, Lan X, Liu R
Clinical and translational medicine 2024 Mar;14(3):e1623

Kinesin KIFC3 is essential for microtubule stability and cytokinesis in oocyte meiosis.

Ju JQ, Zhang HL, Wang Y, Hu LL, Sun SC
Cell communication and signaling : CCS 2024 Mar 29;22(1):199

Acetylation of ELMO1 correlates with Rac1 activity and colorectal cancer progress.

Li C, Yi J, Jie H, Liu Z, Li S, Zeng Z, Zhou Y
Experimental cell research 2024 Jun 1;439(1):114068

GITR exacerbates lysophosphatidylcholine-induced macrophage pyroptosis in sepsis via posttranslational regulation of NLRP3.

Liang S, Zhou J, Cao C, Liu Y, Ming S, Liu X, Shang Y, Lao J, Peng Q, Yang J, Wu M
Cellular & molecular immunology 2024 Jul;21(7):674-688

Sirt6 regulates the proliferation of neural precursor cells and cortical neurogenesis in mice.

Wei Y, Wang X, Ma Z, Xiang P, Liu G, Yin B, Hou L, Shu P, Liu W, Peng X
iScience 2024 Feb 16;27(2):108706

Spinal sirtuin 2 attenuates bone cancer pain by deacetylating FoxO3a.

Yang C, Kang F, Huang X, Wu W, Hou G, Zheng K, Han M, Kan B, Zhang Z, Li J
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167129

SIRT2 regulates apoptosis by inducing mitophagy in sheep cumulus cells.

Fang X, Xia W, Qi Y, Yu Y, Sun Q, Zhang D, Zhou Z, Qin T, Tao C, Li J
Theriogenology 2024 Apr 1;218:163-173

Label-free quantitative proteomic analyses of mouse astrocytes provides insight into the host response mechanism at different developmental stages of Toxoplasma gondii.

Xie H, Sun H, Dong H, Dai L, Xu H, Zhang L, Wang Q, Zhang J, Zhao G, Xu C, Yin K
PLoS neglected tropical diseases 2023 Sep;17(9):e0011102

SIRT2 counteracts primate cardiac aging via deacetylation of STAT3 that silences CDKN2B.

Ye Y, Yang K, Liu H, Yu Y, Song M, Huang D, Lei J, Zhang Y, Liu Z, Chu Q, Fan Y, Zhang S, Jing Y, Esteban CR, Wang S, Belmonte JCI, Qu J, Zhang W, Liu GH
Nature aging 2023 Oct;3(10):1269-1287

A metabolite from commensal Candida albicans enhances the bactericidal activity of macrophages and protects against sepsis.

Gu P, Liu R, Yang Q, Xie L, Wei R, Li J, Mei F, Chen T, Zeng Z, He Y, Zhou H, Peng H, Nandakumar KS, Chu H, Jiang Y, Gong W, Chen Y, Schnabl B, Chen P
Cellular & molecular immunology 2023 Oct;20(10):1156-1170

Role of SIRT2 in intestinal barrier under cold exposure.

Guo J, Xu J, Chen L, Chen Z, Hu H, Nie J, Yuan J, Ma L, Lu J, Ji H, Xu B
Life sciences 2023 Oct 1;330:121949

IPO7 promotes lipopolysaccharide-induced inflammatory responses in human dental pulp cells via p38 MAPK and NF-κB signaling pathways.

Xiao Z, Zhang Y, She Y, Yuan G, Yang G
Molecular immunology 2023 Nov;163:116-126

NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency.

Sun C, Seranova E, Cohen MA, Chipara M, Roberts J, Astuti D, Palhegyi AM, Acharjee A, Sedlackova L, Kataura T, Otten EG, Panda PK, Lara-Reyna S, Korsgen ME, Kauffman KJ, Huerta-Uribe A, Zatyka M, Silva LFSE, Torresi J, Zhang S, Hughes GW, Ward C, Kuechler ER, Cartwright D, Trushin S, Trushina E, Sahay G, Buganim Y, Lavery GG, Gsponer J, Anderson DG, Frickel EM, Rosenstock TR, Barrett T, Maddocks ODK, Tennant DA, Wang H, Jaenisch R, Korolchuk VI, Sarkar S
Cell reports 2023 May 30;42(5):112372

SIRT2 Deficiency Aggravates Diet-Induced Nonalcoholic Fatty Liver Disease through Modulating Gut Microbiota and Metabolites.

Li X, Du Y, Xue C, Kang X, Sun C, Peng H, Fang L, Han Y, Xu X, Zhao C
International journal of molecular sciences 2023 May 18;24(10)

N(6)-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice.

Wang X, Ding Y, Li R, Zhang R, Ge X, Gao R, Wang M, Huang Y, Zhang F, Zhao B, Liao W, Du J
Nature communications 2023 Mar 2;14(1):1185

Neuro death through autophagy via the acetylation of FoxO1 by SIRT2 in the hippocampus of mice in a autism spectrum disorder mice model.

Guo L, Jiang ZM, Zhan YJ, Pan W, Wu QW, Song FX, Zhou X, Zhou XY, Liu LJ, Wang JT
Journal of cellular physiology 2023 Jun;238(6):1275-1287

PGAM5 deacetylation mediated by SIRT2 facilitates lipid metabolism and liver cancer proliferation.

Fu G, Li ST, Jiang Z, Mao Q, Xiong N, Li X, Hao Y, Zhang H
Acta biochimica et biophysica Sinica 2023 Aug 15;55(9):1370-1379

Cold exposure-induced endoplasmic reticulum stress regulates autophagy through the SIRT2/FoxO1 signaling pathway.

Guo J, Nie J, Chen Z, Wang X, Hu H, Xu J, Lu J, Ma L, Ji H, Yuan J, Xu B
Journal of cellular physiology 2022 Oct;237(10):3960-3970

METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.

Li Y, He X, Lu X, Gong Z, Li Q, Zhang L, Yang R, Wu C, Huang J, Ding J, He Y, Liu W, Chen C, Cao B, Zhou D, Shi Y, Chen J, Wang C, Zhang S, Zhang J, Ye J, You H
Nature communications 2022 Oct 26;13(1):6350

SIRT2 promotes the viability, invasion and metastasis of osteosarcoma cells by inhibiting the degradation of Snail.

Tian Y, Liu R, Hou X, Gao Z, Liu X, Zhang W
Cell death & disease 2022 Nov 7;13(11):935

Aberrant methylmalonylation underlies methylmalonic acidemia and is attenuated by an engineered sirtuin.

Head PE, Myung S, Chen Y, Schneller JL, Wang C, Duncan N, Hoffman P, Chang D, Gebremariam A, Gucek M, Manoli I, Venditti CP
Science translational medicine 2022 May 25;14(646):eabn4772

Proteomic profiling of kidney samples in patients with pure membranous and proliferative lupus nephritis.

Chen YY, Ding Y, Li LL, Han SS, Huang M, Wong CC, Yu F, Zhao MH
Lupus 2022 Jun;31(7):837-847

Colchicine Ameliorates Dilated Cardiomyopathy Via SIRT2-Mediated Suppression of NLRP3 Inflammasome Activation.

Sun X, Duan J, Gong C, Feng Y, Hu J, Gu R, Xu B
Journal of the American Heart Association 2022 Jul 5;11(13):e025266

Kinesin KIF15 regulates tubulin acetylation and spindle assembly checkpoint in mouse oocyte meiosis.

Zou YJ, Shan MM, Wan X, Liu JC, Zhang KH, Ju JQ, Xing CH, Sun SC
Cellular and molecular life sciences : CMLS 2022 Jul 14;79(8):422

Spatiotemporal dynamics of SIRT 1, 2 and 3 during in vitro maturation of bovine oocytes.

Ferreira AF, Machado-Simões J, Soares M, Sousa AP, Ramalho-Santos J, Almeida-Santos T
Theriogenology 2022 Jul 1;186:60-69

Response of the Sirtuin/PXR signaling pathway in Mugilogobius chulae exposed to environmentally relevant concentration Paracetamol.

Meinan X, Yimeng W, Chao W, Tianli T, Li J, Peng Y, Xiangping N
Aquatic toxicology (Amsterdam, Netherlands) 2022 Aug;249:106222

SIRT2 Is Critical for Sheep Oocyte Maturation through Regulating Function of Surrounding Granulosa Cells.

Fang X, Xia W, Li S, Qi Y, Liu M, Yu Y, Li H, Li M, Tao C, Wang Z, Li J
International journal of molecular sciences 2022 Apr 30;23(9)

Influence of psychostimulants and opioids on epigenetic modification of class III histone deacetylase (HDAC)-sirtuins in glial cells.

Sivalingam K, Doke M, Khan MA, Samikkannu T
Scientific reports 2021 Oct 29;11(1):21335

Oligodendrocytes enhance axonal energy metabolism by deacetylation of mitochondrial proteins through transcellular delivery of SIRT2.

Chamberlain KA, Huang N, Xie Y, LiCausi F, Li S, Li Y, Sheng ZH
Neuron 2021 Nov 3;109(21):3456-3472.e8

PHD Finger Protein 19 Promotes Cardiac Hypertrophy via Epigenetically Regulating SIRT2.

Gu W, Cheng Y, Wang S, Sun T, Li Z
Cardiovascular toxicology 2021 Jun;21(6):451-461

SIRT2-knockdown rescues GARS-induced Charcot-Marie-Tooth neuropathy.

Zhao Y, Xie L, Shen C, Qi Q, Qin Y, Xing J, Zhou D, Qi Y, Yan Z, Lin X, Dai R, Lin J, Yu W
Aging cell 2021 Jun;20(6):e13391

SIRT2 promotes murine melanoma progression through natural killer cell inhibition.

Zhang M, Acklin S, Gillenwater J, Du W, Patra M, Yu H, Xu B, Yu J, Xia F
Scientific reports 2021 Jun 21;11(1):12988

20-HETE synthesis inhibition attenuates traumatic brain injury-induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC-1α pathway: A translational study.

Cui W, Wu X, Shi Y, Guo W, Luo J, Liu H, Zheng L, Du Y, Wang P, Wang Q, Feng D, Ge S, Qu Y
Cell proliferation 2021 Feb;54(2):e12964

SIRT2 tyrosine nitration by peroxynitrite in response to renal ischemia/reperfusion injury.

Wang Y, Wu CJ, Du Y, Liu YQ, Cai JR, Wu XQ, Hu SQ
Free radical research 2021 Dec;55(11-12):1104-1118

Association of T2285C polymorphism in PARP1 gene coding region with its expression, activity and NSCLC risk along with prognosis.

Wang Y, Xia XB, Tang HZ, Cai JR, Shi XK, Ji HX, Yan XN, Xu T
Mutagenesis 2021 Aug 27;36(4):281-293

TSP50 promotes hepatocyte proliferation and tumour formation by activating glucose-6-phosphate dehydrogenase (G6PD).

Zhang X, Gao F, Ai H, Wang S, Song Z, Zheng L, Wang G, Sun Y, Bao Y
Cell proliferation 2021 Apr;54(4):e13015

A translational program that suppresses metabolism to shield the genome.

Balukoff NC, Ho JJD, Theodoridis PR, Wang M, Bokros M, Llanio LM, Krieger JR, Schatz JH, Lee S
Nature communications 2020 Nov 13;11(1):5755

SIRT2 protects peripheral neurons from cisplatin-induced injury by enhancing nucleotide excision repair.

Zhang M, Du W, Acklin S, Jin S, Xia F
The Journal of clinical investigation 2020 Jun 1;130(6):2953-2965

Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.

Fu Y, Sun Y, Wang M, Hou Y, Huang W, Zhou D, Wang Z, Yang S, Tang W, Zhen J, Li Y, Wang X, Liu M, Zhang Y, Wang B, Liu G, Yu X, Sun J, Zhang C, Yi F
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8

Sirtuin 2 Inhibition Attenuates Sevoflurane-Induced Learning and Memory Deficits in Developing Rats via Modulating Microglial Activation.

Wu Z, Zhang Y, Zhang Y, Zhao P
Cellular and molecular neurobiology 2020 Apr;40(3):437-446

Context-Dependent Roles for SIRT2 and SIRT3 in Tumor Development Upon Calorie Restriction or High Fat Diet.

Ahmed MA, O'Callaghan C, Chang ED, Jiang H, Vassilopoulos A
Frontiers in oncology 2019;9:1462

Comprehensive Analysis of Expression and Prognostic Value of Sirtuins in Ovarian Cancer.

Sun X, Wang S, Li Q
Frontiers in genetics 2019;10:879

SIRT2 functions in aging, autophagy, and apoptosis in post-maturation bovine oocytes.

Xu D, Jiang X, He H, Liu D, Yang L, Chen H, Wu L, Geng G, Li Q
Life sciences 2019 Sep 1;232:116639

PGC-1α acts as an mediator of Sirtuin2 to protect annulus fibrosus from apoptosis induced by oxidative stress through restraining mitophagy.

Xu WN, Yang RZ, Zheng HL, Yu W, Zheng XF, Li B, Jiang SD, Jiang LS
International journal of biological macromolecules 2019 Sep 1;136:1007-1017

SIRT2 Inhibition Results in Meiotic Arrest, Mitochondrial Dysfunction, and Disturbance of Redox Homeostasis during Bovine Oocyte Maturation.

Xu D, Wu L, Jiang X, Yang L, Cheng J, Chen H, Hua R, Geng G, Yang L, Li Q
International journal of molecular sciences 2019 Mar 18;20(6)

Key Role of Microtubule and Its Acetylation in a Zinc Oxide Nanoparticle-Mediated Lysosome-Autophagy System.

Liu J, Kang Y, Yin S, Chen A, Wu J, Liang H, Shao L
Small (Weinheim an der Bergstrasse, Germany) 2019 Jun;15(25):e1901073

RAB35 depletion affects spindle formation and actin-based spindle migration in mouse oocyte meiosis.

Zhang Y, Wan X, Wang HH, Pan MH, Pan ZN, Sun SC
Molecular human reproduction 2019 Jul 1;25(7):359-372

Sirtuin 2-mediated deacetylation of cyclin-dependent kinase 9 promotes STAT1 signaling in type I interferon responses.

Kosciuczuk EM, Mehrotra S, Saleiro D, Kroczynska B, Majchrzak-Kita B, Lisowski P, Driehaus C, Rogalska A, Turner A, Lienhoop T, Gius D, Fish EN, Vassilopoulos A, Platanias LC
The Journal of biological chemistry 2019 Jan 18;294(3):827-837

Rab23/Kif17 regulate meiotic progression in oocytes by modulating tubulin acetylation and actin dynamics.

Wang HH, Zhang Y, Tang F, Pan MH, Wan X, Li XH, Sun SC
Development (Cambridge, England) 2019 Feb 4;146(3)

SIRT2 knockout exacerbates insulin resistance in high fat-fed mice.

Lantier L, Williams AS, Hughey CC, Bracy DP, James FD, Ansari MA, Gius D, Wasserman DH
PloS one 2018;13(12):e0208634

Kif18a regulates Sirt2-mediated tubulin acetylation for spindle organization during mouse oocyte meiosis.

Tang F, Pan MH, Wan X, Lu Y, Zhang Y, Sun SC
Cell division 2018;13:9

NQO1 regulates mitotic progression and response to mitotic stress through modulating SIRT2 activity.

Kang HJ, Song HY, Ahmed MA, Guo Y, Zhang M, Chen C, Cristofanilli M, Horiuchi D, Vassilopoulos A
Free radical biology & medicine 2018 Oct;126:358-371

HDAC6 inhibition protects cardiomyocytes against doxorubicin-induced acute damage by improving α-tubulin acetylation.

Song R, Yang Y, Lei H, Wang G, Huang Y, Xue W, Wang Y, Yao L, Zhu Y
Journal of molecular and cellular cardiology 2018 Nov;124:58-69

Overexpression of FOXQ1 enhances anti-senescence and migration effects of human umbilical cord mesenchymal stem cells in vitro and in vivo.

Zhang T, Wang P, Liu Y, Zhou J, Shi Z, Cheng K, Huang T, Wang X, Yang GL, Yang B, Ma S, Guan F
Cell and tissue research 2018 Aug;373(2):379-393

Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.

Liu M, Liang K, Zhen J, Zhou M, Wang X, Wang Z, Wei X, Zhang Y, Sun Y, Zhou Z, Su H, Zhang C, Li N, Gao C, Peng J, Yi F
Nature communications 2017 Sep 4;8(1):413

Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke.

Xie XQ, Zhang P, Tian B, Chen XQ
Molecular neurobiology 2017 Nov;54(9):7251-7261

Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dysregulates Mitophagy.

Liu G, Park SH, Imbesi M, Nathan WJ, Zou X, Zhu Y, Jiang H, Parisiadou L, Gius D
Antioxidants & redox signaling 2017 May 20;26(15):849-863

RCCD1 depletion attenuates TGF-β-induced EMT and cell migration by stabilizing cytoskeletal microtubules in NSCLC cells.

Wu J, He Z, Yang XM, Li KL, Wang DL, Sun FL
Cancer letters 2017 Aug 1;400:18-29

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The SIRT2-Specific antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human SIRT2-Specific. This antibody recognizes human, mouse, rat antigen. The SIRT2-Specific antibody has been validated for the following applications: ELISA, IHC, WB, IF analysis.
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