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- Antibody Data
- Antigen structure
- References [17]
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- Product number
- 66410-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- SIRT2 antibody
- Antibody type
- Monoclonal
- Description
- SIRT2 antibody (Cat. #66410-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat, pig and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat, Porcine
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1D8G10
- Vial size
- 20ul, 150ul
Submitted references Lactylation Enhances the Activity of Lactate Dehydrogenase A and Promotes the Chemoresistance to Cisplatin Through Facilitating DNA Nonhomologous End Junction in Lung Adenocarcinoma.
GCLC desuccinylation regulated by oxidative stress protects human cancer cells from ferroptosis.
Deacetylation of BAP31 by sirtuin 2 attenuates apoptosis of hepatocytes induced by endoplasmic reticulum stress, in chronic alcoholic liver injury.
S-ketamine Alleviates Neuroinflammation and Attenuates Lipopolysaccharide-Induced Depression Via Targeting SIRT2.
Sirtuin 1-mediated recruitment of non-structural protein 1 to glucocorticoid receptor induces glucocorticoid insensitivity post RSV infection.
SIRT2 suppresses aging-associated cGAS activation and protects aged mice from severe COVID-19.
SIRT2 Promotes NLRP3-Mediated Microglia Pyroptosis and Neuroinflammation via FOXO3a Pathway After Subarachnoid Hemorrhage.
Identification of Circulating Inflammatory Proteins Associated with Calcific Aortic Valve Stenosis by Multiplex Analysis.
FBXO31 is upregulated by METTL3 to promote pancreatic cancer progression via regulating SIRT2 ubiquitination and degradation.
Oxidative stress and regulation of adipogenic differentiation capacity by sirtuins in adipose stem cells derived from female patients of advancing age.
Spinal sirtuin 2 attenuates bone cancer pain by deacetylating FoxO3a.
Development of a multiplex assay to assess activated p300/CBP in circulating prostate tumor cells.
SIRT2 promotes cell proliferation and migration through mediating ERK1/2 activation and lactosylceramide accumulation in prostate cancer.
Bacterial infection promotes tumorigenesis of colorectal cancer via regulating CDC42 acetylation.
Proteomic analysis of the effects of caffeine in a neonatal rat model of hypoxic-ischemic white matter damage.
Nicotinamide riboside alleviates cisplatin-induced peripheral neuropathy via SIRT2 activation.
A redox-mediated conformational change in NQO1 controls binding to microtubules and α-tubulin acetylation.
Li J, Xun W, Wang X, Luo R, Hu Q, Zhou Z, Yuan J, Wang Y, Wan X, Zhao T, Han T, Wang JB
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(3):e10733
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(3):e10733
GCLC desuccinylation regulated by oxidative stress protects human cancer cells from ferroptosis.
Chen Z, Niu K, Li M, Deng Y, Zhang J, Wei D, Wang J, Zhao Y
Cell death and differentiation 2025 Sep;32(9):1679-1690
Cell death and differentiation 2025 Sep;32(9):1679-1690
Deacetylation of BAP31 by sirtuin 2 attenuates apoptosis of hepatocytes induced by endoplasmic reticulum stress, in chronic alcoholic liver injury.
Wang S, Wang Y, Shan W, Li G, Yan R, Wang Z, Zhao Y, Yao J, Zhang N
British journal of pharmacology 2025 Oct;182(20):5023-5037
British journal of pharmacology 2025 Oct;182(20):5023-5037
S-ketamine Alleviates Neuroinflammation and Attenuates Lipopolysaccharide-Induced Depression Via Targeting SIRT2.
Lin C, Zhou X, Li M, Zhang C, Zhai H, Li H, Wang H, Wang X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(23):e2416481
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(23):e2416481
Sirtuin 1-mediated recruitment of non-structural protein 1 to glucocorticoid receptor induces glucocorticoid insensitivity post RSV infection.
Che S, Long X, Mo S, Jiang Z, Xie X, Liu E, Xie J
International journal of biological macromolecules 2025 Aug;320(Pt 1):145811
International journal of biological macromolecules 2025 Aug;320(Pt 1):145811
SIRT2 suppresses aging-associated cGAS activation and protects aged mice from severe COVID-19.
Barthez M, Xue B, Zheng J, Wang Y, Song Z, Mu WC, Wang CL, Guo J, Yang F, Ma Y, Wei X, Ye C, Sims N, Martinez-Sobrido L, Perlman S, Chen D
Cell reports 2025 Apr 22;44(4):115562
Cell reports 2025 Apr 22;44(4):115562
SIRT2 Promotes NLRP3-Mediated Microglia Pyroptosis and Neuroinflammation via FOXO3a Pathway After Subarachnoid Hemorrhage.
Sun JQ, Sheng B, Gao S, Liu XZ, Cui Y, Peng Z, Chen XX, Ding PF, Zhuang Z, Wu LY, Hang CH, Li W
Journal of inflammation research 2024;17:11679-11698
Journal of inflammation research 2024;17:11679-11698
Identification of Circulating Inflammatory Proteins Associated with Calcific Aortic Valve Stenosis by Multiplex Analysis.
Lin R, Zhu Y, Chen W, Wang Z, Wang Y, Du J
Cardiovascular toxicology 2024 May;24(5):499-512
Cardiovascular toxicology 2024 May;24(5):499-512
FBXO31 is upregulated by METTL3 to promote pancreatic cancer progression via regulating SIRT2 ubiquitination and degradation.
Chen K, Wang Y, Dai X, Luo J, Hu S, Zhou Z, Shi J, Pan X, Cao T, Xia J, Li Y, Wang Z, Ma J
Cell death & disease 2024 Jan 12;15(1):37
Cell death & disease 2024 Jan 12;15(1):37
Oxidative stress and regulation of adipogenic differentiation capacity by sirtuins in adipose stem cells derived from female patients of advancing age.
Bernhardt A, Jamil A, Morshed MT, Ponnath P, Gille V, Stephan N, Sauer H, Wartenberg M
Scientific reports 2024 Aug 27;14(1):19885
Scientific reports 2024 Aug 27;14(1):19885
Spinal sirtuin 2 attenuates bone cancer pain by deacetylating FoxO3a.
Yang C, Kang F, Huang X, Wu W, Hou G, Zheng K, Han M, Kan B, Zhang Z, Li J
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167129
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167129
Development of a multiplex assay to assess activated p300/CBP in circulating prostate tumor cells.
Filon M, Yang B, Purohit TA, Schehr J, Singh A, Bigarella M, Lewis P, Denu J, Lang J, Jarrard DF
Oncotarget 2023 Jul 20;14:738-746
Oncotarget 2023 Jul 20;14:738-746
SIRT2 promotes cell proliferation and migration through mediating ERK1/2 activation and lactosylceramide accumulation in prostate cancer.
Lin R, Yang Y, Wu E, Zhou M, Wang S, Zhang Q
The Prostate 2023 Jan;83(1):71-81
The Prostate 2023 Jan;83(1):71-81
Bacterial infection promotes tumorigenesis of colorectal cancer via regulating CDC42 acetylation.
Wang DN, Ni JJ, Li JH, Gao YQ, Ni FJ, Zhang ZZ, Fang JY, Lu J, Yao YF
PLoS pathogens 2023 Feb;19(2):e1011189
PLoS pathogens 2023 Feb;19(2):e1011189
Proteomic analysis of the effects of caffeine in a neonatal rat model of hypoxic-ischemic white matter damage.
Yang L, Yu X, Zhang Y, Liu N, Li D, Xue X, Fu J
CNS neuroscience & therapeutics 2022 Jul;28(7):1019-1032
CNS neuroscience & therapeutics 2022 Jul;28(7):1019-1032
Nicotinamide riboside alleviates cisplatin-induced peripheral neuropathy via SIRT2 activation.
Acklin S, Sadhukhan R, Du W, Patra M, Cholia R, Xia F
Neuro-oncology advances 2022 Jan-Dec;4(1):vdac101
Neuro-oncology advances 2022 Jan-Dec;4(1):vdac101
A redox-mediated conformational change in NQO1 controls binding to microtubules and α-tubulin acetylation.
Siegel D, Bersie S, Harris P, Di Francesco A, Armstrong M, Reisdorph N, Bernier M, de Cabo R, Fritz K, Ross D
Redox biology 2021 Feb;39:101840
Redox biology 2021 Feb;39:101840
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