617102

antibody from BioLegend
Targeting: MAP2 MAP2A, MAP2B, MAP2C
Provider product page for 617102
Western blot
Immunohistochemistry

Antibody data

Product number
617102 - Provider product page
Provider
BioLegend
Product name
Purified anti-Dystroglycan Phospho (Tyr893)
Antibody type
Polyclonal
Antigen
Modified peptide
Description
Dystroglycan (also known as dystrophin-associated glycoprotein 1) is a member of the dystroglycan family that contains the WWW binding motif PPxY. This protein has α and β subunits with approximate molecular weights of 156 kD and 43-50 kD, respectively. The dystroglycan β subunit is an integral membrane protein, the α subunit is a ubiquitously expressed extracellular protein. Muscle and non-muscle isoforms differ by carbohydrate moieties (not protein sequence). Dystroglycan functions as an adhesion molecule responsible for interactions between extracellular matrix and the subsarcolemmal cytoskeleton. Dsytroglycan binds to lamin in the matrix and dystrophin in the cytoskeleton; phosphorylation regulates the association of interacting proteins. Dystroglycan binds to utrophin when unphosphorylated; c-Src, Fyn, Csk, NCK, and SHC when phosphorylated. Dystroglycan interacts with dystrophin through the WW domain. The Poly6171 antibody recognizes human phosphorylated dystroglycan (Tyr893) and has been shown to be useful for Western blotting.
Reactivity
Human
Host
Rabbit
Conjugate
Unconjugated
Vial size
200 µl
Storage
Upon receipt, store frozen at -20° C.
MAP2 protein structure - 617102 shown in red.