AGTO-G058S

antibody from Creative Biolabs

Targeting: PTPRZ1 phosphacan, PTP18, PTPRZ, PTPZ, RPTPB

Functional assay (Recommended by provider)

Antibody Data

Product number

AGTO-G058S

Provider

Creative Biolabs

Product name

Anti-PTPRZ1 immunotoxin 7E4B11 (IgG)-Sap

Antibody type

Monoclonal

Description

This immunotoxin was achieved by conjugating/fusing the Anti-PTPRZ1 monoclonal antibody to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of glioblastoma.

Reactivity

Human

Host

Mouse

Antibody clone number

7E4B11