Antibody data

Product number
312604 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#312604, RRID:AB_2296486
Product name
FITC anti-human CD158b (KIR2DL2/L3, NKAT2)
Antibody type
Monoclonal
Antigen
CD158b (KIR2DL2/L3, NKAT2)
Description
The DX27 monoclonal antibody reacts with a common epitope of KIR2DL2 (CD158b1, p58.2), KIR2DL3 (CD158b2, p58.3), and KIR2DS2 (CD158j, p50.2). It is expressed on natural killer cells and a subset of T cells. KIR-NKAT2 is a member of the immunoglobulin superfamily containing two immunoglobulin C2-type domains. Both variants and alternative isoforms of KIR-NKAT2 have been reported. The interaction of KIR-NKAT2 with specific HLA-C antigens on a target cell (HLA-Cw1, HLA-Cw3, HLA-Cw7 alleles, for example) inhibits cytotoxicity and prevents target cell lysis and death. The interactions between KIR and MHC class I are thought to be important in NK cell and T cell regulation following antigen stimulation. The absence of ligands for KIRs may lower the threshold for activation through activating receptors and increase inflammation and susceptibility to autoimmune disease.
Reactivity
Human
Host
Mouse
Conjugate
Green dye
Isotype
IgG
Vial size
100 tests
Storage
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
KIR2DL2 protein structure - 312604 shown in red.