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- References [26]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 13422-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13422-1-AP, RRID:AB_2168314
- Product name
- PPP3CA antibody
- Antibody type
- Polyclonal
- Description
- PPP3CA antibody (Cat. #13422-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The role of ASIC2 in glioma progression: implications for prognosis and therapeutic targeting.
Transducin-like enhancer of split 3 protects against lipopolysaccharide-induced inflammation through DEAD-box helicase 5-activating transcription factor 1-protein phosphatase 2 regulatory subunit 5A signaling.
HSP90α facilitates the dephosphorylation of DRP1 at the Ser637 residue, thereby promoting NLRP3 inflammasome activation and exacerbating brain injury in sepsis.
Mesenchymal Stem Cell-Derived Exosomes Inhibit Stim1-Orai1 Signaling and Calcium Overload-Induced Mitochondrial Damage of Follicular Helper T Cells in Lupus.
The axis of miR-30a/AIF-1/TRPC6/calcineurin A/NFAT2 regulated the death modalities and inflammation of renal tubular epithelial cells in diabetic kidney disease via exosome.
Activation of ERK/MAPK signaling by MAZ through transcriptional repression of PPP3CA to promote osteoclastogenesis and osteoporosis progression: Functions and mechanisms.
DEC1 deficiency promotes osteoclastic activity by augmenting NFATc1 signaling via transactivation and the Ca(2+)/calcineurin pathway.
Calcium-mediated mitochondrial fission and mitophagy drive glycolysis to facilitate arterivirus proliferation.
IMPDH2 dephosphorylation under FGFR signaling promotes S-phase progression and tumor growth.
Calcineurin governs baseline and homeostatic regulations of non-rapid eye movement sleep in mice.
Calcium blockers protect against sensory epithelial damage and hearing loss in Cx26-cKO mice.
Epithelial sodium channel in dendritic cells participates in high-fat-induced inflammatory responses.
PP2B-Dependent Cerebellar Plasticity Sets the Amplitude of the Vestibulo-ocular Reflex during Juvenile Development.
Dietary Taurine Supplementation Improves the Meat Quality, Muscle Fiber Type, and Mitochondrial Function of Finishing Pigs.
Activation of Kir4.1/Kir5.1 contributes to the cyclosporin A-induced stimulation of the renal NaCl cotransporter and hyperkalemic hypertension.
Taurine promotes muscle fiber type transformation through CaN/NFATc1 signaling in porcine myoblasts.
CDN1163 alleviates SERCA2 dysfunction-induced pulmonary vascular remodeling by inhibiting the phenotypic transition of pulmonary artery smooth muscle cells.
A recurrent SHANK1 mutation implicated in autism spectrum disorder causes autistic-like core behaviors in mice via downregulation of mGluR1-IP3R1-calcium signaling.
The Effect of Cyclosporine A on Proteins Controlling Intracellular Calcium Concentration in Breast Cancer Cells.
MicroRNA-30 regulates left ventricular hypertrophy in chronic kidney disease.
Stachydrine hydrochloride suppresses phenylephrine-induced pathological cardiac hypertrophy by inhibiting the calcineurin/nuclear factor of activated T-cell signalling pathway.
Transcriptional Study Revealed That Boron Supplementation May Alter the Immune-Related Genes Through MAPK Signaling in Ostrich Chick Thymus.
Effect of Hypoxia on the Muscle Fiber Switching Signal Pathways CnA/NFATc1 and Myostatin in Mouse Myocytes.
Major contribution of the 3/6/7 class of TRPC channels to myocardial ischemia/reperfusion and cellular hypoxia/reoxygenation injuries.
Inhibition of Calcineurin A by FK506 Suppresses Seizures and Reduces the Expression of GluN2B in Membrane Fraction.
Calcineurin β protects brain after injury by activating the unfolded protein response.
Tian W, Wang Y, Wang Z, Peng F, Sun J, Qi H, Zhang Z, Wang P, Qiao S, Wang H, Dong J
PeerJ 2026;14:e20583
PeerJ 2026;14:e20583
Transducin-like enhancer of split 3 protects against lipopolysaccharide-induced inflammation through DEAD-box helicase 5-activating transcription factor 1-protein phosphatase 2 regulatory subunit 5A signaling.
Fan D, Zhong Y, Dong Y, Du M, Huang K, Li X
Journal of advanced research 2026 Jan;79:661-677
Journal of advanced research 2026 Jan;79:661-677
HSP90α facilitates the dephosphorylation of DRP1 at the Ser637 residue, thereby promoting NLRP3 inflammasome activation and exacerbating brain injury in sepsis.
Yang H, Zhou X, Zhang B, Shan Y, Jin Y, Pan E, Xu D, Fan L, Zhao P, Sun Y, Dong J
Free radical biology & medicine 2026 Feb 16;244:45-67
Free radical biology & medicine 2026 Feb 16;244:45-67
Mesenchymal Stem Cell-Derived Exosomes Inhibit Stim1-Orai1 Signaling and Calcium Overload-Induced Mitochondrial Damage of Follicular Helper T Cells in Lupus.
Wang Y, Xiang Q, Wu Y, Zhang X, Huang Z, Hou Y, Wang Y, Yang J, Wan W, Zou H, Yang X
Biomaterials research 2025;29:0255
Biomaterials research 2025;29:0255
The axis of miR-30a/AIF-1/TRPC6/calcineurin A/NFAT2 regulated the death modalities and inflammation of renal tubular epithelial cells in diabetic kidney disease via exosome.
Hao J, Wang S, Guo X, Guo X, Hao L
Life sciences 2025 Sep 15;377:123760
Life sciences 2025 Sep 15;377:123760
Activation of ERK/MAPK signaling by MAZ through transcriptional repression of PPP3CA to promote osteoclastogenesis and osteoporosis progression: Functions and mechanisms.
Shang X, Hu W, Zhang L, Wei R
Tissue & cell 2025 Oct;96:103028
Tissue & cell 2025 Oct;96:103028
DEC1 deficiency promotes osteoclastic activity by augmenting NFATc1 signaling via transactivation and the Ca(2+)/calcineurin pathway.
Wang H, Guan Y, Lin L, Qiang Z, Huo Y, Zhu L, Yan B, Shao S, Liu W, Yang J
Biochemical pharmacology 2025 Mar;233:116754
Biochemical pharmacology 2025 Mar;233:116754
Calcium-mediated mitochondrial fission and mitophagy drive glycolysis to facilitate arterivirus proliferation.
Sun Z, Ma Z, Cao W, Jiang C, Guo L, Liu K, Gao Y, Bai J, Pi J, Jiang P, Liu X
PLoS pathogens 2025 Jan;21(1):e1012872
PLoS pathogens 2025 Jan;21(1):e1012872
IMPDH2 dephosphorylation under FGFR signaling promotes S-phase progression and tumor growth.
Zhou B, Zhao Q, Hou G, He J, Sha N, Zheng K, Peng H, Wang W, Zhou Y, Chen T, Jiang Y
Cell reports 2025 Jan 28;44(1):115116
Cell reports 2025 Jan 28;44(1):115116
Calcineurin governs baseline and homeostatic regulations of non-rapid eye movement sleep in mice.
Yin X, Zhang Z, Zhou R, Zuo P, Sang D, Zhou S, Shi B, Chen L, Wu C, Guo Y, Wang F, Zhang EE, Li Q, Yanagisawa M, Liu Q
Proceedings of the National Academy of Sciences of the United States of America 2025 Jan 28;122(4):e2418317122
Proceedings of the National Academy of Sciences of the United States of America 2025 Jan 28;122(4):e2418317122
Calcium blockers protect against sensory epithelial damage and hearing loss in Cx26-cKO mice.
Bai X, Liao B, Hu WH, Wang MQ, Chen XB, Liu YH, Sun Y, Xu K
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Dec;193:118829
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Dec;193:118829
Epithelial sodium channel in dendritic cells participates in high-fat-induced inflammatory responses.
Li X, Zhou SL, Bai L, Yu CL, Niu N
Molecular biology reports 2025 Aug 30;52(1):856
Molecular biology reports 2025 Aug 30;52(1):856
PP2B-Dependent Cerebellar Plasticity Sets the Amplitude of the Vestibulo-ocular Reflex during Juvenile Development.
Wu B, Post L, Lin Z, Schonewille M
The Journal of neuroscience : the official journal of the Society for Neuroscience 2024 Apr 24;44(17)
The Journal of neuroscience : the official journal of the Society for Neuroscience 2024 Apr 24;44(17)
Dietary Taurine Supplementation Improves the Meat Quality, Muscle Fiber Type, and Mitochondrial Function of Finishing Pigs.
An W, Huang Z, Mao Z, Qiao T, Jia G, Zhao H, Liu G, Chen X
Journal of agricultural and food chemistry 2023 Oct 18;71(41):15331-15340
Journal of agricultural and food chemistry 2023 Oct 18;71(41):15331-15340
Activation of Kir4.1/Kir5.1 contributes to the cyclosporin A-induced stimulation of the renal NaCl cotransporter and hyperkalemic hypertension.
Gao ZX, Zhou R, Li MY, Li ST, Mao ZH, Shu TT, Liu DW, Liu ZS, Wu P
Acta physiologica (Oxford, England) 2023 Jun;238(2):e13948
Acta physiologica (Oxford, England) 2023 Jun;238(2):e13948
Taurine promotes muscle fiber type transformation through CaN/NFATc1 signaling in porcine myoblasts.
An W, Huang Z, Mao Z, Jia G, Zhao H, Liu G, Chen X
Journal of cellular physiology 2023 Dec;238(12):2879-2887
Journal of cellular physiology 2023 Dec;238(12):2879-2887
CDN1163 alleviates SERCA2 dysfunction-induced pulmonary vascular remodeling by inhibiting the phenotypic transition of pulmonary artery smooth muscle cells.
Yu W, Zhang Q, Qiu Y, Chen H, Huang X, Xiao L, Xu G, Li S, Hu P, Tong X
Clinical and experimental hypertension (New York, N.Y. : 1993) 2023 Dec 31;45(1):2272062
Clinical and experimental hypertension (New York, N.Y. : 1993) 2023 Dec 31;45(1):2272062
A recurrent SHANK1 mutation implicated in autism spectrum disorder causes autistic-like core behaviors in mice via downregulation of mGluR1-IP3R1-calcium signaling.
Qin Y, Du Y, Chen L, Liu Y, Xu W, Liu Y, Li Y, Leng J, Wang Y, Zhang XY, Feng J, Zhang F, Jin L, Qiu Z, Gong X, Wang H
Molecular psychiatry 2022 Jul;27(7):2985-2998
Molecular psychiatry 2022 Jul;27(7):2985-2998
The Effect of Cyclosporine A on Proteins Controlling Intracellular Calcium Concentration in Breast Cancer Cells.
Caner A, Onal MG, Bitgen N, Sezer G
The Journal of membrane biology 2022 Feb;255(1):33-39
The Journal of membrane biology 2022 Feb;255(1):33-39
MicroRNA-30 regulates left ventricular hypertrophy in chronic kidney disease.
Bao J, Lu Y, She Q, Dou W, Tang R, Xu X, Zhang M, Zhu L, Zhou Q, Li H, Zhou G, Yang Z, Shi S, Liu Z, Zheng C
JCI insight 2021 May 24;6(10)
JCI insight 2021 May 24;6(10)
Stachydrine hydrochloride suppresses phenylephrine-induced pathological cardiac hypertrophy by inhibiting the calcineurin/nuclear factor of activated T-cell signalling pathway.
Zheng J, Tian J, Wang S, Hu P, Wu Q, Shan X, Zhao P, Zhang C, Guo W, Xu M, Chen H, Lu R
European journal of pharmacology 2020 Sep 15;883:173386
European journal of pharmacology 2020 Sep 15;883:173386
Transcriptional Study Revealed That Boron Supplementation May Alter the Immune-Related Genes Through MAPK Signaling in Ostrich Chick Thymus.
Xiao K, Yang K, Wang J, Sun P, Huang H, Khaliq H, Naeem MA, Zhong J, Peng K
Biological trace element research 2019 May;189(1):209-223
Biological trace element research 2019 May;189(1):209-223
Effect of Hypoxia on the Muscle Fiber Switching Signal Pathways CnA/NFATc1 and Myostatin in Mouse Myocytes.
Lixin L, Juan W, Yun B, Jingwei L, Xiuju Y, Xiaomao L, Zhiwei Z, Xiaoyan H, Yanjun D, Hongquan L, Haidong W
Acta histochemica 2019 Jul;121(5):539-545
Acta histochemica 2019 Jul;121(5):539-545
Major contribution of the 3/6/7 class of TRPC channels to myocardial ischemia/reperfusion and cellular hypoxia/reoxygenation injuries.
He X, Li S, Liu B, Susperreguy S, Formoso K, Yao J, Kang J, Shi A, Birnbaumer L, Liao Y
Proceedings of the National Academy of Sciences of the United States of America 2017 Jun 6;114(23):E4582-E4591
Proceedings of the National Academy of Sciences of the United States of America 2017 Jun 6;114(23):E4582-E4591
Inhibition of Calcineurin A by FK506 Suppresses Seizures and Reduces the Expression of GluN2B in Membrane Fraction.
Wen Y, Fu P, Wu K, Si K, Xie Y, Dan W, Zhan Y, Shi Q
Neurochemical research 2017 Aug;42(8):2154-2166
Neurochemical research 2017 Aug;42(8):2154-2166
Calcineurin β protects brain after injury by activating the unfolded protein response.
Chen Y, Holstein DM, Aime S, Bollo M, Lechleiter JD
Neurobiology of disease 2016 Oct;94:139-56
Neurobiology of disease 2016 Oct;94:139-56
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 13422-1-AP(PPP3CA antibody) at dilution of 1:1500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human cervical cancer using 13422-1-AP(PPP3CA antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PPP3CA antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PPP3CA. This antibody recognizes human, mouse, rat antigen. The PPP3CA antibody has been validated for the following applications: ELISA, WB, IHC analysis.
