CABLES1

This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Description

Cdk5 and Abl enzyme substrate 1

Tissue specificity

Tissue enhanced (brain)

Subcell location

Nucleoplasm, Nuclear bodies

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

18 (23134564 - 23260467)

Ensembl ID

ENSG00000134508  (ver. 103.38)

Orthologs

Mouse Cables1: ENSMUSG00000040957

UniProt

Q8TDN4

neXtProt

NX_Q8TDN4

Human splice variants
Mouse splice variants

Protein structure