21774-1-AP
antibody from Proteintech Group
Targeting: CACNA1C
CACH2, CACN2, CACNL1A1, Cav1.2, CCHL1A1, LQT8, TS
Antibody data
- Antibody Data
- Antigen structure
- References [34]
- Comments [0]
- Validations [0]
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Validation data
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- Product number
- 21774-1-AP - Provider product page

- Provider
- Proteintech Group
- Product name
- L-VOCC antibody
- Antibody type
- Polyclonal
- Description
- L-VOCC antibody (Cat. #21774-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references α-Synuclein expression is required for somatodendritic dopamine release and immediate early gene induction.
A bioinspired anisotropic anti-inflammatory scaffold enhances spinal nerve regeneration and neural circuit reconstruction via FGF13/Ca(2+)/CaMK2A/CREB pathway.
Cross-Species evidence for hippocampal CACNA1C as a therapeutic target for alcohol use disorder.
NMDA-Type Glutamate Receptor Activation Promotes Ischemic Arrhythmias by Targeting the AKT1-TBX3-Nav1.5 Axis.
Cinnamaldehyde prevents coronary artery spasm by down-regulating the function and expression of voltage-gated Ca(2+) channels and Ca(2+) -activated Cl(-) channels in the arterial smooth muscle cells.
Deficiency of SCAMP5 Triggers Pancreatic β-Cell Secretory Dysfunction and Apoptosis.
A New Method for Antispastic Effect in Coronary Artery Bypass Grafts by Using a L- and T-Type Calcium Channel Blocker Efonidipine.
Crotonaldehyde paralyzes arteries by inducing impairment of ion channels, vascular histiocytic injury, overproduction of reactive oxygen species, mitochondrial damage, and autophagy.
Empagliflozin Ameliorates Atrial and Ventricular Remodeling and Arrhythmogenesis in an Overweight Rabbit Model.
Development and clinical validation of a seven-gene signature based on tumor stem cell-related genes to predict ovarian cancer prognosis.
Anji white tea relaxes precontracted arteries, represses voltage-gated Ca(2+) channels and voltage-gated K(+) channels in the arterial smooth muscle cells: Comparison with green tea main component (-)-epigallocatechin gallate.
Endothelin-1 potentiated constriction in preeclampsia placental veins: Role of ETAR/ETBR/CaV1.2/CALD1.
Quantitative proteomics analysis reveals the pathogenesis of obstructed defecation syndrome caused by abnormal expression of dystrophin.
Patient-specific iPSC-derived cardiomyocytes reveal variable phenotypic severity of Brugada syndrome.
Berberine attenuates sunitinib-induced cardiac dysfunction by normalizing calcium regulation disorder via SGK1 activation.
In vitro fertilization with frozen embryo transfer increased histamine-mediated contractile sensitivity via PKCβ in human umbilical vein.
Perinatal Fat-Diets Increased Angiotensin II-Mediated Ca(2+) through PKC-L-Type Calcium Channel Axis in Resistance Arteries via Agtr1a-Prkcb Gene Methylation.
Pinocembrin attenuates susceptibility to atrial fibrillation in rats with pulmonary arterial hypertension.
Chronic Administration of COVID-19 Drugs Fluvoxamine and Lopinavir Shortens Action Potential Duration by Inhibiting the Human Ether-à-go-go-Related Gene and Cav1.2.
Cytosolic peptides encoding Ca(V)1 C-termini downregulate the calcium channel activity-neuritogenesis coupling.
Calcium released by osteoclastic resorption stimulates autocrine/paracrine activities in local osteogenic cells to promote coupled bone formation.
Anthracycline-Induced Atrial Structural and Electrical Remodeling Characterizes Early Cardiotoxicity and Contributes to Atrial Conductive Instability and Dysfunction.
Pinocembrin alleviates the susceptibility to atrial fibrillation in isoproterenol-induced rats.
Harm of circadian misalignment to the hearts of the adolescent wistar rats.
Pinocembrin mediates antiarrhythmic effects in rats with isoproterenol-induced cardiac remodeling.
Methylation-reprogrammed CHRM3 results in vascular dysfunction in the human umbilical vein following IVF-ET†.
Exosomal miR-29b found in aqueous humour mediates calcium signaling in diabetic patients with cataract.
Interleukin-6-Mediated-Ca(2+) Handling Abnormalities Contributes to Atrial Fibrillation in Sterile Pericarditis Rats.
Evidence of Ventricular Arrhythmogenicity and Cardiac Sympathetic Hyperinnervation in Early Cirrhotic Cardiomyopathy.
Effects of Angiotensin Receptor-Neprilysin Inhibitor in Arrhythmogenicity Following Left Atrial Appendage Closure in an Animal Model.
Prenatal hypoxia attenuated contraction of offspring coronary artery associated with decreased PKCβ Ser(660) phosphorylation and intracellular calcium.
In utero hypoxia altered Ang II-induced contraction via PKCβ in fetal cerebral arteries.
Quercetin Attenuates Ethanol-Induced Iron Uptake and Myocardial Injury by Regulating the Angiotensin II-L-Type Calcium Channel.
Protective role and mechanism of snakegourd peel against myocardial infarction in rats.
Choi SJ, Frank A, Ben-Johny M, Tang G, Bendig J, Fanourakis S, Hobson BD, Ramalingam N, Dettmer U, Kanter E, Sulzer D, Mosharov EV
Science advances 2026 Jan 30;12(5):eady6978
Science advances 2026 Jan 30;12(5):eady6978
A bioinspired anisotropic anti-inflammatory scaffold enhances spinal nerve regeneration and neural circuit reconstruction via FGF13/Ca(2+)/CaMK2A/CREB pathway.
Jiang M, Lu W, Zhuang J, Song J, Zhao Y, Zhou C, Zhou Y, Shu W, Zhu Z, Jiang L, Wu P, Wu A, Sheng S, Zhu S, Wang Z
Materials today. Bio 2026 Apr;37:102929
Materials today. Bio 2026 Apr;37:102929
Cross-Species evidence for hippocampal CACNA1C as a therapeutic target for alcohol use disorder.
Pareek T, Pham LM, O'Donovan SM, Zamarripa CA, Allen Iv O, Freeman KB, Platt DM, Grant KA, Pantazopoulos H, Gisabella B
Translational psychiatry 2026 Apr 17;
Translational psychiatry 2026 Apr 17;
NMDA-Type Glutamate Receptor Activation Promotes Ischemic Arrhythmias by Targeting the AKT1-TBX3-Nav1.5 Axis.
He Y, Zhang H, Zhang Q, Sun Z, Sun X, Xia L, Zheng L, Wang L
Acta physiologica (Oxford, England) 2025 Sep;241(9):e70085
Acta physiologica (Oxford, England) 2025 Sep;241(9):e70085
Cinnamaldehyde prevents coronary artery spasm by down-regulating the function and expression of voltage-gated Ca(2+) channels and Ca(2+) -activated Cl(-) channels in the arterial smooth muscle cells.
Yang X, Xu X, Liu Y, Wang Y, Hou X, Cao J, Zhang M
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Jul;188:118213
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Jul;188:118213
Deficiency of SCAMP5 Triggers Pancreatic β-Cell Secretory Dysfunction and Apoptosis.
Zhang Y, Tang D, Yang C, Lin C, Yuan Y, He M, Chen Y, Mao Z, Ying Y, Ma X, Kong X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e03072
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e03072
A New Method for Antispastic Effect in Coronary Artery Bypass Grafts by Using a L- and T-Type Calcium Channel Blocker Efonidipine.
Yin XY, Hou HT, Li MR, Yang Q, He GW
Basic & clinical pharmacology & toxicology 2025 Aug;137(2):e70077
Basic & clinical pharmacology & toxicology 2025 Aug;137(2):e70077
Crotonaldehyde paralyzes arteries by inducing impairment of ion channels, vascular histiocytic injury, overproduction of reactive oxygen species, mitochondrial damage, and autophagy.
Yang X, Xu X, Shi X, Wang Y, Hou X, Liu Y, Zhang M
Ecotoxicology and environmental safety 2024 Oct 15;285:117083
Ecotoxicology and environmental safety 2024 Oct 15;285:117083
Empagliflozin Ameliorates Atrial and Ventricular Remodeling and Arrhythmogenesis in an Overweight Rabbit Model.
Cheng WH, Lo LW, Chou YH, Liu SH, Lin WL, Chen SA
Acta Cardiologica Sinica 2024 Nov;40(6):729-739
Acta Cardiologica Sinica 2024 Nov;40(6):729-739
Development and clinical validation of a seven-gene signature based on tumor stem cell-related genes to predict ovarian cancer prognosis.
Wang G, Liu X, You Y, Chen S, Chang X, Yang Q
Journal of ovarian research 2024 Mar 13;17(1):58
Journal of ovarian research 2024 Mar 13;17(1):58
Anji white tea relaxes precontracted arteries, represses voltage-gated Ca(2+) channels and voltage-gated K(+) channels in the arterial smooth muscle cells: Comparison with green tea main component (-)-epigallocatechin gallate.
Xu X, Fan Y, Yang X, Liu Y, Wang Y, Zhang J, Hou X, Fan Y, Zhang M
Journal of ethnopharmacology 2024 Jun 28;328:117855
Journal of ethnopharmacology 2024 Jun 28;328:117855
Endothelin-1 potentiated constriction in preeclampsia placental veins: Role of ETAR/ETBR/CaV1.2/CALD1.
Su H, Li M, Li N, Zhang Y, He Y, Zhang Z, Zhang Y, Gao Q, Xu Z, Tang J
Placenta 2024 Dec;158:165-174
Placenta 2024 Dec;158:165-174
Quantitative proteomics analysis reveals the pathogenesis of obstructed defecation syndrome caused by abnormal expression of dystrophin.
Li WZ, Xiong Y, Wang TK, Chen YY, Wan SL, Li LY, Xu M, Tong JJ, Qian Q, Jiang CQ, Liu WC
World journal of gastroenterology 2024 Dec 7;30(45):4817-4835
World journal of gastroenterology 2024 Dec 7;30(45):4817-4835
Patient-specific iPSC-derived cardiomyocytes reveal variable phenotypic severity of Brugada syndrome.
Sun Y, Su J, Wang X, Wang J, Guo F, Qiu H, Fan H, Cai D, Wang H, Lin M, Wang W, Feng Y, Fu G, Gong T, Liang P, Jiang C
EBioMedicine 2023 Sep;95:104741
EBioMedicine 2023 Sep;95:104741
Berberine attenuates sunitinib-induced cardiac dysfunction by normalizing calcium regulation disorder via SGK1 activation.
Li C, Wu W, Xing J, Yan W, Zhang J, Sun J, Zhang Z, Qiu S, Xu Y, Wang X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 May;175:113743
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 May;175:113743
In vitro fertilization with frozen embryo transfer increased histamine-mediated contractile sensitivity via PKCβ in human umbilical vein.
Tang J, Qi L, He Y, Li N, Zhang Z, Zhou X, Su H, Zheng Q, Zhang Y, Tao J, Xu Z
Reproductive biology and endocrinology : RB&E 2023 Jun 13;21(1):54
Reproductive biology and endocrinology : RB&E 2023 Jun 13;21(1):54
Perinatal Fat-Diets Increased Angiotensin II-Mediated Ca(2+) through PKC-L-Type Calcium Channel Axis in Resistance Arteries via Agtr1a-Prkcb Gene Methylation.
Zheng Q, He Y, Li L, Rui C, Li N, Zhang Y, Ye Y, Zhang Z, Yang X, Tang J, Xu Z
Nutrients 2023 Jan 3;15(1)
Nutrients 2023 Jan 3;15(1)
Pinocembrin attenuates susceptibility to atrial fibrillation in rats with pulmonary arterial hypertension.
Yi Y, Tianxin Y, Zhangchi L, Cui Z, Weiguo W, Bo Y
European journal of pharmacology 2023 Dec 5;960:176169
European journal of pharmacology 2023 Dec 5;960:176169
Chronic Administration of COVID-19 Drugs Fluvoxamine and Lopinavir Shortens Action Potential Duration by Inhibiting the Human Ether-à-go-go-Related Gene and Cav1.2.
Zheng Z, Cai D, Fu Y, Wang Y, Song Y, Lian J
Frontiers in pharmacology 2022;13:889713
Frontiers in pharmacology 2022;13:889713
Cytosolic peptides encoding Ca(V)1 C-termini downregulate the calcium channel activity-neuritogenesis coupling.
Yang Y, Yu Z, Geng J, Liu M, Liu N, Li P, Hong W, Yue S, Jiang H, Ge H, Qian F, Xiong W, Wang P, Song S, Li X, Fan Y, Liu X
Communications biology 2022 May 19;5(1):484
Communications biology 2022 May 19;5(1):484
Calcium released by osteoclastic resorption stimulates autocrine/paracrine activities in local osteogenic cells to promote coupled bone formation.
Ahmed ASI, Sheng MHC, Lau KW, Wilson SM, Wongworawat MD, Tang X, Ghahramanpouri M, Nehme A, Xu Y, Abdipour A, Zhang XB, Wasnik S, Baylink DJ
American journal of physiology. Cell physiology 2022 May 1;322(5):C977-C990
American journal of physiology. Cell physiology 2022 May 1;322(5):C977-C990
Anthracycline-Induced Atrial Structural and Electrical Remodeling Characterizes Early Cardiotoxicity and Contributes to Atrial Conductive Instability and Dysfunction.
Tan R, Cong T, Xu G, Hao Z, Liao J, Xie Y, Lin Y, Yang X, Li Q, Liu Y, Xia YL
Antioxidants & redox signaling 2022 Jul;37(1-3):19-39
Antioxidants & redox signaling 2022 Jul;37(1-3):19-39
Pinocembrin alleviates the susceptibility to atrial fibrillation in isoproterenol-induced rats.
Liu Z, Chen X, Ye T, Wan W, Yu Y, Zhang C, Yang B
Biochemical and biophysical research communications 2022 Dec 25;636(Pt 1):33-40
Biochemical and biophysical research communications 2022 Dec 25;636(Pt 1):33-40
Harm of circadian misalignment to the hearts of the adolescent wistar rats.
Wang Y, Hou Y, Song S, Zuo Y, Yu Y, Chi Y, Zhang T
Journal of translational medicine 2022 Aug 6;20(1):352
Journal of translational medicine 2022 Aug 6;20(1):352
Pinocembrin mediates antiarrhythmic effects in rats with isoproterenol-induced cardiac remodeling.
Chen X, Wan W, Ran Q, Ye T, Sun Y, Liu Z, Liu X, Shi S, Qu C, Zhang C, Yang B
European journal of pharmacology 2022 Apr 5;920:174799
European journal of pharmacology 2022 Apr 5;920:174799
Methylation-reprogrammed CHRM3 results in vascular dysfunction in the human umbilical vein following IVF-ET†.
Shi Y, Liu J, Zhu D, Lu L, Zhang M, Li W, Zeng H, Yu X, Guo J, Zhang Y, Zhou X, Gao Q, Xia F, Chen Y, Li M, Sun M
Biology of reproduction 2022 Apr 26;106(4):687-698
Biology of reproduction 2022 Apr 26;106(4):687-698
Exosomal miR-29b found in aqueous humour mediates calcium signaling in diabetic patients with cataract.
Gao C, Liu X, Fan F, Yang JN, Zhou XY, Mei HJ, Lin XL, Luo Y
International journal of ophthalmology 2021;14(10):1484-1491
International journal of ophthalmology 2021;14(10):1484-1491
Interleukin-6-Mediated-Ca(2+) Handling Abnormalities Contributes to Atrial Fibrillation in Sterile Pericarditis Rats.
Liao J, Zhang S, Yang S, Lu Y, Lu K, Wu Y, Wu Q, Zhao N, Dong Q, Chen L, Du Y
Frontiers in immunology 2021;12:758157
Frontiers in immunology 2021;12:758157
Evidence of Ventricular Arrhythmogenicity and Cardiac Sympathetic Hyperinnervation in Early Cirrhotic Cardiomyopathy.
Liu SH, Lo LW, Chou YH, Lin WL, Tsai TY, Cheng WH, Lin YJ, Chang SL, Hu YF, Chung FP, Huang HC, Chen SA
Frontiers in physiology 2021;12:719883
Frontiers in physiology 2021;12:719883
Effects of Angiotensin Receptor-Neprilysin Inhibitor in Arrhythmogenicity Following Left Atrial Appendage Closure in an Animal Model.
Cheng WH, Lugtu IC, Chang SL, Liu SH, Chen SA, Lo LW
Cardiovascular drugs and therapy 2021 Aug;35(4):759-768
Cardiovascular drugs and therapy 2021 Aug;35(4):759-768
Prenatal hypoxia attenuated contraction of offspring coronary artery associated with decreased PKCβ Ser(660) phosphorylation and intracellular calcium.
Chen X, Qi L, Su H, He Y, Li N, Gao Q, Li H, Xu T, Lu L, Xu Z, Tang J
Life sciences 2020 Nov 15;261:118364
Life sciences 2020 Nov 15;261:118364
In utero hypoxia altered Ang II-induced contraction via PKCβ in fetal cerebral arteries.
Su H, Chen X, Zhang Y, Qi L, He Y, Lv J, Zhang Y, Li X, Tang J, Xu Z
The Journal of endocrinology 2020 Jan;244(1):213-222
The Journal of endocrinology 2020 Jan;244(1):213-222
Quercetin Attenuates Ethanol-Induced Iron Uptake and Myocardial Injury by Regulating the Angiotensin II-L-Type Calcium Channel.
Guo X, Chen M, Zeng H, Liu P, Zhu X, Zhou F, Liu J, Zhang J, Dong Z, Tang Y, Gao C, Yao P
Molecular nutrition & food research 2018 Mar;62(5)
Molecular nutrition & food research 2018 Mar;62(5)
Protective role and mechanism of snakegourd peel against myocardial infarction in rats.
Yang G, Min D, Yan J, Yang M, Lin G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 Mar 15;42:18-24
Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 Mar 15;42:18-24
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