Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS8289 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- GM2A polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human GM2A.
- Description
- GM2-AP (GM2 ganglioside activator), also known as GM2A or SAP-3 (shingolipid activator protein 3), is a 193 amino acid protein that localizes to the lysosome. Existing as a small glycolipid transport protein, GM2-AP acts as a ganglioside-specific cofactor that, together with beta-hexosaminidase A (HEXA), stimulates the breakdown of glycolipid GA2 and ganglioside GM2 and is important for the degradation of proteins containing terminal N-acetyl hexosamines. Mutations in the gene encoding GM2-AP are the cause of GM2-gangliosidosis type AB (GM2GAB), which is also known as Tay-Sachs disease AB variant, and is an autosomal recessive disease that is characterized by ganglioside GM2 accumulation in the presence of both hexosaminidase A and B.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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