11426-1-AP

antibody from Proteintech Group

Targeting: HNRNPK CSBP, HNRPK, TUNP

Provider product page for 11426-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [37]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [1]

Submit

Product number: 11426-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11426-1-AP, RRID:AB_2264314
Product name: HNRNPK antibody
Antibody type: Polyclonal
Description: KD/KO validated HNRNPK antibody (Cat. #11426-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

HNRNPK protein structure - 11426-1-AP shown in red.

Submitted references LINC00571 drives tricarboxylic acid cycle metabolism in triple-negative breast cancer through HNRNPK/ILF2/IDH2 axis.

Xi Z, Huang H, Hu J, Yu Y, Ma X, Xu M, Ming J, Li L, Zhang H, Chen H, Huang T
Journal of experimental & clinical cancer research : CR 2024 Jan 18;43(1):22

Systematic analysis of RNA-binding proteins identifies targetable therapeutic vulnerabilities in osteosarcoma.

Zhou Y, Ray PS, Zhu J, Stein F, Rettel M, Sekaran T, Sahadevan S, Perez-Perri JI, Roth EK, Myklebost O, Meza-Zepeda LA, von Deimling A, Fu C, Brosig AN, Boye K, Nathrath M, Blattmann C, Lehner B, Hentze MW, Kulozik AE
Nature communications 2024 Apr 1;15(1):2810

c-Myc-induced long noncoding RNA MIRE cooperates with hnRNPK to stabilize ELF2 mRNA and promotes clear cell renal cell carcinogenesis.

Li B, Yao B, Guo X, Wang Z, Xie W, Wu X, Wang F, Mei Y
Cancer gene therapy 2023 Sep;30(9):1215-1226

HnRNP K regulates inflammatory gene expression by mediating splicing pattern of transcriptional factors.

Liu S, Duan Y, You R, Chen D, Tan J
Experimental biology and medicine (Maywood, N.J.) 2023 Sep;248(17):1479-1491

Activation of NLRP2 in Triple-Negative Breast Cancer sensitizes chemotherapeutic therapy through facilitating hnRNPK function.

Jin L, Li T, Hong Y, Mao R, Li X, Zhu C, Mu J, Zhou J, Pan L, Que Y, Xia Y, Zhang Y, Li S
Biochemical pharmacology 2023 Sep;215:115703

Characterization of the protein expression and localization of hnRNP family members during murine spermatogenesis.

Wang XL, Li JM, Yuan SQ
Asian journal of andrology 2023 May-Jun;25(3):314-321

CircFhit Modulates GABAergic Synaptic Transmission via Regulating the Parental Gene Fhit Expression in the Spinal Dorsal Horn in a Rat Model of Neuropathic Pain.

Xu T, Li ZY, Liu M, Zhang SB, Ding HH, Wu JY, Lin SY, Liu J, Wei JY, Zhang XQ, Xin WJ
Neuroscience bulletin 2023 Jun;39(6):947-961

MGCG regulates glioblastoma tumorigenicity via hnRNPK/ATG2A and promotes autophagy.

Chu F, Wu P, Mu M, Hu S, Niu C
Cell death & disease 2023 Jul 17;14(7):443

LncRNA BC promotes lung adenocarcinoma progression by modulating IMPAD1 alternative splicing.

Chen QW, Cai QQ, Yang Y, Dong S, Liu YY, Chen ZY, Kang CL, Qi B, Dong YW, Wu W, Zhuang LP, Shen YH, Meng ZQ, Wu XZ
Clinical and translational medicine 2023 Jan;13(1):e1129

Ac4C Enhances the Translation Efficiency of Vegfa mRNA and Mediates Central Sensitization in Spinal Dorsal Horn in Neuropathic Pain.

Xu T, Wang J, Wu Y, Wu JY, Lu WC, Liu M, Zhang SB, Xie D, Xin WJ, Xie JD
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(35):e2303113

N protein of PEDV plays chess game with host proteins by selective autophagy.

Zhai X, Kong N, Zhang Y, Song Y, Qin W, Yang X, Ye C, Ye M, Tong W, Liu C, Zheng H, Yu H, Zhang W, Yang X, Zhang G, Tong G, Shan T
Autophagy 2023 Aug;19(8):2338-2352

mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching.

Shin S, Han MJ, Jedrychowski MP, Zhang Z, Shokat KM, Plas DR, Dephoure N, Yoon SO
Cell reports 2023 Aug 29;42(8):112868

HNRNPK/CLCN3 axis facilitates the progression of LUAD through CAF-tumor interaction.

Li Y, Yang Y, Ma Q, Cheng H, Wang H, Ma C, Li F, Zhao S, Li X, Qi Y, Gu Z
International journal of biological sciences 2022;18(16):6084-6101

Seneca Valley Virus 3C (pro) Cleaves Heterogeneous Nuclear Ribonucleoprotein K to Facilitate Viral Replication.

Song J, Quan R, Wang D, Liu J
Frontiers in microbiology 2022;13:945443

The hnRNPK/A1/R/U Complex Regulates Gene Transcription and Translation and is a Favorable Prognostic Biomarker for Human Colorectal Adenocarcinoma.

Li Y, Wang H, Wan J, Ma Q, Qi Y, Gu Z
Frontiers in oncology 2022;12:845931

N4-acetylcytidine regulates the replication and pathogenicity of enterovirus 71.

Hao H, Liu W, Miao Y, Ma L, Yu B, Liu L, Yang C, Zhang K, Chen Z, Yang J, Zheng Z, Zhang B, Deng F, Gong P, Yuan J, Hu Z, Guan W
Nucleic acids research 2022 Sep 9;50(16):9339-9354

Long noncoding RNA SNHG8 promotes chemoresistance in gastric cancer via binding with hnRNPA1 and stabilizing TROY expression.

Zhu W, Tan L, Ma T, Yin Z, Gao J
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2022 Nov;54(11):1573-1582

hnRNP K Degrades Viral Nucleocapsid Protein and Induces Type I IFN Production to Inhibit Porcine Epidemic Diarrhea Virus Replication.

Qin W, Kong N, Wang C, Dong S, Zhai H, Zhai X, Yang X, Ye C, Ye M, Tong W, Liu C, Yu L, Zheng H, Yu H, Lan D, Zhang W, Tong G, Shan T
Journal of virology 2022 Nov 23;96(22):e0155522

LncRNA CRLM1 inhibits apoptosis and promotes metastasis through transcriptional regulation cooperated with hnRNPK in colorectal cancer.

Wang Z, Chen J, Sun F, Zhao X, Dong Y, Yu S, Li J, Liang H
Cell & bioscience 2022 Jul 30;12(1):120

Novel stress granule-like structures are induced via a paracrine mechanism during viral infection.

Iadevaia V, Burke JM, Eke L, Moller-Levet C, Parker R, Locker N
Journal of cell science 2022 Feb 15;135(4)

SGLT2 promotes pancreatic cancer progression by activating the Hippo signaling pathway via the hnRNPK-YAP1 axis.

Ren D, Sun Y, Zhang D, Li D, Liu Z, Jin X, Wu H
Cancer letters 2021 Oct 28;519:277-288

Transcriptome analysis using patient iPSC-derived skeletal myocytes: Bet1L as a new molecule possibly linked to neuromuscular junction degeneration in ALS.

Lynch EM, Robertson S, FitzGibbons C, Reilly M, Switalski C, Eckardt A, Tey SR, Hayakawa K, Suzuki M
Experimental neurology 2021 Nov;345:113815

Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression.

Tian C, Abudoureyimu M, Lin X, Chu X, Wang R
Cell death & disease 2021 Nov 5;12(11):1047

METTL3 regulates heterochromatin in mouse embryonic stem cells.

Xu W, Li J, He C, Wen J, Ma H, Rong B, Diao J, Wang L, Wang J, Wu F, Tan L, Shi YG, Shi Y, Shen H
Nature 2021 Mar;591(7849):317-321

Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth.

Li WJ, He YH, Yang JJ, Hu GS, Lin YA, Ran T, Peng BL, Xie BL, Huang MF, Gao X, Huang HH, Zhu HH, Ye F, Liu W
Nature communications 2021 Mar 29;12(1):1946

NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis.

Park MK, Zhang L, Min KW, Cho JH, Yeh CC, Moon H, Hormaechea-Agulla D, Mun H, Ko S, Lee JW, Jathar S, Smith AS, Yao Y, Giang NT, Vu HH, Yan VC, Bridges MC, Kourtidis A, Muller F, Chang JH, Song SJ, Nakagawa S, Hirose T, Yoon JH, Song MS
Cell metabolism 2021 Dec 7;33(12):2380-2397.e9

In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs.

Sun L, Li P, Ju X, Rao J, Huang W, Ren L, Zhang S, Xiong T, Xu K, Zhou X, Gong M, Miska E, Ding Q, Wang J, Zhang QC
Cell 2021 Apr 1;184(7):1865-1883.e20

Capturing RNA-protein interaction via CRUIS.

Zhang Z, Sun W, Shi T, Lu P, Zhuang M, Liu JL
Nucleic acids research 2020 May 21;48(9):e52

CircFOXK2 Promotes Growth and Metastasis of Pancreatic Ductal Adenocarcinoma by Complexing with RNA-Binding Proteins and Sponging MiR-942.

Wong CH, Lou UK, Li Y, Chan SL, Tong JH, To KF, Chen Y
Cancer research 2020 Jun 1;80(11):2138-2149

hnRNP K Is a Novel Internal Ribosomal Entry Site-Transacting Factor That Negatively Regulates Foot-and-Mouth Disease Virus Translation and Replication and Is Antagonized by Viral 3C Protease.

Liu W, Yang D, Sun C, Wang H, Zhao B, Zhou G, Yu L
Journal of virology 2020 Aug 17;94(17)

Quantitative proteomic analysis of deer antler stem cells as a model of mammalian organ regeneration.

Dong Z, Coates D, Liu Q, Sun H, Li C
Journal of proteomics 2019 Mar 20;195:98-113

PRC1 collaborates with SMCHD1 to fold the X-chromosome and spread Xist RNA between chromosome compartments.

Wang CY, Colognori D, Sunwoo H, Wang D, Lee JT
Nature communications 2019 Jul 3;10(1):2950

Xist Deletional Analysis Reveals an Interdependency between Xist RNA and Polycomb Complexes for Spreading along the Inactive X.

Colognori D, Sunwoo H, Kriz AJ, Wang CY, Lee JT
Molecular cell 2019 Apr 4;74(1):101-117.e10

Proteomic characterization of the nucleolar linker histone H1 interaction network.

Szerlong HJ, Herman JA, Krause CM, DeLuca JG, Skoultchi A, Winger QA, Prenni JE, Hansen JC
Journal of molecular biology 2015 Jun 5;427(11):2056-71

Cytoplasmic hnRNPK interacts with GSK3β and is essential for the osteoclast differentiation.

Fan X, Xiong H, Wei J, Gao X, Feng Y, Liu X, Zhang G, He QY, Xu J, Liu L
Scientific reports 2015 Dec 7;5:17732

Identification and analysis of glycogen synthase kinase 3 beta1 interactome.

Gao X, Wang JY, Gao LM, Yin XF, Liu L
Cell biology international 2013 Aug;37(8):768-79

Identification of human host proteins contributing to H5N1 influenza virus propagation by membrane proteomics.

Liu C, Zhang A, Guo J, Yang J, Zhou H, Chen H, Jin M
Journal of proteome research 2012 Nov 2;11(11):5396-405

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 11426-1-AP(HNRNPK antibody) at dilution of 1:300
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using HNRNPK antibody 11426-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human breast cancer using 11426-1-AP(HNRNPK antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue