CABT-B9192

antibody from Creative Diagnostics

Targeting: DGKQ DAGK, DAGK4, DAGK7

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-B9192

Provider

Creative Diagnostics

Product name

Mouse anti-Human DGKIJ monoclonal antibody, clone 35

Antibody type

Monoclonal

Description

The protein kinase C pathway is a major signal transduction system that is activated upon stimulation of transmembrane receptors by hormones, neurotransmitters, and growth factors. Key mediators in this pathway are increased intracellular free Ca2+ levels and formation of diacylglycerol (DAG). DGKIJ (diacylglycerol kinase IJ) restricts PKC activation through the phosphorylation of DAG molecules that contain an unsaturated fatty acid at the sn-2 position to produce phosphatidic acid (PA). DGKIJ contains several regions that are found in signaling molecules where they function in lipid-protein and protein-protein interactions. A C-terminal catalytic domain, three CRDs (cysteine rich domains), a PH domain, and an N-terminal proline/glycine rich domain are structural features of DGKIJ. Six potential PKC phosphorylation sites lie between CRD3 and the PH domain. Cell-specific expression differentiate multiple isoforms of DGK. DGKIJ is expressed primarily within the cerebellar cortex and hippocampus of the brain, but is also found in the small intestine and liver. The presence of the RA (Ras-associating) domain suggests that DGKIJ may mediate activity of the Ras-like small GTP binding proteins.

Reactivity

Human, Mouse, Rat, Rabbit

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

35

Vial size

50ug, 150ug

Concentration

250 Ã×g/ml

Storage

Store undiluted at -20°C.