HPA056896

antibody from Atlas Antibodies

Targeting: TEAD4 EFTR-2, RTEF-1, TCF13L1, TEF-3, TEFR-1

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Chromatin Immunoprecipitation (Supportive data in Antibodypedia)

Antibody Data

Product number

HPA056896

Provider

Atlas Antibodies

Proper citation

Atlas Antibodies Cat#HPA056896, RRID:AB_2683268

Product name

Anti-TEAD4

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human TEAD4, Gene description: TEA domain family member 4, Alternative Gene Names: EFTR-2, RTEF-1, TCF13L1, TEF-3, TEFR-1, Validated applications: IHC, ICC, ChIP, Uniprot ID: Q15561, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.1 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

The multifaceted role of GCM1 during trophoblast differentiation in the human placenta

Jeyarajah M, Jaju Bhattad G, Kelly R, Baines K, Jaremek A, Yang F, Okae H, Arima T, Dumeaux V, Renaud S
Proceedings of the National Academy of Sciences 2022;119(49)

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Histone deacetylase 1 and 2 drive differentiation and fusion of progenitor cells in human placental trophoblasts

Jaju Bhattad G, Jeyarajah M, McGill M, Dumeaux V, Okae H, Arima T, Lajoie P, Bérubé N, Renaud S
Cell Death & Disease 2020;11(5)

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TEA Domain Transcription Factor 4 Is the Major Mediator of Yes-Associated Protein Oncogenic Activity in Mouse and Human Hepatoblastoma

Zhang J, Liu P, Tao J, Wang P, Zhang Y, Song X, Che L, Sumazin P, Ribback S, Kiss A, Schaff Z, Cigliano A, Dombrowski F, Cossu C, Pascale R, Calvisi D, Monga S, Chen X
The American Journal of Pathology 2019;189(5):1077-1090

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Comparative analysis of mouse and human placentae across gestation reveals species-specific regulators of placental development

Soncin F, Khater M, To C, Pizzo D, Farah O, Wakeland A, Arul Nambi Rajan K, Nelson K, Chang C, Moretto-Zita M, Natale D, Laurent L, Parast M
Development 2018;145(2)

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TEAD1/4 exerts oncogenic role and is negatively regulated by miR-4269 in gastric tumorigenesis.

Zhou Y, Huang T, Zhang J, Wong CC, Zhang B, Dong Y, Wu F, Tong JHM, Wu WKK, Cheng ASL, Yu J, Kang W, To KF
Oncogene 2017 Nov 23;36(47):6518-6530

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Human pluripotent stem cells as a model of trophoblast differentiation in both normal development and disease

Horii M, Li Y, Wakeland A, Pizzo D, Nelson K, Sabatini K, Laurent L, Liu Y, Parast M
Proceedings of the National Academy of Sciences 2016;113(27)

Chromatin Immunoprecipitation

Supportive validation

Submitted by

Atlas Antibodies (provider)

Main image

Experimental details

ChIP-Exo-Seq composite graph for Anti-TEAD4 (HPA056896, Lot 000041808) tested in K562 cells. Strand-specific reads (blue: forward, red: reverse) and IgG controls (black: forward, grey: reverse) are plotted against the distance from a composite set of reference binding sites. The antibody exhibits robust target enrichment compared to a non-specific IgG control and precisely reveals its structural organization around the binding site. Data generated by Prof. B. F. Pugh´s Lab at Cornell University.