12418-1-AP

antibody from Proteintech Group

Targeting: TEAD4 EFTR-2, RTEF-1, TCF13L1, TEF-3, TEFR-1

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Antibody Data

Product number

12418-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#12418-1-AP, RRID:AB_2203074

Product name

TEAD4 antibody

Antibody type

Polyclonal

Description

TEAD4 antibody (Cat. #12418-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

TEAD1 Enhances Exosome Secretion and Promotes Exosome-Mediated Tissue Regeneration.

Pu Y, Wan Y, Shi W, Li B, Zhang H, Wu J, Li L, Guo W, Ding C, Yang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 May;13(25):e14104

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Early-activated extracellular matrix proteins shape the metabolic and spatial dynamics of the kidney fibrotic microenvironment.

Gui Y, Li W, Liu JJ, Wang Y, Jones C, Bansal R, Mallari SM, Shaffer HW, Yu Y, Fu H, Tang TT, Liu S, Liu Y, Zhou D
Nature metabolism 2026 Mar;8(3):604-623

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Small Nucleolar RNA Snord17 Promotes Self-Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation.

Zhang P, Xu Y, Lan Y, Xiong Z, Yi Z, Wu R, Li C, Du Y, Guo H, Yang Y, Fan Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(13):e12029

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SiO(2) dust induces the transformation of lung fibroblasts to myofibroblasts by activating the S1P-RhoA-YAP signaling pathway.

Zhang H, Huang F, Guan L, Zeng M
Toxicology in vitro : an international journal published in association with BIBRA 2026 Jun;114:106229

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Escherichia coli promotes colorectal cancer metastasis by maintaining enhancer-promoter loops through releasing neutrophil extracellular traps.

Pan B, Yao Y, Zhang Z, Ye D, Wu H, Zhang X, Wang X, Tang N
Nature communications 2026 Feb 3;17(1)

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Liquid-liquid phase separation of EphB4 drives pulmonary hypertension via YAP activation.

Liu JY, Chen J, Chen QY, Li HB, Gui LX, Zhou J, Lin MJ
Cell reports 2026 Feb 24;45(2):116992

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Mesaconine alleviates hyperalgesia in CFA-induced mice by modulating YAP1 to suppress cell ferroptosis within the spinal cord.

Qiu Z, Zhang Z, Zhan G, Li C, Peng G, Tang S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157970

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Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple-Negative Breast Cancer by Disrupting the Hippo-YAP/TEAD4-PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation.

Shang Y, Si W, Zhang Y, Liu J, Zhang H, Li Y, Su H, Jiang W, Ding Z, Wang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 2;:e19006

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Targeting the NAT10/XIST/YAP1 Axis-Mediated Vascular Abnormalization Enhances Immune Checkpoint Blockade in Gastric Cancer.

Lei X, Zheng B, Peng Y, Zhang G, Cheng X, Li W, He J, Li F, Ling R, Fu Z, Yang Q, Ye G, Li G
International journal of biological sciences 2025;21(11):4997-5014

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Nano-Self-Assembled Particles Loaded with Aldehyde Dehydrogenase 2 Agonist Inhibit Ischemia-Reperfusion Injury of Transplanted Kidneys.

Hu Q, Lu Z, Yasen K, Liu A, Shi X, Ye Q, Zhong Z
ACS nano 2025 Oct 14;19(40):35853-35870

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Mechanical signal modulates prostate cancer immune escape by USP8-mediated ubiquitination-dependent degradation of PD-L1 and MHC-1.

Ke ZB, Chen JY, Xue YT, Lin B, Huang Q, Huang XY, Chen DN, Chen SH, Ye XJ, Zheng QS, Wei Y, Xue XY, Xu N
Cell death & disease 2025 May 23;16(1):413

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Improved Black Phosphorus Nanocomposite Hydrogel for Bone Defect Repairing: Mechanisms for Advancing Osteogenesis.

Wu A, Ma G, Chen Y, Gui H, Sun B, Zhang B, Liu Y, Zhang S, Lian G, Song D, Zhang D
Advanced healthcare materials 2025 Mar;14(7):e2404934

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Combining the NanaPPI Toolbox and AI-Driven Virtual Inhibitor Screening for the p53-MDM2 Interaction.

Liu H, Zhang H, Ding S, Xue Y, Du X, Han Z, Li Q, Gao YQ, Peng Q
Analytical chemistry 2025 Jul 29;97(29):15687-15697

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TEAD4 Transcriptionally Activates TRIB3 to Induce Ferroptosis Resistance through the MEK/ERK Signaling Pathway in Colorectal Cancer.

Wang J, Wu X
Gut and liver 2025 Jul 15;19(4):579-591

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TEAD4-mediated upregulation of LPAR3 augments hepatic stellate cell activation in portal hypertension.

Qi R, Chang Z, Zhao W, Qiu Y, Chang W, Zhang Y, Hu X, Li Z
Cell biology and toxicology 2025 Jul 1;41(1):110

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Integrative functional screen of genomic loci uncovers CCND2 and its genetic regulatory mechanism in colorectal cancer development.

Li B, Wu M, Geng H, Li Y, Chen Z, Lu Z, Chen X, Wang Q, Song S, Li X, Zhu X, Wei Y, Zhu Y, Miao X, Tian J, Liu J, Huang C, Yang X
Carcinogenesis 2025 Jan 20;46(1)

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Role of ferroptosis mediated by abnormal membrane structure in DEHP-induced reproductive injury.

Deng W, Zhao J, Wang X, Li D, Wang M, Zheng X, Wang R, Guo Q, Zhao P, Yan H, Shen L, Long C, Wei G, Wu S
Free radical biology & medicine 2025 Aug 1;235:150-161

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The YAP/TEAD4 transcriptional complex in intestinal macrophages promotes M2 polarization and alleviates DSS-induced colitis via the regulation of C/EBPβ.

Wang S, Zou F, Xu M, Wu Z, Xia P, Deng F
Scientific reports 2025 Apr 6;15(1):11796

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TEAD4 promoted proliferation and metastasis of gallbladder cancer by regulation of TMPRSS4.

Lin C, Wang C, Li M, Cai Z
Clinical & experimental metastasis 2025 Apr 11;42(3):22

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The TEAD4-DYNLL1 axis accelerates cell cycle progression and augments malignant properties of lung adenocarcinoma cells.

Li D, Wang A, Wang X, Shi M, Chen X, Lyu Y, Huang D
European journal of medical research 2025 Apr 1;30(1):221

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FATP5 modulates biological activity and lipid metabolism in prostate cancer through the TEAD4-mediated Hippo signaling.

Liu S, He Y, Gu Z
Frontiers in oncology 2024;14:1442911

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TEAD4 Activates PCSK9 to Promote Stomach Adenocarcinoma Cell Stemness through Fatty Acid Metabolism.

Xu D, Han G, Zhou X, Yong H, Jia Y, Zhao F, Shi H
Digestion 2024;105(4):243-256

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An agonist of the adenosine A(2A) receptor, CGS21680, promotes corneal epithelial wound healing via the YAP signalling pathway.

Sun Q, Jiang N, Yao R, Song Y, Li Z, Wang W, Chen J, Guo W
British journal of pharmacology 2024 Oct;181(19):3779-3795

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Natural compound library screening to identify berberine as a treatment for rheumatoid arthritis.

Zhang L, Tan M, Mao J, Zhang J, Wang XY, Zhang Y, Duo RX, Hao JY, Shen HL
Clinical rheumatology 2024 Mar;43(3):959-969

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Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis.

Zhao Y, Ning J, Teng H, Deng Y, Sheldon M, Shi L, Martinez C, Zhang J, Tian A, Sun Y, Nakagawa S, Yao F, Wang H, Ma L
Nature communications 2024 Mar 16;15(1):2384

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IGFBP7 promotes endothelial cell repair in the recovery phase of acute lung injury.

He R, Feng B, Zhang Y, Li Y, Wang D, Yu L
Clinical science (London, England : 1979) 2024 Jul 3;138(13):797-815

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Metformin: A promising clinical therapeutical approach for BPH treatment via inhibiting dysregulated steroid hormones-induced prostatic epithelial cells proliferation.

Yang T, Yuan J, Peng Y, Pang J, Qiu Z, Chen S, Huang Y, Jiang Z, Fan Y, Liu J, Wang T, Zhou X, Qian S, Song J, Xu Y, Lu Q, Yin X
Journal of pharmaceutical analysis 2024 Jan;14(1):52-68

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TT-10 may attenuate ibuprofen-induced ovarian injury in mice by activating COX2-PGE2 and inhibiting Hippo pathway.

Zeng H, Wang Q, Hu Z, Guo D, Yan Z, Fu H, Zhu Y
Reproductive toxicology (Elmsford, N.Y.) 2024 Jan;123:108499

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Epigenetic drug screening for trophoblast syncytialization reveals a novel role for MLL1 in regulating fetoplacental growth.

Wu J, Qin C, Tian F, Liu X, Hu J, Wu F, Chen C, Lin Y
BMC medicine 2024 Feb 5;22(1):57

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YAP/TAZ-TEAD activity promotes the malignant transformation of cervical intraepithelial neoplasia through enhancing the characteristics and Warburg effect of cancer stem cells.

Li S, Li X, Yang YB, Wu SF
Apoptosis : an international journal on programmed cell death 2024 Aug;29(7-8):1198-1210

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Upregulation of CYR61 by TGF-β and YAP signaling exerts a counter-suppression of hepatocellular carcinoma.

Zhang C, Wei W, Tu S, Liang B, Li C, Li Y, Luo W, Wu Y, Dai X, Wang Y, Zheng L, Hao L, Zhang C, Luo Z, Chen YG, Yan X
The Journal of biological chemistry 2024 Apr;300(4):107208

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Derivation of Arbas Cashmere Goat Induced Pluripotent Stem Cells in LCDM with Trophectoderm Lineage Differentiation and Interspecies Chimeric Abilities.

Liu F, Wang J, Yue Y, Li C, Zhang X, Xiang J, Wang H, Li X
International journal of molecular sciences 2023 Sep 29;24(19)

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A role of TRIM59 in pulmonary hypertension: modulating the protein ubiquitylation modification.

Liu Y, Zhu L, Ming Y, Wu Z, Zhang L, Chen Q, Qi Y
Journal of translational medicine 2023 Nov 17;21(1):821

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Long noncoding RNA Malat1 inhibits Tead3-Nfatc1-mediated osteoclastogenesis to suppress osteoporosis and bone metastasis.

Zhao Y, Teng H, Deng Y, Sheldon M, Martinez C, Zhang J, Tian A, Sun Y, Nakagawa S, Yao F, Wang H, Ma L
Research square 2023 Mar 20;

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YAP/TEAD1 and β-catenin/LEF1 synergistically induce estrogen receptor α to promote osteogenic differentiation of bone marrow stromal cells.

Wang P, Huang L, Yang F, Chen W, Bai D, Guo Y
MedComm 2023 Jun;4(3):e246

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Tea domain transcription factor TEAD4 mitigates TGF-β signaling and hepatocellular carcinoma progression independently of YAP.

Luo W, Li Y, Zeng Y, Li Y, Cheng M, Zhang C, Li F, Wu Y, Huang C, Yang X, Kremerskothen J, Zhang J, Zhang C, Tu S, Li Z, Luo Z, Lin Z, Yan X
Journal of molecular cell biology 2023 Jun 13;15(2)

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KIAA1429-mediated m6A modification of CHST11 promotes progression of diffuse large B-cell lymphoma by regulating Hippo-YAP pathway.

Chen X, Lu T, Cai Y, Han Y, Ding M, Chu Y, Zhou X, Wang X
Cellular & molecular biology letters 2023 Apr 19;28(1):32

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TEAD4 functions as a prognostic biomarker and triggers EMT via PI3K/AKT pathway in bladder cancer.

Chi M, Liu J, Mei C, Shi Y, Liu N, Jiang X, Liu C, Xue N, Hong H, Xie J, Sun X, Yin B, Meng X, Wang B
Journal of experimental & clinical cancer research : CR 2022 May 17;41(1):175

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A yes-associated protein 1- Notch1 receptor positive feedback loop promotes breast cancer lung metastasis by attenuating the bone morphogenetic protein 4-SMAD family member 1/5 signaling.

Zhao L, Lei J, Gu S, Zhang Y, Jing X, Wang L, Zhang L, Ning Q, Luo M, Qi Y, Zhao X, Shao S
Carcinogenesis 2022 Dec 31;43(12):1162-1175

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Systematic screening identifies a TEAD4-S100A13 axis modulating cisplatin sensitivity of oral squamous cell carcinoma cells.

Li R, Li W, He F, Zhang M, Luo H, Tang H
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2021 Oct;50(9):882-890

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YAP/TEAD4-induced KIF4A contributes to the progression and worse prognosis of esophageal squamous cell carcinoma.

Li Y, Zhu X, Yang M, Wang Y, Li J, Fang J, Guo W, Ma S, Guan F
Molecular carcinogenesis 2021 Jul;60(7):440-454

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NT5DC2 promotes leiomyosarcoma tumour cell growth via stabilizing unpalmitoylated TEAD4 and generating a positive feedback loop.

Hu B, Zhou S, Hu X, Zhang H, Lan X, Li M, Wang Y, Hu Q
Journal of cellular and molecular medicine 2021 Jul;25(13):5976-5987

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Down-regulation of interferon regulatory factor 2 binding protein 2 suppresses gastric cancer progression by negatively regulating connective tissue growth factor.

Yao Y, Wang Y, Li L, Xiang X, Li J, Chen J, Liu Z, Huang S, Xiong J, Deng J
Journal of cellular and molecular medicine 2019 Dec;23(12):8076-8089

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Thyroid hormone regulates muscle fiber type conversion via miR-133a1.

Zhang D, Wang X, Li Y, Zhao L, Lu M, Yao X, Xia H, Wang YC, Liu MF, Jiang J, Li X, Ying H
The Journal of cell biology 2014 Dec 22;207(6):753-66