BS7220

antibody from Bioworld Technology, Inc
Targeting: SDHA FP, SDH2, SDHF
Provider product page for BS7220
Western blot
Immunohistochemistry

Antibody data

Product number
BS7220 - Provider product page
Provider
Bioworld Technology, Inc
Product name
SDHA polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human SDHA.
Description
In aerobic respiration reactions, succinate dehydrogenase (SDH) catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol. Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB), and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. Mutations to these subunits cause mitochondrial dysfunction, corresponding to several distinct disorders. Mutations in the membrane bound components may cause hereditary paraganglioma, while SDHA mutations are associated with juvenile encephalopathy as well as Leigh Syndrome, a severe neurological disorder. Inactivating mutations in SDHB correlate with inherited, but not necessarily sporadic, cases of pheochromocytoma.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
SDHA protein structure - BS7220 shown in red.