14865-1-AP

antibody from Proteintech Group

Targeting: SDHA FP, SDH2, SDHF

Provider product page for 14865-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [48]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

Submit

Product number: 14865-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14865-1-AP, RRID:AB_11182164
Product name: SDHA antibody
Antibody type: Polyclonal
Description: KD/KO validated SDHA antibody (Cat. #14865-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SDHA protein structure - 14865-1-AP shown in red.

Submitted references The Protective Effect of 1,25(OH)₂D₃ on Myocardial Function is Mediated via Sirtuin 3-Regulated Fatty Acid Metabolism.

Yang J, Zhang Y, Pan Y, Sun C, Liu Z, Liu N, Fu Y, Li X, Li Y, Kong J
Frontiers in cell and developmental biology 2021;9:627135

Increased Expression of DNA2 Was Linked to Poor Prognosis in Breast Cancer.

Han Y, Zhang Z, Wang Z, Sun S
Disease markers 2021;2021:8860728

Celecoxib reverses the glioblastoma chemo-resistance to temozolomide through mitochondrial metabolism.

Yin D, Jin G, He H, Zhou W, Fan Z, Gong C, Zhao J, Xiong H
Aging 2021 Sep 8;13(17):21268-21282

The requirement for pyruvate dehydrogenase in leukemogenesis depends on cell lineage.

Jun S, Mahesula S, Mathews TP, Martin-Sandoval MS, Zhao Z, Piskounova E, Agathocleous M
Cell metabolism 2021 Sep 7;33(9):1777-1792.e8

Proteomic analysis demonstrates the role of the quality control protease LONP1 in mitochondrial protein aggregation.

Pollecker K, Sylvester M, Voos W
The Journal of biological chemistry 2021 Oct;297(4):101134

Global mitochondrial protein import proteomics reveal distinct regulation by translation and translocation machinery.

Schäfer JA, Bozkurt S, Michaelis JB, Klann K, Münch C
Molecular cell 2021 Nov 19;

Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk.

Wang XH, Xu S, Zhou XY, Zhao R, Lin Y, Cao J, Zang WD, Tao H, Xu W, Li MQ, Zhao SM, Jin LP, Zhao JY
Nature communications 2021 Jun 8;12(1):3428

Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination.

Oshima Y, Cartier E, Boyman L, Verhoeven N, Polster BM, Huang W, Kane M, Lederer WJ, Karbowski M
The Journal of cell biology 2021 Jun 7;220(6)

ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import.

Lin BC, Phung TH, Higgins NR, Greenslade JE, Prado MA, Finley D, Karbowski M, Polster BM, Monteiro MJ
Human molecular genetics 2021 Jun 17;30(13):1230-1246

Leber's Hereditary Optic Neuropathy Arising From the Synergy Between ND1 3635G>A Mutation and Mitochondrial YARS2 Mutations.

Jin X, Zhang J, Yi Q, Meng F, Yu J, Ji Y, Mo JQ, Tong Y, Jiang P, Guan MX
Investigative ophthalmology & visual science 2021 Jun 1;62(7):22

An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function.

Jin X, Zhang Z, Nie Z, Wang C, Meng F, Yi Q, Chen M, Sun J, Zou J, Jiang P, Guan MX
The Journal of biological chemistry 2021 Jan-Jun;296:100437

OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development.

Wu Z, Zuo M, Zeng L, Cui K, Liu B, Yan C, Chen L, Dong J, Shangguan F, Hu W, He H, Lu B, Song Z
EMBO reports 2021 Jan 7;22(1):e50827

Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response.

Wang W, Li J, Tan J, Wang M, Yang J, Zhang ZM, Li C, Basnakian AG, Tang HW, Perrimon N, Zhou Q
Nature communications 2021 Jan 20;12(1):476

Deficiency of β-carotene oxygenase 2 induces mitochondrial fragmentation and activates the STING-IRF3 pathway in the mouse hypothalamus.

Wu L, Guo X, Wong SY, Lu P, Hartson SD, Medeiros DM, Wang W, Clarke SL, Lucas EA, Smith BJ, Chowanadisai W, Lin D
The Journal of nutritional biochemistry 2021 Feb;88:108542

Spermine Protects Cardiomyocytes from High Glucose-Induced Energy Disturbance by Targeting the CaSR-gp78-Ubiquitin Proteasome System.

Wang Y, Wang Y, Li F, Zhang X, Li H, Yang G, Xu C, Wei C
Cardiovascular drugs and therapy 2021 Feb;35(1):73-85

Fumarate is a terminal electron acceptor in the mammalian electron transport chain.

Spinelli JB, Rosen PC, Sprenger HG, Puszynska AM, Mann JL, Roessler JM, Cangelosi AL, Henne A, Condon KJ, Zhang T, Kunchok T, Lewis CA, Chandel NS, Sabatini DM
Science (New York, N.Y.) 2021 Dec 3;374(6572):1227-1237

Tissue-specific expression atlas of murine mitochondrial tRNAs.

He Q, He X, Xiao Y, Zhao Q, Ye Z, Cui L, Chen Y, Guan MX
The Journal of biological chemistry 2021 Aug;297(2):100960

APOL1 risk variants affect podocyte lipid homeostasis and energy production in focal segmental glomerulosclerosis.

Ge M, Molina J, Ducasa GM, Mallela SK, Varona Santos J, Mitrofanova A, Kim JJ, Liu X, Sloan A, Mendez AJ, Banerjee S, Liu S, Szeto HH, Shin MK, Hoek M, Kopp JB, Fontanesi F, Merscher S, Fornoni A
Human molecular genetics 2021 Apr 26;30(3-4):182-197

Drp1-mediated mitochondrial fission contributes to baicalein-induced apoptosis and autophagy in lung cancer via activation of AMPK signaling pathway.

Deng X, Liu J, Liu L, Sun X, Huang J, Dong J
International journal of biological sciences 2020;16(8):1403-1416

Histochemical and immunohistochemical staining methods to visualize mitochondrial proteins and activity.

Franco-Iborra S, Tanji K
Methods in cell biology 2020;155:247-270

Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis.

Li ST, Huang, Shen S, Cai Y, Xing S, Wu G, Jiang Z, Hao Y, Yuan M, Wang N, Zhu L, Yan R, Yang D, Wang L, Liu Z, Hu X, Zhou R, Qu K, Li A, Duan X, Zhang H, Gao P
Nature metabolism 2020 Mar;2(3):256-269

p53/PGC‑1α‑mediated mitochondrial dysfunction promotes PC3 prostate cancer cell apoptosis.

Li J, Li Y, Chen L, Yu B, Xue Y, Guo R, Su J, Liu Y, Sun L
Molecular medicine reports 2020 Jul;22(1):155-164

Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis.

Lou F, Sun Y, Xu Z, Niu L, Wang Z, Deng S, Liu Z, Zhou H, Bai J, Yin Q, Cai X, Sun L, Wang H, Li Q, Wu Z, Chen X, Gu J, Shi YL, Tao W, Ginhoux F, Wang H
Immunity 2020 Jul 14;53(1):204-216.e10

Fluoride-induced renal dysfunction via respiratory chain complex abnormal expression and fusion elevation in mice.

Wang HW, Zhu SQ, Liu J, Miao CY, Zhang Y, Zhou BH
Chemosphere 2020 Jan;238:124607

Mitochondrial respiratory chain damage and mitochondrial fusion disorder are involved in liver dysfunction of fluoride-induced mice.

Wang HW, Liu J, Wei SS, Zhao WP, Zhu SQ, Zhou BH
Chemosphere 2020 Feb;241:125099

Ginkgolic Acids Impair Mitochondrial Function by Decreasing Mitochondrial Biogenesis and Promoting FUNDC1-Dependent Mitophagy.

Wang W, Wang M, Ruan Y, Tan J, Wang H, Yang T, Li J, Zhou Q
Journal of agricultural and food chemistry 2019 Sep 11;67(36):10097-10106

Artemisinin suppresses hepatocellular carcinoma cell growth, migration and invasion by targeting cellular bioenergetics and Hippo-YAP signaling.

Li Y, Lu J, Chen Q, Han S, Shao H, Chen P, Jin Q, Yang M, Shangguan F, Fei M, Wang L, Liu Y, Liu N, Lu B
Archives of toxicology 2019 Nov;93(11):3367-3383

Increase of core temperature affected the progression of kidney injury by repeated heat stress exposure.

Sato Y, Roncal-Jimenez CA, Andres-Hernando A, Jensen T, Tolan DR, Sanchez-Lozada LG, Newman LS, Butler-Dawson J, Sorensen C, Glaser J, Miyazaki M, Diaz HF, Ishimoto T, Kosugi T, Maruyama S, Garcia GE, Lanaspa MA, Johnson RJ
American journal of physiology. Renal physiology 2019 Nov 1;317(5):F1111-F1121

Benzoylaconine induces mitochondrial biogenesis in mice via activating AMPK signaling cascade.

Deng XH, Liu JJ, Sun XJ, Dong JC, Huang JH
Acta pharmacologica Sinica 2019 May;40(5):658-665

The combination of metformin and 2-deoxyglucose significantly inhibits cyst formation in miniature pigs with polycystic kidney disease.

Lian X, Wu X, Li Z, Zhang Y, Song K, Cai G, Li Q, Lin S, Chen X, Bai XY
British journal of pharmacology 2019 Mar;176(5):711-724

Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism.

Chen D, Zhang Z, Chen C, Yao S, Yang Q, Li F, He X, Ai C, Wang M, Guan MX
Nucleic acids research 2019 Jun 4;47(10):5341-5355

Mitochondrial respiratory chain dysfunction mediated by ROS is a primary point of fluoride-induced damage in Hepa1-6 cells.

Wang HW, Zhang Y, Tan PP, Jia LS, Chen Y, Zhou BH
Environmental pollution (Barking, Essex : 1987) 2019 Dec;255(Pt 3):113359

Promotion of Mitochondrial Biogenesis via Activation of AMPK-PGC1ɑ Signaling Pathway by Ginger (Zingiber officinale Roscoe) Extract, and Its Major Active Component 6-Gingerol.

Deng X, Zhang S, Wu J, Sun X, Shen Z, Dong J, Huang J
Journal of food science 2019 Aug;84(8):2101-2111

SIRT5-mediated SDHA desuccinylation promotes clear cell renal cell carcinoma tumorigenesis.

Ma Y, Qi Y, Wang L, Zheng Z, Zhang Y, Zheng J
Free radical biology & medicine 2019 Apr;134:458-467

Mitophagy Directs Muscle-Adipose Crosstalk to Alleviate Dietary Obesity.

Fu T, Xu Z, Liu L, Guo Q, Wu H, Liang X, Zhou D, Xiao L, Liu L, Liu Y, Zhu MS, Chen Q, Gan Z
Cell reports 2018 May 1;23(5):1357-1372

AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.

Luo H, Jiang M, Lian G, Liu Q, Shi M, Li TY, Song L, Ye J, He Y, Yao L, Zhang C, Lin ZZ, Zhang CS, Zhao TJ, Jia WP, Li P, Lin SY, Lin SC
Cell metabolism 2018 Apr 3;27(4):843-853.e6

Lack of β, β-carotene-9', 10'-oxygenase 2 leads to hepatic mitochondrial dysfunction and cellular oxidative stress in mice.

Wu L, Guo X, Hartson SD, Davis MA, He H, Medeiros DM, Wang W, Clarke SL, Lucas EA, Smith BJ, von Lintig J, Lin D
Molecular nutrition & food research 2017 May;61(5)

CUE domain-containing protein 2 promotes the Warburg effect and tumorigenesis.

Zhong X, Tian S, Zhang X, Diao X, Dong F, Yang J, Li Z, Sun L, Wang L, He X, Wu G, Hu X, Wang L, Song L, Zhang H, Pan X, Li A, Gao P
EMBO reports 2017 May;18(5):809-825

Calcium sensing receptor protects high glucose-induced energy metabolism disorder via blocking gp78-ubiquitin proteasome pathway.

Wang Y, Gao P, Wei C, Li H, Zhang L, Zhao Y, Wu B, Tian Y, Zhang W, Wu L, Wang R, Xu C
Cell death & disease 2017 May 18;8(5):e2799

The changes in glucose metabolism and cell proliferation in the kidneys of polycystic kidney disease mini-pig models.

Lian X, Zhao J, Wu X, Zhang Y, Li Q, Lin S, Bai XY, Chen X
Biochemical and biophysical research communications 2017 Jun 24;488(2):374-381

DJ-1 modulates mitochondrial response to oxidative stress: clues from a novel diagnosis of PARK7.

Di Nottia M, Masciullo M, Verrigni D, Petrillo S, Modoni A, Rizzo V, Di Giuda D, Rizza T, Niceta M, Torraco A, Bianchi M, Santoro M, Bentivoglio AR, Bertini E, Piemonte F, Carrozzo R, Silvestri G
Clinical genetics 2017 Jul;92(1):18-25

CYC1 Predicts Poor Prognosis in Patients with Breast Cancer.

Han Y, Sun S, Zhao M, Zhang Z, Gong S, Gao P, Liu J, Zhou J, Ma D, Gao Q, Wu P
Disease markers 2016;2016:3528064

Oral quercetin administration transiently protects respiratory function in dystrophin-deficient mice.

Selsby JT, Ballmann CG, Spaulding HR, Ross JW, Quindry JC
The Journal of physiology 2016 Oct 15;594(20):6037-6053

Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.

Li H, Ruan Y, Zhang K, Jian F, Hu C, Miao L, Gong L, Sun L, Zhang X, Chen S, Chen H, Liu D, Song Z
Cell death and differentiation 2016 Mar;23(3):380-92

COA7 (C1orf163/RESA1) mutations associated with mitochondrial leukoencephalopathy and cytochrome c oxidase deficiency.

Martinez Lyons A, Ardissone A, Reyes A, Robinson AJ, Moroni I, Ghezzi D, Fernandez-Vizarra E, Zeviani M
Journal of medical genetics 2016 Dec;53(12):846-849

Exercise Inducible Lactate Dehydrogenase B Regulates Mitochondrial Function in Skeletal Muscle.

Liang X, Liu L, Fu T, Zhou Q, Zhou D, Xiao L, Liu J, Kong Y, Xie H, Yi F, Lai L, Vega RB, Kelly DP, Smith SR, Gan Z
The Journal of biological chemistry 2016 Dec 2;291(49):25306-25318

EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.

Zhang J, Wang C, Chen X, Takada M, Fan C, Zheng X, Wen H, Liu Y, Wang C, Pestell RG, Aird KM, Kaelin WG Jr, Liu XS, Zhang Q
The EMBO journal 2015 Dec 2;34(23):2953-70

Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1.

Ma X, Li C, Sun L, Huang D, Li T, He X, Wu G, Yang Z, Zhong X, Song L, Gao P, Zhang H
Nature communications 2014 Oct 10;5:5212

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HEK-293 cells were subjected to SDS PAGE followed by western blot with 14865-1-AP(SDHA antibody) at dilution of 1:800
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The SDHA antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SDHA. This antibody recognizes human,mouse,rat antigen. The SDHA antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 14865-1-AP.pdf

: Show more