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- Antibody Data
- Antigen structure
- References [9]
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- Validations
- Immunohistochemistry [2]
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- Product number
- 20513-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- SPON2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SPON2 antibody (Cat. #20513-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Downregulation of the biological macromolecule Spondin-2 disrupts maternal-fetal immune tolerance and trophoblast invasion, driving unexplained recurrent pregnancy loss.
SPON2 acts as a tumor promoter in HR-positive/HER2-negative breast cancer by regulating β-catenin signaling.
Impaired natural killer cell maturation in lung adenocarcinoma driven by FABP4 and SPON2 downregulation through disrupted lipid metabolism.
Combining Spatial Transcriptomics, Pseudotime, and Machine Learning Enables Discovery of Biomarkers for Prostate Cancer.
Spatial immune scoring system predicts hepatocellular carcinoma recurrence.
Knockdown of SPON2 inhibits the growth of triple-negative breast cancer.
Integrative Analysis of DNA Methylation and Transcriptome Identifies a Predictive Epigenetic Signature Associated With Immune Infiltration in Gliomas.
Transcriptional Activation of Matricellular Protein Spondin2 (SPON2) by BRG1 in Vascular Endothelial Cells Promotes Macrophage Chemotaxis.
Spondin 2 promotes the proliferation, migration and invasion of gastric cancer cells.
Zhang X, Li PF, Gao Y, Zheng PS
International journal of biological macromolecules 2026 Jan;338(Pt 1):149672
International journal of biological macromolecules 2026 Jan;338(Pt 1):149672
SPON2 acts as a tumor promoter in HR-positive/HER2-negative breast cancer by regulating β-catenin signaling.
Liu GY, Huang DP, Ge C, Li XY, Chen F, Fan JS, Tu HP
Clinical breast cancer 2026 Jan;26(1):298-305
Clinical breast cancer 2026 Jan;26(1):298-305
Impaired natural killer cell maturation in lung adenocarcinoma driven by FABP4 and SPON2 downregulation through disrupted lipid metabolism.
Tian H, Li K, Chen J, Guo W, Guo Z, Zhang S, Xie Z, Huang X, Wu S, Zhong W
Translational lung cancer research 2025 May 30;14(5):1660-1676
Translational lung cancer research 2025 May 30;14(5):1660-1676
Combining Spatial Transcriptomics, Pseudotime, and Machine Learning Enables Discovery of Biomarkers for Prostate Cancer.
Smelik M, Diaz-Roncero Gonzalez D, An X, Heer R, Henningsohn L, Li X, Wang H, Zhao Y, Benson M
Cancer research 2025 Jul 2;85(13):2514-2526
Cancer research 2025 Jul 2;85(13):2514-2526
Spatial immune scoring system predicts hepatocellular carcinoma recurrence.
Jia G, He P, Dai T, Goh D, Wang J, Sun M, Wee F, Li F, Lim JCT, Hao S, Liu Y, Lim TKH, Ngo NT, Tao Q, Wang W, Umar A, Nashan B, Zhang Y, Ding C, Yeong J, Liu L, Sun C
Nature 2025 Apr;640(8060):1031-1041
Nature 2025 Apr;640(8060):1031-1041
Knockdown of SPON2 inhibits the growth of triple-negative breast cancer.
Hu X, Su C, Wei J
Frontiers in oncology 2023;13:1141417
Frontiers in oncology 2023;13:1141417
Integrative Analysis of DNA Methylation and Transcriptome Identifies a Predictive Epigenetic Signature Associated With Immune Infiltration in Gliomas.
Zhang J, Yin J, Luo L, Huang D, Zhai D, Wang G, Xu N, Yang M, Song Y, Zheng G, Zhang Q
Frontiers in cell and developmental biology 2021;9:670854
Frontiers in cell and developmental biology 2021;9:670854
Transcriptional Activation of Matricellular Protein Spondin2 (SPON2) by BRG1 in Vascular Endothelial Cells Promotes Macrophage Chemotaxis.
Li N, Liu S, Zhang Y, Yu L, Hu Y, Wu T, Fang M, Xu Y
Frontiers in cell and developmental biology 2020;8:794
Frontiers in cell and developmental biology 2020;8:794
Spondin 2 promotes the proliferation, migration and invasion of gastric cancer cells.
Lu H, Feng Y, Hu Y, Guo Y, Liu Y, Mao Q, Xue W
Journal of cellular and molecular medicine 2020 Jan;24(1):98-113
Journal of cellular and molecular medicine 2020 Jan;24(1):98-113
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human prostate cancer using 20513-1-AP(SPON2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SPON2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human SPON2. This antibody recognizes human antigen. The SPON2 antibody has been validated for the following applications: ELISA, IHC analysis.
