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- Antigen structure
- References [23]
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- Product number
- 16796-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16796-1-AP, RRID:AB_2266644
- Product name
- MPP8 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MPP8 antibody (Cat. #16796-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Co-transcriptional genome surveillance by HUSH is coupled to termination machinery.
Characterization of Hepatoma-Derived Growth Factor-Related Protein 2 Interactions with Heterochromatin.
MPP8 Governs the Activity of the LIF/STAT3 Pathway and Plays a Crucial Role in the Differentiation of Mouse Embryonic Stem Cells.
Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression.
Genome surveillance by HUSH-mediated silencing of intronless mobile elements.
Discovery of Potent Peptidomimetic Antagonists for Heterochromatin Protein 1 Family Proteins.
Epigenetic Silencing of Recombinant Adeno-associated Virus Genomes by NP220 and the HUSH Complex.
A Peptidomimetic Ligand Targeting the Chromodomain of MPP8 Reveals HRP2's Association with the HUSH Complex.
Silencing of LINE-1 retrotransposons is a selective dependency of myeloid leukemia.
MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells.
Comprehensive nucleosome interactome screen establishes fundamental principles of nucleosome binding.
TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control.
The HUSH complex is a gatekeeper of type I interferon through epigenetic regulation of LINE-1s.
M-phase phosphoprotein 8 promotes gastric cancer growth and metastasis via p53/Bcl-2 and EMT-related signaling pathways.
Pathway-Based High-Throughput Chemical Screen Identifies Compounds That Decouple Heterochromatin Transformations.
The H3K9 Methylation Writer SETDB1 and its Reader MPP8 Cooperate to Silence Satellite DNA Repeats in Mouse Embryonic Stem Cells.
Tri-methylation of ATF7IP by G9a/GLP recruits the chromodomain protein MPP8.
Primate immunodeficiency virus proteins Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex.
Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.
Characterization of a core region in the A2UCOE that confers effective anti-silencing activity.
Physical interaction between MPP8 and PRC1 complex and its implication for regulation of spermatogenesis.
GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.
Mitotic phosphorylation of MPP8 by cyclin-dependent kinases regulates chromatin dissociation.
Spencley AL, Bar S, Swigut T, Flynn RA, Lee CH, Chen LF, Bassik MC, Wysocka J
Molecular cell 2023 May 18;83(10):1623-1639.e8
Molecular cell 2023 May 18;83(10):1623-1639.e8
Characterization of Hepatoma-Derived Growth Factor-Related Protein 2 Interactions with Heterochromatin.
Wistner SC, MacDonald IA, Stanley KA, Hathaway NA
Cells 2023 Jan 14;12(2)
Cells 2023 Jan 14;12(2)
MPP8 Governs the Activity of the LIF/STAT3 Pathway and Plays a Crucial Role in the Differentiation of Mouse Embryonic Stem Cells.
Zhang H, Yang T, Wu H, Yi W, Dai C, Chen X, Zhang W, Ye Y
Cells 2023 Aug 8;12(16)
Cells 2023 Aug 8;12(16)
Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression.
Garland W, Müller I, Wu M, Schmid M, Imamura K, Rib L, Sandelin A, Helin K, Jensen TH
Molecular cell 2022 May 5;82(9):1691-1707.e8
Molecular cell 2022 May 5;82(9):1691-1707.e8
Genome surveillance by HUSH-mediated silencing of intronless mobile elements.
Seczynska M, Bloor S, Cuesta SM, Lehner PJ
Nature 2022 Jan;601(7893):440-445
Nature 2022 Jan;601(7893):440-445
Discovery of Potent Peptidomimetic Antagonists for Heterochromatin Protein 1 Family Proteins.
Lamb KN, Dishman SN, Waybright JM, Engelberg IA, Rectenwald JM, Norris-Drouin JL, Cholensky SH, Pearce KH, James LI, Frye SV
ACS omega 2022 Jan 11;7(1):716-732
ACS omega 2022 Jan 11;7(1):716-732
Epigenetic Silencing of Recombinant Adeno-associated Virus Genomes by NP220 and the HUSH Complex.
Das A, Vijayan M, Walton EM, Stafford VG, Fiflis DN, Asokan A
Journal of virology 2022 Feb 23;96(4):e0203921
Journal of virology 2022 Feb 23;96(4):e0203921
A Peptidomimetic Ligand Targeting the Chromodomain of MPP8 Reveals HRP2's Association with the HUSH Complex.
Waybright JM, Clinkscales SE, Barnash KD, Budziszewski GR, Rectenwald JM, Chiarella AM, Norris-Drouin JL, Cholensky SH, Pearce KH, Herring LE, McGinty RK, Hathaway NA, James LI
ACS chemical biology 2021 Sep 17;16(9):1721-1736
ACS chemical biology 2021 Sep 17;16(9):1721-1736
Silencing of LINE-1 retrotransposons is a selective dependency of myeloid leukemia.
Gu Z, Liu Y, Zhang Y, Cao H, Lyu J, Wang X, Wylie A, Newkirk SJ, Jones AE, Lee M Jr, Botten GA, Deng M, Dickerson KE, Zhang CC, An W, Abrams JM, Xu J
Nature genetics 2021 May;53(5):672-682
Nature genetics 2021 May;53(5):672-682
MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells.
Müller I, Moroni AS, Shlyueva D, Sahadevan S, Schoof EM, Radzisheuskaya A, Højfeldt JW, Tatar T, Koche RP, Huang C, Helin K
Nature communications 2021 May 24;12(1):3034
Nature communications 2021 May 24;12(1):3034
Comprehensive nucleosome interactome screen establishes fundamental principles of nucleosome binding.
Skrajna A, Goldfarb D, Kedziora KM, Cousins EM, Grant GD, Spangler CJ, Barbour EH, Yan X, Hathaway NA, Brown NG, Cook JG, Major MB, McGinty RK
Nucleic acids research 2020 Sep 25;48(17):9415-9432
Nucleic acids research 2020 Sep 25;48(17):9415-9432
TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control.
Douse CH, Tchasovnikarova IA, Timms RT, Protasio AV, Seczynska M, Prigozhin DM, Albecka A, Wagstaff J, Williamson JC, Freund SMV, Lehner PJ, Modis Y
Nature communications 2020 Oct 2;11(1):4940
Nature communications 2020 Oct 2;11(1):4940
The HUSH complex is a gatekeeper of type I interferon through epigenetic regulation of LINE-1s.
Tunbak H, Enriquez-Gasca R, Tie CHC, Gould PA, Mlcochova P, Gupta RK, Fernandes L, Holt J, van der Veen AG, Giampazolias E, Burns KH, Maillard PV, Rowe HM
Nature communications 2020 Nov 3;11(1):5387
Nature communications 2020 Nov 3;11(1):5387
M-phase phosphoprotein 8 promotes gastric cancer growth and metastasis via p53/Bcl-2 and EMT-related signaling pathways.
Wang Y, Xiao H, Wang C, Wu H, He H, Yao C, Cui J, Li W
Journal of cellular biochemistry 2020 Mar;121(3):2330-2342
Journal of cellular biochemistry 2020 Mar;121(3):2330-2342
Pathway-Based High-Throughput Chemical Screen Identifies Compounds That Decouple Heterochromatin Transformations.
MacDonald IA, Butler KV, Herring LE, Clinkscales SE, Yelagandula R, Stecher K, Bell O, Graves LM, Jin J, Hathaway NA
SLAS discovery : advancing life sciences R & D 2019 Sep;24(8):802-816
SLAS discovery : advancing life sciences R & D 2019 Sep;24(8):802-816
The H3K9 Methylation Writer SETDB1 and its Reader MPP8 Cooperate to Silence Satellite DNA Repeats in Mouse Embryonic Stem Cells.
Cruz-Tapias P, Robin P, Pontis J, Maestro LD, Ait-Si-Ali S
Genes 2019 Sep 25;10(10)
Genes 2019 Sep 25;10(10)
Tri-methylation of ATF7IP by G9a/GLP recruits the chromodomain protein MPP8.
Tsusaka T, Kikuchi M, Shimazu T, Suzuki T, Sohtome Y, Akakabe M, Sodeoka M, Dohmae N, Umehara T, Shinkai Y
Epigenetics & chromatin 2018 Oct 4;11(1):56
Epigenetics & chromatin 2018 Oct 4;11(1):56
Primate immunodeficiency virus proteins Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex.
Yurkovetskiy L, Guney MH, Kim K, Goh SL, McCauley S, Dauphin A, Diehl WE, Luban J
Nature microbiology 2018 Dec;3(12):1354-1361
Nature microbiology 2018 Dec;3(12):1354-1361
Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.
Tchasovnikarova IA, Timms RT, Douse CH, Roberts RC, Dougan G, Kingston RE, Modis Y, Lehner PJ
Nature genetics 2017 Jul;49(7):1035-1044
Nature genetics 2017 Jul;49(7):1035-1044
Characterization of a core region in the A2UCOE that confers effective anti-silencing activity.
Zhang F, Santilli G, Thrasher AJ
Scientific reports 2017 Aug 31;7(1):10213
Scientific reports 2017 Aug 31;7(1):10213
Physical interaction between MPP8 and PRC1 complex and its implication for regulation of spermatogenesis.
Murata K, Sato S, Haruta M, Goshima T, Chiba Y, Takahashi S, Sharif J, Koseki H, Nakanishi M, Shimada M
Biochemical and biophysical research communications 2015 Mar 13;458(3):470-475
Biochemical and biophysical research communications 2015 Mar 13;458(3):470-475
GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.
Tchasovnikarova IA, Timms RT, Matheson NJ, Wals K, Antrobus R, Göttgens B, Dougan G, Dawson MA, Lehner PJ
Science (New York, N.Y.) 2015 Jun 26;348(6242):1481-1485
Science (New York, N.Y.) 2015 Jun 26;348(6242):1481-1485
Mitotic phosphorylation of MPP8 by cyclin-dependent kinases regulates chromatin dissociation.
Nishigaki M, Kawada Y, Misaki T, Murata K, Goshima T, Hirokawa T, Yamada C, Shimada M, Nakanishi M
Biochemical and biophysical research communications 2013 Mar 22;432(4):654-9
Biochemical and biophysical research communications 2013 Mar 22;432(4):654-9
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MPP8 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MPP8. This antibody recognizes human,mouse,rat antigen. The MPP8 antibody has been validated for the following applications: ELISA, WB analysis.
