NKX1-1

This gene encodes a transcription factor that belongs to NKX family of homeodomain-containing proteins which are critical regulators of organ development. In mice, the orthologous gene is expressed predominantly in the brainstem, in the vicinity of serotonergic neurons, and is required for the coordinated crosstalk of factors involved in the maintenance of energy homeostasis. Mice with a knockout of the orthologous gene lack subcutaneous fat and intra-abdominal epididymal and mesenteric white adipose tissue two weeks after birth, and die within three weeks after birth. [provided by RefSeq, Jul 2017]

Description

NK1 homeobox 1

Tissue specificity

Not detected

Subcell location

Nucleoli fibrillar center, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Transcription factors

Chromosome

4 (1402932 - 1406442)

Ensembl ID

ENSG00000235608  (ver. 103.38)

Orthologs

Mouse Nkx1-1: ENSMUSG00000029112

UniProt

Q15270

neXtProt

NX_Q15270

Human splice variants
Mouse splice variants

Protein structure