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- Antibody Data
- Antigen structure
- References [19]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 11870-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11870-1-AP, RRID:AB_2215230
- Product name
- VPS37A antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated VPS37A antibody (Cat. #11870-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Transferrin receptor controls both autophagosome formation and closure via phosphatidylinositol 3-phosphate synthesis.
ESCRT-I and PTPN23 mediate microautophagy of ubiquitylated tau aggregates.
Inactivation of necroptosis-promoting protein MLKL creates a therapeutic vulnerability in colorectal cancer cells.
NFκB and JNK pathways mediate metabolic adaptation upon ESCRT-I deficiency.
Transcription factor Nrf1 regulates proteotoxic stress-induced autophagy.
Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain.
Removal of hypersignaling endosomes by simaphagy.
UMAD1 contributes to ESCRT-III dynamic subunit turnover during cytokinetic abscission.
Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes.
Endofin is required for HD-PTP and ESCRT-0 interdependent endosomal sorting of ubiquitinated transmembrane cargoes.
HCRP-1 regulates cell migration, invasion and angiogenesis via Src/ FAK signaling in human prostate cancer.
MicroRNA-19a acts as a prognostic marker and promotes prostate cancer progression via inhibiting VPS37A expression.
HCRP-1 regulates EGFR-AKT-BIM-mediated anoikis resistance and serves as a prognostic marker in human colon cancer.
HCRP1 downregulation confers poor prognosis and induces chemoresistance through regulation of EGFR-AKT pathway in human gastric cancer.
HCRP-1 regulates cell migration and invasion via EGFR-ERK mediated up-regulation of MMP-2 with prognostic significance in human renal cell carcinoma.
The molecular basis for selective assembly of the UBAP1-containing endosome-specific ESCRT-I complex.
The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain.
A founder mutation in Vps37A causes autosomal recessive complex hereditary spastic paraparesis.
UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting.
Puri C, Park SJ, Wrobel L, Rubinsztein DC
Developmental cell 2025 Oct 20;60(20):2715-2729.e8
Developmental cell 2025 Oct 20;60(20):2715-2729.e8
ESCRT-I and PTPN23 mediate microautophagy of ubiquitylated tau aggregates.
Men Y, Hirayama S, Ao S, Sakurai Y, Shibata Y, Lo M, Sato Y, Murata S
The Journal of cell biology 2025 Jun 2;224(6)
The Journal of cell biology 2025 Jun 2;224(6)
Inactivation of necroptosis-promoting protein MLKL creates a therapeutic vulnerability in colorectal cancer cells.
Jiang P, Chipurupalli S, Yoo BH, Liu X, Rosen KV
Cell death & disease 2025 Feb 20;16(1):118
Cell death & disease 2025 Feb 20;16(1):118
NFκB and JNK pathways mediate metabolic adaptation upon ESCRT-I deficiency.
Cendrowski J, Wrobel M, Mazur M, Jary B, Maurya R, Wang S, Korostynski M, Dziewulska A, Rohm M, Kuropka P, Pudelko-Malik N, Mlynarz P, Dobrzyn A, Zeigerer A, Miaczynska M
Cellular and molecular life sciences : CMLS 2024 Nov 19;81(1):458
Cellular and molecular life sciences : CMLS 2024 Nov 19;81(1):458
Transcription factor Nrf1 regulates proteotoxic stress-induced autophagy.
Ward MA, Vangala JR, Kamber Kaya HE, Byers HA, Hosseini N, Diaz A, Cuervo AM, Kaushik S, Radhakrishnan SK
The Journal of cell biology 2024 Jun 3;223(6)
The Journal of cell biology 2024 Jun 3;223(6)
Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain.
Hamamoto K, Liang X, Ito A, Lanza M, Bui V, Zhang J, Opozda DM, Hattori T, Chen L, Haddock D, Imamura F, Wang HG, Takahashi Y
Cell reports 2024 Dec 24;43(12):115016
Cell reports 2024 Dec 24;43(12):115016
Removal of hypersignaling endosomes by simaphagy.
Migliano SM, Schultz SW, Wenzel EM, Takáts S, Liu D, Mørk S, Tan KW, Rusten TE, Raiborg C, Stenmark H
Autophagy 2024 Apr;20(4):769-791
Autophagy 2024 Apr;20(4):769-791
UMAD1 contributes to ESCRT-III dynamic subunit turnover during cytokinetic abscission.
Glover J, Scourfield EJ, Ventimiglia LN, Yang X, Lynham S, Agromayor M, Martin-Serrano J
Journal of cell science 2023 Aug 1;136(15)
Journal of cell science 2023 Aug 1;136(15)
Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes.
Sekar R, Motzler K, Kwon Y, Novikoff A, Jülg J, Najafi B, Wang S, Warnke AL, Seitz S, Hass D, Gancheva S, Kahl S, Yang B, Finan B, Schwarz K, Okun JG, Roden M, Blüher M, Müller TD, Krahmer N, Behrends C, Plettenburg O, Miaczynska M, Herzig S, Zeigerer A
Cell metabolism 2022 Nov 1;34(11):1824-1842.e9
Cell metabolism 2022 Nov 1;34(11):1824-1842.e9
Endofin is required for HD-PTP and ESCRT-0 interdependent endosomal sorting of ubiquitinated transmembrane cargoes.
Kazan JM, Desrochers G, Martin CE, Jeong H, Kharitidi D, Apaja PM, Roldan A, St Denis N, Gingras AC, Lukacs GL, Pause A
iScience 2021 Nov 19;24(11):103274
iScience 2021 Nov 19;24(11):103274
HCRP-1 regulates cell migration, invasion and angiogenesis via Src/ FAK signaling in human prostate cancer.
Chen F, Wu J, Teng J, Li W, Zheng J, Bai J
International journal of biological sciences 2020;16(2):342-352
International journal of biological sciences 2020;16(2):342-352
MicroRNA-19a acts as a prognostic marker and promotes prostate cancer progression via inhibiting VPS37A expression.
Fu F, Wan X, Wang D, Kong Z, Zhang Y, Huang W, Wang C, Wu H, Li Y
Oncotarget 2018 Jan 5;9(2):1931-1943
Oncotarget 2018 Jan 5;9(2):1931-1943
HCRP-1 regulates EGFR-AKT-BIM-mediated anoikis resistance and serves as a prognostic marker in human colon cancer.
Chen F, Zhang L, Wu J, Huo F, Ren X, Zheng J, Pei D
Cell death & disease 2018 Dec 5;9(12):1176
Cell death & disease 2018 Dec 5;9(12):1176
HCRP1 downregulation confers poor prognosis and induces chemoresistance through regulation of EGFR-AKT pathway in human gastric cancer.
Xu H, Miao ZF, Wang ZN, Zhao TT, Xu YY, Song YX, Huang JY, Zhang JY, Liu XY, Wu JH, Xu HM
Virchows Archiv : an international journal of pathology 2017 Dec;471(6):743-751
Virchows Archiv : an international journal of pathology 2017 Dec;471(6):743-751
HCRP-1 regulates cell migration and invasion via EGFR-ERK mediated up-regulation of MMP-2 with prognostic significance in human renal cell carcinoma.
Chen F, Deng J, Liu X, Li W, Zheng J
Scientific reports 2015 Aug 25;5:13470
Scientific reports 2015 Aug 25;5:13470
The molecular basis for selective assembly of the UBAP1-containing endosome-specific ESCRT-I complex.
Wunderley L, Brownhill K, Stefani F, Tabernero L, Woodman P
Journal of cell science 2014 Feb 1;127(Pt 3):663-72
Journal of cell science 2014 Feb 1;127(Pt 3):663-72
The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain.
Agromayor M, Soler N, Caballe A, Kueck T, Freund SM, Allen MD, Bycroft M, Perisic O, Ye Y, McDonald B, Scheel H, Hofmann K, Neil SJ, Martin-Serrano J, Williams RL
Structure (London, England : 1993) 2012 Mar 7;20(3):414-28
Structure (London, England : 1993) 2012 Mar 7;20(3):414-28
A founder mutation in Vps37A causes autosomal recessive complex hereditary spastic paraparesis.
Zivony-Elboum Y, Westbroek W, Kfir N, Savitzki D, Shoval Y, Bloom A, Rod R, Khayat M, Gross B, Samri W, Cohen H, Sonkin V, Freidman T, Geiger D, Fattal-Valevski A, Anikster Y, Waters AM, Kleta R, Falik-Zaccai TC
Journal of medical genetics 2012 Jul;49(7):462-72
Journal of medical genetics 2012 Jul;49(7):462-72
UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting.
Stefani F, Zhang L, Taylor S, Donovan J, Rollinson S, Doyotte A, Brownhill K, Bennion J, Pickering-Brown S, Woodman P
Current biology : CB 2011 Jul 26;21(14):1245-50
Current biology : CB 2011 Jul 26;21(14):1245-50
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human liver tissue were subjected to SDS PAGE followed by western blot with 11870-1-AP(VPS37A antibody) at dilution of 1:400
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The VPS37A antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human VPS37A. This antibody recognizes human, mouse, rat antigen. The VPS37A antibody has been validated for the following applications: ELISA, WB, IHC analysis.
